Neuroprotective effects of group II metabotropic glutamate receptor agonist DCG-IV on hippocampal neurons in transient forebrain ischemia

Neuroscience Letters

Volumn 461, Issue 3, 2009, Pages 266-270

  Yoshioka, Hideyuki ^a   Sugita, Masao ^a   Kinouchi, Hiroyuki ^a  

^a UNIVERSITY OF YAMANASHI   (Japan)

Author keywords

Cerebral ischemia; Glutamate; Metabotropic glutamate receptor; Microdialysis; Neuroprotection

Indexed keywords

2 (2,3 DICARBOXYCYCLOPROPYL)GLYCINE; 2 AMINO 2 (2 CARBOXYCYCLOPROPYL) 3 (XANTHEN 9 YL)PROPIONIC ACID; GLUTAMIC ACID; METABOTROPIC RECEPTOR AGONIST; METABOTROPIC RECEPTOR ANTAGONIST;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; BRAIN NERVE CELL; BRAIN REGION; CAROTID ARTERY OBSTRUCTION; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; FOREBRAIN; HIPPOCAMPUS; HYPOTENSION; MALE; MICRODIALYSIS; NERVE CELL LESION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; SURVIVAL RATE;

AMINO ACIDS; ANIMALS; CAROTID STENOSIS; CEREBROVASCULAR CIRCULATION; CYCLOPROPANES; EXTRACELLULAR SPACE; GLUTAMIC ACID; GLYCINE; HIPPOCAMPUS; ISCHEMIC ATTACK, TRANSIENT; MALE; MICRODIALYSIS; NEURONS; NEUROPROTECTIVE AGENTS; PROSENCEPHALON; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, METABOTROPIC GLUTAMATE; XANTHENES;

EID: 67649967488     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2009.06.056     Document Type: Article

References (23)

1. Berger C., Schabitz W.R., Georgiadis D., Steiner T., Aschoff A., and Schwab S. Effects of hypothermia on excitatory amino acids and metabolism in stroke patients: a microdialysis study. Stroke 33 (2002) 519-524
2. Berger C., Schabitz W.R., Wolf M., Mueller H., Sommer C., and Schwab S. Hypothermia and brain-derived neurotrophic factor reduce glutamate synergistically in acute stroke. Exp. Neurol. 185 (2004) 305-312
3. Bond A., Jones N.M., Hicks C.A., Whiffin G.M., Ward M.A., O'Neill M.F., Kingston A.E., Monn J.A., Ornstein P.L., Schoepp D.D., Lodge D., and O'Neill M.J. Neuroprotective effects of LY379268, a selective mGlu2/3 receptor agonist: investigations into possible mechanism of action in vivo. J. Pharmacol. Exp. Ther. 294 (2000) 800-809
4. Bond A., O'Neill M.J., Hicks C.A., Monn J.A., and Lodge D. Neuroprotective effects of a systemically active group II metabotropic glutamate receptor agonist LY354740 in a gerbil model of global ischaemia. Neuroreport 9 (1998) 1191-1193
5. Bruno V., Battaglia G., Copani A., D'Onofrio M., Di Iorio P., De Blasi A., Melchiorri D., Flor P.J., and Nicoletti F. Metabotropic glutamate receptor subtypes as targets for neuroprotective drugs. J. Cereb. Blood Flow Metab. 21 (2001) 1013-1033
6. D'Onofrio M., Cuomo L., Battaglia G., Ngomba R.T., Storto M., Kingston A.E., Orzi F., De Blasi A., Di Iorio P., Nicoletti F., and Bruno V. Neuroprotection mediated by glial group-II metabotropic glutamate receptors requires the activation of the MAP kinase and the phosphatidylinositol-3-kinase pathways. J. Neurochem. 78 (2001) 435-445
7. Gill R., Foster A.C., and Woodruff G.N. Systemic administration of MK-801 protects against ischemia-induced hippocampal neurodegeneration in the gerbil. J. Neurosci. 7 (1987) 3343-3349
8. Gu G., Lorrain D.S., Wei H., Cole R.L., Zhang X., Daggett L.P., Schaffhauser H.J., Bristow L.J., and Lechner S.M. Distribution of metabotropic glutamate 2 and 3 receptors in the rat forebrain: implication in emotional responses and central disinhibition. Brain Res. 1197 (2008) 47-62
9. Henrich-Noack P., Hatton C.D., and Reymann K.G. The mGlu receptor ligand (S)-4C3HPG protects neurons after global ischaemia in gerbils. Neuroreport 9 (1998) 985-988
10. Kingston A.E., O'Neill M.J., Lam A., Bales K.R., Monn J.A., and Schoepp D.D. Neuroprotection by metabotropic glutamate receptor glutamate receptor agonists: LY354740, LY379268 and LY389795. Eur. J. Pharmacol. 377 (1999) 155-165
11. Kwak S., Miyamoto M., Ishida M., and Shinozaki H. Neurotoxicity of (2S,1′R,2′R,3′R)-2-(2,3-dicarboxycyclopropyl)glycine, a potent agonist for class II metabotropic glutamate receptors, in the rat. Neuroscience 73 (1996) 687-695
12. Lee J.M., Zipfel G.J., and Choi D.W. The changing landscape of ischaemic brain injury mechanisms. Nature 399 (1999) A7-14
13. Miyamoto M., Ishida M., and Shinozaki H. Anticonvulsive and neuroprotective actions of a potent agonist (DCG-IV) for group II metabotropic glutamate receptors against intraventricular kainate in the rat. Neuroscience 77 (1997) 131-140
14. Nicoletti F., Bruno V., Copani A., Casabona G., and Knopfel T. Metabotropic glutamate receptors: a new target for the therapy of neurodegenerative disorders?. Trends Neurosci. 19 (1996) 267-271
15. Nishizawa Y. Glutamate release and neuronal damage in ischemia. Life Sci. 69 (2001) 369-381
16. Simon R.P., Swan J.H., Griffiths T., and Meldrum B.S. Blockade of N-methyl-d-aspartate receptors may protect against ischemic damage in the brain. Science 226 (1984) 850-852
17. Smith M.L., Bendek G., Dahlgren N., Rosen I., Wieloch T., and Siesjo B.K. Models for studying long-term recovery following forebrain ischemia in the rat. 2. A 2-vessel occlusion model. Acta Neurol. Scand. 69 (1984) 385-401
18. Szatkowski M., and Attwell D. Triggering and execution of neuronal death in brain ischaemia: two phases of glutamate release by different mechanisms. Trends Neurosci. 17 (1994) 359-365
19. Walker M.C., Galley P.T., Errington M.L., Shorvon S.D., and Jefferys J.G. Ascorbate and glutamate release in the rat hippocampus after perforant path stimulation: a "dialysis electrode" study. J. Neurochem. 65 (1995) 725-731
20. Winfree C.J., Baker C.J., Connolly Jr. E.S., Fiore A.J., and Solomon R.A. Mild hypothermia reduces penumbral glutamate levels in the rat permanent focal cerebral ischemia model. Neurosurgery 38 (1996) 1216-1222
21. Yano T., Nakayama R., and Ushijima K. Intracerebroventricular propofol is neuroprotective against transient global ischemia in rats: extracellular glutamate level is not a major determinant. Brain Res. 883 (2000) 69-76
22. Yusa T. Effects of nitric oxide synthase inhibition on extracellular glutamate and cerebral blood flow during forebrain ischemia-reperfusion in rat in vivo. J. Anesth. 14 (2000) 24-29
23. Zwienenberg M., Gong Q.Z., Berman R.F., Muizelaar J.P., and Lyeth B.G. The effect of groups II and III metabotropic glutamate receptor activation on neuronal injury in a rodent model of traumatic brain injury. Neurosurgery 48 (2001) 1119-1126 (discussion 1126-7)