Limiting Factors in Murine Hematopoietic Stem Cell Assays

Cell Stem Cell

Volumn 1, Issue 3, 2007, Pages 263-270

  Purton, Louise E ^a   Scadden, David T ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD150 ANTIGEN; RHODAMINE 123;

BONE MARROW CELL; CELL ASSAY; CELL COUNT; CELL CULTURE; CELL DIFFERENTIATION; CELL FUNCTION; CELL GROWTH; CELL LINEAGE; CELL POPULATION; CELL PROLIFERATION; COLONY FORMING CELL; CYTOLOGY; DILUTION; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HOST CELL; IMMUNOPHENOTYPING; IN VITRO STUDY; IN VIVO STUDY; MICROENVIRONMENT; MOLECULAR CLONING; NONHUMAN; ORGANOGENESIS; PRIORITY JOURNAL; PROGENY; PROTEIN FAMILY; RECIPIENT; REVIEW; STEM CELL TRANSPLANTATION; TISSUE REPAIR;

ANIMALS; COLONY-FORMING UNITS ASSAY; HEMATOPOIETIC STEM CELLS; IMMUNOPHENOTYPING; MICE;

MURINAE; MUS;

EID: 34548417118     PISSN: 19345909     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.stem.2007.08.016     Document Type: Review

References (66)

1. Abkowitz J.L., Golinelli D., Harrison D.E., and Guttorp P. In vivo kinetics of murine hemopoietic stem cells. Blood 96 (2000) 3399-3405
2. Adams G.B., Chabner K.T., Alley I.R., Olson D.P., Szczepiorkowski Z.M., Poznansky M.C., Kos C.H., Pollak M.R., Brown E.M., and Scadden D.T. Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptor. Nature 439 (2006) 599-603
3. Adolfsson J., Borge O.J., Bryder D., Theilgaard-Monch K., Astrand-Grundstrom I., Sitnicka E., Sasaki Y., and Jacobsen S.E. Upregulation of Flt3 expression within the bone marrow Lin(-)Sca1(+)c-kit(+) stem cell compartment is accompanied by loss of self-renewal capacity. Immunity 15 (2001) 659-669
4. Bradley T.R., and Metcalf D. The growth of mouse bone marrow cells in vitro. Aust. J. Exp. Biol. Med. Sci. 44 (1966) 287-300
5. Cancelas J.A., Lee A.W., Prabhakar R., Stringer K.F., Zheng Y., and Williams D.A. Rac GTPases differentially integrate signals regulating hematopoietic stem cell localization. Nat. Med. 11 (2005) 886-891
6. Challen G.A., and Little M.H. A side order of stem cells: the SP phenotype. Stem Cells 24 (2006) 3-12
7. Dykstra B., Kent D., Bowie M., McCaffrey L., Hamilton M., Lyons K., Lee S.-J., Brinkman R., and Eaves C. Long-term propagation of distinct hematopoietic differentiation programs in vivo. Cell Stem Cell 1 (2007) 218-229
8. Ema H., Sudo K., Seita J., Matsubara A., Morita Y., Osawa M., Takatsu K., Takaki S., and Nakauchi H. Quantification of self-renewal capacity in single hematopoietic stem cells from normal and Lnk-deficient mice. Dev. Cell 8 (2005) 907-914
9. Ema H., Morita Y., Yamazaki S., Matsubara A., Seita J., Tadokoro Y., Kondo H., Takano H., and Nakauchi H. Adult mouse hematopoietic stem cells: purification and single-cell assays. Nat. Protoc. 1 (2006) 2979-2987
10. Ford C.E., Hamerton J.L., Barnes D.W., and Loutit J.F. Cytological identification of radiation-chimaeras. Nature 177 (1956) 452-454
11. Geissler E.N., and Russell E.S. Analysis of the hematopoietic effects of new dominant spotting (W) mutations of the mouse. I. Influence upon hematopoietic stem cells. Exp. Hematol. 11 (1983) 452-460
12. Goldschneider I., Gordon L.K., and Morris R.J. Demonstration of Thy-1 antigen on pluripotent hemopoietic stem cells in the rat. J. Exp. Med. 148 (1978) 1351-1366
13. Goodell M.A., Brose K., Paradis G., Conner A.S., and Mulligan R.C. Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo. J. Exp. Med. 183 (1996) 1797-1806
14. Harrison D.E. Competitive repopulation: a new assay for long-term stem cell functional capacity. Blood 55 (1980) 77-81
15. Harrison D.E., Jordan C.T., Zhong R.K., and Astle C.M. Primitive hemopoietic stem cells: direct assay of most productive populations by competitive repopulation with simple binomial, correlation and covariance calculations. Exp. Hematol. 21 (1993) 206-219
16. Ichikawa M., Asai T., Saito T., Seo S., Yamazaki I., Yamagata T., Mitani K., Chiba S., Ogawa S., Kurokawa M., and Hirai H. AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis. Nat. Med. 10 (2004) 299-304
17. Ikuta K., and Weissman I.L. Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation. Proc. Natl. Acad. Sci. USA 89 (1992) 1502-1506
18. Jansen M., Yang F.C., Cancelas J.A., Bailey J.R., and Williams D.A. Rac2-deficient hematopoietic stem cells show defective interaction with the hematopoietic microenvironment and long-term engraftment failure. Stem Cells 23 (2005) 335-346
19. Janzen V., Forkert R., Fleming H.E., Saito Y., Waring M.T., Dombkowski D.M., Cheng T., DePinho R.A., Sharpless N.E., and Scadden D.T. Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a. Nature 443 (2006) 421-426
20. Jordan C.T., and Lemischka I.R. Clonal and systemic analysis of long-term hematopoiesis in the mouse. Genes Dev. 4 (1990) 220-232
21. Kiel M.J., Yilmaz O.H., Iwashita T., Yilmaz O.H., Terhorst C., and Morrison S.J. SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell 121 (2005) 1109-1121
22. Lawrence H.J., Christensen J., Fong S., Hu Y.L., Weissman I., Sauvageau G., Humphries R.K., and Largman C. Loss of expression of the Hoxa-9 homeobox gene impairs the proliferation and repopulating ability of hematopoietic stem cells. Blood 106 (2005) 3988-3994
23. Lemischka I., Raulet D.H., and Mulligan R.C. Developmental potential and dynamic behaviour of hematopoietic stem cells. Cell 42 (1986) 917-927
24. Lemischka I.R., Raulet D.H., and Mulligan R.C. Developmental potential and dynamic behavior of hematopoietic stem cells. Cell 45 (1986) 917-927
25. Li C.L., and Johnson G.R. Rhodamine123 reveals heterogeneity within murine Lin-, Sca-1+ hemopoietic stem cells. J. Exp. Med. 175 (1992) 1443-1447
26. Liang Y., Jansen M., Aronow B., Geiger H., and Van Zant G. The quantitative trait gene latexin influences the size of the hematopoietic stem cell population in mice. Nat. Genet. 39 (2007) 178-188
27. Lin K.K., and Goodell M.A. Purification of hematopoietic stem cells using the side population. Methods Enzymol. 420 (2006) 255-264
28. Matsuoka S., Ebihara Y., Xu M., Ishii T., Sugiyama D., Yoshino H., Ueda T., Manabe A., Tanaka R., Ikeda Y., et al. CD34 expression on long-term repopulating hematopoietic stem cells changes during developmental stages. Blood 97 (2001) 419-425
29. Matsuzaki Y., Kinjo K., Mulligan R.C., and Okano H. Unexpectedly efficient homing capacity of purified murine hematopoietic stem cells. Immunity 20 (2004) 87-93
30. McAlister I., Wolf N.S., Pietrzyk M.E., Rabinovitch P.S., Priestley G., and Jaeger B. Transplantation of hematopoietic stem cells obtained by a combined dye method fractionation of murine bone marrow. Blood 75 (1990) 1240-1246
31. McCulloch E.A., and Till J.E. The radiation sensitivity of normal mouse bone marrow cells, determined by quantitative marrow transplantation into irradiated mice. Radiat. Res. 13 (1960) 115-125
32. Miller C.L., and Eaves C.J. Expansion in vitro of adult murine hematopoietic stem cells with transplantable lympho-myeloid reconstituting ability. Proc. Natl. Acad. Sci. USA 94 (1997) 13648-13653
33. Morrison S.J., Wandycz A.M., Akashi K., Globerson A., and Weissman I.L. The aging of hematopoietic stem cells. Nat. Med. 2 (1996) 1011-1016
34. Nocka K., Tan J.C., Chiu E., Chu T.Y., Ray P., Traktman P., and Besmer P. Molecular bases of dominant negative and loss of function mutations at the murine c-kit/white spotting locus: W37, Wv, W41 and W. EMBO J. 9 (1990) 1805-1813
35. Ogawa M., Matsuzaki Y., Nishikawa S., Hayashi S., Kunisada T., Sudo T., Kina T., Nakauchi H., and Nishikawa S. Expression and function of c-kit in hemopoietic progenitor cells. J. Exp. Med. 174 (1991) 63-71
36. Okada S., Nakauchi N., Nagayoshi K., Nishikawa S., Miura Y., and Suda T. In vivo and in vitro cell function of c-kit- and Sca-1-positive murine hematopoietic cells. Blood 80 (1992) 3044-3050
37. Osawa M., Hanada K., Hamada H., and Nakauchi H. Long-term lymphohematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell. Science 273 (1996) 242-245
38. Phillips R.L., Reinhart A.J., and Van Zant G. Genetic control of murine hematopoietic stem cell pool sizes and cycling kinetics. Proc. Natl. Acad. Sci. USA 89 (1992) 11607-11611
39. Purton L.E., Dworkin S., Olsen G.H., Walkley C.R., Fabb S.A., Collins S.J., and Chambon P. RAR{gamma} is critical for maintaining a balance between hematopoietic stem cell self-renewal and differentiation. J. Exp. Med. 203 (2006) 1283-1293
40. Reith A.D., Rottapel R., Giddens E., Brady C., Forrester L., and Bernstein A. W mutant mice with mild or severe developmental defects contain distinct point mutations in the kinase domain of the c-kit receptor. Genes Dev. 4 (1990) 390-400
41. Rosendaal M., Hodgson G.S., and Bradley T.R. Organization of haemopoietic stem cells: the generation-age hypothesis. Cell Tissue Kinet. 12 (1979) 17-29
42. Schmitt T.M., and Zuniga-Pflucker J.C. Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro. Immunity 17 (2002) 749-756
43. Spangrude G.J., and Brooks D.M. Phenotypic analysis of mouse hematopoietic stem cells shows a Thy-1-negative subset. Blood 80 (1992) 1957-1964
44. Spangrude G.J., and Brooks D.M. Mouse strain variability in the expression of the hematopoietic stem cell antigen Ly-6A/E by bone marrow cells. Blood 82 (1993) 3327-3332
45. Spangrude G.J., Heimfeld S., and Weissman I.L. Purification and characterization of mouse hematopoietic stem cells. Science 241 (1988) 58-62
46. Spangrude G.J., Brooks D.M., and Tumas D.B. Long-term repopulation of irradiated mice with limiting numbers of purified hematopoietic stem cells: in vivo expansion of stem cell phenotype but not function. Blood 85 (1995) 1006-1016
47. Szilvassy S.J., Lansdorp P.M., Humphries R.K., Eaves A.C., and Eaves C.J. Isolation in a single step of a highly enriched murine hematopoietic stem cell population with competitive long-term repopulating ability. Blood 74 (1989) 930-939
48. Szilvassy S.J., Humphries R.K., Lansdorp P.M., Eaves A.C., and Eaves C.J. Quantitative assay for totipotent reconstituting hematopoietic stem cells by a competitive repopulation strategy. Proc. Natl. Acad. Sci. USA 87 (1990) 8736-8740
49. Taswell C. Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis. J. Immunol. 126 (1981) 1614-1619
50. Till J., and McCulloch E. A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. Radiat. Res. 14 (1961) 213-222
51. Trevisan M., Yan X.Q., and Iscove N.N. Cycle initiation and colony formation in culture by murine marrow cells with long-term reconstituting potential in vivo. Blood 88 (1996) 4149-4158
52. Uchida N., and Weissman I.L. Searching for hematopoietic stem cells: evidence that Thy-1.1lo Lin- Sca-1+ cells are the only stem cells in C57BL/Ka-Thy-1.1 bone marrow. J. Exp. Med. 175 (1992) 175-184
53. van Os R., Kamminga L.M., and de Haan G. Stem cell assays: something old, something new, something borrowed. Stem Cells 22 (2004) 1181-1190
54. Visser J.W., and Bol S.J. A two-step procedure for obtaining 80-fold enriched suspensions of murine pluripotent hemopoietic stem cells. Stem Cells 1 (1982) 240-249
55. Visser J.W., Bol S.J., and van den Engh G. Characterization and enrichment of murine hemopoietic stem cells by fluorescence activated cell sorting. Exp. Hematol. 9 (1981) 644-655
56. Walkley C.R., and Orkin S.H. Rb is dispensable for self-renewal and multilineage differentiation of adult hematopoietic stem cells. Proc. Natl. Acad. Sci. USA 103 (2006) 9057-9062
57. Walkley C.R., Fero M.L., Chien W.M., Purton L.E., and McArthur G.A. Negative cell-cycle regulators cooperatively control self-renewal and differentiation of haematopoietic stem cells. Nat. Cell Biol. 7 (2005) 172-178
58. Walkley C.R., McArthur G.A., and Purton L.E. Cell division and hematopoietic stem cells: not always exhausting. Cell Cycle 4 (2005) 893-896
59. Walkley C.R., Olsen G.H., Dworkin S., Fabb S.A., Swann J., McArthur G.A., Westmoreland S.V., Chambon P., Scadden D.T., and Purton L.E. A microenvironment-induced myeloproliferative syndrome caused by retinoic acid receptor gamma deficiency. Cell 129 (2007) 1097-1110
60. Walkley C.R., Shea J.M., Sims N.A., Purton L.E., and Orkin S.H. Rb regulates interactions between hematopoietic stem cells and their bone marrow microenvironment. Cell 129 (2007) 1081-1095
61. Whitlock C.A., and Witte O.N. Long-term culture of B lymphocytes and their precursors from murine bone marrow. Proc. Natl. Acad. Sci. USA 79 (1982) 3608-3612
62. Wolf N.S., Kone A., Priestley G.V., and Bartelmez S.H. In vivo and in vitro characterization of long-term repopulating primitive hematopoietic cells isolated by sequential Hoechst 33342-rhodamine 123 FACS selection. Exp. Hematol. 21 (1993) 614-622
63. Yang L., Bryder D., Adolfsson J., Nygren J., Mansson R., Sigvardsson M., and Jacobsen S.E. Identification of Lin(-)Sca1(+)kit(+)CD34(+)Flt3-short-term hematopoietic stem cells capable of rapidly reconstituting and rescuing myeloablated transplant recipients. Blood 105 (2005) 2717-2723
64. Yilmaz O.H., Kiel M.J., and Morrison S.J. SLAM family markers are conserved among hematopoietic stem cells from old and reconstituted mice and markedly increase their purity. Blood 107 (2006) 924-930
65. Yuan R., Astle C.M., Chen J., and Harrison D.E. Genetic regulation of hematopoietic stem cell exhaustion during development and growth. Exp. Hematol. 33 (2005) 243-250
66. Zhang C.C., Kaba M., Ge G., Xie K., Tong W., Hug C., and Lodish H.F. Angiopoietin-like proteins stimulate ex vivo expansion of hematopoietic stem cells. Nat. Med. 12 (2006) 240-245