Neuroprotection mediated by glial group-II metabotropic glutamate receptors requires the activation of the MAP kinase and the phosphatidylinositol-3-kinase pathways

Journal of Neurochemistry

Volumn 78, Issue 3, 2001, Pages 435-445

  D'Onofrio, M ^a   Cuomo, L ^a   Battaglia, G ^a   Ngomba, R T ^a   Storto, M ^a   Kingston, A E ^b   Orzi, F ^a,c   De Blasi, A ^a,d   Di Iorio, P ^e   Nicoletti, F ^a,c   Bruno, V ^a  

^a IRCCS NEUROMED   (Italy)

^b ELI LILLY AND COMPANY   (United States)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^e UNIVERSITY OF CHIETI   (Italy)

Author keywords

Astrocytes; MAP kinase; mGlu receptors; Neuroprotection; Phosphatidylinositol 3 kinase; TGF 1

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 4 AMINO 2 OXABICYCLO[3.1.0]HEXANE 4,6 DICARBOXYLIC ACID; 4 CARBOXY 3 HYDROXYPHENYLGLYCINE; GLUTAMATE RECEPTOR; METABOTROPIC RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ARTICLE; ASTROCYTE; BRAIN SLICE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; FETUS; GLIA; MOUSE; NERVE CELL CULTURE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; AMINO ACIDS; ANIMALS; ASTROCYTES; BICYCLO COMPOUNDS, HETEROCYCLIC; BLOTTING, NORTHERN; CELLS, CULTURED; CHROMONES; CORPUS STRIATUM; ENZYME INHIBITORS; EXCITATORY AMINO ACID AGONISTS; FLAVONOIDS; GLYCINE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MALE; MAP KINASE SIGNALING SYSTEM; MICE; MORPHOLINES; N-METHYLASPARTATE; NEURONS; NEUROPROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, METABOTROPIC GLUTAMATE; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

ANIMALIA;

EID: 17844376201     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2001.00435.x     Document Type: Article

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