Discovery, synthesis, and structure-activity relationship development of a series of N-(4-acetamido)phenylpicolinamides as positive allosteric modulators of metabotropic glutamate receptor 4 (mGlu4) with CNS exposure in rats

Journal of Medicinal Chemistry

Volumn 54, Issue 4, 2011, Pages 1106-1110

  Engers, Darren W ^a,b   Field, Julie R ^a   Le, Uyen ^a   Zhou, Ya ^a,b   Bolinger, Julie D ^a   Zamorano, Rocio ^a,b   Blobaum, Anna L ^a,b   Jones, Carrie K ^a,b,c   Jadhav, Satyawan ^a,b   Weaver, C David ^a   Conn, P Jeffrey ^a,b   Lindsley, Craig W ^a,b,d   Niswender, Colleen M ^a,b   Hopkins, Corey R ^a,b  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^c DEPARTMENT OF VETERANS AFFAIRS   (United States)

^d VANDERBILT UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

METABOTROPIC RECEPTOR 4; N [3 CHLORO 4 (2 CHLOROBENZAMIDO)PHENYL]PICOLINAMIDE; N [3 CHLORO 4 (2 METHYLBENZAMIDO)PHENYL]PICOLINAMIDE; N [4 (2 CHLOROBENZAMIDO) 3 METHOXYPHENYL)PICOLINAMIDE; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CENTRAL NERVOUS SYSTEM; DRUG DEVELOPMENT; DRUG EXPOSURE; DRUG SYNTHESIS; STRUCTURE ACTIVITY RELATION;

ALLOSTERIC REGULATION; ANIMALS; BRAIN; CENTRAL NERVOUS SYSTEM; CHO CELLS; CRICETINAE; CRICETULUS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; PICOLINES; RATS; RECEPTORS, METABOTROPIC GLUTAMATE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79951841137     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm101271s     Document Type: Article

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