Activation of type 5 metabotropic glutamate receptors enhances NMDA responses in mice cortical wedges

British Journal of Pharmacology

Volumn 132, Issue 4, 2001, Pages 799-806

  Attucci, S ^a   Carla V ^a   Mannaioni, G ^a   Moroni, F ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

CBPG; CPCCOEt; DHPG; Epilepsy; Metabotropic glutamate (mGlu) receptors; MPEP; N methyl D aspartate (NMDA); Neurodegeneration

Indexed keywords

2 (3' CARBOXYBICYCLO[1.1.1]PENTYL)GLYCINE; 2 CHLORO 5 HYDROXYPHENYLGLYCINE; 2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; 3,5 DIHYDROXYPHENYLGLYCINE; 7 (HYDROXYIMINO)CYCLOPROPAN[B]CHROMEN 1A CARBOXYLIC ACID ETHYLESTER; CARBOXYLIC ACID DERIVATIVE; GLYCINE DERIVATIVE; INOSITOL PHOSPHATE; METABOTROPIC RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CELL STRAIN BHK; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEPOLARIZATION; DRUG EFFECT; DRUG POTENTIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION;

EID: 0035124349     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703904     Document Type: Article

References (55)

1. 2+ signal transduction
2. Activation of NMDA receptors reverses desensitization of mGluR5 in native and recombinant systems
3. Quisqualate metabotropic receptors modulate NMDA currents and facilitate the induction of long-term potentiation through protein kinase C
4. Metabotropic glutamate receptors potentiate ionotropic glutamate responses in the rat dorsal horn
5. Pharmacology of metabotropic glutamate receptor-mediated enhancement of responses to excitatory and inhibitory amino acids on rat spinal neurons in vivo
6. A quantitative pharmacological analysis of some excitatory amino acid receptors in the mouse neocortex in vitro
7. General anaesthetics inhibit the responses induced by glutamate receptor agonists in the mouse cortex
8. The current status of the dopamine hypothesis of schizophrenia
9. Neurotransmitter aberrations in schizophrenia: New perspectives and therapeutic implications
10. Expression and coupling to polyphosphoinositide hydrolysis of group 1 metabotropic glutamate receptors in early post-natal and adult rat brain
11. Modulation of AMPA and NMDA responses in rat spinal dorsal horn neurons by trans-1-aminocyclopentane-1.3-dicarboxylic acid
12. Excitotoxic cell death
13. Excitatory amino acid receptors in the vertebrate central nervous system
14. The glutamate receptor ion channels
15. (RS)-2-Chloro-5-hydroxyphenylglycine (CHPG) activates mGlu5, but not mGlu1, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus
16. 2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist
17. Quantitative studies of some antagonists of NMDA in slices of rat cerebral cortex
18. Signal transduction pathways involved in the acute potentiation of NMDA responses by IS.3R-ACPD in rat hippocampal slices
19. Cloned glutamate receptors
20. 3,5-Dihydroxyphenylglycine: A potent agonist of metabotropic glutamate receptors
21. Recent advances in the phencyclidine model of schizophrenia
22. Glycine potentiates the NMDA response in cultured mouse brain neurons
23. Interactions between metabotropoipic and ionotropic glutamate receptor agonist in the rat spinal cord in vivo
24. Protein kinase C-mediated enhancement of NMDA currents by metabotropic glutamate receptors in Xenopus oocytes
25. Organization and regulation of proteins at synapses
26. Requirement for glycine in activation of NMDA-receptors expressed in Xenopus oocytes
27. Molecular diversity of the NMDA receptor channel
28. 3H-aspartate output in rat striatum
29. Metabotropic glutamate receptors, transmitter output and fatty acids: Studies in brain slices
30. Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long term potentiation (LTP) but normal CA3 LTP
31. Perisynaptic location of metabotropic glutamate receptors mGluR1 and mGluR5 on dendrites and dendritic spines in the rat hippocampus
32. Biochemical and electrophysiological studies on (S)-(+)-2-(3′-carboxybicyclo[1.1.1]pentyl)-glycine (CBPG), a novel mGlu5 receptor agonist endowed with mGlu 1 receptor antagonist activity
33. Pharmacological characterization of metabotropic glutamate receptors potentiating NMDA responses in mouse cortical wedge preparations
34. Excitatory amino acid neurotoxicity and neurodegenerative disease
35. Mice with reduced NMDA receptor expression display behaviors related to schizophrenia
36. Heteromeric NMDA receptors: Molecular and functional distinction of subtypes
37. Molecular diversity of glutamate receptors and implications for brain function
38. Metabotropic glutamate receptors: Synaptic transmission, modulation and plasticity
39. Magnesium gates glutamate-activated channels in mouse central neurones
40. Long-lasting enhancement of NMDA receptor-mediated synaptic transmission by metabotropic glutamate receptor activation
41. Excitotoxins: An overview
42. Excitotoxic amino acids and neuropsychiatric disorders
43. Excitatory amino acid release from rat hippocampal slices as a consequence of free radical formation
44. (S)-(+)-2-(3-Carboxybicyclo[1.1.1]pentil)-glycine, a structurally new group 1 metabotropic glutamate receptor antagonist
45. The metabotropic glutamate receptors: Structure and functions
46. Enhancement of NMDA responses by group 1 metabotropic glutamate receptor activation in striatal neurones
47. Reversal of glutamate excitotoxicity by activation of PKC-associated metabotropic glutamate receptors in cerebellar granule cells relies on NR2C subunit expression
48. Metabotropic glutamate receptors in brain function and pathology
49. 3,5-Dihydroxyphenilglycine is a highly selective agonist for phosphoinositide-linked metabotropic glutamate receptors in the rat hippocampus
50. Immunohistochemical localization of a metabotropic glutamate receptor, mGluR5, in the rat brain
51. L-2-Amino-4-phosphonobutyrate (L-AP4) is an agonist at the type- IV metabotropic glutamate receptor which is negatively coupled to adenylate cyclase
52. A pharmacological characterization of the mGluR1a subtype of the metabotropic glutamate receptor expressed in baby hamster kidney cell line
53. Potentiation of NMDA and AMPA responses by group 1 mGluR in spinal cord motoneurons
54. 5 agonist CHPG in spinal cord motoneurons
55. Combined oploid-NMDA antagonist therapies. What advantages do they offer for the control of pain syndromes?