Context-dependent regulation of autophagy by IKK-NF- B signaling: Impact on the aging process

International Journal of Cell Biology

Volumn , Issue , 2012, Pages

  Salminen, Antero ^a,b   Hyttinen, Juha M T ^a   Kauppinen, Anu ^a   Kaarniranta, Kai ^a,b  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b KUOPIO UNIVERSITY HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOPHAGY PROTEIN 5; BECLIN 1; GAMMA INTERFERON; HEAT SHOCK PROTEIN 90; HIGH MOBILITY GROUP B1 PROTEIN; HISTONE DEACETYLASE 1; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN BNIP3; PROTEIN P53; PROTEIN P85; REACTIVE OXYGEN METABOLITE; SIRTUIN 1; STRESS ACTIVATED PROTEIN KINASE 1; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; X LINKED INHIBITOR OF APOPTOSIS;

ACETYLATION; APOPTOSIS; AUTOPHAGY; CARCINOGENESIS; CELL AGING; CELL DEATH; CELL SURVIVAL; CYTOPLASM; DIMERIZATION; EXTRACELLULAR SPACE; HUMAN; HYPOTHALAMUS; INSULIN RESISTANCE; IONIZING RADIATION; METABOLIC SYNDROME X; METHYLATION; MITOPHAGY; NITROSYLATION; NONHUMAN; OBESITY; OXIDATIVE STRESS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION; SUMOYLATION; UBIQUITINATION;

EID: 84864928990     PISSN: 16878876     EISSN: 16878884     Source Type: Journal    
DOI: 10.1155/2012/849541     Document Type: Review

References (185)

1. Haigis M. C., Yankner B. A., The aging stress response Molecular Cell 2010 40 2 333 344
2. Koga H., Kaushik S., Cuervo A. M., Protein homeostasis and aging: the importance of exquisite quality control Ageing Research Reviews 2011 10 2 205 215
3. Finkel T., Holbrook N. J., Oxidants, oxidative stress and the biology of ageing Nature 2000 408 6809 239 247
4. Gross O., Thomas C. J., Guarda G., Tschopp J., The inflammasome: an integrated view Immunological Reviews 2011 243 1 136 151
5. Salminen A., Kaarniranta K., Kauppinen A., Inflammaging: disturbed interplay between autophagy and inflammasomes Aging (Albany NY) 2012 4 3 1 10
6. Cuervo A. M., Autophagy and aging: keeping that old broom working Trends in Genetics 2008 24 12 604 612
7. Salminen A., Kaarniranta K., Regulation of the aging process by autophagy Trends in Molecular Medicine 2009 15 5 217 224
8. Rajawat Y. S., Hilioti Z., Bossis I., Aging: central role for autophagy and the lysosomal degradative system Ageing Research Reviews 2009 8 3 199 213
9. Klionsky D. J., Autophagy: from phenomenology to molecular understanding in less than a decade Nature Reviews Molecular Cell Biology 2007 8 11 931 937 (Pubitemid 47622558)
10. Mizushima N., Yoshimori T., Ohsumi Y., The role of Atg proteins in autophagosome formation Annual Reviews in Cell and Developmental Biology 2011 27 1 107 132
11. Tanida I., Autophagosome formation and molecular mechanism of autophagy Antioxidants and Redox Signaling 2011 14 11 2201 2214
12. Funderburk S. F., Wang Q. J., Yue Z., The Beclin 1-VPS34 complexat the crossroads of autophagy and beyond Trends in Cell Biology 2010 20 6 355 362
13. He C., Levine B., The Beclin 1 interactome Current Opinion in Cell Biology 2010 22 2 140 149
14. Matsunaga K., Morita E., Saitoh T., Akira S., Ktistakis N. T., Izumi T., Noda T., Yoshimori T., Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L Journal of Cell Biology 2010 190 4 511 521
15. Sinha S., Levine B., The autophagy effector Beclin 1: a novel BH3-only protein Oncogene 2008 27 1, supplement S137 S148
16. Wei Y., Pattingre S., Sinha S., Bassik M., Levine B., JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy Molecular Cell 2008 30 6 678 688 (Pubitemid 351818252)
17. Bellot G., Garcia-Medina R., Gounon P., Chiche J., Roux D., Pouysségur J., Mazure N. M., Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains Molecular and Cellular Biology 2009 29 10 2570 2581
18. Kang R., Zeh H. J., Lotze M. T., Tang D., The Beclin 1 network regulates autophagy and apoptosis Cell Death and Differentiation 2011 18 4 571 580
19. He C., Klionsky D. J., Regulation mechanisms and signaling pathways of autophagy Annual Review of Genetics 2009 43 67 93
20. Kroemer G., Mario G., Levine B., Autophagy and the Integrated Stress Response Molecular Cell 2010 40 2 280 293
21. Ravikumar B., Sarkar S., Davies J. E., Futter M., Garcia-Arencibia M., Green-Thompson Z. W., Jimenez-Sanchez M., Korolchuk V. I., Lichtenberg M., Luo S., Massey D. C. O., Menzies F. M., Moreau K., Narayanan U., Renna M., Siddiqi F. H., Underwood B. R., Winslow And A. R., Rubinsztein D. C., Regulation of mammalian autophagy in physiology and pathophysiology Physiological Reviews 2010 90 4 1383 1435
22. Caballero B., Coto-Montes A., An insight into the role of autophagy in cell responses in the aging and neurodegenerative brain Histology and Histopathology 2012 27 3 263 275
23. Oeckinghaus A., Ghosh S., The NF-kappaB family of transcription factors and its regulation Cold Spring Harbor Perspectives in Biology 2009 1 4, article a000034
24. Ghosh G., Wang V. Y., Huang D. B., Fusco A., NF- B regulation: lessons from structures Immunological Reviews 2012 246 1 36 58
25. Hinz M., Arslan S. C., Scheidereit C., It takes two to tango: I Bs, the multifunctional partners of NF- B Immunological Reviews 2012 246 1 59 76
26. Tieri P., Termanini A., Bellavista E., Salvioli S., Capri M., Franceschi C., Charting the NF- B pathway interactome map PLoS ONE 2012 7 3
27. Perkins N. D., Integrating cell-signalling pathways with NF- B and IKK function Nature Reviews Molecular Cell Biology 2007 8 1 49 62 (Pubitemid 46012014)
28. Hayden M. S., Ghosh S., Shared Principles in NF- B Signaling Cell 2008 132 3 344 362
29. Oeckinghaus A., Hayden M. S., Ghosh S., Crosstalk in NF- B signaling pathways Nature Immunology 2011 12 8 695 708
30. Chariot A., The NF- B-independent functions of IKK subunits in immunity and cancer Trends in Cell Biology 2009 19 8 404 413
31. Huang B., Yang X. D., Lamb A., Chen L. F., Posttranslational modifications of NF- B: another layer of regulation for NF- B signaling pathway Cellular Signalling 2010 22 9 1282 1290
32. Smale S. T., Hierarchies of NF- B target-gene regulation Nature Immunology 2011 12 8 689 694
33. ] Sen N., Paul B. D., Gadalla M. M., Mustafa A. K., Sen T., Xu R., Kim S., Snyder S. H., Hydrogen sulfide-linked sulfhydration of NF- B mediates its antiapoptotic actions Molecular Cell 2012 45 1 13 24
34. Lawrence T., Fong C., The resolution of inflammation: anti-inflammatory roles for NF- B International Journal of Biochemistry and Cell Biology 2010 42 4 519 523
35. Meng Q., Cai D., Defective hypothalamic autophagy directs the central pathogenesis of obesity via the I B kinase (IKK )/NF- B pathway The Journal of Biological Chemistry 2011 286 37 32324 32332
36. Levine B., Mizushima N., Virgin H. W., Autophagy in immunity and inflammation Nature 2011 469 7330 323 335
37. Salminen A., Hyttinen J. M. T., Kaarniranta K., AMP-activated protein kinase inhibits NF- B signaling and inflammation: impact on healthspan and lifespan Journal of Molecular Medicine 2011 89 7 667 676
38. Yeung F., Hoberg J. E., Ramsey C. S., Keller M. D., Jones D. R., Frye R. A., Mayo M. W., Modulation of NF- B-dependent transcription and cell survival by the SIRT1 deacetylase EMBO Journal 2004 23 12 2369 2380 (Pubitemid 38954844)
39. Lee I. H., Cao L., Mostoslavsky R., Lombard D. B., Liu J., Bruns N. E., Tsokos M., Alt F. W., Finkel T., A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy Proceedings of the National Academy of Sciences of the United States of America 2008 105 9 3374 3379 (Pubitemid 351723560)
40. Trocoli A., Djavaheri-Mergny M., The complex interplay between autophagy and NF- B signaling pathways in cancer cells American Journal of Cancer Research 2011 1 5 629 649
41. Criollo A., Senovilla L., Authier H., Maiuri M. C., Morselli E., Vitale I., Kepp O., Tasdemir E., Galluzzi L., Shen S., Tailler M., Delahaye N., Tesniere A., De Stefano D., Younes A. B., Harper F., Pierron G., Lavandero S., Zitvogel L., Israel A., Baud V., Kroemer G., The IKK complex contributes to the induction of autophagy EMBO Journal 2010 29 3 619 631
42. Comb W. C., Cogswell P., Sitcheran R., Baldwin A. S., IKK-dependent, NF- B-independent control of autophagic gene expression Oncogene 2011 30 14 1727 1732
43. Comb W. C., Hutti J. E., Cogswell P., Cantley L. C., Baldwin A. S., p85 SH2 domain phosphorylation by IKK promotes feedback inhibition of PI3K and Akt in response to cellular starvation Molecular Cell 2012 45 6 719 730
44. Broemer M., Krappmann D., Scheidereit C., Requirement of Hsp90 activity for I B kinase (IKK) biosynthesis and for constitutive and inducible IKK and NF- B activation Oncogene 2004 23 31 5378 5386 (Pubitemid 39005813)
45. Hinz M., Broemer M., Arslan S.., Otto A., Mueller E. C., Dettmer R., Scheidereit C., Signal responsiveness of I B kinases is determined by Cdc37-assisted transient interaction with Hsp90 The Journal of Biological Chemistry 2007 282 44 32311 32319 (Pubitemid 350106474)
46. Salminen A., Paimela T., Suuronen T., Kaarniranta K., Innate immunity meets with cellular stress at the IKK complex: regulation of the IKK complex by HSP70 and HSP90 Immunology Letters 2008 117 1 9 15
47. Pittet J. F., Lee H., Pespeni M., O'Mahony A., Roux J., Welch W. J., Stress-induced inhibition of the NF- B signaling pathway results from the insolubilization of the I B kinase complex following its dissociation from heat shock protein 90 Journal of Immunology 2005 174 1 384 394 (Pubitemid 40007426)
48. Qing G., Yan P., Xiao G., Hsp90 inhibition results in autophagy-mediated proteasome-independent degradation of I B kinase (IKK) Cell Research 2006 16 11 895 901 (Pubitemid 44764199)
49. Qing G., Yan P., Qu Z., Liu H., Xiao G., Hsp90 regulates processing of NF-kB2 p100 involving protection of NF-kB-inducing kinase (NIK) from autophagy-mediated degradation Cell Research 2007 17 6 520 530 (Pubitemid 46980948)
50. Niida M., Tanaka M., Kamitani T., Downregulation of active IKK by Ro52-mediated autophagy Molecular Immunology 2010 47 14 2378 2387
51. Kim J. E., You D. J., Lee C., Ahn C., Seong J. Y., Hwang J. I., Suppression of NF- B signaling by KEAP1 regulation of IKK activity through autophagic degradation and inhibition of phosphorylation Cellular Signalling 2010 22 11 1645 1654
52. Nivon M., Richet E., Codogno P., Arrigo A. P., Kretz-Remy C., Autophagy activation by NF B is essential for cell survival after heat shock Autophagy 2009 5 6 766 783
53. Nivon M., Abou-Samra M., Richet E., Guyot B., Arrigo A. P., Kretz-Remy C., NF- B regulates protein quality control after heat stress through modulation of the BAG3-HspB8 Journal of Cell Science 2012 125 1 1 11
54. Carra S., Seguin S. J., Landry J., HspB8 and Bag3: a new chaperone complex targeting misfolded proteins to macroautophagy Autophagy 2008 4 2 237 239 (Pubitemid 351231189)
55. Kretz-Remy C., Munseh B., Arrigo A. P., NF B-dependent transcriptional activation during heat shock recovery: thermolability of the NF- B I B complex The Journal of Biological Chemistry 2001 276 47 43723 43733
56. Copetti T., Bertoli C., Dalla E., Demarchi F., Schneider C., p65/RelA modulates BECN1 transcription and autophagy Molecular and Cellular Biology 2009 29 10 2594 2608
57. Bhatnagar S., Mittal A., Gupta S. K., Kumar A., TWEAK causes myotubes atrophy through coordinated activation of ubiquitin-proteasome system, autophagy, and caspases Journal of Cellular Physiology 2012 227 3 1042 1051
58. Dogra C., Changotra H., Wedhas N., Qin X., Wergedal J. E., Kumar A., TNF-related weak inducer of apoptosis (TWEAK) is a potent skeletal muscle-wasting cytokine FASEB Journal 2007 21 8 1857 1869 (Pubitemid 46855631)
59. Kumar A., Bhatnagar S., Paul P. K., TWEAK and TRAF6 regulate skeletal muscle atrophy Current Opinion in Clinical Nutrition and Metabolic Care 2012 15 2 233 239
60. Shi C. S., Kehrl J. H., TRAF6 and A20 regulate lysine 63-linked ubiquitination of Beclin-1 to control TLR4-induced Autophagy Science Signaling 2010 3 123, article ra42
61. Jiang Q., Wang Y., Li T., Shi K., Li Z., Ma Y., Li F., Luo H., Yang Y., Xu C., Heat shock protein 90-mediated inactivation of nuclear factor-kB switches autophagy to apoptosis through becn1 transcriptional inhibition in selenite-induced NB4 cells Molecular Biology of the Cell 2011 22 8 1167 1180
62. Romano S., D'Angelillo A., Pacelli R., Staibano S., De Luna E., Bisogni R., Eskelinen E. L., Mascolo M., Cal G., Arra C., Romano M. F., Role of FK506-binding protein 51 in the control of apoptosis of irradiated melanoma cells Cell Death and Differentiation 2010 17 1 145 157
63. Tsuboi Y., Kurimoto M., Nagai S., Hayakawa Y., Kamiyama H., Hayashi N., Kitajima I., Endo S., Induction of autophagic cell death and radiosensitization by the pharmacological inhibition of nuclear factor-kappa B activation in human glioma cell lines: laboratory investigation Journal of Neurosurgery 2009 110 3 594 604
64. Zhang Y., Wu Y., Wu D., Tashiro S. I., Onodera S., Ikejima T., NF- b facilitates oridonin-induced apoptosis and autophagy in HT1080 cells through a p53-mediated pathway Archives of Biochemistry and Biophysics 2009 489 1-2 25 33
65. Hwang J., Lee H. J., Lee W. H., Suk K., NF-B as a common signaling pathway in ganglioside-induced autophagic cell death and activation of astrocytes Journal of Neuroimmunology 2010 226 1-2 66 72
66. Kroemer G., Levine B., Autophagic cell death: the story of a misnomer Nature Reviews Molecular Cell Biology 2008 9 12 1004 1010
67. Djavaheri-Mergny M., Amelotti M., Mathieu J., Besanon F., Bauvy C., Souqure S., Pierron G., Codogno P., NF- B activation represses tumor necrosis factor- -induced autophagy The Journal of Biological Chemistry 2006 281 41 30373 30382 (Pubitemid 44582093)
68. Huang J., Lam G. Y., Brumell J. H., Autophagy signaling through reactive oxygen species Antioxidants and Redox Signaling 2011 14 11 2215 2231
69. Lee D. F., Kuo H. P., Chen C. T., Hsu J. M., Chou C. K., Wei Y., Sun H. L., Li L. Y., Ping B., Huang W. C., He X., Hung J. Y., Lai C. C., Ding Q., Su J. L., Yang J. Y., Sahin A. A., Hortobagyi G. N., Tsai F. J., Tsai C. H., Hung M. C., IKK suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway Cell 2007 130 3 440 455 (Pubitemid 47198298)
70. Dan H. C., Baldwin A. S., Differential involvement of I B kinases and in cytokine- and insulin-induced mammalian target of rapamycin activation determined by Akt Journal of Immunology 2008 180 11 7582 7589
71. Kim S., Domon-Dell C., Kang J., Chung D. H., Freund J. N., Evers B. M., Down-regulation of the tumor Ssuppressor PTEN by the tumor necrosis factor- /nuclear factor- B (NF- B)-inducing kinase/NF- B pathway is linked to a default I B- Autoregulatory Loop The Journal of Biological Chemistry 2004 279 6 4285 4291 (Pubitemid 38199016)
72. Vasudevan K. M., Gurumurthy S., Rangnekar V. M., Suppression of PTEN Expression by NF- B Prevents Apoptosis Molecular and Cellular Biology 2004 24 3 1007 1021 (Pubitemid 38112166)
73. Salminen A., Kaarniranta K., Insulin/IGF-1 paradox of aging: regulation via AKT/IKK/NF- B signaling Cellular Signalling 2010 22 4 573 577
74. Schlottmann S., Buback F., Stahl B., Meierhenrich R., Walther P., Georgieff M., Senftleben U., Prolonged classical NF- B activation prevents autophagy upon E. coli stimulation in vitro: a potential resolving mechanism of inflammation Mediators of Inflammation 2008 2008
75. Zhou F., Yang Y., Xing D., Bcl-2 and Bcl-xL play important roles in the crosstalk between autophagy and apoptosis FEBS Journal 2011 278 3 403 413
76. Zalckvar E., Berissi H., Mizrachy L., Idelchuk Y., Koren I., Eisenstein M., Sabanay H., Pinkas-Kramarski R., Kimchi A., DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy EMBO Reports 2009 10 3 285 292
77. Han Y. K., Ha T. K., Kim Y. G., Lee G. M., Bcl-xL overexpression delays the onset of autophagy and apoptosis in hyperosmotic recombinant Chinese hamster ovary cell cultures Journal of Biotechnology 2011 156 1 52 55
78. Zhang X. D., Wang Y., Wu J. C., Lin F., Han R., Han F., Fukunaga K., Qin Z. H., Down-regulation of Bcl-2 enhances autophagy activation and cell death induced by mitochondrial dysfunction in rat striatum Journal of Neuroscience Research 2009 87 16 3600 3610
79. Tamatani M., Che Y. H., Matsuzaki H., Ogawa S., Okado H., Miyake S. I., Mizuno T., Tohyama M., Tumor necrosis factor induces Bcl-2 and Bcl-x expression through NF B activation in primary hippocampal neurons The Journal of Biological Chemistry 1999 274 13 8531 8538 (Pubitemid 29164643)
80. Chen C., Edelstein L. C., Gélinas C., The Rel/NF- b family directly activates expression of the apoptosis inhibitor BCl-x(L) Molecular and Cellular Biology 2000 20 8 2687 2695 (Pubitemid 30183487)
81. Glasgow J. N., Wood T., Perez-Polo J. R., Identification and characterization of nuclear factor B binding sites in the murine bcl-x promoter Journal of Neurochemistry 2000 75 4 1377 1389
82. Catz S. D., Johnson J. L., Transcriptional regulation of bcl-2 by nuclear factor B and its significance in prostate cancer Oncogene 2001 20 50 7342 7351 (Pubitemid 33078205)
83. Viatour P., Bentires-Alj M., Chariot A., Deregowski V., de Leval L., Merville M. P., Bours V., NF- B2/p100 induces Bcl-2 expression Leukemia 2003 17 7 1349 1356
84. Edelstein L. C., Lagos L., Simmons M., Tirumalai H., Gélinas C., NF- B-dependent assembly of an enhanceosome-like complex on the promoter region of apoptosis inhibitor Bfl-1/A1 Molecular and Cellular Biology 2003 23 8 2749 2761 (Pubitemid 36403075)
85. Kathania M., Raje C. I., Raje M., Dutta R. K., Majumdar S., Bfl-1/A1 acts as a negative regulator of autophagy in mycobacteria infected macrophages International Journal of Biochemistry and Cell Biology 2011 43 4 573 585
86. Chang N. C., Nguyen M., Germain M., Shore G. C., Antagonism of Beclin 1-dependent autophagy by BCL-2 at the endoplasmic reticulum requires NAF-1 EMBO Journal 2010 29 3 606 618
87. Kirshenbaum L. A., Bcl-2 intersects the NF B signalling pathway and suppresses apoptosis in ventricular myocytes Clinical and Investigative Medicine 2000 23 5 322 330
88. Regula K. M., Ens K., Kirshenbaum L. A., IKK is required for Bcl-2-mediated NF- B activation in ventricular myocytes The Journal of Biological Chemistry 2002 277 41 38676 38682 (Pubitemid 35154728)
89. Vereecke L., Beyaert R., van Loo G., The ubiquitin-editing enzyme A20 (TNFAIP3) is a central regulator of immunopathology Trends in Immunology 2009 30 8 383 391
90. Amir-Zilberstein L., Dikstein R., Interplay between E-box and NF- B in regulation of A20 gene by DRB sensitivity-inducing factor (DSIF) The Journal of Biological Chemistry 2008 283 3 1317 1323
91. Verstrepen L., Verhelst K., van Loo G., Carpentier I., Ley S. C., Beyaert R., Expression, biological activities and mechanisms of action of A20 (TNFAIP3) Biochemical Pharmacology 2010 80 12 2009 2020
92. Shembade N., Harhaj E. W., Regulation of NF- B signaling by the A20 deubiquitinase Cellular Molecular Immunology 2012 9 2 123 139
93. Skaug B., Chen J., Du F., He J., Ma A., Chen Z. J., Direct, noncatalytical mechanism of IKK inhibition by A20 Molecular Cell 2011 44 4 559 571
94. Mauro C., Pacifico F., Lavorgna A., Mellone S., Iannetti A., Acquaviva R., Formisano S., Vito P., Leonardi A., ABIN-1 binds to NEMO/IKK and co-operates with A20 in inhibiting NF- B The Journal of Biological Chemistry 2006 281 27 18482 18488 (Pubitemid 44035507)
95. Jounai N., Kobiyama K., Shiina M., Ogata K., Ishii K. J., Takeshita F., NLRP4 negatively regulates autophagic processes through an association with Beclin1 Journal of Immunology 2011 186 3 1646 1655
96. Schroder K., Tschopp J., The Inflammasomes Cell 2010 140 6 821 832
97. Bauernfeind F. G., Horvath G., Stutz A., Alnemri E. S., MacDonald K., Speert D., Fernandes-Alnemri T., Wu J., Monks B. G., Fitzgerald K. A., Hornung V., Latz E., Cutting edge: NF- B activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression Journal of Immunology 2009 183 2 787 791
98. Shi C. S., Shenderov K., Huang N. N., Kabat J., Abu-Asab M., Fitzgerald K. A., Sher A., Kehrl J. H., Activation of autophagy by inflammatory signals limits IL-1 production by targeting ubiquitinated inflammasomes for destruction Nature Immunology 2012 13 3 255 263
99. Bruey J. M., Bruey-Sedano N., Luciano F., Zhai D., Balpai R., Xu C., Kress C. L., Bailly-Maitre B., Li X., Osterman A., Matsuzawa S. I., Terskikh A. V., Faustin B., Reed J. C., Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1 Cell 2007 129 1 45 56 (Pubitemid 46507581)
100. Faustin B., Chen Y., Zhai D., Le Negrate G., Lartigue L., Satterthwait A., Reed J. C., Mechanism of Bcl-2 and Bcl-XL inhibition of NLRP1 inflammasome: loop domain-dependent suppression of ATP binding and oligomerization Proceedings of the National Academy of Sciences of the United States of America 2009 106 10 3935 3940
101. Scherz-Shouval R., Elazar Z., Regulation of autophagy by ROS: physiology and pathology Trends in Biochemical Sciences 2011 36 1 30 38
102. Lee J., Giordano S., Zhang J., Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling Biochemical Journal 2012 441 2 523 540
103. Pautz A., Art J., Hahn S., Nowag S., Voss C., Kleinert H., Regulation of the expression of inducible nitric oxide synthase Nitric Oxide 2010 23 1 75 93
104. Sarkar S., Korolchuk V. I., Renna M., Imarisio S., Fleming A., Williams A., Garcia-Arencibia M., Rose C., Luo S., Underwood B. R., Kroemer G., O'Kane C. J., Rubinsztein D. C., Complex inhibitory effects of nitric oxide on autophagy Molecular Cell 2011 43 1 19 32
105. Alers S., Lffler A. S., Wesselborg S., Stork B., Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks Molecular and Cellular Biology 2012 32 1 2 11
106. Mazure N. M., Pouysségur J., Hypoxia-induced autophagy: cell death or cell survival? Current Opinion in Cell Biology 2010 22 2 177 180
107. Chinnadurai G., Vijayalingam S., Gibson S. B., BNIP3 subfamily BH3-only proteins: mitochondrial stress sensors in normal and pathological functions Oncogene 2008 27 1, supplement S114 S127
108. Feng X., Liu X., Zhang W., Xiao W., p53 directly suppresses BNIP3 expression to protect against hypoxia-induced cell death EMBO Journal 2011 30 16 3397 3415
109. Gang H., Dhingra R., Wang Y., Mughal W., Gordon J. W., Kirshenbaum L. A., Epigenetic regulation of E2F-1-dependent Bnip3 transcription and cell death by nuclear factor- B and histone deacetylase-1 Pediatric Cardiology 2011 32 3 263 266
110. Baetz D., Regula K. M., Ens K., Shaw J., Kothari S., Yurkova N., Kirshenbaum L. A., Nuclear factor- B-mediated cell survival involves transcriptional silencing of the mitochondrial death gene BNIP3 in ventricular myocytes Circulation 2005 112 24 3777 3785 (Pubitemid 43739519)
111. Shaw J., Yurkova N., Zhang T., Gang H., Aguilar F., Weidman D., Scramstad C., Weisman H., Kirshenbaum L. A., Antagonism of E2F-1 regulated Bnip3 transcription by NF- B is essential for basal cell survival Proceedings of the National Academy of Sciences of the United States of America 2008 105 52 20734 20739
112. Singh R., Cuervo A. M., Autophagy in the cellular energetic balance Cell Metabolism 2011 13 5 495 504
113. Pattingre S., Bauvy C., Carpentier S., Levade T., Levine B., Codogno P., Role of JNK1-dependent Bcl-2 phosphorylation in ceramide-induced macroautophagy The Journal of Biological Chemistry 2009 284 5 2719 2728
114. Papa S., Bubici C., Zazzeroni F., Pham C. G., Kuntzen C., Knabb J. R., Dean K., Franzoso G., The NF- B-mediated control of the JNK cascade in the antagonism of programmed cell death in health and disease Cell Death and Differentiation 2006 13 5 712 729
115. Bubici C., Papa S., Pham C. G., Zazzeroni F., Franzoso G., The NF- B-mediated control of ROS and JNK signaling Histology and Histopathology 2006 21 13 69 80 (Pubitemid 43033716)
116. Nakano H., Nakajima A., Sakon-Komazawa S., Piao J. H., Xue X., Okumura K., Reactive oxygen species mediate crosstalk between NF- B and JNK Cell Death and Differentiation 2006 13 5 730 737
117. Liu J., Lin A., Wiring the cell signaling circuitry by the NF- B and JNK1 crosstalk and its applications in human diseases Oncogene 2007 26 22 3267 3278 (Pubitemid 46763020)
118. Lipinski M. M., Zheng B., Lu T., Yan Z., Py B. F., Ng A., Xavier R. J., Li C., Yankner B. A., Scherzer C. R., Yuan J., Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease Proceedings of the National Academy of Sciences of the United States of America 2010 107 32 14164 14169
119. Morgan M. J., Liu Z. G., Crosstalk of reactive oxygen species and NF- B signaling Cell Research 2011 21 1 103 115
120. Maiuri M. C., Tasdemir E., Criollo A., Morselli E., Vicencio J. M., Carnuccio R., Kroemer G., Control of autophagy by oncogenes and tumor suppressor genes Cell Death and Differentiation 2009 16 1 87 93
121. Eskelinen E. L., The dual role of autophagy in cancer Current Opinion in Pharmacology 2011 11 4 294 300
122. Balaburski G. M., Hontz R. D., Murphy M. E., P53 and ARF: unexpected players in autophagy Trends in Cell Biology 2010 20 6 363 369
123. DiDonato J. A., Mercurio F., Karin M., NF- B and the link between inflammation and cancer Immunological Reviews 2012 246 1 379 400
124. Ak P., Levine A. J., p53 and NF- B: different strategies for responding to stress lead to a functional antagonism FASEB Journal 2010 24 10 3643 3652
125. Ryan K. M., P53 and autophagy in cancer: guardian of the genome meets guardian of the proteome European Journal of Cancer 2011 47 1 44 50
126. Franceschi C., Valensin S., Bonaf M., Paolisso G., Yashin A. I., Monti D., De Benedictis G., The network and the remodeling theories of aging: historical background and new perspectives Experimental Gerontology 2000 35 6-7 879 896
127. Larbi A., Franceschi C., Mazzatti D., Solana R., Wikby A., Pawelec G., Aging of the immune system as a prognostic factor for human longevity Physiology 2008 23 2 64 74
128. de Magalhes J. P., Curado J., Church G. M., Meta-analysis of age-related gene expression profiles identifies common signatures of aging Bioinformatics 2009 25 7 875 881
129. Swindell W. R., Genes and gene expression modules associated with caloric restriction and aging in the laboratory mouse BMC Genomics 2009 10, article 585
130. Krabbe K. S., Pedersen M., Bruunsgaard H., Inflammatory mediators in the elderly Experimental Gerontology 2004 39 5 687 699 (Pubitemid 38586809)
131. Singh T., Newman A. B., Inflammatory markers in population studies of aging Ageing Research Reviews 2011 10 3 319 329
132. Helenius M., Hnninen M., Lehtinen S. K., Salminen A., Changes associated with aging and replicative senescence in the regulation of transcription factor nuclear factor- B Biochemical Journal 1996 318 2 603 608 (Pubitemid 26305964)
133. Spencer N. F. L., Poynter M. E., Im S. Y., Daynes R. A., Constitutive activation of NF- B in an animal model of aging International Immunology 1997 9 10 1581 1588 (Pubitemid 27434691)
134. Helenius M., Kyrylenko S., Vehvilinen P., Salminen A., Characterization of aging-associated up-regulation of constitutive nuclear factor- B binding activity Antioxidants and Redox Signaling 2001 3 1 147 156 (Pubitemid 32240637)
135. Adler A. S., Sinha S., Kawahara T. L. A., Zhang J. Y., Segal E., Chang H. Y., Motif module map reveals enforcement of aging by continual NF- B activity Genes and Development 2007 21 24 3244 3257 (Pubitemid 350277752)
136. Rubinsztein D. C., Marino G., Kroemer G., Autophagy and aging Cell 2011 146 5 682 695
137. Wang E., Regulation of apoptosis resistance and ontogeny of age-dependent diseases Experimental Gerontology 1997 32 4-5 471 484 (Pubitemid 27366484)
138. Bye N., Zieba M., Wreford N. G., Nichols N. R., Resistance of the dentate gyrus to induced apoptosis during ageing is associated with increases in transforming growth factor- 1 messenger RNA Neuroscience 2001 105 4 853 862 (Pubitemid 32786798)
139. Zhang Y., Herman B., Ageing and apoptosis Mechanisms of Ageing and Development 2002 123 4 245 260 (Pubitemid 34024915)
140. Kavathia N., Jain A., Walston J., Beamer B. A., Fedarko N. S., Serum markers of apoptosis decrease with age and cancer stage Aging 2009 1 7 652 663
141. Salminen A., Ojala J., Kaarniranta K., Apoptosis and aging: increased resistance to apoptosis enhances the aging process Cellular and Molecular Life Sciences 2011 68 6 1021 1031
142. Monti D., Salvioli S., Capri M., Malorni W., Straface E., Cossarizza A., Botti B., Piacentini M., Baggio G., Barbi C., Valensin S., Bonaf M., Franceschi C., Decreased susceptibility to oxidative stress-induced apoptosis of peripheral blood mononuclear cells from healthy elderly and centenarians Mechanisms of Ageing and Development 2001 121 13 239 250 (Pubitemid 32115417)
143. Krishnamurthy J., Torrice C., Ramsey M. R., Kovalev G. I., Al-Regaiey K., Su L., Sharpless N. E., Ink4a/Arf expression is a biomarker of aging Journal of Clinical Investigation 2004 114 9 1299 1307 (Pubitemid 40385301)
144. Jeyapalan J. C., Ferreira M., Sedivy J. M., Herbig U., Accumulation of senescent cells in mitotic tissue of aging primates Mechanisms of Ageing and Development 2007 128 1 36 44 (Pubitemid 46073058)
145. Rochette P. J., Brash D. E., Progressive apoptosis resistance prior to senescence and control by the anti-apoptotic protein BCL-xL Mechanisms of Ageing and Development 2008 129 4 207 214
146. Campisi J., Andersen J. K., Kapahi P., Melov S., Cellular senescence: a link between cancer and age-related degenerative disease? Seminars in Cancer Biology 2011 21 6 354 359
147. Salminen A., Kauppinen A., Kaarniranta K., Emerging role of NF- B signaling in the induction of senescence-associated secretory phenotype (SASP) Cellular Signaling 2012 24 4 835 845
148. Kang H. T., Lee K. B., Kim S. Y., Choi H. R., Park S. C., Autophagy impairment induces premature senescence in primary human fibroblasts PLoS ONE 2011 6 8, article e23367
149. Young A. R. J., Narita M., Ferreira M., Kirschner K., Sadaie M., Darot J. F. J., Tavaré S., Arakawa S., Shimizu S., Watt F. M., Narita M., Autophagy mediates the mitotic senescence transition Genes and Development 2009 23 7 798 803
150. Elgendy M., Sheridan C., Brumatti G., Martin S. J., Oncogenic ras-induced expression of noxa and beclin-1 promotes autophagic cell death and limits clonogenic survival Molecular Cell 2011 42 1 23 35
151. Brunk U. T., Terman A., The mitochondrial-lysosomal axis theory of aging: accumulation of damaged mitochondria as a result of imperfect autophagocytosis European Journal of Biochemistry 2002 269 8 1996 2002 (Pubitemid 34437840)
152. Strowig T., Henao-Mejia J., Elinav E., Flavell R., Inflammasomes in health and disease Nature 2012 481 7381 278 286
153. Tschopp J., Schroder K., NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production? Nature Reviews Immunology 2010 10 3 210 215
154. Moscat J., Rennert P., Diaz-Meco M. T., PKC at the crossroad of NF- B and Jak1/Stat6 signaling pathways Cell Death and Differentiation 2006 13 5 702 711
155. Festjens N., Vanden Berghe T., Cornelis S., Vandenabeele P., RIP1, a kinase on the crossroads of a cell's decision to live or die Cell Death and Differentiation 2007 14 3 400 410
156. Johansen T., Lamark T., Selective autophagy mediated by autophagic adapter proteins Autophagy 2011 7 3 279 296
157. Hua Y., Zhang Y., Ceylan-Isik A. F., Wold L. E., Nunn J. M., Ren J., Chronic akt activation accentuates aging-induced cardiac hypertrophy and myocardial contractile dysfunction: role of autophagy Basic Research in Cardiology 2011 106 6 1173 1191
158. Wohlgemuth S. E., Julian D., Akin D. E., Fried J., Toscano K., Leeuwenburgh C., Dunn W. A., Autophagy in the heart and liver during normal aging and calorie restriction Rejuvenation Research 2007 10 3 281 292 (Pubitemid 47378708)
159. Migheli A., Cavalla P., Piva R., Giordana M. T., Schiffer D., Bcl-2 protein expression in aged brain and neurodegenerative diseases NeuroReport 1994 5 15 1906 1908
160. Kaufmann J. A., Bickford P. C., Taglialatela G., Oxidative-stress- dependent up-regulation of Bcl-2 expression in the central nervous system of aged Fisher-344 rats Journal of Neurochemistry 2001 76 4 1099 1108 (Pubitemid 32167384)
161. Satou T., Cummings B. J., Cotman C. W., Immunoreactivity for Bcl-2 protein within neurons in the Alzheimer's disease brain increases with disease severity Brain Research 1995 697 1-2 35 43
162. Xu Y. Z., Deng X. H., Bentivoglio M., Differential response of apoptosis-regulatory Bcl-2 and Bax proteins to an inflammatory challenge in the cerebral cortex and hippocampus of aging mice Brain Research Bulletin 2007 74 5 329 335 (Pubitemid 47368883)
163. Wang E., Senescent human fibroblasts resist programmed cell death, and failure to suppress bcl2 is involved Cancer Research 1995 55 11 2284 2292
164. Kumazaki T., Sasaki M., Nishiyama M., Teranishi Y., Sumida H., Eboshida A., Mitsui Y., Life span shortening of normal fibroblasts by overexpression of BCL-2: a result of potent increase in cell death Experimental Cell Research 2003
165. Crescenzi E., Palumbo G., Brady H. J. M., Bcl-2 activates a programme of premature senescence in human carcinoma cells Biochemical Journal 2003 375 2 263 274 (Pubitemid 37315434)
166. Lee J. J., Lee J. H., Ko Y. G., Hong S. I., Lee J. S., Prevention of premature senescence requires JNK regulation of Bcl-2 and reactive oxygen species Oncogene 2010 29 4 561 575
167. Agresti A., Lupo R., Bianchi M. E., Mller S., HMGB1 interacts differentially with members of the Rel family of transcription factors Biochemical and Biophysical Research Communications 2003 302 2 421 426 (Pubitemid 36397940)
168. Kang R., Livesey K. M., Zeh H. J., Lotze M. T., Tang D., HMGB1: a novel Beclin 1-binding protein active in autophagy Autophagy 2010 6 8 1209 1211
169. tros M., HMGB proteins: interactions with DNA and chromatin Biochimica et Biophysica Acta 2010 1799 1-2 101 113
170. Tang D., Kang R., Zeh H. J., Lotze M. T., High-mobility group box 1, oxidative stress, and disease Antioxidants and Redox Signaling 2011 14 7 1315 1335
171. Tang D., Kang R., Livesey K. M., Cheh C. W., Farkas A., Loughran P., Hoppe G., Bianchi M. E., Tracey K. J., Zeh H. J., Lotze M. T., Endogenous HMGB1 regulates autophagy Journal of Cell Biology 2010 190 5 881 892
172. van de Walle L., Kanneganti T. D., Lamkanfi M., HMGB1 release by inflammasomes Virulence 2011 2 2 162 165
173. Prasad S., Thakur M. K., Distribution of high mobility group proteins in different tissues of rats during aging Biochemistry International 1990 20 4 687 695 (Pubitemid 20132217)
174. Enokido Y., Yoshitake A., Ito H., Okazawa H., Age-dependent change of HMGB1 and DNA double-strand break accumulation in mouse brain Biochemical and Biophysical Research Communications 2008 376 1 128 133
175. Tang D., Kang R., Zeh H. J., Lotze M. T., High-mobility group box 1 and cancer Biochimica et Biophysica Acta 2010 1799 1-2 131 140
176. Harman D., Aging: a theory based on free radical and radiation chemistry Journal of gerontology 1956 11 3 298 300
177. Petrovski G., Das D. K., Does autophagy take a front seat in lifespan extension? Journal of Cellular and Molecular Medicine 2010 14 11 2543 2551
178. Hekimi S., Lapointe J., Wen Y., Taking a good look at free radicals in the aging process Trends in Cell Biology 2011 21 10 569 576
179. Ristow M., Schmeisser S., Extending life span by increasing oxidative stress Free Radical Biology and Medicine 2011 51 2 327 336
180. Bauernfeind F., Bartok E., Rieger A., Franchi L., Nez G., Hornung V., Cutting edge: reactive oxygen species inhibitors block priming, but not activation, of the NLRP3 inflammasome Journal of Immunology 2011 187 2 613 617
181. Zhang X., Zhang G., Zhang H., Karin M., Bai H., Cai D., Hypothalamic IKK /NF- B and ER stress link overnutrition to energy imbalance and obesity Cell 2008 135 1 61 73
182. Purkayastha S., Zhang H., Zhang G., Ahmed Z., Wang Y., Cai D., Neural dysregulation of peripheral insulin action and blood pressure by brain endoplasmic reticulum stress Proceedings of the National Academy of Sciences of the United States of America 2011 108 7 2939 2944
183. Cai D., Liu T., Inflammatory cause of metabolic syndrome via brain stress and NF- B Aging (Albany NY) 2012 4 2 98 115
184. Gerondakis S., Grumont R., Gugasyan R., Wong L., Isomura I., Ho W., Banerjee A., Unravelling the complexities of the NF- B signalling pathway using mouse knockout and transgenic models Oncogene 2006 25 51 6781 6799 (Pubitemid 44657852)
185. Swindell W. R., Johnston A., Sun L., Xing X., Fisher G. J., Bulyk M. L., Elder J. T., Gudjonsson J. E., Meta-profiles of gene expression during aging: limited similarities between mouse and human and an unexpectedly decreased inflammatory signature PLoS ONE 2012 7 3, article e33204