Stem cell repopulation efficiency but not pool size is governed by p27(kip1)

Nature Medicine

Volumn 6, Issue 11, 2000, Pages 1235-1240

  Cheng, T ^a   Rodrigues, N ^a   Dombkowski, D ^a   Stier, S ^a   Scadden, D T ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE; PROTEIN P21; PROTEIN P27;

ARTICLE; CELL KINETICS; CELL RENEWAL; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANIMALS; BONE MARROW CELLS; CELL CYCLE; CELL CYCLE PROTEINS; CELLS, CULTURED; COLONY-FORMING UNITS ASSAY; CROSSES, GENETIC; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLIN-DEPENDENT KINASES; FEMALE; FLOW CYTOMETRY; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; HETEROZYGOTE; HOMOZYGOTE; MICE; MICE, INBRED STRAINS; MICE, KNOCKOUT; MICROTUBULE-ASSOCIATED PROTEINS; TUMOR SUPPRESSOR PROTEINS;

EID: 0033694302     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/81335     Document Type: Article

References (45)

1. Stem cell self-renewal considerations in bone marrow transplantation
2. Hematopoietic stem cell compartment: Acute and late effects of radiation therapy and chemotherapy
3. Hematopoietic precursor cell exhaustion is a cause of proliferative defect in primitive hematopoietic stem cells (PHSC) after chemotherapy
4. Hematopoietic stem cell quiescence maintained by p21 (cip1/waf1)
5. p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest
6. Inhibitors of mammalian G1 cyclin-dependent kinases
7. Cancer cell cycles
8. Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1)
9. A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice
10. Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors
11. Complex regulation of CDK2 during phorbol ester-induced hematopoietic differentiation
12. Transcriptional activation of the human p21(WAF1/CIP1) gene by retinoic acid receptor. Correlation with retinoid induction of U937 cell differentiation
13. Inhibition of cyclin-dependent kinase activity triggers neuronal differentiation of mouse neuroblastoma cells
14. Requirement of p27Kip1 for restriction point control of the fibroblast cell cycle
15. Abrogation of p27Kip1 by cDNA antisense suppresses quiescence (G0 state) in fibroblasts
16. Translational control of p27Kip1 accumulation during the cell cycle
17. Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27
18. p27(Kip1) regulates cell cycle withdrawal of late multipotent progenitor cells in the mammalian retina
19. p27Kip1 alters the response of cells to mitogen and is part of a cell-intrinsic timer that arrests the cell cycle and initiates differentiation
20. TGF-β suppresses cell division of Go CD34+ cells while maintaining primitive hematopoietic potential
21. Expression of p21(Cip1/Waf1/Sdi1) and p27(Kip1) cyclin-dependent kinase inhibitors during human hematopoiesis
22. Subcellular and cell-cycle expression profiles of CDK-inhibitors in normal differentiating myeloid cells
23. Reduction in levels of the cyclin-dependent kinase inhibitor p27(kip-1) coupled with transforming growth factor beta neutralization induces cell-cycle entry and increases retroviral transduction of primitive human hematopoietic cell
24. An in vitro limiting-dilution assay of long-term repopulating hematopoietic stem cells in the mouse
25. Use of limiting-dilution type long-term marrow cultures in frequency analysis of marrow-repopulating and spleen colony-forming hematopoietic stem cells in the mouse
26. Involvement of p21cip-1 and p27kip-1 in the molecular mechanisms of steel factor-induced proliferative synergy in vitro and of p21cip-1 in the maintenance of stem/progenitor cells in vivo
27. Purification and characterization of mouse hematopoietic stem cells
28. Functional heterogeneity of human CD34(+) cells isolated in subcompartments of the G0/G1 phase of the cell cycle
29. 5-Fluorouracil spares hemopoietic stem cells responsible for long-term repopulation
30. Functional isolation and characterization of human hematopoietic stem cells
31. Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages
32. ES cells have only a limited lymphopoietic potential after adoptive transfer into mouse recipients
33. New fluorescent dyes for lymphocyte migration studies. Analysis by flow cytometry and fluorescence microscopy
34. Recombinant transforming growth factor beta 1 and beta 2 protect mice from acutely lethal doses of 5-fluorouracil and doxorubicin
35. Competitive repopulation: A new assay for long-term stem cell functional capacity
36. Quantitative assay for totipotent reconstituting hematopoietic stem cells by a competitive repopulation strategy
37. Intrinsic human immunodeficiency virus type 1 resistance of hematopoietic stem cells despite coreceptor expression
38. Adhesion receptor expression by hematopoietic cell lines and murine progenitors: Modulation by cytokines and cell cycle status
39. Expression and function of cell adhesion molecules on fetal liver, cord blood and bone marrow hematopoietic progenitors: Implications for anatomical localization and developmental stage specific regulation of hematopoiesis
40. Temporal mapping of gene expression levels during the differentiation of individual primary hematopoietic cells
41. The transcriptional control of hematopoiesis
42. Transcription factors, normal myeloid development, and leukemia
43. Expression of growth factor receptors in unilineage differentiation culture of purified hematopoietic progenitors
44. Low levels of erythroid and myeloid progenitors in thrombopoletin-and c-mpl-deficient mice
45. Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease