Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage

Journal of Cerebral Blood Flow and Metabolism

Volumn 31, Issue 4, 2011, Pages 1107-1118

  Moyanova, Slavianka G ^a   Mastroiacovo, Federica ^b   Kortenska, Lidia V ^a   Mitreva, Rumiana G ^a   Fardone, Erminia ^b   Santolini, Ines ^b   Sobrado, Mónica ^c   Battaglia, Giuseppe ^b   Bruno, Valeria ^b,d   Nicoletti, Ferdinando ^b,d   Ngomba, Richard T ^b  

^a BULGARIAN ACADEMY OF SCIENCES   (Bulgaria)

^b IRCCS NEUROMED   (Italy)

^c UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^d SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

functional recovery; ischemia; mGlu4 receptor; neuroprotection; PHCCC

Indexed keywords

ENDOTHELIN 1; METABOTROPIC RECEPTOR 4; METABOTROPIC RECEPTOR AGONIST; N PHENYL 7 (HYDROXYIMINO)CYCLOPROPA[B]CHROMEN 1A CABOXAMIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN DAMAGE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BRAIN PROTECTION; CAUDATE NUCLEUS; CONTROLLED STUDY; CONVALESCENCE; DRUG RECEPTOR BINDING; ELECTROCORTICOGRAPHY; ELECTROENCEPHALOGRAPHY; GENE INACTIVATION; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PUTAMEN; RAT; SENSORIMOTOR FUNCTION; WILD TYPE;

ANIMALS; BEHAVIOR, ANIMAL; BRAIN; CEREBRAL INFARCTION; COLORING AGENTS; ELECTROENCEPHALOGRAPHY; EVANS BLUE; FEMALE; FORELIMB; HINDLIMB; INFARCTION, MIDDLE CEREBRAL ARTERY; ISCHEMIC ATTACK, TRANSIENT; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; POSTURAL BALANCE; PSYCHOMOTOR PERFORMANCE; RATS; RATS, WISTAR; RECEPTORS, METABOTROPIC GLUTAMATE; REFLEX;

EID: 79953289177     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1038/jcbfm.2010.201     Document Type: Article

References (40)

1. Backhauss C, Karkoutly C, Welsch M, Krieglstein J (1992) A mouse model of focal cerebral ischemia for screening neuroprotective drug effects. J Pharmacol Toxicol Methods 27:27-32
2. Battaglia G, Bruno V, Pisani A, Centonze D, Catania MV, Calabresi P, Nicoletti F (2001) Selective blockade of type-1 metabotropic glutamate receptors induces neuro-protection by enhancing GABAergic transmission. Mol Cell Neurosci 17:1071-83 (Pubitemid 32641875)
3. Battaglia G, Busceti CL, Molinaro G, Biagioni F, Traficante A, Nicoletti F, Bruno V (2006) Pharmacological activation of mGlu4 metabotropic glutamate receptors reduces nigrostriatal degeneration in mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. J Neuro-sci 26:7222-9
4. Bogaert L, Scheller D, Moonen J, Sarre S, Smolders I, Ebinger G, Michotte Y (2000) Neurochemical changes and laser Doppler flowmetry in the endothelin-1 rat model for focal cerebral ischemia. Brain Res 887: 266-75 (Pubitemid 32008048)
5. Bond A, Jones NM, Hicks CA, Whiffin GM, Ward MA, O'Neill MF, Kingston AE, Monn JA, Ornstein PL, Schoepp DD, Lodge D, O'Neill MJ (2000) Neuroprotec-tive effects of LY379268, a selective mGlu2/3 receptor agonist: investigations into possible mechanism of action in vivo. J Pharmacol Exp Ther 294:800-9 (Pubitemid 30666827)
6. Bond A, Ragumoorthy N, Monn JA, Hicks CA, Ward MA, Lodge D, O'Neill MJ (1999) LY379268, a potent and selective group II metabotropic glutamate receptor agonist, is neuroprotective in gerbil global, but not focal, cerebral ischaemia. Neurosci Lett 273:191-4 (Pubitemid 29430182)
7. Bruno V, Battaglia G, Copani A, D'Onofrio M, Di Iorio P, De Blasi A, Melchiorri D, Flor PJ, Nicoletti F (2001) Metabotropic glutamate receptor subtypes as targets for neuroprotective drugs. J Cereb Blood Flow Metab 21: 1013-33 (Pubitemid 32823739)
8. Bruno V, Battaglia G, Ksiazek I, Van der Putten H, Catania MV, Giuffrida R, Lukic S, Leonhardt T, Inderbitzin W, Gasparini F, Kuhn R, Hampson DR, Nicoletti F, Flor PJ (2000) Selective activation of mGlu4 metabotropic glutamate receptors is protective against excitotoxic neuronal death. J Neurosci 20:6413-20
9. Cai Z, Xiao F, Fratkin JD, Rhodes PG (1999) Protection of neonatal rat brain from hypoxic-ischemic injury by LY379268, a group II metabotropic glutamate receptor agonist. Neuroreport 10:3927-31 (Pubitemid 30004858)
10. Cain SM, Meadows HJ, Dunlop J, Bushell TJ (2008) mGlu4 potentiation of K(2P)2.1 is dependant on C-terminal dephosphorylation. Mol Cell Neurosci 37:32-9 (Pubitemid 350299992)
11. Callaway JK, Lawrence AJ, Jarrott B (2003) AM-36, a novel neuroprotective agent, profoundly reduces reactive oxygen species formation and dopamine release in the striatum of conscious rats after endothelin-1-induced middle cerebral artery occlusion. Neuropharmacology 44:787-800 (Pubitemid 36385143)
12. Choi DW (1988) Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage. Trends Neurosci 11:465-9
13. Conn PJ, Battaglia G, Marino MJ, Nicoletti F (2005) Metabotropic glutamate receptors in the basal ganglia motor circuit. Nat Rev Neurosci 6:787-98 (Pubitemid 41679241)
14. Corti C, Aldegheri L, Somogyi P, Ferraguti F (2002) Distribution and synaptic localisation of the metabo-tropic glutamate receptor 4 (mGluR4) in the rodent CNS. Neuroscience 110:403-20 (Pubitemid 34242771)
15. Corti C, Battaglia G, Molinaro G, Riozzi B, Pittaluga A, Corsi M, Mugnaini M, Nicoletti F, Bruno V (2007) The use of knock-out mice unravels distinct roles for mGlu2 and mGlu3 metabotropic glutamate receptors in mechanisms of neurodegeneration/neuroprotection. J Neurosci 27:8297-308 (Pubitemid 47219630)
16. Cozzi A, Meli E, Carlà V, Pellicciari R, Moroni F, Pellegrini-Giampietro DE (2002) Metabotropic glutamate 1 (mGlu1) receptor antagonists enhance GABAergic neu-rotransmission: a mechanism for the attenuation of post-ischemic injury and epileptiform activity? Neurophar-macology 43:119-30 (Pubitemid 35247600)
17. Hardingham GE, Fukunaga Y, Bading H (2002) Extrasy-naptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways. Nat Neurosci 5:405-14 (Pubitemid 34454245)
18. Henrich-Noack P, Flor PJ, Sabelhaus CF, Prass K, Dirnagl U, Gasparini F, Sauter A, Rudin M, Reymann KG (2000) Distinct influence of the group III metabotropic gluta-mate receptor agonist (R,S)-4-phosphonophenylglycine [(R,S)-PPG] on different forms of neuronal damage. Neuropharmacology 39:911-7 (Pubitemid 30103695)
19. Herz RC, Gaillard PJ, de Wildt DJ, Versteeg DH (1996) Differences in striatal extracellular amino acid concentrations between Wistar and Fischer 344 rats after middle cerebral artery occlusion. Brain Res 715:163-71 (Pubitemid 26141660)
20. Iversen L, Mulvihill E, Haldeman B, Diemer NH, Kaiser F, Sheardown M, Kristensen P (1994) Changes in metabo-tropic glutamate receptor mRNA levels following global ischemia: increase of a putative presynaptic subtype mGluR4 in highly vulnerable rat brain areas. J Neuro-chem 63:625-33 (Pubitemid 24233698)
21. Lee JM, Zipfel GJ, Choi DW (1999) The changing landscape of ischaemic brain injury mechanisms. Nature 399:7-14
22. Maj M, Bruno V, Dragic Z, Yamamoto R, Battaglia G, Inderbitzin W, Stoehr N, Stein T, Gasparini F, Vranesic I, Kuhn R, Nicoletti F, Flor PJ (2003) (-)-PHCCC, a positive allosteric modulator of mGluR4: characterization, mechanism of action, and neuroprotection. Neuropharma-cology 45:895-906 (Pubitemid 37297915)
23. Mastroiacovo F, Busceti CL, Biagioni F, Moyanova SG, Meisler MH, Battaglia G, Caricasole A, Bruno V, Nicoletti F (2009) Induction of the Wnt antagonist, Dickkopf-1, contributes to the development of neuronal death in models of brain focal ischemia. J Cereb Blood Flow Metab 29:264-76
24. Mauler F, Fahrig T, Horváth E, Jork R (2001) Inhibition of evoked glutamate release by the neuroprotective 5-HT(1A) receptor agonist BAY x 3702 in vitro and in vivo. Brain Res 888:150-7 (Pubitemid 32056271)
25. Millán C, Luján R, Shigemoto R, Sánchez-Prieto J (2002) Subtype-specific expression of group III metabotropic glutamate receptors and Ca2+ channels in single nerve terminals. J Biol Chem 277:47796-803 (Pubitemid 36159305)
26. Moyanova S, Kirov R, Kortenska L (2003) Multi-unit activity suppression and sensorimotor deficits after endothelin-1-induced middle cerebral artery occlusion in conscious rats. J Neurol Sci 212:59-67 (Pubitemid 36693966)
27. Moyanova SG, Kortenska LV, Kirov RK, Itzev DE, Usunoff KG (2008) Ketanserin reduces the postischemic EEG and behavioural changes following endothelin-1-induced occlusion of the middle cerebral artery in conscious rats. Cent Eur J Med 3:406-16
28. Moyanova SG, Kortenska LV, Mitreva RG, Pashova VD, Ngomba RT, Nicoletti F (2007) Multimodal assessment of neuroprotection applied to the use of MK-801 in the endothelin-1 model of transient focal brain ischemia. Brain Res 1153:58-67 (Pubitemid 46823888)
29. Ngomba RT, Ferraguti F, Badura A, Citraro R, Santolini I, Battaglia G, Bruno V, De Sarro G, Simonyi A, Van Luijtelaar G, Nicoletti F (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology 54:344-54
30. Panatier A, Poulain DA, Oliet SH (2004) Regulation of transmitter release by high-affinity group III mGluRs in the supraoptic nucleus of the rat hypothalamus. Neuropharmacology 47:333-41 (Pubitemid 38953224)
31. Paxinos G, Watson C (1997) The Rat Brain in Stereotaxic Coordinates. Compact 3rd ed. San Diego, CA: Academic Press
32. 0-carboxybicy-clo[1.1.1] pentyl)-glycine, two mGlu1 receptor-preferring antagonists, reduce neuronal death in in vitro and in vivo models of cerebral ischaemia. Eur J Neurosci 11:3637-47 (Pubitemid 29484260)
33. Pin JP, Duvoisin R (1995) The metabotropic glutamate receptors: structure and functions. Neuropharmacology 34:1-26
34. Rosdahl D, Seitzberg DA, Christensen T, Balchen T, Diemer NH (1994) Changes in mRNAfor metabotropic glutamate receptors after transient cerebral ischaemia. Neuroreport 5:593-6 (Pubitemid 24091347)
35. Schallert T, Fleming SM, Leasure JL, Tillerson JL, Bland ST (2000) CNS plasticity and assessment of forelimb sensorimotor outcome in unilateral rat models of stroke, cortical ablation, parkinsonism and spinal cord injury. Neuropharmacology 39:777-87 (Pubitemid 30103682)
36. Tanabe Y, Nomura A, Masu M, Shigemoto R, Mizuno N, Nakanishi S (1993) Signal transduction, pharmacological properties and expression patterns of two rat metabotropic glutamate receptors, mGluR3 and mGluR4. J Neurosci 13:1372-8 (Pubitemid 23095383)
37. Thomas CG, Miller AJ, Westbrook GL (2006) Synaptic and extrasynaptic NMDA receptor NR2 subunits in cultured hippocampal neurons. J Neurophysiol 95:1727-34
38. Tu W, Xu X, Peng L, Zhong X, Zhang W, Soundarapandian MM, Balel C, Wang M, Jia N, Zhang W, Lew F, Chan SL, Chen Y, Lu Y (2010) DAPK1 interaction with NMDA receptor NR2B subunits mediates brain damage in stroke. Cell 140:222-34
39. Tyson GW, Teasdale GM, Graham DI, McCulloch J (1984) Focal cerebral ischemia in the rat: topography of hemodynamic and histopathological changes. Ann Neurol 15:559-67 (Pubitemid 14124609)
40. Windle V, Szymanska A, Granter-Button S, White C, Buist R, Peeling J, Corbett D (2006) An analysis of four different methods of producing focal cerebral ischemia with endothelin-1 in the rat. Exp Neurol 201:324-34 (Pubitemid 44344225)