Selective activation of group-II metabotropic glutamate receptors is protective against excitotoxic neuronal death

European Journal of Pharmacology

Volumn 356, Issue 2-3, 1998, Pages 271-274

  Battaglia, Giuseppe ^a   Bruno, Valeria ^a   Ngomba, Richard T ^a   Di Grezia, Renato ^a   Copani, Agata ^b   Nicoletti, Ferdinando ^a,b  

^a IRCCS NEUROMED   (Italy)

^b UNIVERSITY OF CATANIA   (Italy)

Author keywords

Aminopyrrolidine 2R,4R dicarboxylated; mGlu2 receptor; mGlu3 receptor; Neuroprotection

Indexed keywords

EXCITOTOXIN; GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR AGONIST; GLUTAMIC ACID DERIVATIVE; GLYCINE DERIVATIVE; METABOTROPIC RECEPTOR; N METHYL DEXTRO ASPARTIC ACID; NEUROPROTECTIVE AGENT; PYRROLIDINE DERIVATIVE;

ANIMAL CELL; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; FETUS; MOUSE; NERVE CELL CULTURE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CELLS, CULTURED; CEREBRAL CORTEX; EXCITATORY AMINO ACID AGONISTS; MICE; N-METHYLASPARTATE; NERVE DEGENERATION; PROLINE; RECEPTORS, METABOTROPIC GLUTAMATE;

EID: 0031786473     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(98)00551-2     Document Type: Article

References (27)

1. Ambrosini, A., Bresciani, L., Fracchia, S., Brunello, N., Racagni, G., 1995. Metabotropic glutamate receptors negatively coupled to adenylate cyclase inhibit N-methyl-D-aspartate receptor activity and prevent neurotoxicity in mesencephalic neurons in vitro. Mol. Pharmacol. 47, 1057.
2. Battaglia, G., Monn, Schoepp, D.D., 1997. In vivo inhibition of veratridine-evoked release of striatal excitatory amino acids by the group-II metabotropic glutamate receptor agonist LY354740 in rats. Neurosci. Lett. 229, 161.
3. 5-mediated responses. Neuropharmacology 34, 895.
4. Bruno, V., Copani, A., Battaglia, G., Raffaele, R., Shinozaki, H., Nicoletti, F., 1994. Protective effect of the metabotropic glutamate receptor agonist, DCG-IV, against excitotoxic neuronal death. Eur. J. Pharmacol. 256, 109-112.
5. Bruno, V., Battaglia, G., Copani, A., Giffard, A., Raciti, G., Raffaele, R., Shinozaki, H., Nicoletti, F., 1995. Activation of class II or III metabotropic glutamate receptors protects cultured cortical neurons against excitotoxic degeneration. Eur. J. Neurosci. 7, 1906.
6. Bruno, V., Sureda, F.X., Storto, M., Casabona, G., Caruso, A., Knopfel, T., Kuhn, R., Nicoletti, F., 1997. The neuroprotective activity of group-II metabotropic glutamate receptors requires new protein synthesis and involves a glial-neuronal signaling. J. Neurosci. 17, 1891.
7. Bruno, V., Wroblewska, B., Wroblewski, J.T., Fiore, L., Nicoletti, F., 1998. Neuroprotective activity of N-acetylaspartylglutammate in cultured cortical cells. Neuroscience, in press.
8. Buisson, A., Choi, D.W., 1995. The inhibitory mGluR agonist, (S)-4-carboxy-3-hydroxyphenylglycine selectively attenuates NMDA neurotoxicity and oxygen-glucose deprivation-induced neuronal death. Neuropharmacology 34, 1081.
9. Buisson, A., Yu, S.P., Choi, D.W., 1994. Effect of metabotropic glutamate receptor agonists on excitotoxic and apoptotic cell death in murine cortical cell culture. Soc. Neurosci. Abstr. 20, 198.5.
10. Buisson, A., Yu, S.P., Choi, D.W., 1996. DCG-IV selectively attenuates rapidly triggered NMDA-induced neurotoxicity in cortical neurons. Eur. J. Neurosci. 8, 138.
11. Copani, A., Bruno, V., Battaglia, G., Leanza, G., Pellitteri, R., Russo, A., Stanzani, S., Nicoletti, F., 1995. Activation of metabotropic glutamate receptors protects neurons against apoptosis induced by β-amyloid peptide. Mol. Pharmacol. 47, 890-897.
12. Hayashi, Y., Momoiyama, A., Takahashi, T., Ohishi, H., Ogawa-Meguro, R., Shigemoto, R., Mizuno, N., Nakanishi, S., 1992. Agonist analysis of 2-(carboxycyclopropyl)glycine isomers for cloned metabotropic glutamate receptor subtypes expressed in Chinese ovary cells. Br. J. Pharmacol. 107, 539.
13. Hayashi, Y., Momiyama, A., Takahashi, T., Ohishi, H., Igawa-Meguro, R., Shigemoto, R., Mizuno, N., Nakanishi, S., 1993. Role of metabotropic glutamate receptors in synaptic modulation in the accessory olfactory bulb. Nature 366, 687.
14. Ishida, M., Saito, T., Shimamoto, K., Ohfune, Y., Shinozaki, H., 1993. A novel metabotropic glutamate receptor agonist: marked depression of monosynaptic excitation in the newborn rat isolated spinal cord. Br. J. Pharmacol. 109, 1169.
15. Kingston, A.E., Bales, K.R., Monn, J.A., Paul, S.M., Pullar, I.A., Schoepp, D.D., 1997. Comparison of the neuroprotective effect of mGluR agonists: (RS)-3,5-dihydroxyphenylglycine, LY354740 and L-amino-4-phosphonobutyric acid on ionotropic glutamate receptor-induced excitotoxicity in rat cortical neurones. Soc. Neurosci. Abstr. 23, 899.1.
16. Nakanishi, S., 1992. Molecular diversity of glutamate receptors and implications for brain function. Science 258, 597.
17. Nicoletti, F., Bruno, V., Copani, A., Casabona, G., Knopfel, T., 1996. Metabotropic glutamate receptors: a new target for the therapy of neurodegenerative disorders?. Trends Neurosci. 19, 267-271.
18. Orlando, L.R., Standaert, D.G., Cha, J.-H., Penney, J.B., Young, A.B., 1995. Metabotropic receptors in excitotoxicity: (S)-4C3HPG protects against striatal quinolinic acid lesions. Soc. Neurosci. Abstr. 21, 529.19.
19. Pin, J.-P., Duvoisin, R., 1995. The metabotropic glutamate receptors: structure and functions. Neuropharmacology 34, 1-26.
20. Rose, K., Goldberg, M.P., Choi, D.W., 1992. Cytotoxicity in murine neocortical cell culture. In: Tyson, C.A., Frezier, J.M. (Eds.), Methods in Toxicology, In Vitro Biological Systems, Vol. 1, Academic Press, San Diego, CA, pp. 46-60.
21. Schoepp, D.D., Salhoff, C.R., Wright, R.A., Johnson, B.G., Burnett, J.P., Mayne, N.G., Belagaje, R., Wu, S., Monn, J.A., 1996. The novel metabotropic glutamate receptor agonist 2R,4R-APDC potentiates stimulation of phosphoinositide hydrolysis in the rat hippocampus by 3,5-dihydroxyphenylglycine: evidence for a synergistic interaction between group 1 and group 2 receptors. Neuropharmacology 35, 1661.
22. Schoepp, D.D., Johnson, B.G., Wright, R.A., Salhoff, C.R., Mayne, N.G., Wu, S., Cockerham, S.L., Burnett, J.P., Belegaje, R., Bleakman, D., Monn, J.A., 1997a. LY354740 is a potent and highly selective group II metabotropic glutamate receptor agonist in cells expressing human glutamate receptors. Neuropharmacology 36, 1.
23. Schoepp, D.D., Johnson, B.G., Wright, R.A., Salhoff, C.R., Monn, J.A., 1997b. Pharmacological Properties and Therapeutic Utilities of Group-II Metabotropic Glutamate Receptor Agonists. Abst. of the 36th Annuam Meeting of the America College of Neuropharmacology, p. 68.
24. Shinozaki, H., 1994. Neuron damage induced by potent kainoids and neuroprotective action of new agonists of metabotropic glutamate receptors. Eur. Neurol. 34, 2.
25. Thomas, N.K., Jane, D.E., Tse, H.-W., Watkins, J.C., 1996. (S)-α-Ethylglutamic acid and (RS)-α-cyclopropyl-4-phosphonophenylglycine as antagonists of L-AP4 and (1S,3S)-ACPD-induced depression of monosynaptic excitation of neonatal rat motoneurones. Br. J. Pharmacol. 117, 70-75.
26. Thomsen, C., Bruno, V., Nicoletti, F., Marinozzi, M., Pellicciari, R., 1996. (2S,1′S,2′S,3′R)-2-(2′-Carboxy-3′- phenylcyclopropyl)glycine, a potent and selective antagonist of type-2 metabotropic glutamate receptors. Mol. Pharmacol. 50, 6-9.
27. Turetsky, D.M., Buisson, A., Choi, D.W., 1995. The metabotropic glutamate receptor agonist, 4C3HPG, reduces kainate-induced death of cortical neurons expressing calcium-permeable AMPA/kainate receptors. Soc. Neurosci. Abstr. 21, 529.20.