Chromosome instability and deregulated proliferation: An unavoidable duo

Cellular and Molecular Life Sciences

Volumn 69, Issue 12, 2012, Pages 2009-2024

  Coschi, Courtney H ^a   Dick, Frederick A ^a,b  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b Cancer Research Labs   (Canada)

Author keywords

APC; Cancer; Cell division cycle; Genome instability; p53; Ras; Retinoblastoma protein; Tumor suppressor

Indexed keywords

APC PROTEIN; BETA CATENIN; BRCA1 PROTEIN; BRCA2 PROTEIN; PROTEIN P53; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR E2F;

APC GENE; BUBR1 GENE; CARCINOGENESIS; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE REGULATION; CELL CYCLE S PHASE; CELL FATE; CELL PROLIFERATION; CHROMOSOMAL INSTABILITY; COLON CANCER; COLON POLYPOSIS; CYTOGENETICS; FLOW CYTOMETRY; GENE FUNCTION; GENE INACTIVATION; GENE MUTATION; GENETIC ASSOCIATION; GENETICS; GENOMIC INSTABILITY; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; M PHASE CELL CYCLE CHECKPOINT; MALIGNANT NEOPLASTIC DISEASE; MISSENSE MUTATION; NONHUMAN; ONCOGENE; PROTEIN FUNCTION; RB1 GENE; RETINOBLASTOMA; REVIEW; TP53 GENE; TUMOR SUPPRESSOR GENE;

ADENOMATOUS POLYPOSIS COLI; ANEUPLOIDY; ANIMALS; CELL CYCLE CHECKPOINTS; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; CHROMOSOMAL INSTABILITY; HUMANS; MICE; MITOTIC SPINDLE APPARATUS; NEOPLASMS; ONCOGENES; RAS PROTEINS; RATS; RETINAL NEOPLASMS; RETINOBLASTOMA; RETINOBLASTOMA PROTEIN; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84862891760     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-011-0910-4     Document Type: Review

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