-
1
-
-
1842526076
-
Active repression of antiapoptotic gene expression by RelA(p65) NFkappa B
-
Campbell, K. J., Rocha, S., and Perkins, N. D. (2004) Active repression of antiapoptotic gene expression by RelA(p65) NFkappa B. Mol. Cell 13, 853-865
-
(2004)
Mol. Cell
, vol.13
, pp. 853-865
-
-
Campbell, K.J.1
Rocha, S.2
Perkins, N.D.3
-
2
-
-
0034689773
-
Role of NF-kappaB in p53-mediated programmed cell death
-
Ryan, K. M., Ernst, M. K., Rice, N. R., and Vousden, K. H. (2000) Role of NF-kappaB in p53-mediated programmed cell death. Nature 404, 892-897
-
(2000)
Nature
, vol.404
, pp. 892-897
-
-
Ryan, K.M.1
Ernst, M.K.2
Rice, N.R.3
Vousden, K.H.4
-
3
-
-
69949150673
-
A crucial role for adipose tissue p53 in the regulation of insulin resistance
-
Minamino, T., Orimo, M., Shimizu, I., Kunieda, T., Yokoyama, M., Ito, T., Nojima, A., Nabetani, A., Oike, Y., Matsubara, H., Ishikawa, F., and Komuro, I. (2009) A crucial role for adipose tissue p53 in the regulation of insulin resistance. Nat. Med. 15, 1082-1087
-
(2009)
Nat. Med.
, vol.15
, pp. 1082-1087
-
-
Minamino, T.1
Orimo, M.2
Shimizu, I.3
Kunieda, T.4
Yokoyama, M.5
Ito, T.6
Nojima, A.7
Nabetani, A.8
Oike, Y.9
Matsubara, H.10
Ishikawa, F.11
Komuro, I.12
-
4
-
-
0017153683
-
Aerobic glycolysis during lymphocyte proliferation
-
Wang, T., Marquardt, C., and Foker, J. (1976) Aerobic glycolysis during lymphocyte proliferation. Nature 261, 702-705
-
(1976)
Nature
, vol.261
, pp. 702-705
-
-
Wang, T.1
Marquardt, C.2
Foker, J.3
-
5
-
-
33646794425
-
Keeping p53 in check: Essential and synergistic functions of Mdm2 and Mdm4
-
DOI 10.1038/sj.cdd.4401912, PII 4401912
-
Marine, J. C., Francoz, S., Maetens, M., Wahl, G., Toledo, F., and Lozano, G. (2006) Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4. Cell Death Differ. 13, 927-934 (Pubitemid 43753483)
-
(2006)
Cell Death and Differentiation
, vol.13
, Issue.6
, pp. 927-934
-
-
Marine, J.-C.1
Francoz, S.2
Maetens, M.3
Wahl, G.4
Toledo, F.5
Lozano, G.6
-
6
-
-
0035339357
-
ATM-dependent phosphorylation of Mdm2 on serine 395: Role in p53 activation by DNA damage
-
Maya, R., Balass, M., Kim, S. T., Shkedy, D., Leal, J. F., Shifman, O., Moas, M., Buschmann, T., Ronai, Z., Shiloh, Y., Kastan, M. B., Katzir, E., and Oren, M. (2001) ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage. Genes Dev. 15, 1067-1077
-
(2001)
Genes Dev.
, vol.15
, pp. 1067-1077
-
-
Maya, R.1
Balass, M.2
Kim, S.T.3
Shkedy, D.4
Leal, J.F.5
Shifman, O.6
Moas, M.7
Buschmann, T.8
Ronai, Z.9
Shiloh, Y.10
Kastan, M.B.11
Katzir, E.12
Oren, M.13
-
7
-
-
25444478027
-
ATM-mediated phosphorylations inhibit Mdmx/Mdm2 stabilization by HAUSP in favor of p53 activation
-
Meulmeester, E., Pereg, Y., Shiloh, Y., and Jochemsen, A. G. (2005) ATM-mediated phosphorylations inhibit Mdmx/Mdm2 stabilization by HAUSP in favor of p53 activation. Cell Cycle 4, 1166-1170
-
(2005)
Cell Cycle
, vol.4
, pp. 1166-1170
-
-
Meulmeester, E.1
Pereg, Y.2
Shiloh, Y.3
Jochemsen, A.G.4
-
8
-
-
53249142431
-
Cooperation between the ribosomal proteins L5 and L11 in the p53 pathway
-
Horn, H. F., and Vousden, K. H. (2008) Cooperation between the ribosomal proteins L5 and L11 in the p53 pathway. Oncogene 27, 5774-5784
-
(2008)
Oncogene
, vol.27
, pp. 5774-5784
-
-
Horn, H.F.1
Vousden, K.H.2
-
9
-
-
0037309326
-
Tumor suppression by Ink4a-Arf: Progress and puzzles
-
Lowe, S. W., and Sherr, C. J. (2003) Tumor suppression by Ink4a-Arf: progress and puzzles. Curr. Opin. Genet. Dev. 13, 77-83
-
(2003)
Curr. Opin. Genet. Dev.
, vol.13
, pp. 77-83
-
-
Lowe, S.W.1
Sherr, C.J.2
-
10
-
-
33749334018
-
A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization
-
Aylon, Y., Michael, D., Shmueli, A., Yabuta, N., Nojima, H., and Oren, M. (2006) A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization. Genes Dev. 20, 2687-2700
-
(2006)
Genes Dev.
, vol.20
, pp. 2687-2700
-
-
Aylon, Y.1
Michael, D.2
Shmueli, A.3
Yabuta, N.4
Nojima, H.5
Oren, M.6
-
11
-
-
0036234459
-
Missing pieces in the NFkappaB puzzle
-
Ghosh, S., and Karin, M. (2002) Missing pieces in the NFkappaB puzzle. Cell 109(Suppl.), S81-S96
-
(2002)
Cell
, vol.109
, Issue.SUPPL.
-
-
Ghosh, S.1
Karin, M.2
-
12
-
-
0023724778
-
IkappaB: A specific inhibitor of the NF-kappaB transcription factor
-
Baeuerle, P. A., and Baltimore, D. (1988) I kappa B: a specific inhibitor of the NF-kappa B transcription factor. Science 242, 540-546 (Pubitemid 18263193)
-
(1988)
Science
, vol.242
, Issue.4878
, pp. 540-546
-
-
Baeuerle, P.A.1
Baltimore, D.2
-
13
-
-
0028971289
-
Rel/NF-kappa B/I kappa B family: Intimate tales of association and dissociation
-
Verma, I. M., Stevenson, J. K., Schwarz, E. M., Van Antwerp, D., and Miyamoto, S. (1995) Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation. Genes Dev. 9, 2723-2735
-
(1995)
Genes Dev.
, vol.9
, pp. 2723-2735
-
-
Verma, I.M.1
Stevenson, J.K.2
Schwarz, E.M.3
Van Antwerp, D.4
Miyamoto, S.5
-
14
-
-
0029670083
-
Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation
-
DiDonato, J., Mercurio, F., Rosette, C., Wu-Li, J., Suyang, H., Ghosh, S., and Karin, M. (1996) Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation. Mol. Cell Biol. 16, 1295-1304
-
(1996)
Mol. Cell Biol.
, vol.16
, pp. 1295-1304
-
-
DiDonato, J.1
Mercurio, F.2
Rosette, C.3
Wu-Li, J.4
Suyang, H.5
Ghosh, S.6
Karin, M.7
-
15
-
-
0028970734
-
Stimulation-dependent IkappaBalpha phosphorylation marks the NF-kappaB inhibitor for degradation via the ubiquitin-proteasome pathway
-
Alkalay, I., Yaron, A., Hatzubai, A., Orian, A., Ciechanover, A., and Ben-Neriah, Y. (1995) Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway. Proc. Natl. Acad. Sci. U. S. A. 92, 10599-10603 (Pubitemid 3009135)
-
(1995)
Proceedings of the National Academy of Sciences of the United States of America
, vol.92
, Issue.23
, pp. 10599-10603
-
-
Alkalay, I.1
Yaron, A.2
Hatzubai, A.3
Orian, A.4
Ciechanover, A.5
Ben-Neriah, Y.6
-
16
-
-
0033596121
-
Activators and target genes of Rel/NFkappaB transcription factors
-
Pahl, H. L. (1999) Activators and target genes of Rel/NFkappaB transcription factors. Oncogene 18, 6853-6866
-
(1999)
Oncogene
, vol.18
, pp. 6853-6866
-
-
Pahl, H.L.1
-
17
-
-
0028174294
-
Autoregulation of I kappa B alpha activity
-
Chiao, P. J., Miyamoto, S., and Verma, I. M. (1994) Autoregulation of I kappa B alpha activity. Proc. Natl. Acad. Sci. U. S. A. 91, 28-32
-
(1994)
Proc. Natl. Acad. Sci. U. S. A.
, vol.91
, pp. 28-32
-
-
Chiao, P.J.1
Miyamoto, S.2
Verma, I.M.3
-
18
-
-
0344305376
-
Sequential modification of NEMO/IKK-gamma by SUMO-1 and ubiquitin mediates NF-kappaB activation by genotoxic stress
-
Huang, T. T., Wuerzberger-Davis, S. M., Wu, Z. H., and Miyamoto, S. (2003) Sequential modification of NEMO/IKK-gamma by SUMO-1 and ubiquitin mediates NF-kappaB activation by genotoxic stress. Cell 115, 565-576
-
(2003)
Cell
, vol.115
, pp. 565-576
-
-
Huang, T.T.1
Wuerzberger-Davis, S.M.2
Wu, Z.H.3
Miyamoto, S.4
-
19
-
-
1942506067
-
The tumor suppressor p53 down-regulates glucose transporters GLUT1 and GLUT4 gene expression
-
Schwartzenberg-Bar-Yoseph, F., Armoni, M., and Karnieli, E. (2004) The tumor suppressor p53 down-regulates glucose transporters GLUT1 and GLUT4 gene expression. Cancer Res. 64, 2627-2633
-
(2004)
Cancer Res.
, vol.64
, pp. 2627-2633
-
-
Schwartzenberg-Bar-Yoseph, F.1
Armoni, M.2
Karnieli, E.3
-
20
-
-
33745918951
-
TIGAR, a p53-inducible regulator of glycolysis and apoptosis
-
Bensaad, K., Tsuruta, A., Selak, M. A., Vidal, M. N., Nakano, K., Bartrons, R., Gottlieb, E., and Vousden, K. H. (2006) TIGAR, a p53-inducible regulator of glycolysis and apoptosis. Cell 126, 107-120
-
(2006)
Cell
, vol.126
, pp. 107-120
-
-
Bensaad, K.1
Tsuruta, A.2
Selak, M.A.3
Vidal, M.N.4
Nakano, K.5
Bartrons, R.6
Gottlieb, E.7
Vousden, K.H.8
-
21
-
-
33745149291
-
P53 regulates mitochondrial respiration
-
Matoba, S., Kang, J. G., Patino, W. D., Wragg, A., Boehm, M., Gavrilova, O., Hurley, P. J., Bunz, F., and Hwang, P. M. (2006) p53 regulates mitochondrial respiration. Science 312, 1650-1653
-
(2006)
Science
, vol.312
, pp. 1650-1653
-
-
Matoba, S.1
Kang, J.G.2
Patino, W.D.3
Wragg, A.4
Boehm, M.5
Gavrilova, O.6
Hurley, P.J.7
Bunz, F.8
Hwang, P.M.9
-
22
-
-
0031127305
-
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha
-
Alessi, D. R., James, S. R., Downes, C. P., Holmes, A. B., Gaffney, P. R., Reese, C. B., and Cohen, P. (1997) Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha. Curr. Biol. 7, 261-269
-
(1997)
Curr. Biol.
, vol.7
, pp. 261-269
-
-
Alessi, D.R.1
James, S.R.2
Downes, C.P.3
Holmes, A.B.4
Gaffney, P.R.5
Reese, C.B.6
Cohen, P.7
-
23
-
-
0031039024
-
Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate
-
Franke, T. F., Kaplan, D. R., Cantley, L. C., and Toker, A. (1997) Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4- bisphosphate. Science 275, 665-668
-
(1997)
Science
, vol.275
, pp. 665-668
-
-
Franke, T.F.1
Kaplan, D.R.2
Cantley, L.C.3
Toker, A.4
-
24
-
-
2342466109
-
Physiological functions of protein kinase B/Akt
-
Yang, Z. Z., Tschopp, O., Baudry, A., Dummler, B., Hynx, D., and Hemmings, B. A. (2004) Physiological functions of protein kinase B/Akt. Biochem. Soc. Trans. 32, 350-354
-
(2004)
Biochem. Soc. Trans.
, vol.32
, pp. 350-354
-
-
Yang, Z.Z.1
Tschopp, O.2
Baudry, A.3
Dummler, B.4
Hynx, D.5
Hemmings, B.A.6
-
25
-
-
0030702123
-
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
-
Datta, S. R., Dudek, H., Tao, X., Masters, S., Fu, H., Gotoh, Y., and Greenberg, M. E. (1997) Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91, 231-241
-
(1997)
Cell
, vol.91
, pp. 231-241
-
-
Datta, S.R.1
Dudek, H.2
Tao, X.3
Masters, S.4
Fu, H.5
Gotoh, Y.6
Greenberg, M.E.7
-
26
-
-
0037077230
-
Akt enhances Mdm2-mediated ubiquitination and degradation of p53
-
DOI 10.1074/jbc.M109745200
-
Ogawara, Y., Kishishita, S., Obata, T., Isazawa, Y., Suzuki, T., Tanaka, K., Masuyama, N., and Gotoh, Y. (2002) Akt enhances Mdm2-mediated ubiquitination and degradation of p53. J. Biol. Chem. 277, 21843-21850 (Pubitemid 34952337)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.24
, pp. 21843-21850
-
-
Ogawara, Y.1
Kishishita, S.2
Obata, T.3
Isazawa, Y.4
Suzuki, T.5
Tanaka, K.6
Masuyama, N.7
Gotoh, Y.8
-
27
-
-
0036120725
-
Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors
-
Kops, G. J., Medema, R. H., Glassford, J., Essers, M. A., Dijkers, P. F., Coffer, P. J., Lam, E. W., and Burgering, B. M. (2002) Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors. Mol. Cell Biol. 22, 2025-2036
-
(2002)
Mol. Cell Biol.
, vol.22
, pp. 2025-2036
-
-
Kops, G.J.1
Medema, R.H.2
Glassford, J.3
Essers, M.A.4
Dijkers, P.F.5
Coffer, P.J.6
Lam, E.W.7
Burgering, B.M.8
-
28
-
-
0033546439
-
Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B
-
Rena, G., Guo, S., Cichy, S. C., Unterman, T. G., and Cohen, P. (1999) Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B. J. Biol. Chem. 274, 17179-17183
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 17179-17183
-
-
Rena, G.1
Guo, S.2
Cichy, S.C.3
Unterman, T.G.4
Cohen, P.5
-
29
-
-
0039425278
-
Negative regulation of the forkhead transcription factor FKHR by Akt
-
Tang, E. D., Nunez, G., Barr, F. G., and Guan, K. L. (1999) Negative regulation of the forkhead transcription factor FKHR by Akt. J. Biol. Chem. 274, 16741-16746
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 16741-16746
-
-
Tang, E.D.1
Nunez, G.2
Barr, F.G.3
Guan, K.L.4
-
30
-
-
0033582929
-
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
-
Brunet, A., Bonni, A., Zigmond, M. J., Lin, M. Z., Juo, P., Hu, L. S., Anderson, M. J., Arden, K. C., Blenis, J., and Greenberg, M. E. (1999) Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96, 857-868
-
(1999)
Cell
, vol.96
, pp. 857-868
-
-
Brunet, A.1
Bonni, A.2
Zigmond, M.J.3
Lin, M.Z.4
Juo, P.5
Hu, L.S.6
Anderson, M.J.7
Arden, K.C.8
Blenis, J.9
Greenberg, M.E.10
-
31
-
-
72449194919
-
Akt-mediated regulation of NFkappaB and the essentialness of NFkappaB for the oncogenicity of PI3K and Akt
-
Bai, D., Ueno, L., and Vogt, P. K. (2009) Akt-mediated regulation of NFkappaB and the essentialness of NFkappaB for the oncogenicity of PI3K and Akt. Int. J. Cancer 125, 2863-2870
-
(2009)
Int. J. Cancer
, vol.125
, pp. 2863-2870
-
-
Bai, D.1
Ueno, L.2
Vogt, P.K.3
-
32
-
-
0033521621
-
Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53
-
DOI 10.1093/emboj/18.1.22
-
Honda, R., and Yasuda, H. (1999) Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53. EMBO J. 18, 22-27 (Pubitemid 29005019)
-
(1999)
EMBO Journal
, vol.18
, Issue.1
, pp. 22-27
-
-
Honda, R.1
Yasuda, H.2
-
33
-
-
33646861005
-
P14ARF activates a Tip60-dependent and p53-independent ATM/ATR/CHK pathway in response to genotoxic stress
-
Eymin, B., Claverie, P., Salon, C., Leduc, C., Col, E., Brambilla, E., Khochbin, S., and Gazzeri, S. (2006) p14ARF activates a Tip60-dependent and p53-independent ATM/ATR/CHK pathway in response to genotoxic stress. Mol. Cell Biol. 26, 4339-4350
-
(2006)
Mol. Cell Biol.
, vol.26
, pp. 4339-4350
-
-
Eymin, B.1
Claverie, P.2
Salon, C.3
Leduc, C.4
Col, E.5
Brambilla, E.6
Khochbin, S.7
Gazzeri, S.8
-
34
-
-
17144422434
-
Regulation of NF-kappaB and p53 through activation of ATR and Chk1 by the ARF tumour suppressor
-
Rocha, S., Garrett, M. D., Campbell, K. J., Schumm, K., and Perkins, N. D. (2005) Regulation of NF-kappaB and p53 through activation of ATR and Chk1 by the ARF tumour suppressor. EMBO J. 24, 1157-1169
-
(2005)
EMBO J.
, vol.24
, pp. 1157-1169
-
-
Rocha, S.1
Garrett, M.D.2
Campbell, K.J.3
Schumm, K.4
Perkins, N.D.5
-
35
-
-
62449257012
-
Phosphorylation of p53 by IkappaB kinase 2 promotes its degradation by beta-TrCP
-
Xia, Y., Padre, R. C., De Mendoza, T. H., Bottero, V., Tergaonkar, V. B., and Verma, I. M. (2009) Phosphorylation of p53 by IkappaB kinase 2 promotes its degradation by beta-TrCP. Proc. Natl. Acad. Sci. U. S. A. 106, 2629-2634
-
(2009)
Proc. Natl. Acad. Sci. U. S. A.
, vol.106
, pp. 2629-2634
-
-
Xia, Y.1
Padre, R.C.2
De Mendoza, T.H.3
Bottero, V.4
Tergaonkar, V.B.5
Verma, I.M.6
-
36
-
-
0032954928
-
Transcriptional cross talk between NF-kappaB and p53
-
Webster, G. A., and Perkins, N. D. (1999) Transcriptional cross talk between NF-kappaB and p53. Mol. Cell. Biol. 19, 3485-3495
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 3485-3495
-
-
Webster, G.A.1
Perkins, N.D.2
-
37
-
-
0032532070
-
P53-mediated repression of nuclear factor-kappaB RelA via the transcriptional integrator p300
-
Ravi, R., Mookerjee, B., van Hensbergen, Y., Bedi, G. C., Giordano, A., El-Deiry, W. S., Fuchs, E. J., and Bedi, A. (1998) p53-mediated repression of nuclear factor-kappaB RelA via the transcriptional integrator p300. Cancer Res. 58, 4531-4536
-
(1998)
Cancer Res.
, vol.58
, pp. 4531-4536
-
-
Ravi, R.1
Mookerjee, B.2
Van Hensbergen, Y.3
Bedi, G.C.4
Giordano, A.5
El-Deiry, W.S.6
Fuchs, E.J.7
Bedi, A.8
-
38
-
-
25444527174
-
T-oligo treatment decreases constitutive and UVB-induced COX-2 levels through p53- and NFkappaB-dependent repression of the COX-2 promoter
-
Marwaha, V., Chen, Y. H., Helms, E., Arad, S., Inoue, H., Bord, E., Kishore, R., Sarkissian, R. D., Gilchrest, B. A., and Goukassian, D. A. (2005) T-oligo treatment decreases constitutive and UVB-induced COX-2 levels through p53- and NFkappaB-dependent repression of the COX-2 promoter. J. Biol. Chem. 280, 32379-32388
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 32379-32388
-
-
Marwaha, V.1
Chen, Y.H.2
Helms, E.3
Arad, S.4
Inoue, H.5
Bord, E.6
Kishore, R.7
Sarkissian, R.D.8
Gilchrest, B.A.9
Goukassian, D.A.10
-
39
-
-
0033593217
-
CREB-binding Protein Is a Nuclear Integrator of Nuclear Factor-kappaB and p53 Signaling
-
Wadgaonkar, R., Phelps, K. M., Haque, Z., Williams, A. J., Silverman, E. S., and Collins, T. (1999) CREB-binding protein is a nuclear integrator of nuclear factor-kappaB and p53 signaling. J. Biol. Chem. 274, 1879-1882 (Pubitemid 129621714)
-
(1999)
Journal of Biological Chemistry
, vol.274
, Issue.4
, pp. 1879-1882
-
-
Wadgaonkar, R.1
Phelps, K.M.2
Haque, Z.3
Williams, A.J.4
Silverman, E.S.5
Collins, T.6
-
40
-
-
0034616639
-
P300/CBP-dependent and -independent transcriptional interference between NF-kappaB RelA and p53
-
Ikeda, A., Sun, X., Li, Y., Zhang, Y., Eckner, R., Doi, T. S., Takahashi, T., Obata, Y., Yoshioka, K., and Yamamoto, K. (2000) p300/CBP-dependent and -independent transcriptional interference between NF-kappaB RelA and p53. Biochem. Biophys. Res. Commun. 272, 375-379
-
(2000)
Biochem. Biophys. Res. Commun.
, vol.272
, pp. 375-379
-
-
Ikeda, A.1
Sun, X.2
Li, Y.3
Zhang, Y.4
Eckner, R.5
Doi, T.S.6
Takahashi, T.7
Obata, Y.8
Yoshioka, K.9
Yamamoto, K.10
-
41
-
-
0141569519
-
Reciprocal inhibition of p53 and nuclear factor-kappaB transcriptional activities determines cell survival or death in neurons
-
Culmsee, C., Siewe, J., Junker, V., Retiounskaia, M., Schwarz, S., Camandola, S., El-Metainy, S., Behnke, H., Mattson, M. P., and Krieglstein, J. (2003) Reciprocal inhibition of p53 and nuclear factor-kappaB transcriptional activities determines cell survival or death in neurons. J. Neurosci. 23, 8586-8595
-
(2003)
J. Neurosci.
, vol.23
, pp. 8586-8595
-
-
Culmsee, C.1
Siewe, J.2
Junker, V.3
Retiounskaia, M.4
Schwarz, S.5
Camandola, S.6
El-Metainy, S.7
Behnke, H.8
Mattson, M.P.9
Krieglstein, J.10
-
42
-
-
0026561121
-
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
-
Donehower, L. A., Harvey, M., Slagle, B. L., McArthur, M. J., Montgomery, C. A., Jr., Butel, J. S., and Bradley, A. (1992) Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 356, 215-221
-
(1992)
Nature
, vol.356
, pp. 215-221
-
-
Donehower, L.A.1
Harvey, M.2
Slagle, B.L.3
McArthur, M.J.4
Montgomery Jr., C.A.5
Butel, J.S.6
Bradley, A.7
-
43
-
-
20444437233
-
P53 is a suppressor of inflammatory response in mice
-
Komarova, E. A., Krivokrysenko, V., Wang, K., Neznanov, N., Chernov, M. V., Komarov, P. G., Brennan, M. L., Golovkina, T. V., Rokhlin, O. W., Kuprash, D. V., Nedospasov, S. A., Hazen, S. L., Feinstein, E., and Gudkov, A. V. (2005) p53 is a suppressor of inflammatory response in mice. FASEB J. 19, 1030-1032
-
(2005)
FASEB J.
, vol.19
, pp. 1030-1032
-
-
Komarova, E.A.1
Krivokrysenko, V.2
Wang, K.3
Neznanov, N.4
Chernov, M.V.5
Komarov, P.G.6
Brennan, M.L.7
Golovkina, T.V.8
Rokhlin, O.W.9
Kuprash, D.V.10
Nedospasov, S.A.11
Hazen, S.L.12
Feinstein, E.13
Gudkov, A.V.14
-
44
-
-
0028864667
-
Induction of the growth inhibitor IGF-binding protein 3 by p53
-
Buckbinder, L., Talbott, R., Velasco-Miguel, S., Takenaka, I., Faha, B., Seizinger, B. R., and Kley, N. (1995) Induction of the growth inhibitor IGF-binding protein 3 by p53. Nature 377, 646-649
-
(1995)
Nature
, vol.377
, pp. 646-649
-
-
Buckbinder, L.1
Talbott, R.2
Velasco-Miguel, S.3
Takenaka, I.4
Faha, B.5
Seizinger, B.R.6
Kley, N.7
-
45
-
-
34248194200
-
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: Stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways
-
Feng, Z., Hu, W., de Stanchina, E., Teresky, A. K., Jin, S., Lowe, S., and Levine, A. J. (2007) The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways. Cancer Res. 67, 3043-3053
-
(2007)
Cancer Res.
, vol.67
, pp. 3043-3053
-
-
Feng, Z.1
Hu, W.2
De Stanchina, E.3
Teresky, A.K.4
Jin, S.5
Lowe, S.6
Levine, A.J.7
-
46
-
-
78651144681
-
The feedback control of sugar nucleotide biosynthesis in liver
-
Kornfeld, S., Kornfeld, R., Neufeld, E. F., and O'Brien, P. J. (1964) The feedback control of sugar nucleotide biosynthesis in liver. Proc. Natl. Acad. Sci. U. S. A. 52, 371-379
-
(1964)
Proc. Natl. Acad. Sci. U. S. A.
, vol.52
, pp. 371-379
-
-
Kornfeld, S.1
Kornfeld, R.2
Neufeld, E.F.3
O'Brien, P.J.4
-
47
-
-
0025193520
-
Enzymatic addition of O-GlcNAc to nuclear and cytoplasmic proteins. Identification of a uridine diphospho-N-acetylglucosamine: Peptide beta-N-acetylglucosaminyltransferase
-
Haltiwanger, R. S., Holt, G. D., and Hart, G. W. (1990) Enzymatic addition of O-GlcNAc to nuclear and cytoplasmic proteins. Identification of a uridine diphospho-N-acetylglucosamine: peptide beta-N- acetylglucosaminyltransferase. J. Biol. Chem. 265, 2563-2568
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 2563-2568
-
-
Haltiwanger, R.S.1
Holt, G.D.2
Hart, G.W.3
-
48
-
-
4644262462
-
O-GlcNAc transferase is in a functional complex with protein phosphatase 1 catalytic subunits
-
Wells, L., Kreppel, L. K., Comer, F. I., Wadzinski, B. E., and Hart, G. W. (2004) O-GlcNAc transferase is in a functional complex with protein phosphatase 1 catalytic subunits. J. Biol. Chem. 279, 38466-38470
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 38466-38470
-
-
Wells, L.1
Kreppel, L.K.2
Comer, F.I.3
Wadzinski, B.E.4
Hart, G.W.5
-
49
-
-
33749160125
-
Modification of p53 with O-linked N-acetylglucosamine regulates p53 activity and stability
-
Yang, W. H., Kim, J. E., Nam, H. W., Ju, J. W., Kim, H. S., Kim, Y. S., and Cho, J. W. (2006) Modification of p53 with O-linked N-acetylglucosamine regulates p53 activity and stability. Nat. Cell Biol. 8, 1074-1083
-
(2006)
Nat. Cell Biol.
, vol.8
, pp. 1074-1083
-
-
Yang, W.H.1
Kim, J.E.2
Nam, H.W.3
Ju, J.W.4
Kim, H.S.5
Kim, Y.S.6
Cho, J.W.7
-
50
-
-
62549161375
-
Loss of p53 enhances catalytic activity of IKKbeta through O-linked beta-N-acetyl glucosamine modification
-
Kawauchi, K., Araki, K., Tobiume, K., and Tanaka, N. (2009) Loss of p53 enhances catalytic activity of IKKbeta through O-linked beta-N-acetyl glucosamine modification. Proc. Natl. Acad. Sci. U. S. A. 106, 3431-3436
-
(2009)
Proc. Natl. Acad. Sci. U. S. A.
, vol.106
, pp. 3431-3436
-
-
Kawauchi, K.1
Araki, K.2
Tobiume, K.3
Tanaka, N.4
-
51
-
-
43049139541
-
P53 regulates glucose metabolism through an IKK-NF-kappaB pathway and inhibits cell transformation
-
DOI 10.1038/ncb1724, PII NCB1724
-
Kawauchi, K., Araki, K., Tobiume, K., and Tanaka, N. (2008) p53 regulates glucose metabolism through an IKK-NF-kappaB pathway and inhibits cell transformation. Nat. Cell Biol. 10, 611-618 (Pubitemid 351627381)
-
(2008)
Nature Cell Biology
, vol.10
, Issue.5
, pp. 611-618
-
-
Kawauchi, K.1
Araki, K.2
Tobiume, K.3
Tanaka, N.4
-
52
-
-
0035490419
-
Hyperglycemia activates p53 and p53-regulated genes leading to myocyte cell death
-
Fiordaliso, F., Leri, A., Cesselli, D., Limana, F., Safai, B., Nadal-Ginard, B., Anversa, P., and Kajstura, J. (2001) Hyperglycemia activates p53 and p53-regulated genes leading to myocyte cell death. Diabetes 50, 2363-2375
-
(2001)
Diabetes
, vol.50
, pp. 2363-2375
-
-
Fiordaliso, F.1
Leri, A.2
Cesselli, D.3
Limana, F.4
Safai, B.5
Nadal-Ginard, B.6
Anversa, P.7
Kajstura, J.8
-
53
-
-
56249095514
-
NFkappaB activation is associated with its O-GlcNAcylation state under hyperglycemic conditions
-
Yang, W. H., Park, S. Y., Nam, H. W., Kim Do, H., Kang, J. G., Kang, E. S., Kim, Y. S., Lee, H. C., Kim, K. S., and Cho, J. W. (2008) NFkappaB activation is associated with its O-GlcNAcylation state under hyperglycemic conditions. Proc. Natl. Acad. Sci. U. S. A. 105, 17345-17350
-
(2008)
Proc. Natl. Acad. Sci. U. S. A.
, vol.105
, pp. 17345-17350
-
-
Yang, W.H.1
Park, S.Y.2
Nam, H.W.3
Kim Do, H.4
Kang, J.G.5
Kang, E.S.6
Kim, Y.S.7
Lee, H.C.8
Kim, K.S.9
Cho, J.W.10
-
54
-
-
0025965455
-
P53 mutations: Gains or losses?
-
Michalovitz, D., Halevy, O., and Oren, M. (1991) p53 mutations: gains or losses? J. Cell Biochem. 45, 22-29
-
(1991)
J. Cell Biochem.
, vol.45
, pp. 22-29
-
-
Michalovitz, D.1
Halevy, O.2
Oren, M.3
-
55
-
-
0027210981
-
Gain of function mutations in p53
-
Dittmer, D., Pati, S., Zambetti, G., Chu, S., Teresky, A. K., Moore, M., Finlay, C., and Levine, A. J. (1993) Gain of function mutations in p53. Nat. Genet. 4, 42-46
-
(1993)
Nat. Genet.
, vol.4
, pp. 42-46
-
-
Dittmer, D.1
Pati, S.2
Zambetti, G.3
Chu, S.4
Teresky, A.K.5
Moore, M.6
Finlay, C.7
Levine, A.J.8
-
56
-
-
0037063173
-
Novel gain of function activity of p53 mutants: Activation of the dUTPase gene expression leading to resistance to 5-fluorouracil
-
Pugacheva, E. N., Ivanov, A. V., Kravchenko, J. E., Kopnin, B. P., Levine, A. J., and Chumakov, P. M. (2002) Novel gain of function activity of p53 mutants: activation of the dUTPase gene expression leading to resistance to 5-fluorouracil. Oncogene 21, 4595-4600
-
(2002)
Oncogene
, vol.21
, pp. 4595-4600
-
-
Pugacheva, E.N.1
Ivanov, A.V.2
Kravchenko, J.E.3
Kopnin, B.P.4
Levine, A.J.5
Chumakov, P.M.6
-
57
-
-
0034671945
-
Oncogenic mutations of the p53 tumor suppressor: The demons of the guardian of the genome
-
Sigal, A., and Rotter, V. (2000) Oncogenic mutations of the p53 tumor suppressor: the demons of the guardian of the genome. Cancer Res. 60, 6788-6793
-
(2000)
Cancer Res.
, vol.60
, pp. 6788-6793
-
-
Sigal, A.1
Rotter, V.2
-
58
-
-
13644260907
-
Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome
-
DOI 10.1016/j.cell.2004.11.006, PII S0092867404010487
-
Lang, G. A., Iwakuma, T., Suh, Y. A., Liu, G., Rao, V. A., Parant, J. M., Valentin-Vega, Y. A., Terzian, T., Caldwell, L. C., Strong, L. C., El-Naggar, A. K., and Lozano, G. (2004) Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome. Cell 119, 861-872 (Pubitemid 40017691)
-
(2004)
Cell
, vol.119
, Issue.6
, pp. 861-872
-
-
Lang, G.A.1
Iwakuma, T.2
Suh, Y.-A.3
Liu, G.4
Rao, V.A.5
Parant, J.M.6
Valentin-Vega, Y.A.7
Terzian, T.8
Caldwell, L.C.9
Strong, L.C.10
El-Naggar, A.K.11
Lozano, G.12
-
59
-
-
10944236962
-
Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome
-
DOI 10.1016/j.cell.2004.11.004, PII S0092867404010463
-
Olive, K. P., Tuveson, D. A., Ruhe, Z. C., Yin, B., Willis, N. A., Bronson, R. T., Crowley, D., and Jacks, T. (2004) Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome. Cell 119, 847-860 (Pubitemid 40017690)
-
(2004)
Cell
, vol.119
, Issue.6
, pp. 847-860
-
-
Olive, K.P.1
Tuveson, D.A.2
Ruhe, Z.C.3
Yin, B.4
Willis, N.A.5
Bronson, R.T.6
Crowley, D.7
Jacks, T.8
-
60
-
-
0028176453
-
Tumour incidence, spectrum and ploidy in mice with a large deletion in the p53 gene
-
Purdie, C. A., Harrison, D. J., Peter, A., Dobbie, L., White, S., Howie, S. E., Salter, D. M., Bird, C. C., Wyllie, A. H., Hooper, M. L., and Clarke, A. R. (1994) Tumour incidence, spectrum and ploidy in mice with a large deletion in the p53 gene. Oncogene 9, 603-609
-
(1994)
Oncogene
, vol.9
, pp. 603-609
-
-
Purdie, C.A.1
Harrison, D.J.2
Peter, A.3
Dobbie, L.4
White, S.5
Howie, S.E.6
Salter, D.M.7
Bird, C.C.8
Wyllie, A.H.9
Hooper, M.L.10
Clarke, A.R.11
-
61
-
-
34047263449
-
Mutant p53 enhances nuclear factor kappaB activation by tumor necrosis factor alpha in cancer cells
-
Weisz, L., Damalas, A., Liontos, M., Karakaidos, P., Fontemaggi, G., Maor-Aloni, R., Kalis, M., Levrero, M., Strano, S., Gorgoulis, V. G., Rotter, V., Blandino, G., and Oren, M. (2007) Mutant p53 enhances nuclear factor kappaB activation by tumor necrosis factor alpha in cancer cells. Cancer Res. 67, 2396-2401
-
(2007)
Cancer Res.
, vol.67
, pp. 2396-2401
-
-
Weisz, L.1
Damalas, A.2
Liontos, M.3
Karakaidos, P.4
Fontemaggi, G.5
Maor-Aloni, R.6
Kalis, M.7
Levrero, M.8
Strano, S.9
Gorgoulis, V.G.10
Rotter, V.11
Blandino, G.12
Oren, M.13
|