Prevention of premature senescence requires JNK regulation of Bcl-2 and reactive oxygen species

Oncogene

Volumn 29, Issue 4, 2010, Pages 561-575

  Lee, J J ^a,b   Lee, J H ^c   Ko, Y G ^b   Hong, S I ^a   Lee, J S ^a  

^a Korea Institute of Radiation and Medical Science   (South Korea)

^b Korea University   (South Korea)

^c The Catholic University of Korea   (South Korea)

Author keywords

Bcl 2; DNA damage; JNK; Premature senescence; ROS

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; ANTHRA(1,9 CD)PYRAZOL 6(2H) ONE; ANTHRA(1,9-CD)PYRAZOL-6(2H)-ONE; ANTHRACENE DERIVATIVE; PROTEIN KINASE INHIBITOR; SMALL INTERFERING RNA;

APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE PROGRESSION; CONTROLLED STUDY; DNA DAMAGE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; HUMAN; HUMAN CELL; MITOCHONDRION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SENESCENCE; TUMOR CELL; CELL AGING; CELL DIFFERENTIATION; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; METABOLISM; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ANTHRACENES; CELL AGING; CELL DIFFERENTIATION; CELL LINE, TUMOR; DNA DAMAGE; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE SIGNALING SYSTEM; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING;

EID: 75749148308     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2009.355     Document Type: Article

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