Selective activation of mGlu4 metabotropic glutamate receptors is protective against excitotoxic neuronal death

Journal of Neuroscience

Volumn 20, Issue 17, 2000, Pages 6413-6420

  Bruno, V ^a   Battaglia, G ^a   Ksiazek, I ^b   Van Der Putten, H ^b   Catania, M V ^c   Giuffrida, R ^c   Lukic, S ^b   Leonhardt, T ^b   Inderbitzin, W ^b   Gasparini, F ^b   Kuhn, R ^b   Hampson, D R ^d   Nicoletti, F ^a,e   Flor, P J ^b  

^a IRCCS NEUROMED   (Italy)

^b NOVARTIS PHARMA AG   (Switzerland)

^c CNR   (Italy)

^d UNIVERSITY OF TORONTO   (Canada)

^e UNIVERSITY OF CATANIA   (Italy)

Author keywords

Cortical cultures; Excitotoxicity; Gene targeting; Knock out mice; Metabotropic glutamate receptors; Neurodegeneration

Indexed keywords

2 AMINO 4 PHOSPHONOBUTYRIC ACID; GLUTAMATE RECEPTOR AGONIST; METABOTROPIC RECEPTOR; N METHYL DEXTRO ASPARTIC ACID; PHENYLGLYCINE; PHOSPHOSERINE; RECEPTOR SUBTYPE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN CELL; CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; ENANTIOMER; GENE TARGETING; HOMEOSTASIS; KNOCKOUT MOUSE; MICRODIALYSIS; MOUSE; NERVE CELL NECROSIS; NERVE DEGENERATION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; STRAIN DIFFERENCE;

EID: 0034280739     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.20-17-06413.2000     Document Type: Article

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