LY379268, a potent and selective Group II metabotropic glutamate receptor agonist, is neuroprotective in gerbil global, but not focal, cerebral ischaemia

Neuroscience Letters

Volumn 273, Issue 3, 1999, Pages 191-194

  Bond, Ann ^a   Ragumoorthy, Nella ^a   Monn, James A ^a   Hicks, Caroline A ^a   Ward, Mark A ^a   Lodge, David ^a   O'Neill, Michael J ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

Focal ischaemia, Neuroprotection; Global ischaemia; LY379268; Metabotropic glutamate receptor; Mglur2; mGluR3

Indexed keywords

4 AMINO 2 OXABICYCLO[3.1.0]HEXANE 4,6 DICARBOXYLIC ACID; EGLUMETAD; ENDOTHELIN 1; GLUTAMATE RECEPTOR AGONIST; METABOTROPIC RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; BRAIN CORTEX; BRAIN INFARCTION; BRAIN ISCHEMIA; CELL DEATH; CONTROLLED STUDY; DRUG EFFECT; GERBIL; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NERVE DEGENERATION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; SHORT SURVEY;

EID: 0032822044     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(99)00663-1     Document Type: Article

References (16)

1. Battaglia G., Monn J.A., Schoepp D.D. In vivo inhibition of veratridine-evoked release of striatal excitatory amino acids by the group II metabotropic glutamate receptor agonist LY354740 in rats. Neurosci. Lett. 229:1997;161-164.
2. Bond A., O'Neill M.J., Hicks C.A., Monn J.A., Lodge D. Neuroprotective effects of a systemically active Group II metabotropic glutamate receptor agonist LY354740 in a gerbil model of global ischaemia. NeuroReport. 9:1998;1191-1193.
3. Bruno V., Battaglia G., Casabona G., Copani A., Caciagli F., Nicoletti F. Neuroprotection by glial metabotropic glutamate receptors is mediated by transforming growth factor-beta. J. Neurosci. 18:1998;9594-9600.
4. Bruno V., Battaglia G., Copani A., Casabona G., Storto M., Gerevini V.G., Ngomba R., Nicoletti F. Metabotropic glutamate receptors and neurodegeneration. Prog. Brain Res. 116:1998;209-221.
5. Buission A., Choi D.W. The inhibitory mGluR agonist S-4-carboxy-3-hydroxy-phenglyine selectively attenuates NMDA neurotoxicity and oxygen-glucose deprivation neuronal death. Neuropharmacology. 34:1995;1081-1087.
6. Buission A., Yu S.P., Choi D.W. DCG-IV selectively attenuates rapidly triggered NMDA-induced neurotoxicity in cortical neurons. Eur. J. Neurosci. 8:1996;138-143.
7. Chiamulera C., Albertini P., Valerio E., Reggiani A. Activation of metabotropic receptors has a neuroprotective effect in a rodent model of focal ischaemia. Eur. J. Pharmacol. 216:1996;335-336.
8. Kilbride J., Huang L-Q., Rowan M.J., Anwyl R. Presynaptic inhibitory action of the group II metabotropic glutamate receptor agonists LY354740 and DCG-IV. Eur. J. Pharmacol. 356:1998;149-157.
9. Kingston A.E., O'Neill M.J., Lam A.G.M., Bales K.R., Monn J.A., Schoepp D.D. Neuroprotection by metabotropic glutamate receptor agonists: LY354740, LY379268 and LY389795. Eur. J. Pharamacol. 377:1999;155-165.
10. Kirino T. Delayed neuronal death in the gerbil hippocampus following ischemia. Brain Res. 1:1982;494-498.
11. Lam A.G.M., Soriano M.A., Monn J.A., Schoepp D.D., Lodge D., McCulloch J. Effects of the selective metabotropic glutamate agonist LY354740 in a rat model of permanent ischaemia. Neurosci. Lett. 254:1998;121-123.
12. Miyamoto M., Ishida M., Shinozaki H. Anticonvulsive and neuroprotective actions of a potent agonist (DCG-IV) for group II metabotropic glutamate receptors against intraventricular kainate in the rat. Neuroscience. 1997;131-140.
13. Monn J.A., Valli M.J., Massey S.M., Hansen M.M., Kress T.J., Wepsiec J.P., Harkness A.R., Grutsch J.L., Wright R.A., Johnson B.G., Andis S.L., Kingston A., Tomlinson R., Lewis R., Griffey K.R., Tizzano J.P., Schoepp D.D. Synthesis, pharmacological characterization, and molecular modeling of heterobicyclic amino acids related to (+)-2-amino[3.1.0]heane-2,6-dicarboxylic acid (LY354740): identification of two new potent, selective, and systemically active agonists for group II metabotropic glutamate receptors. J. Med. Chem. 42:1999;1027-1040.
14. Pin J.P., Duvoisin R. The metabotropic glutamate receptors: structure and functions. Neuropharmacology. 34:1995;1-26.
15. Schoepp D.D., Johnson B.G., Wright R.A., Salhoff C.R., Mayne N.G., Wu S., Cockerham S.L., Burnett J.P., Belagaje R., Bleakman D., Monn J.A. LY354740 is a potent and highly selective group II metabotropic glutamate receptor agonist in cells expressing human glutamtate receptors Neuropharmacology. 36:1997;1-11.
16. Sharkey J., Ritchie I.M., Kelly P.A.T. Perivascular microapplication of endothelin-1: a new model of focal cerebral ischaemia in the rat. J. Cereb. Blood Flow Metab. 13:1993;865-871.