Dual neurotoxic and neuroprotective role of metabotropic glutamate receptor 1 in conditions of trophic deprivation - Possible role as a dependence receptor

Neuropharmacology

Volumn 55, Issue 4, 2008, Pages 500-508

  Pshenichkin, Sergey ^a   Dolińska, Monika ^a   Klauzińska, Małgorzata ^a   Luchenko, Victoria ^a   Grajkowska, Ewa ^a   Wroblewski, Jarda T ^a  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Cerebellar granule cells; Dependence receptors; Metabotropic glutamate receptor; Neuroprotection; Neurotoxicity; Trophic deprivation

Indexed keywords

GLUTAMIC ACID; METABOTROPIC RECEPTOR 1; METABOTROPIC RECEPTOR ANTAGONIST; SMALL INTERFERING RNA;

ADENOVIRUS; ANIMAL CELL; APOPTOSIS; ARTICLE; BRAIN CELL; CELL DEATH; CELL SURVIVAL; CONTROLLED STUDY; GRANULE CELL; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; CELL SURVIVAL; CELLS, CULTURED; CEREBELLUM; CEREBRAL CORTEX; CHROMONES; DIOXOLANES; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; GENE EXPRESSION; GLUTAMIC ACID; GREEN FLUORESCENT PROTEINS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; NEURONS; POTASSIUM CHLORIDE; PURINES; PYRIDINES; RATS; RECEPTORS, METABOTROPIC GLUTAMATE; RNA, SMALL INTERFERING; TIME FACTORS; TRANSFECTION;

EID: 49949110710     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2008.06.039     Document Type: Article

References (56)

1. Ango F., Prezeau L., Muller T., Tu J.C., Xiao B., Worley P.F., Pin J.P., Bockaert J., and Fagni L. Agonist-independent activation of metabotropic glutamate receptors by the intracellular protein Homer. Nature 411 (2001) 962-965
2. Bordeaux M.C., Forcet C., Granger L., Corset V., Bidaud C., Billaud M., Bredesen D.E., Edery P., and Mehlen P. The RET proto-oncogene induces apoptosis: a novel mechanism for Hirschsprung disease. EMBO J. 19 (2000) 4056-4063
3. Brakeman P.R., Lanahan A.A., O'Brien R., Roche K., Barnes C.A., Huganir R.L., and Worley P.F. Homer: a protein that selectively binds metabotropic glutamate receptors. Nature 386 (1997) 284-288
4. Bruno V., Wroblewska B., Wroblewski J.T., Fiore L., and Nicoletti F. Neuroprotective activity of N-acetylaspartylglutamate in cultured cortical cells. Neuroscience 85 (1998) 751-757
5. Casabona G., Knopfel T., Kuhn R., Gasparini F., Baumann P., Sortino M.A., Copani A., and Nicoletti F. Expression and coupling to polyphosphoinositide hydrolysis of group I metabotropic glutamate receptors in early postnatal and adult rat brain. Eur. J. Neurosci. 9 (1997) 12-17
6. Catania M.V., Bellomo M., Di Giorgi-Gerevini V., Seminara G., Giuffrida R., Romeo R., De Blasi A., and Nicoletti F. Endogenous activation of group-I metabotropic glutamate receptors is required for differentiation and survival of cerebellar Purkinje cells. J. Neurosci. 21 (2001) 7664-7673
7. Ciruela F., Robbins M.J., Willis A.C., and McIlhinney R.A. Interactions of the C terminus of metabotropic glutamate receptor type 1alpha with rat brain proteins: evidence for a direct interaction with tubulin. J. Neurochem. 72 (1999) 346-354
8. Conn P.J., and Pin J.P. Pharmacology and functions of metabotropic glutamate receptors. Annu. Rev. Pharmacol. Toxicol. 37 (1997) 205-237
9. Contestabile A. Cerebellar granule cells as a model to study mechanisms of neuronal apoptosis or survival in vivo and in vitro. Cerebellum 1 (2002) 41-55
10. Copani A., Casabona G., Bruno V., Caruso A., Condorelli D.F., Messina A., Di Giorgi Gerevini V., Pin J.P., Kuhn R., Knopfel T., and Nicoletti F. The metabotropic glutamate receptor MGlu5 controls the onset of developmental apoptosis in cultured cerebellar neurons. Eur. J. Neurosci. 10 (1998) 2173-2184
11. Croci C., Sticht H., Brandstatter J.H., and Enz R. Group I metabotropic glutamate receptors bind to protein phosphatase 1C. Mapping and modeling of interacting sequences. J. Biol. Chem. 278 (2003) 50682-50690
12. D'Mello S.R., Borodezt K., and Soltoff S.P. Insulin-like growth factor and potassium depolarization maintain neuronal survival by distinct pathways: possible involvement of PI 3-kinase in IGF-1 signaling. J. Neurosci. 17 (1997) 1548-1560
13. D'Mello S.R., Galli C., Ciotti T., and Calissano P. Induction of apoptosis in cerebellar granule neurons by low potassium: inhibition of death by insulin-like growth factor I and CAMP. Proc. Natl. Acad. Sci. U S A 90 (1993) 10989-10993
14. Dale L.B., Bhattacharya M., Anborgh P.H., Murdoch B., Bhatia M., Nakanishi S., and Ferguson S.S. G protein-coupled receptor kinase-mediated desensitization of metabotropic glutamate receptor 1A protects against cell death. J. Biol. Chem. 275 (2000) 38213-38220
15. Forcet C., Ye X., Granger L., Corset V., Shin H., Bredesen D.E., and Mehlen P. The dependence receptor DCC (deleted in colorectal cancer) defines an alternative mechanism for caspase activation. Proc. Natl. Acad. Sci. U S A 98 (2001) 3416-3421
16. Heck S., Enz R., Richter-Landsberg C., and Blohm D.H. Expression of eight metabotropic glutamate receptor subtypes during neuronal differentiation of P19 embryocarcinoma cells: a study by RT-PCR and in situ hybridization. Brain Res. Dev. Brain Res. 101 (1997) 85-91
17. Hermans E., and Challiss R.A. Structural, signalling and regulatory properties of the group I metabotropic glutamate receptors: prototypic family C G-protein-coupled receptors. Biochem. J. 359 (2001) 465-484
18. Hou L., and Klann E. Activation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway is required for metabotropic glutamate receptor-dependent long-term depression. J. Neurosci. 24 (2004) 6352-6361
19. 2+/calmodulin with the cytoplasmic tail of group 1 metabotropic glutamate receptors. Genes Cells 4 (1999) 381-390
20. Kammermeier P.J., and Ikeda S.R. A role for seven in absentia homolog (Siah1a) in metabotropic glutamate receptor signaling. BMC Neurosci. 2 (2001) 15
21. Kammermeier P.J., and Yun J. Activation of metabotropic glutamate receptor 1 dimers requires glutamate binding in both subunits. J. Pharmacol. Exp. Ther. 312 (2005) 502-508
22. Kitano J., Kimura K., Yamazaki Y., Soda T., Shigemoto R., Nakajima Y., and Nakanishi S. Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins. J. Neurosci. 22 (2002) 1280-1289
23. Kubo T., Nonomura T., Enokido Y., and Hatanaka H. Brain-derived neurotrophic factor (BDNF) can prevent apoptosis of rat cerebellar granule neurons in culture. Brain Res. Dev. Brain Res. 85 (1995) 249-258
24. Kunishima N., Shimada Y., Tsuji Y., Sato T., Yamamoto M., Kumasaka T., Nakanishi S., Jingami H., and Morikawa K. Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor. Nature 407 (2000) 971-977
25. Litschig S., Gasparini F., Rueegg D., Stoehr N., Flor P.J., Vranesic I., Prezeau L., Pin J.P., Thomsen C., and Kuhn R. CPCCOEt, a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding. Mol. Pharmacol. 55 (1999) 453-461
26. Llambi F., Causeret F., Bloch-Gallego E., and Mehlen P. Netrin-1 acts as a survival factor via its receptors UNC5H and DCC. EMBO J. 20 (2001) 2715-2722
27. Lopez-Bendito G., Shigemoto R., Fairen A., and Lujan R. Differential distribution of group I metabotropic glutamate receptors during rat cortical development. Cereb. Cortex 12 (2002) 625-638
28. Marin Y.E., and Chen S. Involvement of metabotropic glutamate receptor 1, a G protein coupled receptor, in melanoma development. J. Mol. Med. 82 (2004) 735-749
29. Mehlen P., and Bredesen D.E. The dependence receptor hypothesis. Apoptosis 9 (2004) 37-49
30. Mehlen P., and Fearon E.R. Role of the dependence receptor DCC in colorectal cancer pathogenesis. J. Clin. Oncol. 22 (2004) 3420-3428
31. Mehlen P., Rabizadeh S., Snipas S.J., Assa-Munt N., Salvesen G.S., and Bredesen D.E. The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis. Nature 395 (1998) 801-804
32. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 65 (1983) 55-63
33. Nash M.S., Selkirk J.V., Gaymer C.E., Challiss R.A., and Nahorski S.R. Enhanced inducible MGlu1alpha receptor expression in Chinese hamster ovary cells. J. Neurochem. 77 (2001) 1664-1667
34. Nicoletti F., Bruno V., Catania M.V., Battaglia G., Copani A., Barbagallo G., Cena V., Sanchez-Prieto J., Spano P.F., and Pizzi M. Group-I metabotropic glutamate receptors: hypotheses to explain their dual role in neurotoxicity and neuroprotection. Neuropharmacology 38 (1999) 1477-1484
35. Parmentier M.L., Prezeau L., Bockaert J., and Pin J.P. A model for the functioning of family 3 GPCRs. Trends Pharmacol. Sci. 23 (2002) 268-274
36. van den Pol A.N., Kogelman L., Ghosh P., Liljelund P., and Blackstone C. Developmental regulation of the hypothalamic metabotropic glutamate receptor MGluR1. J. Neurosci. 14 (1994) 3816-3834
37. Pollock P.M., Cohen-Solal K., Sood R., Namkoong J., Martino J.J., Koganti A., Zhu H., Robbins C., Makalowska I., Shin S.S., Marin Y., Roberts K.G., Yudt L.M., Chen A., Cheng J., Incao A., Pinkett H.W., Graham C.L., Dunn K., Crespo-Carbone S.M., Mackason K.R., Ryan K.B., Sinsimer D., Goydos J., Reuhl K.R., Eckhaus M., Meltzer P.S., Pavan W.J., Trent J.M., and Chen S. Melanoma mouse model implicates metabotropic glutamate signaling in melanocytic neoplasia. Nat. Genet. 34 (2003) 108-112
38. Porter A.G., and Dhakshinamoorthy S. Apoptosis initiated by dependence receptors: a new paradigm for cell death?. Bioessays 26 (2004) 656-664
39. Pshenichkin S.P., and Wise B.C. Okadaic acid increases nerve growth factor secretion, mRNA stability, and gene transcription in primary cultures of cortical astrocytes. J. Biol. Chem. 270 (1995) 5994-5999
40. Rabizadeh S., Oh J., Zhong L.T., Yang J., Bitler C.M., Butcher L.L., and Bredesen D.E. Induction of apoptosis by the low-affinity NGF receptor. Science 261 (1993) 345-348
41. Resink A., Hack N., Boer G.J., and Balazs R. Growth conditions differentially modulate the vulnerability of developing cerebellar granule cells to excitatory amino acids. Brain Res. 655 (1994) 222-232
42. Rong R., Ahn J.Y., Huang H., Nagata E., Kalman D., Kapp J.A., Tu J., Worley P.F., Snyder S.H., and Ye K. PI3 kinase enhancer-homer complex couples MGluRI to PI3 kinase, preventing neuronal apoptosis. Nat. Neurosci. 6 (2003) 1153-1161
43. Ryu B.R., Choi D.W., Hartley D.M., Costa E., Jou I., and Gwag B.J. Attenuation of cortical neuronal apoptosis by gangliosides. J. Pharmacol. Exp. Ther. 290 (1999) 811-816
44. Santi M.R., Ikonomovic S., Wroblewski J.T., and Grayson D.R. Temporal and depolarization-induced changes in the absolute amounts of mRNAs encoding metabotropic glutamate receptors in cerebellar granule neurons in vitro. J. Neurochem. 63 (1994) 1207-1217
45. Storto M., de Grazia U., Battaglia G., Felli M.P., Maroder M., Gulino A., Ragona G., Nicoletti F., Screpanti I., Frati L., and Calogero A. Expression of metabotropic glutamate receptors in murine thymocytes and thymic stromal cells. J. Neuroimmunol. 109 (2000) 112-120
46. Storto M., Sallese M., Salvatore L., Poulet R., Condorelli D.F., Dell'Albani P., Marcello M.F., Romeo R., Piomboni P., Barone N., Nicoletti F., Nicoletti F., and De Blasi A. Expression of metabotropic glutamate receptors in the rat and human testis. J. Endocrinol. 170 (2001) 71-78
47. Subramaniam S., Strelau J., and Unsicker K. Growth differentiation factor-15 prevents low potassium-induced cell death of cerebellar granule neurons by differential regulation of Akt and ERK pathways. J. Biol. Chem. 278 (2003) 8904-8912
48. Suzuki Y., Moriyoshi E., Tsuchiya D., and Jingami H. Negative cooperativity of glutamate binding in the dimeric metabotropic glutamate receptor subtype 1. J. Biol. Chem. 279 (2004) 35526-35534
49. Tateyama M., Abe H., Nakata H., Saito O., and Kubo Y. Ligand-induced rearrangement of the dimeric metabotropic glutamate receptor 1alpha. Nat. Struct. Mol. Biol. 11 (2004) 637-642
50. Thibert C., Teillet M.A., Lapointe F., Mazelin L., Le Douarin N.M., and Mehlen P. Inhibition of neuroepithelial patched-induced apoptosis by sonic hedgehog. Science 301 (2003) 843-846
51. Thiebault K., Mazelin L., Pays L., Llambi F., Joly M.O., Scoazec J.Y., Saurin J.C., Romeo G., and Mehlen P. The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment. Proc. Natl. Acad. Sci. U S A 100 (2003) 4173-4178
52. Tu J.C., Xiao B., Naisbitt S., Yuan J.P., Petralia R.S., Brakeman P., Doan A., Aakalu V.K., Lanahan A.A., Sheng M., and Worley P.F. Coupling of MGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins. Neuron 23 (1999) 583-592
53. Valenti O., Conn P.J., and Marino M.J. Distinct physiological roles of the Gq-coupled metabotropic glutamate receptors co-expressed in the same neuronal populations. J. Cell Physiol. 191 (2002) 125-137
54. Wood A.M., Tiwari P., and Bristow D.R. Media composition modulates excitatory amino acid-induced death of rat cerebellar granule cells. Hum. Exp. Toxicol. 16 (1997) 350-355
55. 2+ channels in primary cultures of cerebellar granule cells. Neuropharmacology 24 (1985) 919-921
56. Zhu H., Ryan K., and Chen S. Cloning of novel splice variants of mouse MGluR1. Brain Res. Mol. Brain Res. 73 (1999) 93-103