Distinct influence of the group III metabotropic glutamate receptor agonist (R,S)-4-phosphonophenylglycine [(R,S)-PPG] on different forms of neuronal damage

Neuropharmacology

Volumn 39, Issue 5, 2000, Pages 911-917

  Henrich Noack, P ^a,b   Flor, P J ^c   Sabelhaus, C F ^a,b   Prass, K ^d   Dirnagl, U ^d   Gasparini, F ^c   Sauter, A ^c   Rudin, M ^c   Reymann, K G ^a,b  

^a LEIBNIZ INSTITUTE FOR NEUROBIOLOGY   (Germany)

^b Research Institute for Applied Neuroscience (FAN gGmbH)   (Germany)

^c NOVARTIS PHARMA AG   (Switzerland)

^d CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

(R,S) PPG; Excitotoxicity; Ischaemia; Metabotropic glutamate receptors; Neuroprotection

Indexed keywords

4 PHOSPHONOPHENYLGLYCINE; GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR AGONIST; METABOTROPIC RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; ELECTROPHYSIOLOGY; GERBIL; HIPPOCAMPUS; MALE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT;

ACTION POTENTIALS; ANIMALS; BRAIN DISEASES; BRAIN ISCHEMIA; CELL HYPOXIA; CORPUS STRIATUM; CYTOPROTECTION; DISEASE MODELS, ANIMAL; GERBILLINAE; GLYCINE; HIPPOCAMPUS; MALE; MICE; MICE, INBRED C57BL; NEURONS; NEUROPROTECTIVE AGENTS; QUINOLINIC ACID; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; RECEPTORS, METABOTROPIC GLUTAMATE;

EID: 0033980570     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(99)00256-7     Document Type: Article

References (32)

1. Abdul-Ghani A., Attwell P.J.E., Sing Kent N., Bradford H.F., Croucher M.J., Jane D.E. Anti-epileptogenic and anticonvulsant activity of L-2-amino-4-phosphonobutyrate, a presynaptic glutamate receptor agonist. Brain Research. 755:1997;202-212.
2. Andersen P., Bliss T.V.P., Skrede K.K. Unit analysis of hippocampal population spikes. Experimental Brain Research. 13:1971;2008-2221.
3. Bigge C.F., Drummond J.T., Johnson G., Malone T., Probert A.W. Jr., Marcoux F.W.et al. Exploration of phenyl-spaced 2-amino-(5,9)-phosphonoalkanoic acids as competitive N-methyl-D-aspartic acid antagonists. Journal of Medicinal Chemistry. 32:1989;1580-1590.
4. Bederson J.B., Pitts L.H., Tsuji M., Nishimura M.C., Davis R.L., Bartowski H. Rat cerebral artery occlusion: evaluation of the model and development of a neurologic examination. Stroke. 17:1986;472-476.
5. Bond A., O'Neill M.J., Hicks C.A., Monn J.A., Lodge D. Neuroprotective effects of a systemically active group II metabotropic glutamate receptor agonist LY354740 in a gerbil model of global ischaemia. NeuroReport. 9:1998;1191-1193.
6. Bradley S.R., Levey A.I., Hersch S.M., Conn P.J. Immunocytochemical localization of group III metabotropic glutamate receptors in the hippocampus with subtype-specific antibodies. Journal of Neuroscience. 16:1996;2044-2056.
7. Bruno V., Battaglia G., Kingston A., O'Neill M.J., Catania M.V., Di Grezia R.et al. Neuroprotective activity of the potent and selective mGlu1a metabotropic glutamate receptor antagonist, (+)-2-methyl-4-carboxyphenylglycine (LY367385): comparison with LY357366, a broader spectrum antagonist with equal affinity for mGlu1a and mGlu5 receptors. Neuropharmacology. 38:1999;199-207.
8. Dirnagl U., Thorén P., Villringer A., Sixt G., Them A., Einhäupl K.K. Global forebrain ischaemia in the rat: controlled reduction of cerebral blood flow by hypobaric hypotension and two-vessel occlusion. Neurological Research. 15:1993;128-130.
9. Gasparini F., Bruno V., Battaglia G., Lukic S., Leonhardt T., Inderbitzin W.et al. (R,S)-4-Phosphonophenylglycine, a potent and selective group III metabotropic glutamate receptor agonist, is anticonvulsive and neuroprotective in vivo. Journal of Pharmacology and Experimental Therapeutics. 290:1999;1678-1687.
10. Hara H., Huang P.L., Panahian N., Fishman M.C., Moskowitz M.A. Reduced brain edema and infarction volume in mice lacking the neuronal isoform of nitric oxide synthase after transient MCA occlusion. Journal of Cerebral Blood Flow and Metabolism. 16:1996;605-611.
11. c but not in cAMP mediates L-AP4 inhibition of glutamate release: PKC-mediated suppression of this inhibitory pathway. European Journal of Neuroscience. 8:1996;700-709.
12. Iversen L., Mulvihill E., Haldeman B., Diemer N.H., Kaiser F., Sheardown M.et al. Changes in metabotropic glutamate receptor mRNA levels following global ischaemia: increase of a putative presynaptic subtype (mGluR4) in highly vulnerable rat brain areas. Journal of Neurochemistry. 63:1994;625-633.
13. Lafon-Cazal M., Viennois G., Kuhn R., Malitschek B., Pin J.P., Shigemoto R.et al. mGluR7-like receptor and GABA(B) receptor activation enhance neurotoxic effects of N-methyl-D-aspartate in cultured mouse striatal GABAergic neurones. Neuropharmacology. 38:1999;1631-1640.
14. Lombardi G., Alesiani M., Leonardi P., Cherizi G., Pellicciari R., Moroni F. Pharmacological characterization of the metabotropic glutamate receptor inhibiting the D-[(3)H]-aspartate output in rat striatum. British Journal of Pharmacology. 110:1993;1407-1412.
15. Manahan-Vaughan D., Reymann K.G. Regional and developmental profile of modulation of hippocampal synaptic transmission and LTP by AP4-sensitive mGluRs in vivo. Neuropharmacology. 34:1995;991-1001.
16. Martin G., Nie Z., Siggins G.R. Metabotropic glutamate receptors regulate N-methyl-D-aspartate-mediated synaptic transmission in nucleus accumbens. Journal of Neurophysiology. 78:1997;3028-30038.
17. Meldrum B.S., Swan J.H., Leach M.J., Millan M.H., Gwinn R., Kadota K.et al. Reduction of glutamate release and protection against ischaemic brain damage by BW 1003C87. Brain Research. 593:1992;1-6.
18. Meldrum B.S., Smith S.E., Lekiffre D., Vhapman A.G., Graham J.L., Pearce P.C. Sodium-channel blockade and glutamate release: the mechanism of cerebroprotection by lamotrigine, BW 1003C87 and BW 619C89. Krieglstein J., Oberpichler-Schwenk H. Pharmacology of Cerebral Ischaemia. 1994;203-209 medpharm Scientific Publisher, Stuttgart.
19. Nakanishi S. Molecular diversity of glutamate receptors and implications for brain function. Science. 258:1992;597-603.
20. Nakanishi S. Metabotropic glutamate receptors: synaptic transmission, modulation and plasticity. Neuron. 13(5):1994;1031-1037.
21. Ohishi H., Akazawa C., Shigemoto R., Nakanishi S., Mizuno N. Distribution of the mRNAs for L-2-amino-4-phosphonobutyrate-sensitive metabotropic glutamate receptors, mGluR4 and mGluR7, in the rat brain. Journal of Comparative Neurology. 360:1995;555-570.
22. Opitz T., Richter P., Carter A.J., Kozikowski A.P., Shinozaki H., Reymann K.G. Metabotropic glutamate receptor subtypes differentially influence neuronal recovery from in vitro hypoxia/hypoglycemia in rat hippocampal slices. Neuroscience. 68:1995;989-1001.
23. Rosdahl D., Seitzberg D.A., Christensen T., Balchen T., Diemer N.H. Changes in mRNA for metabotropic glutamate receptors after transient cerebral ischaemia. NeuroReport. 5:1994;593-596.
24. Saugstad J.A., Kinzie J.M., Segereson T.P., Westerbrook G.L. Characterization of a new metabotropic glutamate receptor homologous to the AP4 receptor. Abstract book of the Annual Meeting of the American Society for Neuroscience. 19:1993;68.
25. Schoepp D.D. The biochemical pharmacology of metabotropic glutamate receptors. Biochemical Society Transactions. 21:1993;97-103.
26. Schurr A., West C.A., Rigor M. Quinolinate: an endogenous potentiator of excitotoxicity in hypoxic and glucose-deprived neuronal tissue. Krieglstein J., Oberpichler-Schwenk H. Pharmacology of Cerebral Ischaemia. 1992;73-79 Wissenschaftliche Verlagsgesellschaft, Stuttgart.
27. Suzuki K., Mori N., Kittaka H., Iwata Y., Yamada Y., Osonoe K.et al. Anticonvulsant action of metabotropic glutamate receptor agonists in kindled amygdala of rats. Neuroscience Letters. 204:1996;41-44.
28. Tanabe Y., Masu M., Ishii T., Shigemoto R., Nakanishi S. A family of metabotropic glutamate receptors. Neuron. 8:1992;169-179.
29. Thomsen C., Kristensen P., Mulvihill E., Haldeman B., Suzdak P.D. L-2-Amino-4-phosphonobutyrate (L-AP4) is an agonist at the type IV metabotropic glutamate receptor which is negatively coupled to adenylate cyclase. European Journal of Pharmacology. 227:1992;361-362.
30. 2+ influx by D- and L-2-amino-4-phosphonobutanoic acid (D- and L-AP4) and L-serine-O-phosphate (L-SOP) in cultured cerebellar granule cells. Neuropharmacology. 36:1997;335-343.
31. Urwyler S., Campbell E., Fricker G., Jenner P., Lemaire M., McAllister K.H.et al. Biphenyl-derivatives of 2-amino-7-phosphono-heptanoic acid, a novel class of potent competitive N-methyl-D-aspartate receptor agonists. II. Pharmacological characterization in vivo. Neuropharmacology. 35:1996;655-669.
32. Wigmore M.A., Lacey M.G. Metabotropic glutamate receptors depress glutamate-mediated synaptic input to rat midbrain dopamine neurones in vivo. British Journal of Pharmacology. 123:1998;667-674.