메뉴 건너뛰기




Volumn 61, Issue 4, 2012, Pages 559-565

Metabotropic glutamate receptors in neurodegeneration/neuroprotection: Still a hot topic?

Author keywords

Brain ischemia; Chronic neurodegenerative disorders; Metabotropic glutamate receptors; Neurodegeneration; Neuroprotection; Neurotrophic factors

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; 2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; 3 [(2 METHYL 4 THIAZOLYL)ETHYNYL]PYRIDINE; 4 AMINO 2 OXABICYCLO[3.1.0]HEXANE 4,6 DICARBOXYLIC ACID; BRAIN DERIVED NEUROTROPHIC FACTOR; LEVODOPA; METABOTROPIC RECEPTOR; METABOTROPIC RECEPTOR 1; METABOTROPIC RECEPTOR 2; METABOTROPIC RECEPTOR 3; METABOTROPIC RECEPTOR 4; METABOTROPIC RECEPTOR 5; METABOTROPIC RECEPTOR ANTAGONIST; N PHENYL 7 (HYDROXYIMINO)CYCLOPROPA[B]CHROMEN 1A CARBOXAMIDE; NERVE GROWTH FACTOR; NEURITE PROMOTING FACTOR; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

EID: 84865741390     PISSN: 01970186     EISSN: 18729754     Source Type: Journal    
DOI: 10.1016/j.neuint.2012.01.017     Document Type: Article
Times cited : (69)

References (122)
  • 1
    • 0024559799 scopus 로고
    • N-methyl-d-aspartate antagonists: Ready for clinical trial in brain ischemia?
    • G.W. Albers, M.P. Goldberg, and D.W. Choi N-methyl-d-aspartate antagonists: ready for clinical trial in brain ischemia? Ann. Neurol. 125 1989 398 403
    • (1989) Ann. Neurol. , vol.125 , pp. 398-403
    • Albers, G.W.1    Goldberg, M.P.2    Choi, D.W.3
  • 2
    • 0029031548 scopus 로고
    • Metabotropic glutamate receptors negatively coupled to adenylate cyclase inhibit N-methyl-d-aspartate receptor activity and prevent neurotoxicity in mesencephalic neurons in vitro
    • A. Ambrosini, L. Bresciani, S. Fracchia, N. Brunello, and G. Racagni Metabotropic glutamate receptors negatively coupled to adenylate cyclase inhibit N-methyl-d-aspartate receptor activity and prevent neurotoxicity in mesencephalic neurons in vitro Mol. Pharmacol. 47 1995 1057 1064
    • (1995) Mol. Pharmacol. , vol.47 , pp. 1057-1064
    • Ambrosini, A.1    Bresciani, L.2    Fracchia, S.3    Brunello, N.4    Racagni, G.5
  • 3
    • 33645090418 scopus 로고    scopus 로고
    • Prolonged blockade of NMDA or mGluR5 glutamate receptors reduces nigrostriatal degeneration while inducing selective metabolic changes in the basal ganglia circuitry in a rodent model of Parkinson's disease
    • M.T. Armentero, R. Fancellu, G. Nappi, P. Bramanti, and F. Blandini Prolonged blockade of NMDA or mGluR5 glutamate receptors reduces nigrostriatal degeneration while inducing selective metabolic changes in the basal ganglia circuitry in a rodent model of Parkinson's disease Neurobiol. Dis. 22 2006 1 9
    • (2006) Neurobiol. Dis. , vol.22 , pp. 1-9
    • Armentero, M.T.1    Fancellu, R.2    Nappi, G.3    Bramanti, P.4    Blandini, F.5
  • 4
    • 0035958752 scopus 로고    scopus 로고
    • Immunohistochemical localization of group i and II metabotropic glutamate receptors in control and amyotrophic lateral sclerosis human spinal cord: Upregulation in reactive astrocytes
    • E. Aronica, M.V. Catania, J. Geurts, B. Yankaya, and D. Troost Immunohistochemical localization of group I and II metabotropic glutamate receptors in control and amyotrophic lateral sclerosis human spinal cord: upregulation in reactive astrocytes Neuroscience 105 2001 509 520
    • (2001) Neuroscience , vol.105 , pp. 509-520
    • Aronica, E.1    Catania, M.V.2    Geurts, J.3    Yankaya, B.4    Troost, D.5
  • 5
    • 0038810014 scopus 로고    scopus 로고
    • Expression and functional role of mGluR3 and mGluR5 in human astrocytes and glioma cells: Opposite regulation of glutamate transporter proteins
    • E. Aronica, J.A. Gorter, H. Ijlst-Keizers, A.J. Rozemuller, B. Yankaya, S. Leenstra, and D. Troost Expression and functional role of mGluR3 and mGluR5 in human astrocytes and glioma cells: opposite regulation of glutamate transporter proteins Eur. J. Neurosci. 17 2003 2106 2118
    • (2003) Eur. J. Neurosci. , vol.17 , pp. 2106-2118
    • Aronica, E.1    Gorter, J.A.2    Ijlst-Keizers, H.3    Rozemuller, A.J.4    Yankaya, B.5    Leenstra, S.6    Troost, D.7
  • 6
    • 0035124349 scopus 로고    scopus 로고
    • Activation of type 5 metabotropic glutamate receptors enhances NMDA responses in mice cortical wedges
    • S. Attucci, V. Carlà, G. Mannaioni, and F. Moroni Activation of type 5 metabotropic glutamate receptors enhances NMDA responses in mice cortical wedges Br. J. Pharmacol. 132 2001 799 806
    • (2001) Br. J. Pharmacol. , vol.132 , pp. 799-806
    • Attucci, S.1    Carlà, V.2    Mannaioni, G.3    Moroni, F.4
  • 7
    • 1842293327 scopus 로고    scopus 로고
    • Metabotropic glutamate receptor mGluR5 in astrocytes: Pharmacological properties and agonist regulation
    • R. Balázs, S. Miller, C. Romano, A. de Vries, Y. Chun, and C.W. Cotman Metabotropic glutamate receptor mGluR5 in astrocytes: pharmacological properties and agonist regulation J. Neurochem. 69 1997 151 163
    • (1997) J. Neurochem. , vol.69 , pp. 151-163
    • Balázs, R.1    Miller, S.2    Romano, C.3    De Vries, A.4    Chun, Y.5    Cotman, C.W.6
  • 8
    • 0031786473 scopus 로고    scopus 로고
    • Selective activation of group-II metabotropic glutamate receptors is protective against excitotoxic neuronal death
    • G. Battaglia, V. Bruno, R.T. Ngomba, R. Di Grezia, A. Copani, and F. Nicoletti Selective activation of group-II metabotropic glutamate receptors is protective against excitotoxic neuronal death Eur. J. Pharmacol. 356 1998 271 274
    • (1998) Eur. J. Pharmacol. , vol.356 , pp. 271-274
    • Battaglia, G.1    Bruno, V.2    Ngomba, R.T.3    Di Grezia, R.4    Copani, A.5    Nicoletti, F.6
  • 9
    • 0034948146 scopus 로고    scopus 로고
    • Selective blockade of type-1 metabotropic glutamate receptors induces neuroprotection by enhancing gabaergic transmission
    • G. Battaglia, V. Bruno, A. Pisani, D. Centonze, M.V. Catania, P. Calabresi, and F. Nicoletti Selective blockade of type-1 metabotropic glutamate receptors induces neuroprotection by enhancing gabaergic transmission Mol. Cell. Neurosci. 17 2001 1071 1083
    • (2001) Mol. Cell. Neurosci. , vol.17 , pp. 1071-1083
    • Battaglia, G.1    Bruno, V.2    Pisani, A.3    Centonze, D.4    Catania, M.V.5    Calabresi, P.6    Nicoletti, F.7
  • 10
    • 0742322858 scopus 로고    scopus 로고
    • Endogenous activation of mGlu5 metabotropic glutamate receptors contributes to the development of nigro-striatal damage induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice
    • G. Battaglia, C.L. Busceti, G. Molinaro, F. Biagioni, M. Storto, F. Fornai, F. Nicoletti, and V. Bruno Endogenous activation of mGlu5 metabotropic glutamate receptors contributes to the development of nigro-striatal damage induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice J. Neurosci. 24 2004 828 835
    • (2004) J. Neurosci. , vol.24 , pp. 828-835
    • Battaglia, G.1    Busceti, C.L.2    Molinaro, G.3    Biagioni, F.4    Storto, M.5    Fornai, F.6    Nicoletti, F.7    Bruno, V.8
  • 11
    • 33746233386 scopus 로고    scopus 로고
    • Pharmacological activation of mGlu4 metabotropic glutamate receptors reduces nigrostriatal degeneration in mice treated with 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine
    • G. Battaglia, C.L. Busceti, G. Molinaro, F. Biagioni, A. Traficante, F. Nicoletti, and V. Bruno Pharmacological activation of mGlu4 metabotropic glutamate receptors reduces nigrostriatal degeneration in mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine J. Neurosci. 26 2006 7222 7229
    • (2006) J. Neurosci. , vol.26 , pp. 7222-7229
    • Battaglia, G.1    Busceti, C.L.2    Molinaro, G.3    Biagioni, F.4    Traficante, A.5    Nicoletti, F.6    Bruno, V.7
  • 16
    • 78049359990 scopus 로고    scopus 로고
    • Protective effect of metabotropic glutamate mGluR5 receptor elimination in a 6-hydroxydopamine model of Parkinson's disease
    • Y.D. Black, D. Xiao, D. Pellegrino, A. Kachroo, A.L. Brownell, and M.A. Schwarzschild Protective effect of metabotropic glutamate mGluR5 receptor elimination in a 6-hydroxydopamine model of Parkinson's disease Neurosci. Lett. 486 2010 161 165
    • (2010) Neurosci. Lett. , vol.486 , pp. 161-165
    • Black, Y.D.1    Xiao, D.2    Pellegrino, D.3    Kachroo, A.4    Brownell, A.L.5    Schwarzschild, M.A.6
  • 17
    • 0032550103 scopus 로고    scopus 로고
    • Neuroprotective effects of a systemically active group II metabotropic glutamate receptor agonist LY354740 in a gerbil model of global ischaemia
    • A. Bond, M.J. O'Neill, C.A. Hicks, J.A. Monn, and D. Lodge Neuroprotective effects of a systemically active group II metabotropic glutamate receptor agonist LY354740 in a gerbil model of global ischaemia Neuroreport 9 1998 1191 1193
    • (1998) Neuroreport , vol.9 , pp. 1191-1193
    • Bond, A.1    O'Neill, M.J.2    Hicks, C.A.3    Monn, J.A.4    Lodge, D.5
  • 18
    • 0032822044 scopus 로고    scopus 로고
    • LY379268, a potent and selective Group II metabotropic glutamate receptor agonist, is neuroprotective in gerbil global, but not focal, cerebral ischaemia
    • A. Bond, N. Ragumoorthy, J.A. Monn, C.A. Hicks, M.A. Ward, D. Lodge, and M.J. O'Neill LY379268, a potent and selective Group II metabotropic glutamate receptor agonist, is neuroprotective in gerbil global, but not focal, cerebral ischaemia Neurosci. Lett. 273 1999 191 194
    • (1999) Neurosci. Lett. , vol.273 , pp. 191-194
    • Bond, A.1    Ragumoorthy, N.2    Monn, J.A.3    Hicks, C.A.4    Ward, M.A.5    Lodge, D.6    O'Neill, M.J.7
  • 21
    • 0035499454 scopus 로고    scopus 로고
    • Ten years of protein kinase B signalling: A hard Akt to follow
    • D.P. Brazil, and B.A. Hemmings Ten years of protein kinase B signalling: a hard Akt to follow Trends Biochem. Sci. 26 2001 657 664
    • (2001) Trends Biochem. Sci. , vol.26 , pp. 657-664
    • Brazil, D.P.1    Hemmings, B.A.2
  • 22
    • 0028351384 scopus 로고
    • Protective effect of the metabotropic glutamate receptor agonist, DCG-IV, against excitotoxic neuronal death
    • V. Bruno, A. Copani, G. Battaglia, R. Raffaele, H. Shinozaki, and F. Nicoletti Protective effect of the metabotropic glutamate receptor agonist, DCG-IV, against excitotoxic neuronal death Eur. J. Pharmacol. 256 1994 109 112
    • (1994) Eur. J. Pharmacol. , vol.256 , pp. 109-112
    • Bruno, V.1    Copani, A.2    Battaglia, G.3    Raffaele, R.4    Shinozaki, H.5    Nicoletti, F.6
  • 23
    • 0029121515 scopus 로고
    • Activation of class II or class III metabotropic glutamate receptors protects cultured cortical neurons against excitotoxic degeneration
    • V. Bruno, G. Battaglia, A. Copani, R.G. Giffard, G. Raciti, R. Raffaele, H. Shinozaki, and F. Nicoletti Activation of class II or class III metabotropic glutamate receptors protects cultured cortical neurons against excitotoxic degeneration Eur. J. Neurosci. 7 1995 1906 1913
    • (1995) Eur. J. Neurosci. , vol.7 , pp. 1906-1913
    • Bruno, V.1    Battaglia, G.2    Copani, A.3    Giffard, R.G.4    Raciti, G.5    Raffaele, R.6    Shinozaki, H.7    Nicoletti, F.8
  • 25
    • 0031032470 scopus 로고    scopus 로고
    • The neuroprotective activity of group-II metabotropic glutamate receptors requires new protein synthesis and involves a glial-neuronal signaling
    • V. Bruno, F.X. Sureda, M. Storto, G. Casabona, A. Caruso, T. Knopfel, R. Kuhn, and F. Nicoletti The neuroprotective activity of group-II metabotropic glutamate receptors requires new protein synthesis and involves a glial-neuronal signaling J. Neurosci. 17 1997 1891 1897
    • (1997) J. Neurosci. , vol.17 , pp. 1891-1897
    • Bruno, V.1    Sureda, F.X.2    Storto, M.3    Casabona, G.4    Caruso, A.5    Knopfel, T.6    Kuhn, R.7    Nicoletti, F.8
  • 27
    • 0032403407 scopus 로고    scopus 로고
    • Neuroprotection by glial metabotropic glutamate receptors is mediated by transforming growth factor-beta
    • V. Bruno, G. Battaglia, G. Casabona, A. Copani, F. Caciagli, and F. Nicoletti Neuroprotection by glial metabotropic glutamate receptors is mediated by transforming growth factor-beta J. Neurosci. 18 1998 9594 9600
    • (1998) J. Neurosci. , vol.18 , pp. 9594-9600
    • Bruno, V.1    Battaglia, G.2    Casabona, G.3    Copani, A.4    Caciagli, F.5    Nicoletti, F.6
  • 30
    • 0029156276 scopus 로고
    • The inhibitory mGluR agonist, S-4-carboxy-3-hydroxy-phenylglycine selectively attenuates NMDA neurotoxicity and oxygen-glucose deprivation-induced neuronal death
    • A. Buisson, and D.W. Choi The inhibitory mGluR agonist, S-4-carboxy-3-hydroxy-phenylglycine selectively attenuates NMDA neurotoxicity and oxygen-glucose deprivation-induced neuronal death Neuropharmacology 34 1995 1081 1087
    • (1995) Neuropharmacology , vol.34 , pp. 1081-1087
    • Buisson, A.1    Choi, D.W.2
  • 31
    • 79951975389 scopus 로고    scopus 로고
    • Targeting group II metabotropic glutamate (mGlu) receptors for the treatment of psychosis associated with Alzheimer's disease: Selective activation of mGlu2 receptors amplifies beta-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective
    • F. Caraci, G. Molinaro, G. Battaglia, M.L. Giuffrida, B. Riozzi, A. Traficante, V. Bruno, M. Cannella, S. Merlo, X. Wang, B.A. Heinz, E.S. Nisenbaum, T.C. Britton, F. Drago, M.A. Sortino, A. Copani, and F. Nicoletti Targeting group II metabotropic glutamate (mGlu) receptors for the treatment of psychosis associated with Alzheimer's disease: selective activation of mGlu2 receptors amplifies beta-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective Mol. Pharmacol. 79 2011 618 626
    • (2011) Mol. Pharmacol. , vol.79 , pp. 618-626
    • Caraci, F.1    Molinaro, G.2    Battaglia, G.3    Giuffrida, M.L.4    Riozzi, B.5    Traficante, A.6    Bruno, V.7    Cannella, M.8    Merlo, S.9    Wang, X.10    Heinz, B.A.11    Nisenbaum, E.S.12    Britton, T.C.13    Drago, F.14    Sortino, M.A.15    Copani, A.16    Nicoletti, F.17
  • 34
    • 0024093449 scopus 로고
    • Glutamate neurotoxicity and diseases of the nervous system
    • D.W. Choi Glutamate neurotoxicity and diseases of the nervous system Neuron 1 1988 623 634
    • (1988) Neuron , vol.1 , pp. 623-634
    • Choi, D.W.1
  • 35
    • 0028016077 scopus 로고
    • Glutamate receptors and the induction of excitotoxic neuronal death
    • D.W. Choi Glutamate receptors and the induction of excitotoxic neuronal death Prog. Brain Res. 100 1994 47 51
    • (1994) Prog. Brain Res. , vol.100 , pp. 47-51
    • Choi, D.W.1
  • 36
    • 0033198777 scopus 로고    scopus 로고
    • Activation of A(1) adenosine or mGlu3 metabotropic glutamate receptors enhances the release of nerve growth factor and S-100beta protein from cultured astrocytes
    • R. Ciccarelli, P. Di Iorio, V. Bruno, G. Battaglia, I. D'Alimonte, M. D'Onofrio, F. Nicoletti, and F. Caciagli Activation of A(1) adenosine or mGlu3 metabotropic glutamate receptors enhances the release of nerve growth factor and S-100beta protein from cultured astrocytes Glia 27 1999 275 281
    • (1999) Glia , vol.27 , pp. 275-281
    • Ciccarelli, R.1    Di Iorio, P.2    Bruno, V.3    Battaglia, G.4    D'Alimonte, I.5    D'Onofrio, M.6    Nicoletti, F.7    Caciagli, F.8
  • 37
    • 77950344420 scopus 로고    scopus 로고
    • Alcohol-induced neurodegeneration, suppression of transforming growth factor-beta, and cognitive impairment in rats: Prevention by group II metabotropic glutamate receptor activation
    • A. Cippitelli, R. Damadzic, K. Frankola, A. Goldstein, A. Thorsell, E. Singley, R.L. Eskay, and M. Heilig Alcohol-induced neurodegeneration, suppression of transforming growth factor-beta, and cognitive impairment in rats: prevention by group II metabotropic glutamate receptor activation Biol. Psychiatry 67 2010 823 830
    • (2010) Biol. Psychiatry , vol.67 , pp. 823-830
    • Cippitelli, A.1    Damadzic, R.2    Frankola, K.3    Goldstein, A.4    Thorsell, A.5    Singley, E.6    Eskay, R.L.7    Heilig, M.8
  • 38
    • 27944470972 scopus 로고    scopus 로고
    • Metabotropic glutamate receptors in the basal ganglia motor circuit
    • P.J. Conn, G. Battaglia, M.J. Marino, and F. Nicoletti Metabotropic glutamate receptors in the basal ganglia motor circuit Nat. Rev. Neurosci. 6 2005 787 798
    • (2005) Nat. Rev. Neurosci. , vol.6 , pp. 787-798
    • Conn, P.J.1    Battaglia, G.2    Marino, M.J.3    Nicoletti, F.4
  • 39
    • 0029016730 scopus 로고
    • Activation of metabotropic glutamate receptors protects cultured neurons against apoptosis induced by beta-amyloid peptide
    • A. Copani, V. Bruno, G. Battaglia, G. Leanza, R. Pellitteri, A. Russo, S. Stanzani, and F. Nicoletti Activation of metabotropic glutamate receptors protects cultured neurons against apoptosis induced by beta-amyloid peptide Mol. Pharmacol. 47 1995 890 897
    • (1995) Mol. Pharmacol. , vol.47 , pp. 890-897
    • Copani, A.1    Bruno, V.2    Battaglia, G.3    Leanza, G.4    Pellitteri, R.5    Russo, A.6    Stanzani, S.7    Nicoletti, F.8
  • 40
    • 55249091338 scopus 로고    scopus 로고
    • The cell cycle molecules behind neurodegeneration in Alzheimer's disease: Perspectives for drug development
    • A. Copani, S. Guccione, L. Giurato, F. Caraci, M. Calafiore, M.A. Sortino, and F. Nicoletti The cell cycle molecules behind neurodegeneration in Alzheimer's disease: perspectives for drug development Curr. Med. Chem. 15 2008 2420 2432
    • (2008) Curr. Med. Chem. , vol.15 , pp. 2420-2432
    • Copani, A.1    Guccione, S.2    Giurato, L.3    Caraci, F.4    Calafiore, M.5    Sortino, M.A.6    Nicoletti, F.7
  • 41
    • 34547686245 scopus 로고    scopus 로고
    • The use of knock-out mice unravels distinct roles for mGlu2 and mGlu3 metabotropic glutamate receptors in mechanisms of neurodegeneration/ neuroprotection
    • C. Corti, G. Battaglia, G. Molinaro, B. Riozzi, A. Pittaluga, M. Corsi, M. Mugnaini, F. Nicoletti, and V. Bruno The use of knock-out mice unravels distinct roles for mGlu2 and mGlu3 metabotropic glutamate receptors in mechanisms of neurodegeneration/neuroprotection J. Neurosci. 27 2007 8297 8308
    • (2007) J. Neurosci. , vol.27 , pp. 8297-8308
    • Corti, C.1    Battaglia, G.2    Molinaro, G.3    Riozzi, B.4    Pittaluga, A.5    Corsi, M.6    Mugnaini, M.7    Nicoletti, F.8    Bruno, V.9
  • 42
    • 0036669578 scopus 로고    scopus 로고
    • Metabotropic glutamate 1 (mGlu1) receptor antagonists enhance GABAergic neurotransmission: A mechanism for the attenuation of post-ischemic injury and epileptiform activity?
    • A. Cozzi, E. Meli, V. Carlà, R. Pellicciari, F. Moroni, and D.E. Pellegrini-Giampietro Metabotropic glutamate 1 (mGlu1) receptor antagonists enhance GABAergic neurotransmission: a mechanism for the attenuation of post-ischemic injury and epileptiform activity? Neuropharmacology 43 2002 119 130
    • (2002) Neuropharmacology , vol.43 , pp. 119-130
    • Cozzi, A.1    Meli, E.2    Carlà, V.3    Pellicciari, R.4    Moroni, F.5    Pellegrini-Giampietro, D.E.6
  • 44
    • 0035812645 scopus 로고    scopus 로고
    • Neuroprotective and behavioral effects of the selective metabotropic glutamate mGlu(1) receptor antagonist BAY 36-7620
    • J. De Vry, E. Horváth, and R. Schreiber Neuroprotective and behavioral effects of the selective metabotropic glutamate mGlu(1) receptor antagonist BAY 36-7620 Eur. J. Pharmacol. 428 2001 203 214
    • (2001) Eur. J. Pharmacol. , vol.428 , pp. 203-214
    • De Vry, J.1    Horváth, E.2    Schreiber, R.3
  • 45
    • 72749108602 scopus 로고    scopus 로고
    • Group II metabotropic glutamate receptor activation by agonist LY379268 treatment increases the expression of brain derived neurotrophic factor in the mouse brain
    • V. Di Liberto, A. Bonomo, M. Frinchi, N. Belluardo, and G. Mudò Group II metabotropic glutamate receptor activation by agonist LY379268 treatment increases the expression of brain derived neurotrophic factor in the mouse brain Neuroscience 165 2010 863 873
    • (2010) Neuroscience , vol.165 , pp. 863-873
    • Di Liberto, V.1    Bonomo, A.2    Frinchi, M.3    Belluardo, N.4    Mudò, G.5
  • 46
    • 0030894148 scopus 로고    scopus 로고
    • (RS)-2-Chloro-5-hydroxyphenylglycine (CHPG) activates mGlu5, but no mGlu1, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus
    • A.J. Doherty, M.J. Palmer, J.M. Henley, G.L. Collingridge, and D.E. Jane (RS)-2-Chloro-5-hydroxyphenylglycine (CHPG) activates mGlu5, but no mGlu1, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus Neuropharmacology 36 1997 265 267
    • (1997) Neuropharmacology , vol.36 , pp. 265-267
    • Doherty, A.J.1    Palmer, M.J.2    Henley, J.M.3    Collingridge, G.L.4    Jane, D.E.5
  • 48
    • 77954330278 scopus 로고    scopus 로고
    • Therapeutic potential of targeting group III metabotropic glutamate receptors in the treatment of Parkinson's disease
    • S. Duty Therapeutic potential of targeting group III metabotropic glutamate receptors in the treatment of Parkinson's disease Br. J. Pharmacol. 161 2010 271 287
    • (2010) Br. J. Pharmacol. , vol.161 , pp. 271-287
    • Duty, S.1
  • 49
    • 77956211421 scopus 로고    scopus 로고
    • The Protective Signaling of Metabotropic Glutamate Receptor 1 Is Mediated by Sustained, β-Arrestin-1-dependent ERK Phosphorylation
    • A.C. Emery, S. Pshenichkin, G.R. Takoudjou, E. Grajkowska, B.B. Wolfe, and J.T. Wroblewski The Protective Signaling of Metabotropic Glutamate Receptor 1 Is Mediated by Sustained, β-Arrestin-1-dependent ERK Phosphorylation J. Biol. Chem. 285 2010 26041 26048
    • (2010) J. Biol. Chem. , vol.285 , pp. 26041-26048
    • Emery, A.C.1    Pshenichkin, S.2    Takoudjou, G.R.3    Grajkowska, E.4    Wolfe, B.B.5    Wroblewski, J.T.6
  • 51
    • 79951841137 scopus 로고    scopus 로고
    • Discovery, synthesis, and structure-activity relationship development of a series of N-(4-acetamido)phenylpicolinamides as positive allosteric modulators of metabotropic glutamate receptor 4 (mGlu(4)) with CNS exposure in rats
    • D.W. Engers, J.R. Field, U. Le, Y. Zhou, J.D. Bolinger, R. Zamorano, A.L. Blobaum, C.K. Jones, S. Jadhav, C.D. Weaver, P.J. Conn, C.W. Lindsley, C.M. Niswender, and C.R. Hopkins Discovery, synthesis, and structure-activity relationship development of a series of N-(4-acetamido)phenylpicolinamides as positive allosteric modulators of metabotropic glutamate receptor 4 (mGlu(4)) with CNS exposure in rats J. Med. Chem. 54 2011 1106 1110
    • (2011) J. Med. Chem. , vol.54 , pp. 1106-1110
    • Engers, D.W.1    Field, J.R.2    Le, U.3    Zhou, Y.4    Bolinger, J.D.5    Zamorano, R.6    Blobaum, A.L.7    Jones, C.K.8    Jadhav, S.9    Weaver, C.D.10    Conn, P.J.11    Lindsley, C.W.12    Niswender, C.M.13    Hopkins, C.R.14
  • 52
    • 33748924690 scopus 로고    scopus 로고
    • Metabotropic glutamate receptors
    • F. Ferraguti, and R. Shigemoto Metabotropic glutamate receptors Cell Tissue Res. 326 2006 483 504
    • (2006) Cell Tissue Res. , vol.326 , pp. 483-504
    • Ferraguti, F.1    Shigemoto, R.2
  • 55
    • 77956917231 scopus 로고    scopus 로고
    • Synaptic versus extra synaptic NMDA receptor signalling: Implications for neurodegenerative disorders
    • G.E. Hardingham, and H. Bading Synaptic versus extra synaptic NMDA receptor signalling: implications for neurodegenerative disorders Nat. Rev. Neurosci. 11 2010 682 696
    • (2010) Nat. Rev. Neurosci. , vol.11 , pp. 682-696
    • Hardingham, G.E.1    Bading, H.2
  • 56
    • 0032550097 scopus 로고    scopus 로고
    • The mGlu receptor ligand (S)-4C3HPG protects neurons after global ischaemia in gerbils
    • P. Henrich-Noack, C.D. Hatton, and K.G. Reymann The mGlu receptor ligand (S)-4C3HPG protects neurons after global ischaemia in gerbils Neuroreport 9 1998 985 988
    • (1998) Neuroreport , vol.9 , pp. 985-988
    • Henrich-Noack, P.1    Hatton, C.D.2    Reymann, K.G.3
  • 57
    • 0033980570 scopus 로고    scopus 로고
    • Distinct influence of the group III metabotropic glutamate receptor agonist (R,S)-4-phosphonophenylglycine [(R,S)-PPG] on different forms of neuronal damage
    • P. Henrich-Noack, P.J. Flor, C.F. Sabelhaus, K. Prass, U. Dirnagl, F. Gasparini, A. Sauter, M. Rudin, and K.G. Reymann Distinct influence of the group III metabotropic glutamate receptor agonist (R,S)-4-phosphonophenylglycine [(R,S)-PPG] on different forms of neuronal damage Neuropharmacology 39 2000 911 917
    • (2000) Neuropharmacology , vol.39 , pp. 911-917
    • Henrich-Noack, P.1    Flor, P.J.2    Sabelhaus, C.F.3    Prass, K.4    Dirnagl, U.5    Gasparini, F.6    Sauter, A.7    Rudin, M.8    Reymann, K.G.9
  • 58
    • 0031941372 scopus 로고    scopus 로고
    • Functional switch from facilitation to inhibition in the control of glutamate release by metabotropic glutamate receptors
    • I. Herrero, M.T. Miras-Portugal, and J. Sánchez-Prieto Functional switch from facilitation to inhibition in the control of glutamate release by metabotropic glutamate receptors J. Biol. Chem. 273 1998 1951 1958
    • (1998) J. Biol. Chem. , vol.273 , pp. 1951-1958
    • Herrero, I.1    Miras-Portugal, M.T.2    Sánchez-Prieto, J.3
  • 59
    • 84865784266 scopus 로고    scopus 로고
    • Developmental regulation of group i metabotropic glutamate receptors in the premature brain and their protective role in a rodent model of periventricular leukomalacia
    • L.L. Jantzie, D.M. Talos, D.B. Selip, L. An, M.C. Jackson, R.D. Folkerth, W. Deng, and F.E. Jensen Developmental regulation of group I metabotropic glutamate receptors in the premature brain and their protective role in a rodent model of periventricular leukomalacia Neuron Glia Biol. 14 2011 1 12
    • (2011) Neuron Glia Biol. , vol.14 , pp. 1-12
    • Jantzie, L.L.1    Talos, D.M.2    Selip, D.B.3    An, L.4    Jackson, M.C.5    Folkerth, R.D.6    Deng, W.7    Jensen, F.E.8
  • 61
    • 0032791811 scopus 로고    scopus 로고
    • Neuroprotection by metabotropic glutamate receptor agonists: LY354740, LY379268 and LY389795
    • A.E. Kingston, M.J. O'Neill, A. Lam, K.R. Bales, J.A. Monn, and D.D. Schoepp Neuroprotection by metabotropic glutamate receptor agonists: LY354740, LY379268 and LY389795 Eur. J. Pharmacol. 377 1999 155 165
    • (1999) Eur. J. Pharmacol. , vol.377 , pp. 155-165
    • Kingston, A.E.1    O'Neill, M.J.2    Lam, A.3    Bales, K.R.4    Monn, J.A.5    Schoepp, D.D.6
  • 63
    • 38349050158 scopus 로고    scopus 로고
    • Neuroprotective effects of the selective type 1 metabotropic glutamate receptor antagonist YM-202074 in rat stroke models
    • A. Kohara, M. Takahashi, S. Yatsugi, S. Tamura, Y. Shitaka, S. Hayashibe, S. Kawabata, and M. Okada Neuroprotective effects of the selective type 1 metabotropic glutamate receptor antagonist YM-202074 in rat stroke models Brain Res. 1191 2008 168 179
    • (2008) Brain Res. , vol.1191 , pp. 168-179
    • Kohara, A.1    Takahashi, M.2    Yatsugi, S.3    Tamura, S.4    Shitaka, Y.5    Hayashibe, S.6    Kawabata, S.7    Okada, M.8
  • 64
    • 78649301895 scopus 로고    scopus 로고
    • Novel N-methyl-d-aspartate receptor antagonists: A review of compounds patented since 2006
    • M. Koller, and S. Urwyler Novel N-methyl-d-aspartate receptor antagonists: a review of compounds patented since 2006 Exp. Opin. Ther. Pat. 20 2010 1683 1702
    • (2010) Exp. Opin. Ther. Pat. , vol.20 , pp. 1683-1702
    • Koller, M.1    Urwyler, S.2
  • 65
    • 0037194903 scopus 로고    scopus 로고
    • Fine-tuning motor neuron properties: Signaling from the periphery
    • S.J. Koo, and S.L. Pfaff Fine-tuning motor neuron properties: signaling from the periphery Neuron 35 2002 823 826
    • (2002) Neuron , vol.35 , pp. 823-826
    • Koo, S.J.1    Pfaff, S.L.2
  • 66
    • 0032566556 scopus 로고    scopus 로고
    • Effects of the selective metabotropic glutamate agonist LY354740 in a rat model of permanent ischaemia
    • A.G. Lam, M.A. Soriano, J.A. Monn, D.D. Schoepp, D. Lodge, and J. McCulloch Effects of the selective metabotropic glutamate agonist LY354740 in a rat model of permanent ischaemia Neurosci. Lett. 254 1998 121 123
    • (1998) Neurosci. Lett. , vol.254 , pp. 121-123
    • Lam, A.G.1    Soriano, M.A.2    Monn, J.A.3    Schoepp, D.D.4    Lodge, D.5    McCulloch, J.6
  • 67
    • 67650082990 scopus 로고    scopus 로고
    • Involvement of endocannabinoid signaling in the neuroprotective effects of subtype 1 metabotropic glutamate receptor antagonists in models of cerebral ischemia
    • E. Landucci, F. Boscia, E. Gerace, T. Scartabelli, A. Cozzi, F. Moroni, G. Mannaioni, and D.E. Pellegrini-Giampietro Involvement of endocannabinoid signaling in the neuroprotective effects of subtype 1 metabotropic glutamate receptor antagonists in models of cerebral ischemia Int. Rev. Neurobiol. 85 2009 337 350
    • (2009) Int. Rev. Neurobiol. , vol.85 , pp. 337-350
    • Landucci, E.1    Boscia, F.2    Gerace, E.3    Scartabelli, T.4    Cozzi, A.5    Moroni, F.6    Mannaioni, G.7    Pellegrini-Giampietro, D.E.8
  • 68
    • 79251598843 scopus 로고    scopus 로고
    • CB1 receptors and post-ischemic brain damage: Studies on the toxic and neuroprotective effects of cannabinoids in rat organotypic hippocampal slices
    • E. Landucci, T. Scartabelli, E. Gerace, F. Moroni, and D.E. Pellegrini-Giampietro CB1 receptors and post-ischemic brain damage: studies on the toxic and neuroprotective effects of cannabinoids in rat organotypic hippocampal slices Neuropharmacology 60 2011 674 682
    • (2011) Neuropharmacology , vol.60 , pp. 674-682
    • Landucci, E.1    Scartabelli, T.2    Gerace, E.3    Moroni, F.4    Pellegrini-Giampietro, D.E.5
  • 69
    • 0027285510 scopus 로고
    • GDNF: A glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons
    • L.F. Lin, D.H. Doherty, J.D. Lile, S. Bektesh, and F. Collins GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons Science 260 1993 1130 1132
    • (1993) Science , vol.260 , pp. 1130-1132
    • Lin, L.F.1    Doherty, D.H.2    Lile, J.D.3    Bektesh, S.4    Collins, F.5
  • 70
    • 0032845121 scopus 로고    scopus 로고
    • Ischemic cell death in brain neurons
    • P. Lipton Ischemic cell death in brain neurons Physiol. Rev. 79 1999 1431 1568
    • (1999) Physiol. Rev. , vol.79 , pp. 1431-1568
    • Lipton, P.1
  • 71
    • 33645095476 scopus 로고    scopus 로고
    • Paradigm shift in neuroprotection by NMDA receptor blockade: Memantine and beyond
    • S.A. Lipton Paradigm shift in neuroprotection by NMDA receptor blockade: memantine and beyond Nat. Rev. Drug Discov. 5 2006 160 170
    • (2006) Nat. Rev. Drug Discov. , vol.5 , pp. 160-170
    • Lipton, S.A.1
  • 74
    • 33645846952 scopus 로고    scopus 로고
    • Neuroprotective potential of group i metabotropic glutamate receptor antagonists in two ischemic models
    • D. Makarewicz, M. Duszczyk, R. Gadamski, W. Danysz, and J.W. Łazarewicz Neuroprotective potential of group I metabotropic glutamate receptor antagonists in two ischemic models Neurochem. Int. 48 2006 485 490
    • (2006) Neurochem. Int. , vol.48 , pp. 485-490
    • Makarewicz, D.1    Duszczyk, M.2    Gadamski, R.3    Danysz, W.4    Łazarewicz, J.W.5
  • 75
    • 0035882474 scopus 로고    scopus 로고
    • Metabotropic glutamate receptors 1 and 5 differentially regulate CA1 pyramidal cell function
    • G. Mannaioni, M.J. Marino, O. Valenti, S.F. Traynelis, and P.J. Conn Metabotropic glutamate receptors 1 and 5 differentially regulate CA1 pyramidal cell function J. Neurosci. 21 2001 5925 5934
    • (2001) J. Neurosci. , vol.21 , pp. 5925-5934
    • Mannaioni, G.1    Marino, M.J.2    Valenti, O.3    Traynelis, S.F.4    Conn, P.J.5
  • 77
    • 79959739592 scopus 로고    scopus 로고
    • Metabotropic glutamate receptor 5 antagonist protects dopaminergic and noradrenergic neurons from degeneration in MPTP-treated monkeys
    • G.J. Masilamoni, J.W. Bogenpohl, D. Alagille, K. Delevich, G. Tamagnan, J.R. Votaw, T. Wichmann, and Y. Smith Metabotropic glutamate receptor 5 antagonist protects dopaminergic and noradrenergic neurons from degeneration in MPTP-treated monkeys Brain 134 2011 2057 2073
    • (2011) Brain , vol.134 , pp. 2057-2073
    • Masilamoni, G.J.1    Bogenpohl, J.W.2    Alagille, D.3    Delevich, K.4    Tamagnan, G.5    Votaw, J.R.6    Wichmann, T.7    Smith, Y.8
  • 78
    • 0025390880 scopus 로고
    • Protection against ischaemic neuronal damage by drugs acting on excitatory neurotransmission
    • B. Meldrum Protection against ischaemic neuronal damage by drugs acting on excitatory neurotransmission Cerebrovasc. Brain Metab. Rev. 2 1990 27 57
    • (1990) Cerebrovasc. Brain Metab. Rev. , vol.2 , pp. 27-57
    • Meldrum, B.1
  • 80
    • 63549123749 scopus 로고    scopus 로고
    • Membrane-localised oestrogen receptor alpha and beta influence neuronal activity through activation of metabotropic glutamate receptors
    • P.G. Mermelstein Membrane-localised oestrogen receptor alpha and beta influence neuronal activity through activation of metabotropic glutamate receptors J. Neuroendocrinol. 21 2009 257 262
    • (2009) J. Neuroendocrinol. , vol.21 , pp. 257-262
    • Mermelstein, P.G.1
  • 81
    • 53749104246 scopus 로고    scopus 로고
    • Membrane estrogen receptors acting through metabotropic glutamate receptors: An emerging mechanism of estrogen action in brain
    • P.E. Micevych, and P.G. Mermelstein Membrane estrogen receptors acting through metabotropic glutamate receptors: an emerging mechanism of estrogen action in brain Mol. Neurobiol. 38 2008 66 77
    • (2008) Mol. Neurobiol. , vol.38 , pp. 66-77
    • Micevych, P.E.1    Mermelstein, P.G.2
  • 82
    • 0029027073 scopus 로고
    • Growth factor upregulation of a phosphoinositide-coupled metabotropic glutamate receptor in cortical astrocytes
    • S. Miller, C. Romano, and C.W. Cotman Growth factor upregulation of a phosphoinositide-coupled metabotropic glutamate receptor in cortical astrocytes J. Neurosci. 15 1995 6103 6109
    • (1995) J. Neurosci. , vol.15 , pp. 6103-6109
    • Miller, S.1    Romano, C.2    Cotman, C.W.3
  • 83
    • 0029790022 scopus 로고    scopus 로고
    • Exposure of astrocytes to thrombin reduces levels of the metabotropic glutamate receptor mGluR5
    • S. Miller, N. Sehati, C. Romano, and C.W. Cotman Exposure of astrocytes to thrombin reduces levels of the metabotropic glutamate receptor mGluR5 J. Neurochem. 67 1996 1435 1447
    • (1996) J. Neurochem. , vol.67 , pp. 1435-1447
    • Miller, S.1    Sehati, N.2    Romano, C.3    Cotman, C.W.4
  • 86
    • 43549091334 scopus 로고    scopus 로고
    • MGluR1 antagonist decreases tyrosine phosphorylation of NMDA receptor and attenuates infarct size after transient focal cerebral ischemia
    • K. Murotomi, N. Takagi, G. Takayanagi, M. Ono, S. Takeo, and K. Tanonaka MGluR1 antagonist decreases tyrosine phosphorylation of NMDA receptor and attenuates infarct size after transient focal cerebral ischemia J. Neurochem. 105 2008 1625 1634
    • (2008) J. Neurochem. , vol.105 , pp. 1625-1634
    • Murotomi, K.1    Takagi, N.2    Takayanagi, G.3    Ono, M.4    Takeo, S.5    Tanonaka, K.6
  • 87
    • 77956314285 scopus 로고    scopus 로고
    • MGluR1 antagonist decreased NADPH oxidase activity and superoxide production after transient focal cerebral ischemia
    • K. Murotomi, N. Takagi, R. Mizutani, T.A. Honda, M. Ono, S. Takeo, and K. Tanonaka MGluR1 antagonist decreased NADPH oxidase activity and superoxide production after transient focal cerebral ischemia J. Neurochem. 114 2010 1711 1719
    • (2010) J. Neurochem. , vol.114 , pp. 1711-1719
    • Murotomi, K.1    Takagi, N.2    Mizutani, R.3    Honda, T.A.4    Ono, M.5    Takeo, S.6    Tanonaka, K.7
  • 91
    • 77949516412 scopus 로고    scopus 로고
    • Metabotropic glutamate receptors: Physiology, pharmacology, and disease
    • C.M. Niswender, and P.J. Conn Metabotropic glutamate receptors: physiology, pharmacology, and disease Annu. Rev. Pharmacol. Toxicol. 50 2010 295 322
    • (2010) Annu. Rev. Pharmacol. Toxicol. , vol.50 , pp. 295-322
    • Niswender, C.M.1    Conn, P.J.2
  • 92
    • 0020263571 scopus 로고
    • The toxic effects of glutamate and related compounds in the retina and the brain
    • J.W. Olney The toxic effects of glutamate and related compounds in the retina and the brain Retina 2 1982 341 359
    • (1982) Retina , vol.2 , pp. 341-359
    • Olney, J.W.1
  • 93
    • 0030782939 scopus 로고    scopus 로고
    • Excitotoxic neurodegeneration in Alzheimer disease. New hypothesis and new therapeutic strategies
    • J.W. Olney, D.F. Wozniak, and N.B. Farber Excitotoxic neurodegeneration in Alzheimer disease. New hypothesis and new therapeutic strategies Arch. Neurol. 54 1997 1234 1240
    • (1997) Arch. Neurol. , vol.54 , pp. 1234-1240
    • Olney, J.W.1    Wozniak, D.F.2    Farber, N.B.3
  • 95
    • 0041878682 scopus 로고    scopus 로고
    • The distinct role of mGlu1 receptors in post-ischemic neuronal death
    • D.E. Pellegrini-Giampietro The distinct role of mGlu1 receptors in post-ischemic neuronal death Trends Pharmacol. Sci. 24 2003 461 470
    • (2003) Trends Pharmacol. Sci. , vol.24 , pp. 461-470
    • Pellegrini-Giampietro, D.E.1
  • 96
    • 0035959976 scopus 로고    scopus 로고
    • Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl-d-aspartate responses in medium spiny striatal neurons
    • A. Pisani, P. Gubellini, P. Bonsi, F. Conquet, B. Picconi, D. Centonze, G. Bernardi, and P. Calabresi Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl-d-aspartate responses in medium spiny striatal neurons Neuroscience 106 2001 579 587
    • (2001) Neuroscience , vol.106 , pp. 579-587
    • Pisani, A.1    Gubellini, P.2    Bonsi, P.3    Conquet, F.4    Picconi, B.5    Centonze, D.6    Bernardi, G.7    Calabresi, P.8
  • 98
    • 49949110710 scopus 로고    scopus 로고
    • Dual neurotoxic and neuroprotective role of metabotropic glutamate receptor 1 in conditions of trophic deprivation - Possible role as a dependence receptor
    • S. Pshenichkin, M. Dolińska, M. Klauzińska, V. Luchenko, E. Grajkowska, and J.T. Wroblewski Dual neurotoxic and neuroprotective role of metabotropic glutamate receptor 1 in conditions of trophic deprivation - possible role as a dependence receptor Neuropharmacology 55 2008 500 508
    • (2008) Neuropharmacology , vol.55 , pp. 500-508
    • Pshenichkin, S.1    Dolińska, M.2    Klauzińska, M.3    Luchenko, V.4    Grajkowska, E.5    Wroblewski, J.T.6
  • 102
    • 0022620257 scopus 로고
    • Glutamate and the pathophysiology of hypoxic-ischemic brain damage
    • S.M. Rothman, and J.W. Olney Glutamate and the pathophysiology of hypoxic-ischemic brain damage Ann. Neurol. 19 1986 105 111
    • (1986) Ann. Neurol. , vol.19 , pp. 105-111
    • Rothman, S.M.1    Olney, J.W.2
  • 103
    • 0029435316 scopus 로고    scopus 로고
    • 1995-1996. Excitotoxicity and neurodegeneration in amyotrophic lateral sclerosis
    • Rothstein, J.D.; 1995-1996. Excitotoxicity and neurodegeneration in amyotrophic lateral sclerosis. Clin. Neurosci. 3, 348-359.
    • Clin. Neurosci. , vol.3 , pp. 348-359
    • Rothstein, J.D.1
  • 104
    • 49949098409 scopus 로고    scopus 로고
    • Neuroprotection by group i mGlu receptors in a rat hippocampal slice model of cerebral ischemia is associated with the PI3K-Akt signaling pathway: A novel postconditioning strategy?
    • T. Scartabelli, E. Gerace, E. Landucci, F. Moroni, and D.E. Pellegrini-Giampietro Neuroprotection by group I mGlu receptors in a rat hippocampal slice model of cerebral ischemia is associated with the PI3K-Akt signaling pathway: a novel postconditioning strategy? Neuropharmacology 55 2008 509 516
    • (2008) Neuropharmacology , vol.55 , pp. 509-516
    • Scartabelli, T.1    Gerace, E.2    Landucci, E.3    Moroni, F.4    Pellegrini-Giampietro, D.E.5
  • 105
    • 84874217998 scopus 로고    scopus 로고
    • Neuroprotection following postconditioning via group i mGlu receptor activation is coupled to the PI3K/Akt/GSK3β signaling pathway in a rat organotypic hippocampal slice model of cerebral ischemia
    • Scartabelli, T.; Gerace, E.; Landucci, E.; Moroni, F. and Pellegrini-Giampietro, D.E.; 2011. Neuroprotection following postconditioning via group I mGlu receptor activation is coupled to the PI3K/Akt/GSK3β signaling pathway in a rat organotypic hippocampal slice model of cerebral ischemia. Curr. Neuropharmacol. 9(S1), 57.
    • (2011) Curr. Neuropharmacol. , vol.9 , Issue.S1 , pp. 57
    • Scartabelli, T.1    Gerace, E.2    Landucci, E.3    Moroni, F.4    Pellegrini-Giampietro, D.E.5
  • 106
    • 33846294812 scopus 로고    scopus 로고
    • GDNF applied to the MPTP-lesioned nigrostriatal system requires TGF-beta for its neuroprotective action
    • A. Schober, H. Peterziel, C.S. von Bartheld, H. Simon, K. Krieglstein, and K. Unsicker GDNF applied to the MPTP-lesioned nigrostriatal system requires TGF-beta for its neuroprotective action Neurobiol. Dis. 25 2007 378 391
    • (2007) Neurobiol. Dis. , vol.25 , pp. 378-391
    • Schober, A.1    Peterziel, H.2    Von Bartheld, C.S.3    Simon, H.4    Krieglstein, K.5    Unsicker, K.6
  • 107
    • 0032834028 scopus 로고    scopus 로고
    • Pharmacological agents acting at subtypes of metabotropic glutamate receptors
    • D.D. Schoepp, D.E. Jane, and J.A. Monn Pharmacological agents acting at subtypes of metabotropic glutamate receptors Neuropharmacology 38 1999 1431 1476
    • (1999) Neuropharmacology , vol.38 , pp. 1431-1476
    • Schoepp, D.D.1    Jane, D.E.2    Monn, J.A.3
  • 109
    • 14844311296 scopus 로고    scopus 로고
    • Improvement of bilateral motor functions in patients with Parkinson disease through the unilateral intraputaminal infusion of glial cell line-derived neurotrophic factor
    • J.T. Slevin, G.A. Gerhardt, C.D. Smith, D.M. Gash, R. Kryscio, and B. Young Improvement of bilateral motor functions in patients with Parkinson disease through the unilateral intraputaminal infusion of glial cell line-derived neurotrophic factor J. Neurosurg. 102 2005 216 222
    • (2005) J. Neurosurg. , vol.102 , pp. 216-222
    • Slevin, J.T.1    Gerhardt, G.A.2    Smith, C.D.3    Gash, D.M.4    Kryscio, R.5    Young, B.6
  • 110
  • 111
    • 0037444442 scopus 로고    scopus 로고
    • Activation of microglial group III metabotropic glutamate receptors protects neurons against microglial neurotoxicity
    • D.L. Taylor, L.T. Diemel, and J.M. Pocock Activation of microglial group III metabotropic glutamate receptors protects neurons against microglial neurotoxicity J. Neurosci. 23 2003 2150 2160
    • (2003) J. Neurosci. , vol.23 , pp. 2150-2160
    • Taylor, D.L.1    Diemel, L.T.2    Pocock, J.M.3
  • 113
    • 0035955418 scopus 로고    scopus 로고
    • Neuroprotection mediated by glutamate carboxypeptidase II (NAALADase) inhibition requires TGF-beta
    • A.G. Thomas, W. Liu, J.L. Olkowski, Z. Tang, Q. Lin, X.C. Lu, and B.S. Slusher Neuroprotection mediated by glutamate carboxypeptidase II (NAALADase) inhibition requires TGF-beta Eur. J. Pharmacol. 430 2001 33 40
    • (2001) Eur. J. Pharmacol. , vol.430 , pp. 33-40
    • Thomas, A.G.1    Liu, W.2    Olkowski, J.L.3    Tang, Z.4    Lin, Q.5    Lu, X.C.6    Slusher, B.S.7
  • 114
    • 0029891195 scopus 로고    scopus 로고
    • (2S,1′S,2′S,3′R)-2-(2′-Carboxy-3′- phenylcyclopropyl)glycine, a potent and selective antagonist of type 2 metabotropic glutamate receptors
    • C. Thomsen, V. Bruno, F. Nicoletti, M. Marinozzi, and R. Pellicciari (2S,1′S,2′S,3′R)-2-(2′-Carboxy-3′- phenylcyclopropyl)glycine, a potent and selective antagonist of type 2 metabotropic glutamate receptors Mol. Pharmacol. 50 1996 6 9
    • (1996) Mol. Pharmacol. , vol.50 , pp. 6-9
    • Thomsen, C.1    Bruno, V.2    Nicoletti, F.3    Marinozzi, M.4    Pellicciari, R.5
  • 115
    • 0032192487 scopus 로고    scopus 로고
    • Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors
    • J.C. Tu, B. Xiao, J.P. Yuan, A.A. Lanahan, K. Leoffert, M. Li, D.J. Linden, and P.F. Worley Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors Neuron 21 1998 717 726
    • (1998) Neuron , vol.21 , pp. 717-726
    • Tu, J.C.1    Xiao, B.2    Yuan, J.P.3    Lanahan, A.A.4    Leoffert, K.5    Li, M.6    Linden, D.J.7    Worley, P.F.8
  • 117
  • 119
    • 33846502748 scopus 로고    scopus 로고
    • Calpain-mediated mGluR1alpha truncation: A key step in excitotoxicity
    • W. Xu, T.P. Wong, N. Chery, T. Gaertner, Y.T. Wang, and M. Baudry Calpain-mediated mGluR1alpha truncation: a key step in excitotoxicity Neuron 53 2007 399 412
    • (2007) Neuron , vol.53 , pp. 399-412
    • Xu, W.1    Wong, T.P.2    Chery, N.3    Gaertner, T.4    Wang, Y.T.5    Baudry, M.6
  • 120
    • 67649967488 scopus 로고    scopus 로고
    • Neuroprotective effects of group II metabotropic glutamate receptor agonist DCG-IV on hippocampal neurons in transient forebrain ischemia
    • H. Yoshioka, M. Sugita, and H. Kinouchi Neuroprotective effects of group II metabotropic glutamate receptor agonist DCG-IV on hippocampal neurons in transient forebrain ischemia Neurosci. Lett. 461 2009 266 270
    • (2009) Neurosci. Lett. , vol.461 , pp. 266-270
    • Yoshioka, H.1    Sugita, M.2    Kinouchi, H.3
  • 121
    • 67349277708 scopus 로고    scopus 로고
    • Neuroprotection against neonatal hypoxia/ischemia-induced cerebral cell death by prevention of calpain-mediated mGluR1alpha truncation
    • M. Zhou, W. Xu, G. Liao, X. Bi, and M. Baudry Neuroprotection against neonatal hypoxia/ischemia-induced cerebral cell death by prevention of calpain-mediated mGluR1alpha truncation Exp. Neurol. 218 2009 75 82
    • (2009) Exp. Neurol. , vol.218 , pp. 75-82
    • Zhou, M.1    Xu, W.2    Liao, G.3    Bi, X.4    Baudry, M.5
  • 122
    • 0033547372 scopus 로고    scopus 로고
    • Reducing calcium overload in the ischemic brain
    • G.J. Zipfel, J.M. Lee, and D.W. Choi Reducing calcium overload in the ischemic brain N. Engl. J Med. 341 1999 1543 1544
    • (1999) N. Engl. J Med. , vol.341 , pp. 1543-1544
    • Zipfel, G.J.1    Lee, J.M.2    Choi, D.W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.