(R,S)-4-phosphonophenylglycine, a potent and selective group III metabotropic glutamate receptor agonist, is anticonvulsive and neuroprotective in vivo

Journal of Pharmacology and Experimental Therapeutics

Volumn 289, Issue 3, 1999, Pages 1678-1687

  Gasparini, F ^a   Bruno, V ^b   Battaglia, G ^b   Lukic, S ^a   Leonhardt, T ^a   Inderbitzin, W ^a   Laurie, D ^a   Sommer, B ^a   Varney, M A ^c   Hess, S D ^c   Johnson, E C ^c   Kuhn, R ^a   Urwyler, S ^a   Sauer, D ^a   Portet, C ^a   Schmutz, M ^a   Nicoletti, F ^b,d   Flor, Peter J ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b IRCCS NEUROMED   (Italy)

^c MERCK RESEARCH LABORATORIES   (United States)

^d UNIVERSITY OF CATANIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

4 PHOSPHONOPHENYLGLYCINE; ALPHA ETHYLGLUTAMATE; ALPHA METHYLSERINE O PHOSPHATE; GLUTAMATE RECEPTOR AGONIST; GLUTAMATE RECEPTOR ANTAGONIST; GLUTAMIC ACID DERIVATIVE; METABOTROPIC RECEPTOR; N METHYL DEXTRO ASPARTIC ACID; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

AGONIST; ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; BINDING AFFINITY; DRUG POTENCY; DRUG SELECTIVITY; MALE; NEUROPROTECTION; NEUROTRANSMITTER RELEASE; NONHUMAN; PATHOPHYSIOLOGY; PRESYNAPTIC INHIBITION; PRIORITY JOURNAL; RAT;

ANIMALS; ANTICONVULSANTS; BRAIN; CELL LINE; CELL MEMBRANE; CORPUS STRIATUM; CYCLIC AMP; ELECTROSHOCK; FORSKOLIN; GLUTAMIC ACID; GLYCINE; HUMANS; KINETICS; MALE; MICE; MICE, INBRED STRAINS; N-METHYLASPARTATE; NEUROPROTECTIVE AGENTS; PHOSPHATIDYLINOSITOLS; PROTEIN ISOFORMS; QUINOLINIC ACID; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, METABOTROPIC GLUTAMATE; RECOMBINANT PROTEINS; SECOND MESSENGER SYSTEMS; SEIZURES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0033034991     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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