Suppression of high-fidelity double-strand break repair in mammalian chromosomes by pifithrin-α, a chemical inhibitor of p53

DNA Repair

Volumn 2, Issue 1, 2003, Pages 1-11

  Lin, Yunfu ^a   Waldman, Barbara Criscuolo ^a   Waldman, Alan S ^a  

^a UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Double strand break repair; Endonuclease I SceI; Nonhomologous end joining; p53; Pifithrin

Indexed keywords

DEOXYRIBONUCLEASE I; GENOMIC DNA; PIFITHRIN ALPHA; PROTEIN INHIBITOR; PROTEIN P53; THYMIDINE KINASE; UNCLASSIFIED DRUG; BENZOTHIAZOLE DERIVATIVE; DRUG DERIVATIVE; PIFITHRIN; THIAZOLE DERIVATIVE; TOLUENE;

ANIMAL CELL; ARTICLE; BINDING SITE; CHROMOSOME; CONTROLLED STUDY; DNA REPAIR; DNA STRAND BREAKAGE; FIBROBLAST; GENE DELETION; GENETIC TRANSFECTION; MOUSE; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANIMAL; CELL LINE; DRUG ANTAGONISM; DRUG EFFECT; IN VITRO STUDY;

HERPES; MAMMALIA; SIMPLEXVIRUS;

ANIMALS; BENZOTHIAZOLES; CELL LINE; DNA REPAIR; FIBROBLASTS; MICE; THIAZOLES; TOLUENE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0037413371     PISSN: 15687864     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1568-7864(02)00183-0     Document Type: Article

References (38)

1. Jackson S.P. Detecting, signaling and repairing DNA double-strand breaks. Biochem. Soc. Trans. 29:2001;655-661.
2. Johnson R.D., Jasin M. Double-strand-break-induced homologous recombination in mammalian cells. Biochem. Soc. Trans. 29:2001;196-201.
3. Khanna K.K., Jackson S.P. DNA double-strand breaks: signaling, repair and the cancer connection. Nat. Genet. 27:2001;247-254.
4. Van Gent D.C., Hoeijmakers J.H.J., Kanaar R. Chromosomal stability and the DNA double-stranded break connection. Nat. Rev. Genet. 2:2001;196-206.
5. Haber J. Partners and pathways repairing a double-strand break. Trends Genet. 16:2000;259-264.
6. Karran P. DNA double-strand break repair in mammalian cells. Curr. Opin. Genet. Dev. 10:2000;144-150.
7. Lin Y., Lukacsovich T., Waldman A.S. Multiple pathways for repair of DNA double-strand breaks in mammalian chromosomes. Mol. Cell. Biol. 19:1999;8353-8360.
8. Liang F., Han M., Romanienko P.J., Jasin M. Homology-directed repair is a major double-strand break repair pathway in mammalian cells. Proc. Natl. Acad. Sci. U.S.A. 95:1998;5172-5177.
9. Lin Y., Waldman A.S. Capture of DNA sequences at double-strand breaks in mammalian chromosomes. Genetics. 158:2001;1665-1674.
10. Lin Y., Waldman A.S. Promiscuous patching of broken chromosomes in mammalian cells with extrachromosomal DNA. Nucleic Acids Res. 29:2001;3975-3981.
11. Lukacsovich T., Yang D., Waldman A.S. Repair of a specific double-strand break generated within a mammalian chromosome by yeast endonuclease I-SceI. Nucleic Acids Res. 22:1994;5649-5657.
12. Liu Y., Kulesz-Martin M. p53 protein at the hub of cellular DNA damage response pathways through sequence-specific and non-sequence-specific DNA binding. Carcinogenesis. 22:2001;851-860.
13. Levine A.J. p53, the cellular gatekeeper for growth and division. Cell. 88:1997;323-331.
14. Ko L.J., Prives C. p53: puzzle and paradigm. Genes Dev. 10:1996;1054-1072.
15. Saintigny Y., Rouillard D., Chaput B., Soussi T., Lopez B.S. Mutant p53 proteins stimulate spontaneous and radiation-induced intrachromosomal homologous recombination independently of the alteration of the transactivation activity and of the G1 checkpoint. Oncogene. 18:1999;3553-3563.
16. Mekeel K.L., Tang W., Kachnic L.A., Luo C.-M., DeFrank J.S., Powell S.N. Inactivation of p53 results in high rates of homologous recombination. Oncogene. 14:1997;1847-1857.
17. Bertrand P., Rouillard D., Boulet A., Levalois C., Soussi T., Lopez B.S. Increase in spontaneous intrachromosomal homologous recombination in mammalian cells expressing a mutant p53 protein. Oncogene. 14:1997;1117-1122.
18. Komarov P.G., Komarova E.A., Kondratov R.V., Christov-Tselkov K., Coon J.S., Chernov M.V., Gudkov A.V. A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. Science. 285:1999;1733-1737.
19. Toillon R.A., Chopin V., Jouy N., Fauquette W., Boilly B., Le Bourthis X. Normal breast epithelial cells induce p53-dependent apoptosis and p53-independent cell cycle arrrest of breast cancer cells. Breast Cancer Res. Treat. 71:2002;269-280.
20. Zhang Z., Huang C., Li J., Shi X. Vanadate-induced cell growth arrest is p53-dependent through activation of p21 in C141 cells. J. Inorg. Biochem. 89:2002;142-148.
21. Pani L., Horal M., Loeken M.R. Rescue of neural tube defects in Pax-3-deficient embryos by p53 loss of function: implications for Pax-3-dependent development and tumorigenesis. Genes. Dev. 16:2002;676-680.
22. Alves da Costa C., Paitel E., Mattson M.P., Amson R., Telerman A., Ancolio K., Checler F. Wild-type and mutated presenilins 2 trigger p53-dependent apoptosis and down-regulate presenilin 1 expression in HEK293 human cells and in murine neurons. Proc. Natl. Acad. Sci. U.S.A. 99:2002;4043-4048.
23. Shih A., Davis F.B., Lin H.Y., Davis P.J. Resveratrol induces apoptosis in thyroid cancer cell lines via a MAPK- and p53-dependent mechanism. J. Clin. Endocrinol. Metab. 87:2002;1223-1232.
24. Havre P.A., O'Reilly S., McCormick J.J., Brash D.E. Transformed and tumor-derived human cells exhibit preferential sensitivity to the thiol antioxidants, N-acetyl cysteine and penicillamine. Cancer Res. 62:2002;1443-1449.
25. Bassi L., Carloni M., Fonti E., Palma de la Pena N., Meschini R., Palitti F. Pifithrin-alpha, an inhibitor of p53, enhances the genetic instability induced by etoposide (VP16) in human lymphoblastoid cells treated in vitro. Mutat. Res. 499:2002;163-176.
26. Chopin V., Toillon R.A., Jouy N., Le Bourhis X. Sodium butyrate induces p53-independent, Fas-mediated apoptosis in MCF-7 human breast cancer cells. Br. J. Pharmacol. 135:2002;79-86.
27. Lorenzo E., Ruiz-Ruiz C., Quesada A.J., Hernandez G., Rodriguez A., Lopez-Rivas A., Redondo J.M. Doxorubicin induces apoptosis and CD95 gene expression in human primary endothelial cells through a p53-dependent mechanism. J. Biol. Chem. 277:2002;10883-10892.
28. Mahyar-Roemer M., Roemer K. p21 Waf1/Cip1 can protect human colon carcinoma cells p53-dependent and p53-independent apoptosis induced by natural chemopreventive and therapeutic agents. Oncogene. 20:2001;3387-3398.
29. Arango D., Corner G.A., Wadler S., Catalano P.J., Augenlicht L.H. c-myc/p53 interaction determines sensitivity of human colon carcinoma cells to 5-fluorouracil in vitro and in vivo. Cancer Res. 61:2001;4910-4915.
30. Lakkaraju A., Dubinsky J.M., Low W.C., Rahman Y.E. Neurons are protected from excitotoxic death by p53 antisense oligonucleotides delivered in anionic liposomes. J. Biol. Chem. 276:2001;32000-32007.
31. Culmsee C., Zhu X., Yu Q.S., Chan S.L., Camandola S., Guo Z., Greig N.H., Mattson M.P. A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide. J. Neurochem. 77:2001;220-228.
32. Komarova E.A., Gudkov A.V. Suppression of p53: a new approach to overcome side effects of antitumor therapy. Biochem. (Moscow). 65:2000;41-48.
33. Wagner M.J., Sharp J.A., Summers W.C. Nucleotide sequence of the thymidine kinase of herpes simplex virus type 1. Proc. Natl. Acad. Sci. U.S.A. 78:1981;1441-1445.
34. Rouet P., Smith F., Jasin M. Expression of a site-specific endonuclease stimulates homologous recombination in mammalian cells. Proc. Natl. Acad. Sci. U.S.A. 91:1994;6064-6068.
35. Sun X., Shimizu H., Yamamoto K.-I. Identification of a novel p53 promoter element involved in genotoxic stress-inducible p53 expression. Mol. Cell. Biol. 15:1995;4489-4496.
36. Tang W., Willers H., Powell S.N. p53 directly enhances rejoining of DNA double-strand breaks with cohesive ends in gamma-irradiated mouse fibroblasts. Cancer Res. 59:1999;2562-2566.
37. Bill C.A., Yongjia Y., Miselis N.R., Little J.B., Nickoloff J.A. A role for p53 in DNA endjoining by human cell extracts. Mutat. Res. 385:1997;21-29.
38. Okorokov A.L., Warnock L., Milner J. Effect of wild-type, S15D and R175H p53 proteins on DNA end joining in vitro: potential mechanism of DNA double-strand break repair modulation. Carcinogenenesis. 23:2002;549-557.