Bfl-1/A1 acts as a negative regulator of autophagy in mycobacteria infected macrophages

International Journal of Biochemistry and Cell Biology

Volumn 43, Issue 4, 2011, Pages 573-585

  Kathania, Mahesh ^a   Raje, Chaaya Iyengar ^a,b   Raje, Manoj ^a   Dutta, Rajesh Kumar ^a   Majumdar, Sekhar ^a  

^a INSTITUTE OF MICROBIAL TECHNOLOGY   (India)

^b NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

Author keywords

Autophagy; Bfl 1 A1; mTOR; Mycobacteria; Rapamycin

Indexed keywords

BCL2 RELATED PROTEIN A1; BECLIN 1; MAMMALIAN TARGET OF RAPAMYCIN; RAPAMYCIN; SMALL INTERFERING RNA;

ARTICLE; ATYPICAL MYCOBACTERIOSIS; AUTOPHAGY; BACTERIAL GROWTH; BACTERIAL STRAIN; BACTERIAL SURVIVAL; BACTERIAL VIABILITY; BACTERIAL VIRULENCE; CELL LEVEL; CELL MATURATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DOWN REGULATION; GENE OVEREXPRESSION; GROWTH INHIBITION; HOST PARASITE INTERACTION; HOST RESISTANCE; HUMAN; HUMAN CELL; MACROPHAGE; MYCOBACTERIUM TUBERCULOSIS; PHAGOSOME; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; STABLE TRANSFECTION;

APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; CELL LINE; DOWN-REGULATION; GENE KNOCKDOWN TECHNIQUES; HUMANS; INTRACELLULAR SPACE; MACROPHAGES; MEMBRANE PROTEINS; MICROBIAL VIABILITY; MYCOBACTERIUM TUBERCULOSIS; PHAGOSOMES; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-BCL-2; RNA, SMALL INTERFERING; SIROLIMUS; TOR SERINE-THREONINE KINASES;

BACILLI (CLASS); BACTERIA (MICROORGANISMS); CORYNEBACTERINEAE; MYCOBACTERIUM TUBERCULOSIS;

EID: 79952102958     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biocel.2010.12.014     Document Type: Article

References (44)

1. R.M. Andrade, M. Wessendarp, M.J. Gubbels, B. Striepen, and C.S. Subauste CD40 induces macrophage anti-Toxoplasma gondii activity by triggering autophagy-dependent fusion of pathogen-containing vacuoles and lysosomes J Clin Invest 116 2006 2366 2377 (Pubitemid 44330135)
2. J.A. Armstrong, and P.D. Hart Response of cultured macrophages to Mycobacterium tuberculosis, with observations on fusion of lysosomes with phagosomes J Exp Med 134 1971 713 740
3. P. Boya, R.A. Gonzalez-Polo, N. Casares, J.L. Perfettini, P. Dessen, and N. Larochette Inhibition of macroautophagy triggers apoptosis Mol Cell Biol 25 2005 1025 1040 (Pubitemid 40165810)
4. E. Campoy, and M.I. Colombo Autophagy in intracellular bacterial infection Biochim Biophys Acta 1793 2009 1465 1477
5. L. Chen, S.N. Willis, A. Wei, B.J. Smith, J.I. Fletcher, and M.G. Hinds Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function Mol Cell 17 2005 393 403 (Pubitemid 40193310)
6. D.L. Clemens, and M.A. Horwitz Characterization of the Mycobacterium tuberculosis phagosome and evidence that phagosomal maturation is inhibited J Exp Med 181 1995 257 270
7. V. Deretic Autophagy, an immunologic magic bullet: Mycobacterium tuberculosis phagosome maturation block and how to bypass it Future Microbiol 3 2008 517 524
8. R. Dhiman, M. Kathania, M. Raje, and S. Majumdar Inhibition of bfl-1/A1 by siRNA inhibits mycobacterial growth in THP-1 cells by enhancing phagosomal acidification Biochim Biophys Acta 1780 2008 733 742
9. R. Dhiman, M. Raje, and S. Majumdar Differential expression of NF-kappaB in mycobacteria infected THP-1 affects apoptosis Biochim Biophys Acta 1770 2007 649 658 (Pubitemid 46281465)
10. M. Djavaheri-Mergny, M. Amelotti, J. Mathieu, F. Besancon, C. Bauvy, and S. Souquere NF-kappaB activation represses tumor necrosis factor-alpha-induced autophagy J Biol Chem 281 2006 30373 30382 (Pubitemid 44582093)
11. C. D'Sa-Eipper, and G. Chinnadurai Functional dissection of Bfl-1, a Bcl-2 homolog: anti-apoptosis, oncogene-cooperation and cell proliferation activities Oncogene 16 1998 3105 3114 (Pubitemid 28318781)
12. S. Erlich, L. Mizrachy, O. Segev, L. Lindenboim, O. Zmira, and S. Adi-Harel Differential interactions between Beclin 1 and Bcl-2 family members Autophagy 3 2007 561 568 (Pubitemid 350060052)
13. G. Ferrari, H. Langen, M. Naito, and J. Pieters A coat protein on phagosomes involved in the intracellular survival of mycobacteria Cell 97 1999 435 447 (Pubitemid 29231167)
14. C. Frehel, C. de Chastellier, T. Lang, and N. Rastogi Evidence for inhibition of fusion of lysosomal and prelysosomal compartments with phagosomes in macrophages infected with pathogenic Mycobacterium avium Infect Immun 52 1986 252 262 (Pubitemid 16137710)
15. N. Furuya, J. Yu, M. Byfield, S. Pattingre, and B. Levine The evolutionarily conserved domain of Beclin 1 is required for Vps34 binding, autophagy and tumor suppressor function Autophagy 1 2005 46 52
16. M.G. Gutierrez, S.S. Master, S.B. Singh, G.A. Taylor, M.I. Colombo, and V. Deretic Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages Cell 119 2004 753 766 (Pubitemid 40017683)
17. J. Harris, S.A. De Haro, S.S. Master, J. Keane, E.A. Roberts, and M. Delgado T helper 2 cytokines inhibit autophagic control of intracellular Mycobacterium tuberculosis Immunity 27 2007 505 517 (Pubitemid 47418681)
18. J. Harris, S.S. Master, S.A. De Haro, M. Delgado, E.A. Roberts, and J.C. Hope Th1-Th2 polarisation and autophagy in the control of intracellular mycobacteria by macrophages Vet Immunol Immunopathol 128 2009 37 43
19. M.D. Herman, T. Nyman, M. Welin, L. Lehtio, S. Flodin, and L. Tresaugues Completing the family portrait of the anti-apoptotic Bcl-2 proteins: crystal structure of human Bfl-1 in complex with Bim FEBS Lett 582 2008 3590 3594
20. R. Jayachandran, V. Sundaramurthy, B. Combaluzier, P. Mueller, H. Korf, and K. Huygen Survival of mycobacteria in macrophages is mediated by coronin 1-dependent activation of calcineurin Cell 130 2007 37 50 (Pubitemid 47031320)
21. Y. Kabeya, N. Mizushima, T. Ueno, A. Yamamoto, T. Kirisako, and T. Noda LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing EMBO J 19 2000 5720 5728
22. S.H. Kaufmann How can immunology contribute to the control of tuberculosis? Nat Rev Immunol 1 2001 20 30 (Pubitemid 33741972)
23. J.M. Kinchen, and K.S. Ravichandran Phagosome maturation: going through the acid test Nat Rev Mol Cell Biol 9 2008 781 795
24. A. Koul, T. Herget, B. Klebl, and A. Ullrich Interplay between mycobacteria and host signalling pathways Nat Rev Microbiol 2 2004 189 202 (Pubitemid 39490082)
25. A.L. Kovacs, G. Rez, Z. Palfia, and J. Kovacs Autophagy in the epithelial cells of murine seminal vesicle in vitro. Formation of large sheets of nascent isolation membranes, sequestration of the nucleus and inhibition by wortmannin and 3-ethyladenine Cell Tissue Res 302 2000 253 261
26. B. Levine, and V. Deretic Unveiling the roles of autophagy in innate and adaptive immunity Nat Rev Immunol 7 2007 767 777 (Pubitemid 47480305)
27. B. Levine, S. Sinha, and G. Kroemer Bcl-2 family members: dual regulators of apoptosis and autophagy Autophagy 4 2008 600 606
28. X.H. Liang, S. Jackson, M. Seaman, K. Brown, B. Kempkes, and H. Hibshoosh Induction of autophagy and inhibition of tumorigenesis by beclin 1 Nature 402 1999 672 676 (Pubitemid 129516338)
29. P.T. Liu, and R.L. Modlin Human macrophage host defense against Mycobacterium tuberculosis Curr Opin Immunol 20 2008 371 376
30. M.C. Maiuri, A. Criollo, E. Tasdemir, J.M. Vicencio, N. Tajeddine, and J.A. Hickman BH3-only proteins and BH3 mimetics induce autophagy by competitively disrupting the interaction between Beclin 1 and Bcl-2/Bcl-X(L) Autophagy 3 2007 374 376 (Pubitemid 46986348)
31. M.C. Maiuri, G. Le Toumelin, A. Criollo, J.C. Rain, F. Gautier, and P. Juin Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1 EMBO J 26 2007 2527 2539 (Pubitemid 46788315)
32. A.J. Meijer, and P. Codogno Regulation and role of autophagy in mammalian cells Int J Biochem Cell Biol 36 2004 2445 2462 (Pubitemid 39119758)
33. N. Mizushima, Y. Ohsumi, and T. Yoshimori Autophagosome formation in mammalian cells Cell Struct Funct 27 2002 421 429 (Pubitemid 36267711)
34. I. Nakagawa, A. Amano, N. Mizushima, A. Yamamoto, H. Yamaguchi, and T. Kamimoto Autophagy defends cells against invading group A Streptococcus Science 306 2004 1037 1040 (Pubitemid 39482907)
35. M. Ogawa, T. Yoshimori, T. Suzuki, H. Sagara, N. Mizushima, and C. Sasakawa Escape of intracellular Shigella from autophagy Science 307 2005 727 731 (Pubitemid 40194643)
36. A. Orvedahl, and B. Levine Eating the enemy within: autophagy in infectious diseases Cell Death Differ 16 2009 57 69
37. S. Pattingre, A. Tassa, X. Qu, R. Garuti, X.H. Liang, and N. Mizushima Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy Cell 122 2005 927 939 (Pubitemid 41345209)
38. A. Petiot, E. Ogier-Denis, E.F. Blommaart, A.J. Meijer, and P. Codogno Distinct classes of phosphatidylinositol 3′-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells J Biol Chem 275 2000 992 998 (Pubitemid 30051145)
39. M. Ponpuak, M.A. Delgado, R.A. Elmaoued, and V. Deretic Monitoring autophagy during Mycobacterium tuberculosis infection Methods Enzymol 452 2009 345 361
40. F. Reggiori, and D.J. Klionsky Autophagy in the eukaryotic cell Eukaryot Cell 1 2002 11 21 (Pubitemid 36562345)
41. S. Sarkar, and D.C. Rubinsztein Huntington's disease: degradation of mutant huntington by autophagy FEBS J 275 2008 4263 4270
42. S.B. Singh, A.S. Davis, G.A. Taylor, and V. Deretic Human IRGM induces autophagy to eliminate intracellular mycobacteria Science 313 2006 1438 1441 (Pubitemid 44360272)
43. S. Sturgill-Koszycki, P.H. Schlesinger, P. Chakraborty, P.L. Haddix, H.L. Collins, and A.K. Fok Lack of acidification in Mycobacterium phagosomes produced by exclusion of the vesicular proton-ATPase Science 263 1994 678 681
44. Z. Talloczy, W. Jiang, H.Wt. Virgin, D.A. Leib, D. Scheuner, and R.J. Kaufman Regulation of starvation- and virus-induced autophagy by the eIF2alpha kinase signaling pathway Proc Natl Acad Sci USA 99 2002 190 195 (Pubitemid 34060339)