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Volumn 4, Issue 8, 2009, Pages

Activation of mGlu3 receptors stimulates the production of GDNF in striatal neurons

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 AMINO 2 (2 CARBOXYCYCLOPROPYL) 3 (XANTHEN 9 YL)PROPIONIC ACID; 2 MORPHOLINO 8 PHENYLCHROMONE; 4 AMINO 2 OXABICYCLO[3.1.0]HEXANE 4,6 DICARBOXYLIC ACID; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; GLIAL FIBRILLARY ACIDIC PROTEIN; MESSENGER RNA; METABOTROPIC RECEPTOR 2; METABOTROPIC RECEPTOR 3; MITOGEN ACTIVATED PROTEIN KINASE; NERVE GROWTH FACTOR; PHOSPHATIDYLINOSITOL 3 KINASE; TYROSINE 3 MONOOXYGENASE; AMINO ACID; FUSED HETEROCYCLIC RINGS; METABOTROPIC RECEPTOR;

EID: 68949151921     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0006591     Document Type: Article
Times cited : (43)

References (61)
  • 1
    • 0030029427 scopus 로고    scopus 로고
    • Metabotropic glutamate receptors: A new target for the therapy of neurodegenerative disorders?
    • Nicoletti F, Bruno V, Copani A, Casabona G, Knöpfel T (1996) Metabotropic glutamate receptors: a new target for the therapy of neurodegenerative disorders? Trends Neurosci 19: 267-271.
    • (1996) Trends Neurosci , vol.19 , pp. 267-271
    • Nicoletti, F.1    Bruno, V.2    Copani, A.3    Casabona, G.4    Knöpfel, T.5
  • 3
    • 0025870943 scopus 로고
    • Trans-1-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD) decreases synaptic excitation in rat striatal slices through a presynaptic action
    • Lovinger DM (1991) Trans-1-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD) decreases synaptic excitation in rat striatal slices through a presynaptic action. Neurosci Lett 129: 17-21.
    • (1991) Neurosci Lett , vol.129 , pp. 17-21
    • Lovinger, D.M.1
  • 4
    • 0028933282 scopus 로고
    • Metabotropic glutamate receptor-mediated presynaptic depression at corticostriatal synapses involves mGLuR2 or 3
    • Lovinger DM, McCool BA (1995) Metabotropic glutamate receptor-mediated presynaptic depression at corticostriatal synapses involves mGLuR2 or 3. J Neurophysiol 73: 1076-183.
    • (1995) J Neurophysiol , vol.73 , pp. 1076-1183
    • Lovinger, D.M.1    McCool, B.A.2
  • 5
    • 0030852182 scopus 로고    scopus 로고
    • In vivo inhibition of veratridine-evoked release of striatal excitatory amino acids by the group II metabotropic glutamate receptor agonist LY354740 in rats
    • Battaglia G, Monn JA, Schoepp DD (1997) In vivo inhibition of veratridine-evoked release of striatal excitatory amino acids by the group II metabotropic glutamate receptor agonist LY354740 in rats. Neurosci Lett 229: 161-164.
    • (1997) Neurosci Lett , vol.229 , pp. 161-164
    • Battaglia, G.1    Monn, J.A.2    Schoepp, D.D.3
  • 6
    • 0030873754 scopus 로고    scopus 로고
    • Type 2 metabotropic glutamate (mGlu) receptors tonically inhibit transmitter release in rat caudate nucleus: In vivo studies with (2S,1'S,2'S,3'R)-2-(2′-carboxy-3′-phenylcyclopropyl)glycine, a new potent and selective antagonist
    • Cozzi A, Attucci S, Peruginelli F, Marinozzi M, Luneia R, et al. (1997) Type 2 metabotropic glutamate (mGlu) receptors tonically inhibit transmitter release in rat caudate nucleus: in vivo studies with (2S,1'S,2'S,3'R)-2-(2′-carboxy-3′-phenylcyclopropyl)glycine, a new potent and selective antagonist. Eur J Neurosci 9: 1350-1355.
    • (1997) Eur J Neurosci , vol.9 , pp. 1350-1355
    • Cozzi, A.1    Attucci, S.2    Peruginelli, F.3    Marinozzi, M.4    Luneia, R.5
  • 7
    • 0028912822 scopus 로고
    • The metabotropic glutamate receptors: Structure and functions
    • Pin JP, Duvoisin R (1995) The metabotropic glutamate receptors: structure and functions. Neuropharmacology 34: 1-26.
    • (1995) Neuropharmacology , vol.34 , pp. 1-26
    • Pin, J.P.1    Duvoisin, R.2
  • 8
    • 0030901576 scopus 로고    scopus 로고
    • Positive and negative coupling of the metabotropic glutamate receptors to a G protein-activated K+ channel, GIRK, in Xenopus oocytes
    • Sharon D, Vorobiov D, Dascal N (1997) Positive and negative coupling of the metabotropic glutamate receptors to a G protein-activated K+ channel, GIRK, in Xenopus oocytes. J Gen Physiol 109: 477-490.
    • (1997) J Gen Physiol , vol.109 , pp. 477-490
    • Sharon, D.1    Vorobiov, D.2    Dascal, N.3
  • 9
    • 0031032470 scopus 로고    scopus 로고
    • The neuroprotective activity of group-II metabotropic glutamate receptors requires new protein synthesis and involves a glial-neuronal signaling
    • Bruno V, Sureda FX, Storto M, Casabona G, Caruso A, et al. (1997) The neuroprotective activity of group-II metabotropic glutamate receptors requires new protein synthesis and involves a glial-neuronal signaling. J Neurosci 17: 1891-1897.
    • (1997) J Neurosci , vol.17 , pp. 1891-1897
    • Bruno, V.1    Sureda, F.X.2    Storto, M.3    Casabona, G.4    Caruso, A.5
  • 10
    • 0032403407 scopus 로고    scopus 로고
    • Neuroprotection by glial metabotropic glutamate receptors is mediated by transforming growth factor-β
    • Bruno V, Battaglia G, Casabona G, Copani A, Caciagli F, et al. (1998) Neuroprotection by glial metabotropic glutamate receptors is mediated by transforming growth factor-β. J Neurosci 18: 9594-9600.
    • (1998) J Neurosci , vol.18 , pp. 9594-9600
    • Bruno, V.1    Battaglia, G.2    Casabona, G.3    Copani, A.4    Caciagli, F.5
  • 11
    • 0033198777 scopus 로고    scopus 로고
    • Activation of A(1) adenosine or mGlu3 metabotropic glutamate receptors enhances the release of nerve growth factor and S-100beta protein from cultured astrocytes
    • Ciccarelli R, Di Iorio P, Bruno V, Battaglia G, D'Alimonte I, et al. (1999) Activation of A(1) adenosine or mGlu3 metabotropic glutamate receptors enhances the release of nerve growth factor and S-100beta protein from cultured astrocytes. Glia 27: 275-281.
    • (1999) Glia , vol.27 , pp. 275-281
    • Ciccarelli, R.1    Di Iorio, P.2    Bruno, V.3    Battaglia, G.4    D'Alimonte, I.5
  • 12
    • 17844376201 scopus 로고    scopus 로고
    • Neuroprotection mediated by glial group-II metabotropic glutamate receptors requires the activation of the MAP kinase and the phosphatidylinositol-3-kinase pathways
    • D'Onofrio M, Cuomo L, Battaglia G, Ngomba TR, Storto M, et al. (2001) Neuroprotection mediated by glial group-II metabotropic glutamate receptors requires the activation of the MAP kinase and the phosphatidylinositol-3-kinase pathways. J Neurochem 78: 435-445.
    • (2001) J Neurochem , vol.78 , pp. 435-445
    • D'Onofrio, M.1    Cuomo, L.2    Battaglia, G.3    Ngomba, T.R.4    Storto, M.5
  • 14
    • 34547686245 scopus 로고    scopus 로고
    • The use of knockout mice unravels distinct roles for mGlu2 and mGlu3 metabotropic glutamate receptors in mechanisms of neurodegeneration/ neuroprotection
    • Corti C, Battaglia G, Molinaro G, Riozzi B, Pittaluga A, et al. (2007) The use of knockout mice unravels distinct roles for mGlu2 and mGlu3 metabotropic glutamate receptors in mechanisms of neurodegeneration/ neuroprotection. J Neurosci 27: 8297-308.
    • (2007) J Neurosci , vol.27 , pp. 8297-8308
    • Corti, C.1    Battaglia, G.2    Molinaro, G.3    Riozzi, B.4    Pittaluga, A.5
  • 15
    • 27944470972 scopus 로고    scopus 로고
    • Metabotropic glutamate receptors in the basal ganglia motor circuit
    • Conn JP, Battaglia G, Marino MJ, Nicoletti F (2005) Metabotropic glutamate receptors in the basal ganglia motor circuit. Nat Rev Neurosci 6: 787-798.
    • (2005) Nat Rev Neurosci , vol.6 , pp. 787-798
    • Conn, J.P.1    Battaglia, G.2    Marino, M.J.3    Nicoletti, F.4
  • 16
    • 0037056034 scopus 로고    scopus 로고
    • DCG-IV but not other group-II metabotropic receptor agonists induces microglial BDNF mRNA expression in the rat striatum. Correlation with neuronal injury
    • Venero JL, Santiago M, Tomas-Camardiel M, Matarredona ER, Cano J, et al. (2002) DCG-IV but not other group-II metabotropic receptor agonists induces microglial BDNF mRNA expression in the rat striatum. Correlation with neuronal injury. Neuroscience 113: 857-869.
    • (2002) Neuroscience , vol.113 , pp. 857-869
    • Venero, J.L.1    Santiago, M.2    Tomas-Camardiel, M.3    Matarredona, E.R.4    Cano, J.5
  • 17
    • 0037088928 scopus 로고    scopus 로고
    • Selective blockade of mGlu5 metabotropic glutamate receptors is protective against methamphetamine neurotoxicity
    • Battaglia G, Fornai F, Busceti LC, Aloisi G, Cerrito F, et al. (2002) Selective blockade of mGlu5 metabotropic glutamate receptors is protective against methamphetamine neurotoxicity. J Neurosci 22: 2135-2141.
    • (2002) J Neurosci , vol.22 , pp. 2135-2141
    • Battaglia, G.1    Fornai, F.2    Busceti, L.C.3    Aloisi, G.4    Cerrito, F.5
  • 18
    • 0037493477 scopus 로고    scopus 로고
    • Protective role of group-II metabotropic glutamate receptors against nigrostriatal degeneration induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice
    • Battaglia G, Busceti LC, Pontarelli F, Fornai F, Paparelli A, et al. (2003) Protective role of group-II metabotropic glutamate receptors against nigrostriatal degeneration induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice. Neuropharmacology 45: 155-166.
    • (2003) Neuropharmacology , vol.45 , pp. 155-166
    • Battaglia, G.1    Busceti, L.C.2    Pontarelli, F.3    Fornai, F.4    Paparelli, A.5
  • 19
    • 0742322858 scopus 로고    scopus 로고
    • Endogenous activation of mGlu5 metabotropic glutamate receptors contributes to the development of nigro-striatal damage induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice
    • Battaglia G, Busceti LC, Molinaro G, Biagioni F, Storto M, et al. (2004) Endogenous activation of mGlu5 metabotropic glutamate receptors contributes to the development of nigro-striatal damage induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice. J Neurosci 24: 828-835.
    • (2004) J Neurosci , vol.24 , pp. 828-835
    • Battaglia, G.1    Busceti, L.C.2    Molinaro, G.3    Biagioni, F.4    Storto, M.5
  • 20
    • 33746233386 scopus 로고    scopus 로고
    • Pharmacological activation of mGlu4 metabotropic glutamate receptors reduces nigro-striatal degeneration in mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
    • Battaglia G, Busceti CL, Molinaro G, Biagioni F, Traficante F, et al. (2006) Pharmacological activation of mGlu4 metabotropic glutamate receptors reduces nigro-striatal degeneration in mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. J Neurosci 26: 7222-7229.
    • (2006) J Neurosci , vol.26 , pp. 7222-7229
    • Battaglia, G.1    Busceti, C.L.2    Molinaro, G.3    Biagioni, F.4    Traficante, F.5
  • 21
    • 19944430985 scopus 로고    scopus 로고
    • Protection but maintained dysfunction of nigral dopaminergic nerve cell bodies and striatal dopaminergic terminals in MPTP-lesioned mice after acute treatment with the mGluR5 antagonist MPEP
    • Aguirre JA, Kehr J, Yoshitake T, Liu FL, Rivera A, et al. (2005) Protection but maintained dysfunction of nigral dopaminergic nerve cell bodies and striatal dopaminergic terminals in MPTP-lesioned mice after acute treatment with the mGluR5 antagonist MPEP. Brain Res 1033: 216-220.
    • (2005) Brain Res , vol.1033 , pp. 216-220
    • Aguirre, J.A.1    Kehr, J.2    Yoshitake, T.3    Liu, F.L.4    Rivera, A.5
  • 22
    • 0027285510 scopus 로고
    • GDNF: A glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons
    • Lin LF, Doherty DH, Lile JD, Bektesh S, Collins F (1993) GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Science 260: 1130-1132.
    • (1993) Science , vol.260 , pp. 1130-1132
    • Lin, L.F.1    Doherty, D.H.2    Lile, J.D.3    Bektesh, S.4    Collins, F.5
  • 23
    • 0031662603 scopus 로고    scopus 로고
    • Neuroprotective and neurorestorative properties of GDNF
    • Gash DM, Zhang Z, Gerhardt G (1998) Neuroprotective and neurorestorative properties of GDNF. Ann Neurol 44: S121-S125.
    • (1998) Ann Neurol , vol.44
    • Gash, D.M.1    Zhang, Z.2    Gerhardt, G.3
  • 24
    • 0037378036 scopus 로고    scopus 로고
    • In vivo gene delivery of glial cell line-derived neurotrophic factor for Parkinson's disease
    • Kordower JH (2003) In vivo gene delivery of glial cell line-derived neurotrophic factor for Parkinson's disease. Ann Neurol 53: S120-S132.
    • (2003) Ann Neurol , vol.53
    • Kordower, J.H.1
  • 25
    • 31844440769 scopus 로고    scopus 로고
    • Assessment in primate models of Parkinson's disease: Comparison with human studies
    • Eslamboli A (2005) Assessment in primate models of Parkinson's disease: comparison with human studies. Rev Neurosci 16: 303-310.
    • (2005) Rev Neurosci , vol.16 , pp. 303-310
    • Eslamboli, A.1
  • 26
    • 33846501598 scopus 로고    scopus 로고
    • GDNF family complexes are emerging drug targets
    • Bespalov MM, Saarma M (2007) GDNF family complexes are emerging drug targets. Trends Pharmacol Sci 28: 68-74.
    • (2007) Trends Pharmacol Sci , vol.28 , pp. 68-74
    • Bespalov, M.M.1    Saarma, M.2
  • 27
    • 33846294812 scopus 로고    scopus 로고
    • GDNF applied to the MPTP-lesioned nigrostriatal system requires TGF-β for its neuroprotective action
    • Schober A, Peterziel H, von Bartheld CS, Simon H, Krieglstein K, et al. (2007) GDNF applied to the MPTP-lesioned nigrostriatal system requires TGF-β for its neuroprotective action. Neurobiol Dis 25: 378-91.
    • (2007) Neurobiol Dis , vol.25 , pp. 378-391
    • Schober, A.1    Peterziel, H.2    von Bartheld, C.S.3    Simon, H.4    Krieglstein, K.5
  • 28
    • 0033602516 scopus 로고    scopus 로고
    • Synthesis, pharmacological characterization, and molecular modeling of heterobicyclic amino acids related to (+)-2-aminobicyclo [3.1.0]hexane-2,6-dicarboxylic acid (LY354740): Identification of two new potent, selective, and systemically active agonists for group II metabotropic glutamate receptors
    • Monn JA, Valli MJ, Massey SM, Hansen MM, Kress TJ, et al. (1999) Synthesis, pharmacological characterization, and molecular modeling of heterobicyclic amino acids related to (+)-2-aminobicyclo [3.1.0]hexane-2,6-dicarboxylic acid (LY354740): identification of two new potent, selective, and systemically active agonists for group II metabotropic glutamate receptors. J Med Chem 42: 1027-1040.
    • (1999) J Med Chem , vol.42 , pp. 1027-1040
    • Monn, J.A.1    Valli, M.J.2    Massey, S.M.3    Hansen, M.M.4    Kress, T.J.5
  • 29
    • 4043164771 scopus 로고    scopus 로고
    • The metabotropic glutamate receptor 5 antagonist MPEP and the mGluR2 agonist LY379268 modify disease progression in a transgenic mouse model of Huntington's disease
    • Schiefer J, Sprünken A, Puls C, Lüesse HG, Milkereit A, et al. (2004) The metabotropic glutamate receptor 5 antagonist MPEP and the mGluR2 agonist LY379268 modify disease progression in a transgenic mouse model of Huntington's disease. Brain Res 1019: 246-254.
    • (2004) Brain Res , vol.1019 , pp. 246-254
    • Schiefer, J.1    Sprünken, A.2    Puls, C.3    Lüesse, H.G.4    Milkereit, A.5
  • 30
    • 17744369682 scopus 로고    scopus 로고
    • Phencyclidine-induced impairment in attention and response control depends on the background genotype of mice: Reversal by the mGlu(2/3) receptor agonist LY379268
    • Greco B, Invernizzi RW, Carli M (2005) Phencyclidine-induced impairment in attention and response control depends on the background genotype of mice: reversal by the mGlu(2/3) receptor agonist LY379268. Psychopharmacology 179: 68-76.
    • (2005) Psychopharmacology , vol.179 , pp. 68-76
    • Greco, B.1    Invernizzi, R.W.2    Carli, M.3
  • 31
    • 41949085829 scopus 로고    scopus 로고
    • Effects of the mGluR2/3 agonist LY379268 and the mGluR5 antagonist MPEP on handling-induced convulsions during ethanol withdrawal in mice
    • Olive MF, Becker HC (2008) Effects of the mGluR2/3 agonist LY379268 and the mGluR5 antagonist MPEP on handling-induced convulsions during ethanol withdrawal in mice. Alcohol 42: 191-197.
    • (2008) Alcohol , vol.42 , pp. 191-197
    • Olive, M.F.1    Becker, H.C.2
  • 32
    • 51549111390 scopus 로고    scopus 로고
    • Glutamate receptor ligands attenuate allodynia and hyperalgesia and potentiate morphine effects in a mouse model of neuropathic pain
    • Osikowicz M, Mika J, Makuch W, Przewlocka B (2008) Glutamate receptor ligands attenuate allodynia and hyperalgesia and potentiate morphine effects in a mouse model of neuropathic pain. Pain 139: 117-26.
    • (2008) Pain , vol.139 , pp. 117-126
    • Osikowicz, M.1    Mika, J.2    Makuch, W.3    Przewlocka, B.4
  • 33
    • 38949207272 scopus 로고    scopus 로고
    • The mGlu2 but not the mGlu3 receptor mediates the actions of the mGluR2/3 agonist, LY379268, in mouse models predictive of antipsychotic activity
    • Woolley ML, Pemberton DJ, Bate S, Corti C, Jones DN (2008) The mGlu2 but not the mGlu3 receptor mediates the actions of the mGluR2/3 agonist, LY379268, in mouse models predictive of antipsychotic activity. Psychopharmacology 196: 431-440.
    • (2008) Psychopharmacology , vol.196 , pp. 431-440
    • Woolley, M.L.1    Pemberton, D.J.2    Bate, S.3    Corti, C.4    Jones, D.N.5
  • 34
    • 34948858402 scopus 로고    scopus 로고
    • Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: A randomized Phase 2 clinical trial
    • Patil ST, Zhang L, Martenyi F, Lowe SL, Jackson KA, et al. (2007) Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial. Nat Med 13: 1102-1107.
    • (2007) Nat Med , vol.13 , pp. 1102-1107
    • Patil, S.T.1    Zhang, L.2    Martenyi, F.3    Lowe, S.L.4    Jackson, K.A.5
  • 35
    • 45749139623 scopus 로고    scopus 로고
    • Evidence for the role of metabotropic glutamate (mGlu)2 not mGlu3 receptors in the preclinical antipsychotic pharmacology of the mGlu2/3 receptor agonist (-)-(1R,4S,5S,6S)-4-amino-2-sulfonylbicyclo[3.1.0]hexane-4,6- dicarboxylic acid (LY404039)
    • Fell MJ, Svensson KA, Johnson BG, Schoepp DD (2008) Evidence for the role of metabotropic glutamate (mGlu)2 not mGlu3 receptors in the preclinical antipsychotic pharmacology of the mGlu2/3 receptor agonist (-)-(1R,4S,5S,6S)-4-amino-2-sulfonylbicyclo[3.1.0]hexane-4,6- dicarboxylic acid (LY404039). J Pharmacol Exp Ther 326: 209-217.
    • (2008) J Pharmacol Exp Ther , vol.326 , pp. 209-217
    • Fell, M.J.1    Svensson, K.A.2    Johnson, B.G.3    Schoepp, D.D.4
  • 36
    • 40449139964 scopus 로고    scopus 로고
    • Identification of a serotonin/glutamate receptor complex implicated in psychosis
    • González-Maeso J, Ang RL, Yuen T, Chan P, Weisstaub NV, et al. (2008) Identification of a serotonin/glutamate receptor complex implicated in psychosis. Nature 452: 93-97.
    • (2008) Nature , vol.452 , pp. 93-97
    • González-Maeso, J.1    Ang, R.L.2    Yuen, T.3    Chan, P.4    Weisstaub, N.V.5
  • 37
    • 0028096652 scopus 로고
    • Glial cell-line derived neurotrophic factor (GDNF) mRNA upregulation in striatum and cortical areas after pilocarpine-induced status epilepticus in rats
    • Schmidt-Kastner R, Tomac A, Hoffer B, Bektesh S, Rosenzweig B, et al. (1994) Glial cell-line derived neurotrophic factor (GDNF) mRNA upregulation in striatum and cortical areas after pilocarpine-induced status epilepticus in rats. Brain Res Mol Brain Res 26: 325-330.
    • (1994) Brain Res Mol Brain Res , vol.26 , pp. 325-330
    • Schmidt-Kastner, R.1    Tomac, A.2    Hoffer, B.3    Bektesh, S.4    Rosenzweig, B.5
  • 38
    • 0029801527 scopus 로고    scopus 로고
    • Cellular expression of GDNF mRNA suggests multiple functions inside and outside the nervous system
    • Nosrat CA, Tomac A, Lindqvist E, Lindskog S, Humpel C, et al. (1996) Cellular expression of GDNF mRNA suggests multiple functions inside and outside the nervous system. Cell Tissue Res 286: 191-207.
    • (1996) Cell Tissue Res , vol.286 , pp. 191-207
    • Nosrat, C.A.1    Tomac, A.2    Lindqvist, E.3    Lindskog, S.4    Humpel, C.5
  • 39
    • 0032834028 scopus 로고    scopus 로고
    • Pharmacological agents acting at subtypes of metabotropic glutamate receptors
    • Schoepp DD, Jane DE, Monn JA (1999) Pharmacological agents acting at subtypes of metabotropic glutamate receptors. Neuropharmacology 38: 1431-1476.
    • (1999) Neuropharmacology , vol.38 , pp. 1431-1476
    • Schoepp, D.D.1    Jane, D.E.2    Monn, J.A.3
  • 40
    • 0036581222 scopus 로고    scopus 로고
    • The GDNF family: Signalling, biological functions and therapeutic value
    • Airaksinen MS, Saarma M (2002) The GDNF family: signalling, biological functions and therapeutic value. Nat Rev Neurosci 3: 383-394.
    • (2002) Nat Rev Neurosci , vol.3 , pp. 383-394
    • Airaksinen, M.S.1    Saarma, M.2
  • 41
    • 0033559397 scopus 로고    scopus 로고
    • Glial cell line-derived neurotrophic factor rescues target-deprived sympathetic spinal cord neurons but requires transforming growth factor-b as cofactor in vivo
    • Schober A, Hertel R, Arumae U, Farkas L, Jaszai J, et al. (1999) Glial cell line-derived neurotrophic factor rescues target-deprived sympathetic spinal cord neurons but requires transforming growth factor-b as cofactor in vivo. J Neurosci 19: 2008-2015.
    • (1999) J Neurosci , vol.19 , pp. 2008-2015
    • Schober, A.1    Hertel, R.2    Arumae, U.3    Farkas, L.4    Jaszai, J.5
  • 42
    • 0028170589 scopus 로고
    • TGF beta 2 and TGF beta 3 are potent survival factors for midbrain dopaminergic neurons
    • Poulsen KT, Armanini MP, Klein RD, Hynes MA, Phillips HS, et al. (1994) TGF beta 2 and TGF beta 3 are potent survival factors for midbrain dopaminergic neurons. Neuron 13: 1245-1252.
    • (1994) Neuron , vol.13 , pp. 1245-1252
    • Poulsen, K.T.1    Armanini, M.P.2    Klein, R.D.3    Hynes, M.A.4    Phillips, H.S.5
  • 43
    • 0032850453 scopus 로고    scopus 로고
    • Clinicopathological findings following intraventricular glial-derived neurotrophic factor treatment in a patient with Parkinson's disease
    • Kordower JH, Palfi S, Chen EY, Ma SY, Sendera T, et al. (1999) Clinicopathological findings following intraventricular glial-derived neurotrophic factor treatment in a patient with Parkinson's disease. Ann Neurol 46: 419-424.
    • (1999) Ann Neurol , vol.46 , pp. 419-424
    • Kordower, J.H.1    Palfi, S.2    Chen, E.Y.3    Ma, S.Y.4    Sendera, T.5
  • 44
    • 0038249170 scopus 로고    scopus 로고
    • Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease
    • Gill SS, Patel NK, Hotton GR, O'Sullivan K, McCarter R, et al. (2003) Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease. Nat Med 9: 589-595.
    • (2003) Nat Med , vol.9 , pp. 589-595
    • Gill, S.S.1    Patel, N.K.2    Hotton, G.R.3    O'Sullivan, K.4    McCarter, R.5
  • 45
    • 14844311296 scopus 로고    scopus 로고
    • Improvement of bilateral motor functions in patients with Parkinson disease through the unilateral intraputaminal infusion of glial cell line-derived neurotrophic factor
    • Slevin JT, Gerhardt GA, Smith CD, Gash DM, Kryscio R, et al. (2005) Improvement of bilateral motor functions in patients with Parkinson disease through the unilateral intraputaminal infusion of glial cell line-derived neurotrophic factor. J Neurosurg 102: 216-222.
    • (2005) J Neurosurg , vol.102 , pp. 216-222
    • Slevin, J.T.1    Gerhardt, G.A.2    Smith, C.D.3    Gash, D.M.4    Kryscio, R.5
  • 46
    • 33644833272 scopus 로고    scopus 로고
    • Randomized controlled trial of intraputamenal glial cell line-derived growth factor infusion in Parkinson's disease
    • Lang AE, Gill S, Patel NK, Lozano A, Nutt JG, et al. (2006) Randomized controlled trial of intraputamenal glial cell line-derived growth factor infusion in Parkinson's disease. Ann Neurol 59: 459-466.
    • (2006) Ann Neurol , vol.59 , pp. 459-466
    • Lang, A.E.1    Gill, S.2    Patel, N.K.3    Lozano, A.4    Nutt, J.G.5
  • 47
    • 46749109164 scopus 로고    scopus 로고
    • PYM50028, a novel, orally active, nonpeptide neurotrophic factor inducer, prevents and reverses neuronal damage induced by MPP+ in mesencephalic neurons and by MPTP in a mouse model of Parkinson's disease
    • Visanji NP, Orsi A, Johnston TH, Howson PA, Dixon K, et al. (2008) PYM50028, a novel, orally active, nonpeptide neurotrophic factor inducer, prevents and reverses neuronal damage induced by MPP+ in mesencephalic neurons and by MPTP in a mouse model of Parkinson's disease. FASEB J 22: 2488-2497.
    • (2008) FASEB J , vol.22 , pp. 2488-2497
    • Visanji, N.P.1    Orsi, A.2    Johnston, T.H.3    Howson, P.A.4    Dixon, K.5
  • 48
    • 34548721105 scopus 로고    scopus 로고
    • Rasagiline promotes regeneration of substantia nigra dopaminergic neurons in post-MPTP-induced Parkinsonism via activation of tyrosine kinase receptor signaling pathway
    • Mandel SA, Sagi Y, Amit T (2007) Rasagiline promotes regeneration of substantia nigra dopaminergic neurons in post-MPTP-induced Parkinsonism via activation of tyrosine kinase receptor signaling pathway. Neurochem Res 32: 1694-1699.
    • (2007) Neurochem Res , vol.32 , pp. 1694-1699
    • Mandel, S.A.1    Sagi, Y.2    Amit, T.3
  • 49
    • 37049015753 scopus 로고    scopus 로고
    • Induction of neurotrophic factors GDNF and BDNF associated with the mechanism of neurorescue action of rasagiline and ladostigil: New insights and implications for therapy
    • Weinreb O, Amit T, Bar-Am O, Youdim MB (2007) Induction of neurotrophic factors GDNF and BDNF associated with the mechanism of neurorescue action of rasagiline and ladostigil: new insights and implications for therapy. Ann N Y Acad Sci 1122: 155-168.
    • (2007) Ann N Y Acad Sci , vol.1122 , pp. 155-168
    • Weinreb, O.1    Amit, T.2    Bar-Am, O.3    Youdim, M.B.4
  • 50
    • 0031689603 scopus 로고    scopus 로고
    • LY354740, a group II metabotropic glutamate receptor agonist with potential antiparkinsonian properties in rats
    • Konieczny J, Ossowska K, Wolfarth S, Pilc A (1998) LY354740, a group II metabotropic glutamate receptor agonist with potential antiparkinsonian properties in rats. Naunyn Schmiedebergs Arch Pharmacol 358: 500-502.
    • (1998) Naunyn Schmiedebergs Arch Pharmacol , vol.358 , pp. 500-502
    • Konieczny, J.1    Ossowska, K.2    Wolfarth, S.3    Pilc, A.4
  • 51
    • 0033967160 scopus 로고    scopus 로고
    • The group II metabotropic glutamate receptor agonist, DCG-IV, alleviates akinesia following intranigral or intraventricular administration in the reserpine-treated rat
    • Dawson L, Chadha A, Megalou M, Duty S (2000) The group II metabotropic glutamate receptor agonist, DCG-IV, alleviates akinesia following intranigral or intraventricular administration in the reserpine-treated rat. Br J Pharmacol 129: 541-546.
    • (2000) Br J Pharmacol , vol.129 , pp. 541-546
    • Dawson, L.1    Chadha, A.2    Megalou, M.3    Duty, S.4
  • 52
    • 9344255435 scopus 로고    scopus 로고
    • Impairment of hippocampal mossy fiber LTD in mice lacking mGluR2
    • Yokoi M, Kobayashi K, Manabe T, Takahashi T, Sakaguchi I, et al. (1996) Impairment of hippocampal mossy fiber LTD in mice lacking mGluR2. Science 273: 645-647.
    • (1996) Science , vol.273 , pp. 645-647
    • Yokoi, M.1    Kobayashi, K.2    Manabe, T.3    Takahashi, T.4    Sakaguchi, I.5
  • 53
    • 68949095864 scopus 로고    scopus 로고
    • Rose K, Goldberg MP, Choi DW (1992) Cytotoxicity in murine neocortical cell cultures. In: Tyson CA, Frazier JM, eds. Methods in toxicology, 1, In Vitro Biological System. San Diego: San Diego Academics. pp 46-60.
    • Rose K, Goldberg MP, Choi DW (1992) Cytotoxicity in murine neocortical cell cultures. In: Tyson CA, Frazier JM, eds. Methods in toxicology, Vol. 1, In Vitro Biological System. San Diego: San Diego Academics. pp 46-60.
  • 55
    • 0030915959 scopus 로고    scopus 로고
    • Complementary and overlapping expression of glial cell line-derived neurotrophic factor (GDNF), c-ret proto-oncogene, and GDNF receptor-alpha indicates multiple mechanisms of trophic actions in the adult rat CNS
    • Trupp M, Belluardo N, Funakoshi H, Ibanez CF (1997) Complementary and overlapping expression of glial cell line-derived neurotrophic factor (GDNF), c-ret proto-oncogene, and GDNF receptor-alpha indicates multiple mechanisms of trophic actions in the adult rat CNS. J Neurosci 17: 3554-3567.
    • (1997) J Neurosci , vol.17 , pp. 3554-3567
    • Trupp, M.1    Belluardo, N.2    Funakoshi, H.3    Ibanez, C.F.4
  • 56
    • 68949100727 scopus 로고    scopus 로고
    • Lehmann A. Atlas stereotaxique du cerveau de la souris. Ed. Du centre National de la recherche, Paris, 1974.
    • Lehmann A. Atlas stereotaxique du cerveau de la souris. Ed. Du centre National de la recherche, Paris, 1974.
  • 57
    • 20444401182 scopus 로고    scopus 로고
    • Transcription factor gene expression profiling after acute intermittent nicotine treatment in the rat cerebral cortex
    • Belluardo N, Olsson PA, Mudo' G, Sommer WH, Amato G, et al. (2005) Transcription factor gene expression profiling after acute intermittent nicotine treatment in the rat cerebral cortex. Neuroscience 133: 787-796.
    • (2005) Neuroscience , vol.133 , pp. 787-796
    • Belluardo, N.1    Olsson, P.A.2    Mudo', G.3    Sommer, W.H.4    Amato, G.5
  • 58
    • 0023760665 scopus 로고
    • The new stereological tools: Disector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis
    • Gundersen HJG, Bagger P, Bendtsen TF, Evans SM, Korbo L, et al. (1988) The new stereological tools: disector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis. Acta Pathol Microbiol Immunol Scand 96: 857-881.
    • (1988) Acta Pathol Microbiol Immunol Scand , vol.96 , pp. 857-881
    • Gundersen, H.J.G.1    Bagger, P.2    Bendtsen, T.F.3    Evans, S.M.4    Korbo, L.5
  • 59
    • 0033045425 scopus 로고    scopus 로고
    • The efficiency of systematic sampling in stereology: Reconsidered
    • Gundersen HJG, Jensen EB, Kiâu K, Nielsen J (1999) The efficiency of systematic sampling in stereology: reconsidered. J Microsc 193: 199-211.
    • (1999) J Microsc , vol.193 , pp. 199-211
    • Gundersen, H.J.G.1    Jensen, E.B.2    Kiâu, K.3    Nielsen, J.4
  • 60
    • 0023950504 scopus 로고
    • Total number of neurons and glial cells in human brain nuclei estimated by disector and fractionator
    • Pakkenberg B, Gundersen HJG (1988) Total number of neurons and glial cells in human brain nuclei estimated by disector and fractionator. J Microsc 150: 1-20.
    • (1988) J Microsc , vol.150 , pp. 1-20
    • Pakkenberg, B.1    Gundersen, H.J.G.2
  • 61
    • 0029968229 scopus 로고    scopus 로고
    • If you assume, you can make an ass out of u and me: A decade of the dissector for stereological counting of particles in 3D space
    • Mayhew TM, Gundersen HJG (1996) "If you assume, you can make an ass out of u and me": a decade of the dissector for stereological counting of particles in 3D space. J Anat 188: 1-15.
    • (1996) J Anat , vol.188 , pp. 1-15
    • Mayhew, T.M.1    Gundersen, H.J.G.2


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