메뉴 건너뛰기




Volumn 161, Issue 2, 2012, Pages 188-197

Drug targeting to the diseased liver

Author keywords

Drug carriers; Drug targeting; Hepatic inflammation; Hepatocellular carcinoma; Liver fibrosis

Indexed keywords

DRUG CARRIER; DRUG-TARGETING; HEPATIC INFLAMMATION; HEPATOCELLULAR CARCINOMA; LIVER FIBROSIS;

EID: 84862683094     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.02.011     Document Type: Review
Times cited : (153)

References (174)
  • 1
    • 37049038626 scopus 로고    scopus 로고
    • A quantitative assay for measuring clearance of adenovirus vectors by Kupffer cells
    • J.S. Smith, Z. Xu, A.P. Byrnes, A quantitative assay for measuring clearance of adenovirus vectors by Kupffer cells, J. Virol. Methods 147 (2008) 54-60.
    • (2008) J. Virol. Methods , vol.147 , pp. 54-60
    • Smith, J.S.1    Xu, Z.2    Byrnes, A.P.3
  • 2
    • 34548306754 scopus 로고    scopus 로고
    • Noninvasive diagnosis and monitoring of nonalcoholic steatohepatitis: Present and future
    • A. Wieckowska, A.J. McCullough, A.E. Feldstein, Noninvasive diagnosis and monitoring of nonalcoholic steatohepatitis: present and future, Hepatology 46 (2007) 582-589.
    • (2007) Hepatology , vol.46 , pp. 582-589
    • Wieckowska, A.1    McCullough, A.J.2    Feldstein, A.E.3
  • 4
    • 33644499498 scopus 로고    scopus 로고
    • Reversal of hepatic fibrosis - Fact or fantasy?
    • S.L. Friedman, M.B. Bansal, Reversal of hepatic fibrosis - fact or fantasy? Hepatology 43 (2, Suppl. 1) (2006) S82-S88.
    • (2006) Hepatology , vol.43 , Issue.2 SUPPL. 1
    • Friedman, S.L.1    Bansal, M.B.2
  • 5
    • 34247334927 scopus 로고    scopus 로고
    • Biliary epithelial-mesenchymal transition in posttransplantation recurrence of primary biliary cirrhosis
    • H. Robertson, J.A. Kirby, W.W. Yip, D.E.J. Jones, A.D. Burt, Biliary epithelial-mesenchymal transition in posttransplantation recurrence of primary biliary cirrhosis, Hepatology 45 (2007) 977-981.
    • (2007) Hepatology , vol.45 , pp. 977-981
    • Robertson, H.1    Kirby, J.A.2    Yip, W.W.3    Jones, D.E.J.4    Burt, A.D.5
  • 6
    • 34247602670 scopus 로고    scopus 로고
    • Survival and apoptosis: A dysregulated balance in liver cancer
    • I. Fabregat, C. Roncero, M. Fernandez, Survival and apoptosis: a dysregulated balance in liver cancer, Liver Int. 27 (2007) 155-162.
    • (2007) Liver Int. , vol.27 , pp. 155-162
    • Fabregat, I.1    Roncero, C.2    Fernandez, M.3
  • 8
    • 12844281900 scopus 로고    scopus 로고
    • Galactosylated ternary DNA/polyphosphoramidate nanoparticles mediate high gene transfection efficiency in hepatocytes
    • X.-Q. Zhang, X.-L. Wang, P.-C. Zhang, Z.-L. Liu, R.-X. Zhuo, H.-Q. Mao, K.W. Leong, Galactosylated ternary DNA/polyphosphoramidate nanoparticles mediate high gene transfection efficiency in hepatocytes, J. Control. Release 102 (2005) 749-763.
    • (2005) J. Control. Release , vol.102 , pp. 749-763
    • Zhang, X.-Q.1    Wang, X.-L.2    Zhang, P.-C.3    Liu, Z.-L.4    Zhuo, R.-X.5    Mao, H.-Q.6    Leong, K.W.7
  • 9
    • 1642362613 scopus 로고    scopus 로고
    • Targeted gene delivery into HepG2 cells using complexes containing DNA, cationized asialoorosomucoid and activated cationic liposomes
    • M. Singh, M. Ariatti, Targeted gene delivery into HepG2 cells using complexes containing DNA, cationized asialoorosomucoid and activated cationic liposomes, J. Control. Release 92 (2003) 383-394.
    • (2003) J. Control. Release , vol.92 , pp. 383-394
    • Singh, M.1    Ariatti, M.2
  • 10
    • 0036518616 scopus 로고    scopus 로고
    • Targeting hepatocytes for drug and gene delivery: Emerging novel approaches and applications
    • J. Wu, M.H. Nantz, M.A. Zern, Targeting hepatocytes for drug and gene delivery: emerging novel approaches and applications, Front. Biosci. 7 (2002) d717-d725.
    • (2002) Front. Biosci. , vol.7
    • Wu, J.1    Nantz, M.H.2    Zern, M.A.3
  • 12
    • 0030868838 scopus 로고    scopus 로고
    • Ribavirin conjugated with lactosaminated poly-L-lysine. Selective delivery to the liver and increased antiviral activity in mice with viral hepatitis
    • G. Di Stefano, F.P. Colonna, A. Bongini, C. Busi, A. Mattioli, L. Fiume, Ribavirin conjugated with lactosaminated poly-L-lysine. Selective delivery to the liver and increased antiviral activity in mice with viral hepatitis, Biochem. Pharmacol. 54 (1997) 357-363.
    • (1997) Biochem. Pharmacol. , vol.54 , pp. 357-363
    • Di Stefano, G.1    Colonna, F.P.2    Bongini, A.3    Busi, C.4    Mattioli, A.5    Fiume, L.6
  • 13
    • 33745589227 scopus 로고    scopus 로고
    • A conjugate of doxorubicin with lactosaminated albumin enhances the drug concentrations in all the forms of rat hepatocellular carcinomas independently of their differentiation grade
    • G. Di Stefano, L. Fiume, M. Baglioni, L. Bolondi, C. Busi, P. Chieco, F. Kratz, F. Manaresi, M. Pariali, A conjugate of doxorubicin with lactosaminated albumin enhances the drug concentrations in all the forms of rat hepatocellular carcinomas independently of their differentiation grade, Liver Int. 26 (2006) 726-733.
    • (2006) Liver Int. , vol.26 , pp. 726-733
    • Di Stefano, G.1    Fiume, L.2    Baglioni, M.3    Bolondi, L.4    Busi, C.5    Chieco, P.6    Kratz, F.7    Manaresi, F.8    Pariali, M.9
  • 14
    • 24344508224 scopus 로고    scopus 로고
    • Doxorubicin coupled to lactosaminated albumin inhibits the growth of hepatocellular carcinomas induced in rats by diethylnitrosamine
    • L. Fiume, L. Bolondi, C. Busi, P. Chieco, F. Kratz, M. Lanza, A. Mattioli, G. Di Stefano, Doxorubicin coupled to lactosaminated albumin inhibits the growth of hepatocellular carcinomas induced in rats by diethylnitrosamine, J. Hepatol. 43 (2005) 645-652.
    • (2005) J. Hepatol. , vol.43 , pp. 645-652
    • Fiume, L.1    Bolondi, L.2    Busi, C.3    Chieco, P.4    Kratz, F.5    Lanza, M.6    Mattioli, A.7    Di Stefano, G.8
  • 15
    • 70349987594 scopus 로고    scopus 로고
    • Development of HPMA copolymer-anticancer conjugates: Clinical experience and lessons learnt
    • R. Duncan, Development of HPMA copolymer-anticancer conjugates: clinical experience and lessons learnt, Adv. Drug Deliv. Rev. 61 (2009) 1131-1148.
    • (2009) Adv. Drug Deliv. Rev. , vol.61 , pp. 1131-1148
    • Duncan, R.1
  • 16
    • 0029153418 scopus 로고
    • Targeting of drugs to the liver
    • D.K.F. Meijer, G. Molema, Targeting of drugs to the liver, Semin. Liver Dis. 15 (1995) 202-256.
    • (1995) Semin. Liver Dis. , vol.15 , pp. 202-256
    • Meijer, D.K.F.1    Molema, G.2
  • 17
    • 78649260473 scopus 로고    scopus 로고
    • Targeted delivery of siRNA to hepatocytes and hepatic stellate cells by bioconjugation
    • L. Zhu, R.I. Mahato, Targeted delivery of siRNA to hepatocytes and hepatic stellate cells by bioconjugation, Bioconjug. Chem. 21 (2010) 2119-2127.
    • (2010) Bioconjug. Chem. , vol.21 , pp. 2119-2127
    • Zhu, L.1    Mahato, R.I.2
  • 18
    • 79960002359 scopus 로고    scopus 로고
    • Hepatocyte-targeted psiRNA delivery mediated by galactosylated poly(ethylene glycol)-graft-polyethylenimine in vitro
    • C. Nie, C. Liu, G. Chen, J. Dai, H. Li, X. Shuai, Hepatocyte-targeted psiRNA delivery mediated by galactosylated poly(ethylene glycol)-graft- polyethylenimine in vitro, J. Biomater. Appl. 26 (2011) 255-275.
    • (2011) J. Biomater. Appl. , vol.26 , pp. 255-275
    • Nie, C.1    Liu, C.2    Chen, G.3    Dai, J.4    Li, H.5    Shuai, X.6
  • 19
    • 79952960255 scopus 로고    scopus 로고
    • Pharmacological interventions for improving adenovirus usage in gene therapy
    • H.J. Haisma, A.R. Bellu, Pharmacological interventions for improving adenovirus usage in gene therapy, Mol. Pharm. 8 (2011) 50-55.
    • (2011) Mol. Pharm. , vol.8 , pp. 50-55
    • Haisma, H.J.1    Bellu, A.R.2
  • 20
    • 65949090277 scopus 로고    scopus 로고
    • Two key challenges for effective adenovirus-mediated liver gene therapy: Innate immune responses and hepatocytespecific transduction
    • D. Descamps, K. Benihoud, Two key challenges for effective adenovirus-mediated liver gene therapy: innate immune responses and hepatocytespecific transduction, Curr. Gene Ther. 9 (2009) 115-127.
    • (2009) Curr. Gene Ther. , vol.9 , pp. 115-127
    • Descamps, D.1    Benihoud, K.2
  • 21
    • 5444237545 scopus 로고    scopus 로고
    • Liver gene therapy: Advances and hurdles
    • T.H. Nguyen, N. Ferry, Liver gene therapy: advances and hurdles, Gene Ther. 11 (Suppl. 1) (2004) S76-S84.
    • (2004) Gene Ther. , vol.11 , Issue.SUPPL. 1
    • Nguyen, T.H.1    Ferry, N.2
  • 22
    • 14844331419 scopus 로고    scopus 로고
    • Recent advances in hepatic gene transfer: More efficacy and less immunogenicity
    • R.W. Herzog, Recent advances in hepatic gene transfer: more efficacy and less immunogenicity, Curr. Opin. Drug Discov. Dev. 8 (2005) 199-206.
    • (2005) Curr. Opin. Drug Discov. Dev. , vol.8 , pp. 199-206
    • Herzog, R.W.1
  • 23
  • 25
    • 0036171327 scopus 로고    scopus 로고
    • Efficient gene delivery and targeted expression to hepatocytes in vivo by improved lentiviral vectors
    • A. Follenzi, G. Sabatino, A. Lombardo, C. Boccaccio, L. Naldini, Efficient gene delivery and targeted expression to hepatocytes in vivo by improved lentiviral vectors, Hum. Gene Ther. 13 (2002) 243-260.
    • (2002) Hum. Gene Ther. , vol.13 , pp. 243-260
    • Follenzi, A.1    Sabatino, G.2    Lombardo, A.3    Boccaccio, C.4    Naldini, L.5
  • 26
    • 0035026903 scopus 로고    scopus 로고
    • Improvements in gene therapy technologies
    • Y. Kaneda, Improvements in gene therapy technologies, Mol. Urol. 5 (2001) 85-89.
    • (2001) Mol. Urol. , vol.5 , pp. 85-89
    • Kaneda, Y.1
  • 28
    • 0035989024 scopus 로고    scopus 로고
    • Preferential transduction of human hepatocytes with lentiviral vectors pseudotyped by Sendai virus F protein
    • C.M. Kowolik, J.K. Yee, Preferential transduction of human hepatocytes with lentiviral vectors pseudotyped by Sendai virus F protein, Mol. Ther. 5 (2002) 762-769.
    • (2002) Mol. Ther. , vol.5 , pp. 762-769
    • Kowolik, C.M.1    Yee, J.K.2
  • 31
    • 22844448409 scopus 로고    scopus 로고
    • Treatment of experimental hepatic fibrosis by combinational delivery of urokinase-type plasminogen activator and hepatocyte growth factor genes
    • Y. Lin, W.-F. Xie, Y.-X. Chen, X. Zhang, X. Zeng, H. Qiang, W.-Z. Chen, X.-J. Yang, Z.-G. Han, Z.-B. Zhang, Treatment of experimental hepatic fibrosis by combinational delivery of urokinase-type plasminogen activator and hepatocyte growth factor genes, Liver Int. 25 (2005) 796-807.
    • (2005) Liver Int. , vol.25 , pp. 796-807
    • Lin, Y.1    Xie, W.-F.2    Chen, Y.-X.3    Zhang, X.4    Zeng, X.5    Qiang, H.6    Chen, W.-Z.7    Yang, X.-J.8    Han, Z.-G.9    Zhang, Z.-B.10
  • 32
    • 33947583453 scopus 로고    scopus 로고
    • In vivo administration of lentiviral vectors triggers a type I interferon response that restricts hepatocyte gene transfer and promotes vector clearance
    • B.D. Brown, G. Sitia, A. Annoni, E. Hauben, L.S. Sergi, A. Zingale, M.G. Roncarolo, L.G. Guidotti, L. Naldini, In vivo administration of lentiviral vectors triggers a type I interferon response that restricts hepatocyte gene transfer and promotes vector clearance, Blood 109 (2007) 2797-2805.
    • (2007) Blood , vol.109 , pp. 2797-2805
    • Brown, B.D.1    Sitia, G.2    Annoni, A.3    Hauben, E.4    Sergi, L.S.5    Zingale, A.6    Roncarolo, M.G.7    Guidotti, L.G.8    Naldini, L.9
  • 33
    • 34250191828 scopus 로고    scopus 로고
    • Current advances and future challenges in adenoviral vector biology and targeting
    • S.K. Campos, M.A. Barry, Current advances and future challenges in adenoviral vector biology and targeting, Curr. Gene Ther. 7 (2007) 189-204.
    • (2007) Curr. Gene Ther. , vol.7 , pp. 189-204
    • Campos, S.K.1    Barry, M.A.2
  • 34
    • 34249279852 scopus 로고    scopus 로고
    • Systemic and specific delivery of small interfering RNAs to the liver mediated by apolipoprotein A-I
    • S.I. Kim, D. Shin, T.H. Choi, J.C. Lee, G.-J. Cheon, K.-Y. Kim, M. Park, M. Kim, Systemic and specific delivery of small interfering RNAs to the liver mediated by apolipoprotein A-I, Mol. Ther. 15 (2007) 1145-1152.
    • (2007) Mol. Ther. , vol.15 , pp. 1145-1152
    • Kim, S.I.1    Shin, D.2    Choi, T.H.3    Lee, J.C.4    Cheon, G.-J.5    Kim, K.-Y.6    Park, M.7    Kim, M.8
  • 37
    • 79953301730 scopus 로고    scopus 로고
    • Micro- RNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins
    • K.C. Vickers, B.T. Palmisano, B.M. Shoucri, R.D. Shamburek, A.T. Remaley, Micro- RNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins, Nat. Cell Biol. 13 (2011) 423-433.
    • (2011) Nat. Cell Biol. , vol.13 , pp. 423-433
    • Vickers, K.C.1    Palmisano, B.T.2    Shoucri, B.M.3    Shamburek, R.D.4    Remaley, A.T.5
  • 38
    • 3142705894 scopus 로고    scopus 로고
    • Liver-targeted doxorubicin: Effects on rat regenerating hepatocytes
    • G. Di Stefano, M. Derenzini, F. Kratz, M. Lanza, L. Fiume, Liver-targeted doxorubicin: effects on rat regenerating hepatocytes, Liver Int. 24 (2004) 246-252.
    • (2004) Liver Int. , vol.24 , pp. 246-252
    • Di Stefano, G.1    Derenzini, M.2    Kratz, F.3    Lanza, M.4    Fiume, L.5
  • 39
    • 34548660545 scopus 로고    scopus 로고
    • Early virologic response after peginterferon alpha-2a plus ribavirin or peginterferon alpha-2b plus ribavirin treatment in patients with chronic hepatitis C
    • A.M. Di Bisceglie, R.H. Ghalib, F.M. Hamzeh, V.K. Rustgi, Early virologic response after peginterferon alpha-2a plus ribavirin or peginterferon alpha-2b plus ribavirin treatment in patients with chronic hepatitis C, J. Viral Hepat. 14 (2007) 721-729.
    • (2007) J. Viral Hepat. , vol.14 , pp. 721-729
    • Di Bisceglie, A.M.1    Ghalib, R.H.2    Hamzeh, F.M.3    Rustgi, V.K.4
  • 40
    • 33644507139 scopus 로고    scopus 로고
    • Viral hepatitis
    • H. Alter, Viral hepatitis, Hepatology 43 (2, Suppl. 1) (2006) S230-S234.
    • (2006) Hepatology , vol.43 , Issue.2 SUPPL. 1
    • Alter, H.1
  • 41
    • 79959478969 scopus 로고    scopus 로고
    • Chronic hepatitis C infection
    • H.R. Rosen, Chronic hepatitis C infection, N. Engl. J. Med. 364 (2011) 2429-2438.
    • (2011) N. Engl. J. Med. , vol.364 , pp. 2429-2438
    • Rosen, H.R.1
  • 43
    • 36749064497 scopus 로고    scopus 로고
    • Inhibition of tumor necrosis factor alpha secretion in rat Kupffer cells by siRNA: In vivo efficacy of siRNA-liposomes
    • Y. Jing, A. Shishkov, B.C. Ponnappa, Inhibition of tumor necrosis factor alpha secretion in rat Kupffer cells by siRNA: in vivo efficacy of siRNA-liposomes, Biochim. Biophys. Acta, Gen. Subj. 1780 (2008) 34-40.
    • (2008) Biochim. Biophys. Acta, Gen. Subj. , vol.1780 , pp. 34-40
    • Jing, Y.1    Shishkov, A.2    Ponnappa, B.C.3
  • 45
    • 35948985622 scopus 로고    scopus 로고
    • Innate immune response and hepatic inflammation
    • G. Szabo, P. Mandrekar, A. Dolganiuc, Innate immune response and hepatic inflammation, Semin. Liver Dis. 27 (2007) 339-350.
    • (2007) Semin. Liver Dis. , vol.27 , pp. 339-350
    • Szabo, G.1    Mandrekar, P.2    Dolganiuc, A.3
  • 46
    • 34247844680 scopus 로고    scopus 로고
    • Erythrophagocytosis by liver macrophages (Kupffer cells) promotes oxidative stress, inflammation, and fibrosis in a rabbit model of steatohepatitis: Implications for the pathogenesis of human nonalcoholic steatohepatitis
    • K. Otogawa, K. Kinoshita, H. Fujii, M. Sakabe, R. Shiga, K. Nakatani, K. Ikeda, Y. Nakajima, Y. Ikura, M. Ueda, T. Arakawa, F. Hato, N. Kawada, Erythrophagocytosis by liver macrophages (Kupffer cells) promotes oxidative stress, inflammation, and fibrosis in a rabbit model of steatohepatitis: implications for the pathogenesis of human nonalcoholic steatohepatitis, Am. J. Pathol. 170 (2007) 967-980.
    • (2007) Am. J. Pathol. , vol.170 , pp. 967-980
    • Otogawa, K.1    Kinoshita, K.2    Fujii, H.3    Sakabe, M.4    Shiga, R.5    Nakatani, K.6    Ikeda, K.7    Nakajima, Y.8    Ikura, Y.9    Ueda, M.10    Arakawa, T.11    Hato, F.12    Kawada, N.13
  • 47
    • 33748307666 scopus 로고    scopus 로고
    • Role of neutrophils in acute inflammatory liver injury
    • H. Jaeschke, T. Hasegawa, Role of neutrophils in acute inflammatory liver injury, Liver Int. 26 (2006) 912-919.
    • (2006) Liver Int. , vol.26 , pp. 912-919
    • Jaeschke, H.1    Hasegawa, T.2
  • 48
    • 79955943145 scopus 로고    scopus 로고
    • Reactivation of hepatitis B virus infection after cytotoxic chemotherapy or immunosuppressive therapy
    • M.L. Manzano-Alonso, G. Castellano-Tortajada, Reactivation of hepatitis B virus infection after cytotoxic chemotherapy or immunosuppressive therapy, World J. Gastroenterol. 17 (2011) 1531-1537.
    • (2011) World J. Gastroenterol. , vol.17 , pp. 1531-1537
    • Manzano-Alonso, M.L.1    Castellano-Tortajada, G.2
  • 53
    • 0038746701 scopus 로고    scopus 로고
    • The pharmacokinetic and biological activity profile of dexamethasone targeted to sinusoidal endothelial and Kupffer cells
    • B.N. Melgert, B. Weert, H. Schellekens, D.K.F. Meijer, K. Poelstra, The pharmacokinetic and biological activity profile of dexamethasone targeted to sinusoidal endothelial and Kupffer cells, J. Drug Target. 11 (2003) 1-10.
    • (2003) J. Drug Target. , vol.11 , pp. 1-10
    • Melgert, B.N.1    Weert, B.2    Schellekens, H.3    Meijer, D.K.F.4    Poelstra, K.5
  • 54
    • 0034068404 scopus 로고    scopus 로고
    • Dexamethasone coupled to albumin is selectively taken up by rat nonparenchymal liver cells and attenuates LPS-induced activation of hepatic cells
    • B.N. Melgert, P. Olinga, V.K. Jack, G. Molema, D.K.F. Meijer, K. Poelstra, Dexamethasone coupled to albumin is selectively taken up by rat nonparenchymal liver cells and attenuates LPS-induced activation of hepatic cells, J. Hepatol. 32 (2000) 603-611.
    • (2000) J. Hepatol. , vol.32 , pp. 603-611
    • Melgert, B.N.1    Olinga, P.2    Jack, V.K.3    Molema, G.4    Meijer, D.K.F.5    Poelstra, K.6
  • 56
    • 0032191706 scopus 로고    scopus 로고
    • Targeting of sugar- and charge-modified albumins to fibrotic rat livers: The accessibility of hepatic cells after chronic bile duct ligation
    • L. Beljaars, K. Poelstra, G. Molema, D.K.F. Meijer, Targeting of sugar- and charge-modified albumins to fibrotic rat livers: the accessibility of hepatic cells after chronic bile duct ligation, J. Hepatol. 29 (1998) 579-588.
    • (1998) J. Hepatol. , vol.29 , pp. 579-588
    • Beljaars, L.1    Poelstra, K.2    Molema, G.3    Meijer, D.K.F.4
  • 57
    • 0036001401 scopus 로고    scopus 로고
    • Massive and selective delivery of lipid-coated cationic lipoplexes of oligonucleotides targeted in vivo to hepatic endothelial cells
    • M. Bartsch, A.H. Weeke-Klimp, D.K.F. Meijer, G.L. Scherphof, J.A.A.M. Kamps, Massive and selective delivery of lipid-coated cationic lipoplexes of oligonucleotides targeted in vivo to hepatic endothelial cells, Pharm. Res. 19 (2002) 676-680.
    • (2002) Pharm. Res. , vol.19 , pp. 676-680
    • Bartsch, M.1    Weeke-Klimp, A.H.2    Meijer, D.K.F.3    Scherphof, G.L.4    Kamps, J.A.A.M.5
  • 58
    • 1842836554 scopus 로고    scopus 로고
    • Production of interleukin-1 activity of Kupffer cells from mice treated with the acidic mannan fraction of bakers' yeast
    • Y. Okawa, K. Abe, T. Watanabe, H. Sasaki, M. Suzuki, Production of interleukin-1 activity of Kupffer cells from mice treated with the acidic mannan fraction of bakers' yeast, Biol. Pharm. Bull. 25 (2002) 1506-1508.
    • (2002) Biol. Pharm. Bull. , vol.25 , pp. 1506-1508
    • Okawa, Y.1    Abe, K.2    Watanabe, T.3    Sasaki, H.4    Suzuki, M.5
  • 59
    • 8444251716 scopus 로고    scopus 로고
    • Uptake characteristics of mannosylated and fucosylated bovine serum albumin in primary cultured rat sinusoidal endothelial cells and Kupffer cells
    • Y. Higuchi, M. Nishikawa, S. Kawakami, F. Yamashita, M. Hashida, Uptake characteristics of mannosylated and fucosylated bovine serum albumin in primary cultured rat sinusoidal endothelial cells and Kupffer cells, Int. J. Pharm. 287 (2004) 147-154.
    • (2004) Int. J. Pharm. , vol.287 , pp. 147-154
    • Higuchi, Y.1    Nishikawa, M.2    Kawakami, S.3    Yamashita, F.4    Hashida, M.5
  • 61
    • 33344461571 scopus 로고    scopus 로고
    • Improved antioxidant activity of superoxide dismutase by direct chemical modification
    • N. Ishimoto, T. Nemoto, K. Nagayoshi, F. Yamashita, M. Hashida, Improved antioxidant activity of superoxide dismutase by direct chemical modification, J. Control. Release 111 (2006) 204-211.
    • (2006) J. Control. Release , vol.111 , pp. 204-211
    • Ishimoto, N.1    Nemoto, T.2    Nagayoshi, K.3    Yamashita, F.4    Hashida, M.5
  • 63
    • 33745169297 scopus 로고    scopus 로고
    • Intravenous administration of mannosylated cationic liposome/NFκB decoy complexes effectively prevent LPS-induced cytokine production in a murine liver failure model
    • Y. Higuchi, S. Kawakami, M. Oka, Y. Yabe, F. Yamashita, M. Hashida, Intravenous administration of mannosylated cationic liposome/NFκB decoy complexes effectively prevent LPS-induced cytokine production in a murine liver failure model, FEBS Lett. 580 (2006) 3706-3714.
    • (2006) FEBS Lett. , vol.580 , pp. 3706-3714
    • Higuchi, Y.1    Kawakami, S.2    Oka, M.3    Yabe, Y.4    Yamashita, F.5    Hashida, M.6
  • 65
    • 0034070797 scopus 로고    scopus 로고
    • The liver as a crucial organ in the first line of host defense: The roles of Kupffer cells, natural killer (NK) cells and NK1.1 Ag+ T cells in T helper 1 immune responses
    • S. Seki, Y. Habu, T. Kawamura, K. Takeda, H. Dobashi, T. Ohkawa, H. Hiraide, The liver as a crucial organ in the first line of host defense: the roles of Kupffer cells, natural killer (NK) cells and NK1.1 Ag+ T cells in T helper 1 immune responses, Immunol. Rev. 174 (2000) 35-46.
    • (2000) Immunol. Rev. , vol.174 , pp. 35-46
    • Seki, S.1    Habu, Y.2    Kawamura, T.3    Takeda, K.4    Dobashi, H.5    Ohkawa, T.6    Hiraide, H.7
  • 66
    • 0035183770 scopus 로고    scopus 로고
    • Pharmacokinetic analysis of lectin-dependent biodistribution of fucosylated bovine serum albumin: A possible carrier for Kupffer cells
    • P. Opanasopit, M. Nishikawa, F. Yamashita, Y. Takakura, M. Hashida, Pharmacokinetic analysis of lectin-dependent biodistribution of fucosylated bovine serum albumin: a possible carrier for Kupffer cells, J. Drug Target. 9 (2001) 341-351.
    • (2001) J. Drug Target. , vol.9 , pp. 341-351
    • Opanasopit, P.1    Nishikawa, M.2    Yamashita, F.3    Takakura, Y.4    Hashida, M.5
  • 68
    • 79960333577 scopus 로고    scopus 로고
    • Synthesis and evaluation of stearylated hyaluronic acid for the active delivery of liposomes to liver endothelial cells
    • N. Toriyabe, Y. Hayashi, M. Hyodo, H. Harashima, Synthesis and evaluation of stearylated hyaluronic acid for the active delivery of liposomes to liver endothelial cells, Biol. Pharm. Bull. 34 (2011) 1084-1089.
    • (2011) Biol. Pharm. Bull. , vol.34 , pp. 1084-1089
    • Toriyabe, N.1    Hayashi, Y.2    Hyodo, M.3    Harashima, H.4
  • 69
    • 0028927435 scopus 로고
    • Recognition and clearance of liposomes containing phosphatidylserine are mediated by serum opsonin
    • D. Liu, F. Liu, Y.K. Song, Recognition and clearance of liposomes containing phosphatidylserine are mediated by serum opsonin, Biochim. Biophys. Acta-Biomembr. 1235 (1995) 140-146.
    • (1995) Biochim. Biophys. Acta-Biomembr. , vol.1235 , pp. 140-146
    • Liu, D.1    Liu, F.2    Song, Y.K.3
  • 71
    • 33847051292 scopus 로고    scopus 로고
    • Pharmacokinetics of poly(hydroxyethyl-l-asparagine)-coated liposomes is superior over that of PEG-coated liposomes at low lipid dose and upon repeated administration
    • B. Romberg, C. Oussoren, C.J. Snel, M.G. Carstens, W.E. Hennink, G. Storm, Pharmacokinetics of poly(hydroxyethyl-l-asparagine)-coated liposomes is superior over that of PEG-coated liposomes at low lipid dose and upon repeated administration, Biochim. Biophys. Acta-Biomembr. 1768 (2007) 737-743.
    • (2007) Biochim. Biophys. Acta-Biomembr. , vol.1768 , pp. 737-743
    • Romberg, B.1    Oussoren, C.2    Snel, C.J.3    Carstens, M.G.4    Hennink, W.E.5    Storm, G.6
  • 72
    • 33750324646 scopus 로고    scopus 로고
    • Spleen plays an important role in the induction of accelerated blood clearance of PEGylated liposomes
    • T. Ishida, M. Ichihara, X. Wang, H. Kiwada, Spleen plays an important role in the induction of accelerated blood clearance of PEGylated liposomes, J. Control. Release 115 (2006) 243-250.
    • (2006) J. Control. Release , vol.115 , pp. 243-250
    • Ishida, T.1    Ichihara, M.2    Wang, X.3    Kiwada, H.4
  • 73
    • 33645815708 scopus 로고    scopus 로고
    • Injection of PEGylated liposomes in rats elicits PEG-specific IgM, which is responsible for rapid elimination of a second dose of PEGylated liposomes
    • T. Ishida, M. Ichihara, X. Wang, K. Yamamoto, J. Kimura, E. Majima, H. Kiwada, Injection of PEGylated liposomes in rats elicits PEG-specific IgM, which is responsible for rapid elimination of a second dose of PEGylated liposomes, J. Control. Release 112 (2006) 15-25.
    • (2006) J. Control. Release , vol.112 , pp. 15-25
    • Ishida, T.1    Ichihara, M.2    Wang, X.3    Yamamoto, K.4    Kimura, J.5    Majima, E.6    Kiwada, H.7
  • 76
    • 76549084356 scopus 로고    scopus 로고
    • Obesity, inflammatory signaling, and hepatocellular carcinoma - An enlarging link
    • S. Toffanin, S.L. Friedman, J.M. Llovet, Obesity, inflammatory signaling, and hepatocellular carcinoma - an enlarging link, Cancer Cell 17 (2010) 115-117.
    • (2010) Cancer Cell , vol.17 , pp. 115-117
    • Toffanin, S.1    Friedman, S.L.2    Llovet, J.M.3
  • 77
    • 0034723290 scopus 로고    scopus 로고
    • Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury
    • S.L. Friedman, Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury, J. Biol. Chem. 275 (2000) 2247-2250.
    • (2000) J. Biol. Chem. , vol.275 , pp. 2247-2250
    • Friedman, S.L.1
  • 79
    • 54549100263 scopus 로고    scopus 로고
    • Preface. Hepatic fibrosis: Pathogenesis, diagnosis, and emerging therapies
    • S.L. Friedman, Preface. Hepatic fibrosis: pathogenesis, diagnosis, and emerging therapies, Clin. Liver Dis. 12 (2008) xiii-xiv.
    • (2008) Clin. Liver Dis. , vol.12
    • Friedman, S.L.1
  • 80
    • 40049097359 scopus 로고    scopus 로고
    • Liver cirrhosis
    • D. Schuppan, N.H. Afdhal, Liver cirrhosis, Lancet 71 (2008) 838-851.
    • (2008) Lancet , vol.71 , pp. 838-851
    • Schuppan, D.1    Afdhal, N.H.2
  • 81
    • 33847363203 scopus 로고    scopus 로고
    • Models of liver fibrosis: Exploring the dynamic nature of inflammation and repair in a solid organ
    • J.P. Iredale, Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ, J. Clin. Invest. 117 (2007) 539-548.
    • (2007) J. Clin. Invest. , vol.117 , pp. 539-548
    • Iredale, J.P.1
  • 82
    • 14944343292 scopus 로고    scopus 로고
    • Fibrosis in chronic liver diseases: Diagnosis and management
    • M. Pinzani, K. Rombouts, S. Colagrande, Fibrosis in chronic liver diseases: diagnosis and management, J. Hepatol. 42 (Suppl. 1) (2005) S22-S36.
    • (2005) J. Hepatol. , vol.42 , Issue.SUPPL. 1
    • Pinzani, M.1    Rombouts, K.2    Colagrande, S.3
  • 84
    • 0032899156 scopus 로고    scopus 로고
    • Albumin modified with mannose 6-phosphate: A potential carrier for selective delivery of antifibrotic drugs to rat and human hepatic stellate cells
    • L. Beljaars, G. Molema, B. Weert, H. Bonnema, P. Olinga, G.M.M. Groothuis, D.K.F. Meijer, K. Poelstra, Albumin modified with mannose 6-phosphate: a potential carrier for selective delivery of antifibrotic drugs to rat and human hepatic stellate cells, Hepatology 29 (1999) 1486-1493.
    • (1999) Hepatology , vol.29 , pp. 1486-1493
    • Beljaars, L.1    Molema, G.2    Weert, B.3    Bonnema, H.4    Olinga, P.5    Groothuis, G.M.M.6    Meijer, D.K.F.7    Poelstra, K.8
  • 85
    • 0036456869 scopus 로고    scopus 로고
    • Hepatic fibrosis: From bench to bedside
    • D. Schuppan, Y. Popov, Hepatic fibrosis: from bench to bedside, J. Gastroenterol. Hepatol. 17 (Suppl. 3) (2002) S300-S305.
    • (2002) J. Gastroenterol. Hepatol. , vol.17 , Issue.SUPPL. 3
    • Schuppan, D.1    Popov, Y.2
  • 86
    • 0038455747 scopus 로고    scopus 로고
    • Cirrhosis: New research provides a basis for rational and targeted treatments
    • J.P. Iredale, Cirrhosis: new research provides a basis for rational and targeted treatments, BMJ 327 (2003) 143-147.
    • (2003) BMJ , vol.327 , pp. 143-147
    • Iredale, J.P.1
  • 87
    • 0037220482 scopus 로고    scopus 로고
    • Liver fibrosis - From bench to bedside
    • S.L. Friedman, Liver fibrosis - from bench to bedside, J. Hepatol. 38 (Suppl. 1) (2003) S38-S53.
    • (2003) J. Hepatol. , vol.38 , Issue.SUPPL. 1
    • Friedman, S.L.1
  • 88
    • 0034724911 scopus 로고    scopus 로고
    • Successful targeting to rat hepatic stellate cells using albumin modified with cyclic peptides that recognize the collagen type VI receptor
    • L. Beljaars, G. Molema, D. Schuppan, A. Geerts, P.J. De Bleser, B. Weert, D.K.F. Meijer, K. Poelstra, Successful targeting to rat hepatic stellate cells using albumin modified with cyclic peptides that recognize the collagen type VI receptor, J. Biol. Chem. 275 (2000) 12743-12751.
    • (2000) J. Biol. Chem. , vol.275 , pp. 12743-12751
    • Beljaars, L.1    Molema, G.2    Schuppan, D.3    Geerts, A.4    De Bleser, P.J.5    Weert, B.6    Meijer, D.K.F.7    Poelstra, K.8
  • 89
    • 0141740706 scopus 로고    scopus 로고
    • The preferential homing of a platelet derived growth factor receptor-recognizing macromolecule to fibroblast-like cells in fibrotic tissue
    • L. Beljaars, B. Weert, A. Geerts, D.K.F. Meijer, K. Poelstra, The preferential homing of a platelet derived growth factor receptor-recognizing macromolecule to fibroblast-like cells in fibrotic tissue, Biochem. Pharmacol. 66 (2003) 1307-1317.
    • (2003) Biochem. Pharmacol. , vol.66 , pp. 1307-1317
    • Beljaars, L.1    Weert, B.2    Geerts, A.3    Meijer, D.K.F.4    Poelstra, K.5
  • 92
    • 33645868663 scopus 로고    scopus 로고
    • The antiproliferative drug doxorubicin inhibits liver fibrosis in bile duct-ligated rats and can be selectively delivered to hepatic stellate cells in vivo
    • R. Greupink, H.I. Bakker, W. Bouma, C. Reker-Smit, D.K.F. Meijer, L. Beljaars, K. Poelstra, The antiproliferative drug doxorubicin inhibits liver fibrosis in bile duct-ligated rats and can be selectively delivered to hepatic stellate cells in vivo, J. Pharmacol. Exp. Ther. 317 (2006) 514-521.
    • (2006) J. Pharmacol. Exp. Ther. , vol.317 , pp. 514-521
    • Greupink, R.1    Bakker, H.I.2    Bouma, W.3    Reker-Smit, C.4    Meijer, D.K.F.5    Beljaars, L.6    Poelstra, K.7
  • 97
    • 0346874204 scopus 로고    scopus 로고
    • Synthesis of a targeting drug for antifibrosis of liver; a conjugate for delivering glycyrrhetin to hepatic stellate cells
    • J. Zhang, Q.-S. Zhang, X.-M. Chen, G.-Y. Tian, Synthesis of a targeting drug for antifibrosis of liver; a conjugate for delivering glycyrrhetin to hepatic stellate cells, Glycoconj. J. 19 (2002) 423-429.
    • (2002) Glycoconj. J. , vol.19 , pp. 423-429
    • Zhang, J.1    Zhang, Q.-S.2    Chen, X.-M.3    Tian, G.-Y.4
  • 99
    • 15544382666 scopus 로고    scopus 로고
    • Targeted delivery of a triplex-forming oligonucleotide to hepatic stellate cells
    • Z. Ye, K. Cheng, R.V. Guntaka, R.I. Mahato, Targeted delivery of a triplex-forming oligonucleotide to hepatic stellate cells, Biochemistry 44 (2005) 4466-4476.
    • (2005) Biochemistry , vol.44 , pp. 4466-4476
    • Ye, Z.1    Cheng, K.2    Guntaka, R.V.3    Mahato, R.I.4
  • 100
    • 33646933490 scopus 로고    scopus 로고
    • Receptor-mediated hepatic uptake of M6P-BSA-conjugated triplex-forming oligonucleotides in rats
    • Z. Ye, K. Cheng, R.V. Guntaka, R.I. Mahato, Receptor-mediated hepatic uptake of M6P-BSA-conjugated triplex-forming oligonucleotides in rats, Bioconjugate Chem. 17 (2006) 823-830.
    • (2006) Bioconjugate Chem. , vol.17 , pp. 823-830
    • Ye, Z.1    Cheng, K.2    Guntaka, R.V.3    Mahato, R.I.4
  • 103
    • 79961166830 scopus 로고    scopus 로고
    • Increased liver uptake and reduced hepatic stellate cell activation with a cell-specific conjugate of the Rho-kinase inhibitor Y27632
    • M.M. van Beuge, J. Prakash, M. Lacombe, E. Post, C. Reker-Smit, L. Beljaars, K. Poelstra, Increased liver uptake and reduced hepatic stellate cell activation with a cell-specific conjugate of the Rho-kinase inhibitor Y27632, Pharm. Res. 28 (2011) 2045-2054.
    • (2011) Pharm. Res. , vol.28 , pp. 2045-2054
    • Van Beuge, M.M.1    Prakash, J.2    Lacombe, M.3    Post, E.4    Reker-Smit, C.5    Beljaars, L.6    Poelstra, K.7
  • 106
    • 79960718862 scopus 로고    scopus 로고
    • Novel engineered targeted interferon-gamma blocks hepatic fibrogenesis in mice
    • R. Bansal, J. Prakash, E. Post, L. Beljaars, D. Schuppan, K. Poelstra, Novel engineered targeted interferon-gamma blocks hepatic fibrogenesis in mice, Hepatology 54 (2011) 586-596.
    • (2011) Hepatology , vol.54 , pp. 586-596
    • Bansal, R.1    Prakash, J.2    Post, E.3    Beljaars, L.4    Schuppan, D.5    Poelstra, K.6
  • 107
    • 33645509277 scopus 로고    scopus 로고
    • Arg-gly-asp-mannose-6-phosphate inhibits activation and proliferation of hepatic stellate cells in vitro
    • L.-S. Wang, Y.-W. Chen, D.-G. Li, H.-M. Lu, Arg-gly-asp-mannose-6- phosphate inhibits activation and proliferation of hepatic stellate cells in vitro, World J. Gastroenterol. 12 (2006) 1303-1307.
    • (2006) World J. Gastroenterol. , vol.12 , pp. 1303-1307
    • Wang, L.-S.1    Chen, Y.-W.2    Li, D.-G.3    Lu, H.-M.4
  • 108
    • 21044445446 scopus 로고    scopus 로고
    • Generation of a monoclonal human single chain antibody fragment to hepatic stellate cells - A potential mechanism for targeting liver anti-fibrotic therapeutics
    • L.J. Elrick, V. Leel, M.G. Blaylock, L. Duncan, M.R. Drever, G. Strachan, K.A. Charlton, M. Koruth, A.J. Porter, M.C. Wright, Generation of a monoclonal human single chain antibody fragment to hepatic stellate cells - a potential mechanism for targeting liver anti-fibrotic therapeutics, J. Hepatol. 42 (2005) 888-896.
    • (2005) J. Hepatol. , vol.42 , pp. 888-896
    • Elrick, L.J.1    Leel, V.2    Blaylock, M.G.3    Duncan, L.4    Drever, M.R.5    Strachan, G.6    Charlton, K.A.7    Koruth, M.8    Porter, A.J.9    Wright, M.C.10
  • 113
    • 34248204485 scopus 로고    scopus 로고
    • Delivery of viral vectors to hepatic stellate cells in fibrotic livers using HVJ envelopes fused with targeted liposomes
    • J.E. Adrian, J.A.A.M. Kamps, K. Poelstra, G.L. Scherphof, D.K.F. Meijer, Y. Kaneda, Delivery of viral vectors to hepatic stellate cells in fibrotic livers using HVJ envelopes fused with targeted liposomes, J. Drug Target. 15 (2007) 75-82.
    • (2007) J. Drug Target. , vol.15 , pp. 75-82
    • Adrian, J.E.1    Kamps, J.A.A.M.2    Poelstra, K.3    Scherphof, G.L.4    Meijer, D.K.F.5    Kaneda, Y.6
  • 114
    • 34547137386 scopus 로고    scopus 로고
    • Cyclic Arg-Gly-Asp peptide-labeled liposomes for targeting drug therapy of hepatic fibrosis in rats
    • S.-L. Du, H. Pan, W.-Y. Lu, J. Wang, J. Wu, J.-Y. Wang, Cyclic Arg-Gly-Asp peptide-labeled liposomes for targeting drug therapy of hepatic fibrosis in rats, J. Pharmacol. Exp. Ther. 322 (2007) 560-568.
    • (2007) J. Pharmacol. Exp. Ther. , vol.322 , pp. 560-568
    • Du, S.-L.1    Pan, H.2    Lu, W.-Y.3    Wang, J.4    Wu, J.5    Wang, J.-Y.6
  • 116
    • 33645891179 scopus 로고    scopus 로고
    • Enhanced hepatic uptake and bioactivity of type α1(I) collagen gene promoter-specific triplex-forming oligonucleotides after conjugation with cholesterol
    • K. Cheng, Z. Ye, R.V. Guntaka, R.I. Mahato, Enhanced hepatic uptake and bioactivity of type α1(I) collagen gene promoter-specific triplex-forming oligonucleotides after conjugation with cholesterol, J. Pharmacol. Exp. Ther. 317 (2006) 797-805.
    • (2006) J. Pharmacol. Exp. Ther. , vol.317 , pp. 797-805
    • Cheng, K.1    Ye, Z.2    Guntaka, R.V.3    Mahato, R.I.4
  • 117
    • 0034121518 scopus 로고    scopus 로고
    • Gene transfer of the neuronal NO synthase isoform to cirrhotic rat liver ameliorates portal hypertension
    • Q. Yu, R. Shao, H.S. Qian, S.E. George, D.C. Rockey, Gene transfer of the neuronal NO synthase isoform to cirrhotic rat liver ameliorates portal hypertension, J. Clin. Invest. 105 (2000) 741-748.
    • (2000) J. Clin. Invest. , vol.105 , pp. 741-748
    • Yu, Q.1    Shao, R.2    Qian, H.S.3    George, S.E.4    Rockey, D.C.5
  • 118
    • 0036087413 scopus 로고    scopus 로고
    • Adenovirus-mediated gene transfer to nonparenchymal cells in normal and injured liver
    • Q. Yu, L.G. Que, D.C. Rockey, Adenovirus-mediated gene transfer to nonparenchymal cells in normal and injured liver, Am. J. Physiol. Gastrointest. Liver Physiol. 282 (2002) G565-G572.
    • (2002) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.282
    • Yu, Q.1    Que, L.G.2    Rockey, D.C.3
  • 119
    • 0034681457 scopus 로고    scopus 로고
    • Inhibition of experimental liver cirrhosis in mice by telomerase gene delivery
    • K.L. Rudolph, S. Chang, M. Millard, N. Schreiber-Agus, R.A. DePinho, Inhibition of experimental liver cirrhosis in mice by telomerase gene delivery, Science 287 (2000) 1253-1258.
    • (2000) Science , vol.287 , pp. 1253-1258
    • Rudolph, K.L.1    Chang, S.2    Millard, M.3    Schreiber-Agus, N.4    DePinho, R.A.5
  • 122
    • 0033515099 scopus 로고    scopus 로고
    • Blockade of type â transforming growth factor signaling prevents liver fibrosis and dysfunction in the rat
    • Z. Qi, N. Atsuchi, A. Ooshima, A. Takeshita, H. Ueno, Blockade of type â transforming growth factor signaling prevents liver fibrosis and dysfunction in the rat, Proc. Nat. Acad. Sci. U. S. A. 96 (1999) 2345-2349.
    • (1999) Proc. Nat. Acad. Sci. U. S. A. , vol.96 , pp. 2345-2349
    • Qi, Z.1    Atsuchi, N.2    Ooshima, A.3    Takeshita, A.4    Ueno, H.5
  • 123
    • 39249083049 scopus 로고    scopus 로고
    • Matrix metalloproteinase gene delivery for liver fibrosis
    • Y. Iimuro, D.A. Brenner, Matrix metalloproteinase gene delivery for liver fibrosis, Pharm. Res. 25 (2008) 249-258.
    • (2008) Pharm. Res. , vol.25 , pp. 249-258
    • Iimuro, Y.1    Brenner, D.A.2
  • 124
    • 0037458826 scopus 로고    scopus 로고
    • Targeted cancer gene therapy: The flexibility of adenoviral gene therapy vectors
    • M.G. Rots, D.T. Curiel, W.R. Gerritsen, H.J. Haisma, Targeted cancer gene therapy: the flexibility of adenoviral gene therapy vectors, J. Control. Release 87 (2003) 159-165.
    • (2003) J. Control. Release , vol.87 , pp. 159-165
    • Rots, M.G.1    Curiel, D.T.2    Gerritsen, W.R.3    Haisma, H.J.4
  • 126
    • 1542709516 scopus 로고    scopus 로고
    • CSRP2, TIMP-1, and SM22α promoter fragments direct hepatic stellate cell-specific transgene expression in vitro, but not in vivo
    • J. Herrmann, M. Arias, E. Van de Leur, A.M. Gressner, R. Weiskirchen, CSRP2, TIMP-1, and SM22α promoter fragments direct hepatic stellate cell-specific transgene expression in vitro, but not in vivo, Liver Int. 24 (2004) 69-79.
    • (2004) Liver Int. , vol.24 , pp. 69-79
    • Herrmann, J.1    Arias, M.2    Van De Leur, E.3    Gressner, A.M.4    Weiskirchen, R.5
  • 127
    • 67649114586 scopus 로고    scopus 로고
    • Targeted delivery of drugs for liver fibrosis
    • F. Li, J.-Y. Wang, Targeted delivery of drugs for liver fibrosis, Expert Opin. Drug Discovery 6 (2009) 531-541.
    • (2009) Expert Opin. Drug Discovery , vol.6 , pp. 531-541
    • Li, F.1    Wang, J.-Y.2
  • 128
    • 84860389169 scopus 로고    scopus 로고
    • Targeted therapy of liver fibrosis/cirrhosis and its complications
    • K. Poelstra, D. Schuppan, Targeted therapy of liver fibrosis/cirrhosis and its complications, J. Hepatol. 55 (2011) 726-728.
    • (2011) J. Hepatol. , vol.55 , pp. 726-728
    • Poelstra, K.1    Schuppan, D.2
  • 129
    • 33845495383 scopus 로고    scopus 로고
    • Concept on the pathogenesis and treatment of primary biliary cirrhosis
    • V.I. Reshetnyak, Concept on the pathogenesis and treatment of primary biliary cirrhosis, World J. Gastroenterol. 12 (2006) 7250-7262.
    • (2006) World J. Gastroenterol. , vol.12 , pp. 7250-7262
    • Reshetnyak, V.I.1
  • 134
  • 135
    • 77956148273 scopus 로고    scopus 로고
    • Epithelial-to-mesenchymal transition in liver fibrosis: Dead or alive?
    • Y. Popov, D. Schuppan, Epithelial-to-mesenchymal transition in liver fibrosis: dead or alive? Gastroenterology 139 (2010) 722-725.
    • (2010) Gastroenterology , vol.139 , pp. 722-725
    • Popov, Y.1    Schuppan, D.2
  • 136
    • 34548630561 scopus 로고    scopus 로고
    • Development of autoimmune hepatitis in primary biliary cirrhosis
    • A.A. Gossard, K.D. Lindor, Development of autoimmune hepatitis in primary biliary cirrhosis, Liver Int. 27 (2007) 1086-1090.
    • (2007) Liver Int. , vol.27 , pp. 1086-1090
    • Gossard, A.A.1    Lindor, K.D.2
  • 137
    • 0032860375 scopus 로고    scopus 로고
    • Management of patients with primary biliary cirrhosis. A practical guide
    • A. Nishio, J. Neuberger, M.E. Gershwin, Management of patients with primary biliary cirrhosis. A practical guide, BioDrugs 12 (1999) 159-173.
    • (1999) BioDrugs , vol.12 , pp. 159-173
    • Nishio, A.1    Neuberger, J.2    Gershwin, M.E.3
  • 138
    • 34547642138 scopus 로고    scopus 로고
    • Ursodeoxycholic acid for patients with primary biliary cirrhosis: An updated systematic review and metaanalysis of randomized clinical trials using Bayesian approach as sensitivity analyses
    • Y. Gong, Z. Huang, E. Christensen, C. Gluud, Ursodeoxycholic acid for patients with primary biliary cirrhosis: an updated systematic review and metaanalysis of randomized clinical trials using Bayesian approach as sensitivity analyses, Am. J. Gastroenterol. 102 (2007) 1799-1807.
    • (2007) Am. J. Gastroenterol. , vol.102 , pp. 1799-1807
    • Gong, Y.1    Huang, Z.2    Christensen, E.3    Gluud, C.4
  • 139
    • 33750442885 scopus 로고    scopus 로고
    • Secretin receptors in the human liver: Expression in biliary tract and cholangiocarcinoma, but not in hepatocytes or hepatocellular carcinoma
    • M. Körner, G.M. Hayes, R. Rehmann, A. Zimmermann, A. Scholz, B. Wiedenmann, L.J. Miller, J.C. Reubi, Secretin receptors in the human liver: expression in biliary tract and cholangiocarcinoma, but not in hepatocytes or hepatocellular carcinoma, J. Hepatol. 45 (2006) 825-835.
    • (2006) J. Hepatol. , vol.45 , pp. 825-835
    • Körner, M.1    Hayes, G.M.2    Rehmann, R.3    Zimmermann, A.4    Scholz, A.5    Wiedenmann, B.6    Miller, L.J.7    Reubi, J.C.8
  • 140
    • 39149111929 scopus 로고    scopus 로고
    • Integrin αvβ6 is a marker of the progression of biliary and portal liver fibrosis and a novel target for antifibrotic therapies
    • Y. Popov, E. Patsenker, F. Stickel, J. Zaks, K.R. Bhaskar, G. Niedobitek, A. Kolb, H. Friess, D. Schuppan, Integrin αvβ6 is a marker of the progression of biliary and portal liver fibrosis and a novel target for antifibrotic therapies, J. Hepatol. 48 (2008) 453-464.
    • (2008) J. Hepatol. , vol.48 , pp. 453-464
    • Popov, Y.1    Patsenker, E.2    Stickel, F.3    Zaks, J.4    Bhaskar, K.R.5    Niedobitek, G.6    Kolb, A.7    Friess, H.8    Schuppan, D.9
  • 142
    • 77955817977 scopus 로고    scopus 로고
    • Molecular targeted therapy of advanced hepatocellular carcinoma beyond sorafenib
    • T. Yau, R. Pang, P. Chan, R.T. Poon, Molecular targeted therapy of advanced hepatocellular carcinoma beyond sorafenib, Expert Opin. Pharmacother. 11 (2010) 2187-2198.
    • (2010) Expert Opin. Pharmacother. , vol.11 , pp. 2187-2198
    • Yau, T.1    Pang, R.2    Chan, P.3    Poon, R.T.4
  • 144
    • 0027488670 scopus 로고
    • Distribution of asialoglycoprotein receptor in human hepatocellular carcinoma
    • I. Hyodo, M. Mizuno, G. Yamada, T. Tsuji, Distribution of asialoglycoprotein receptor in human hepatocellular carcinoma, Liver 13 (1993) 80-85.
    • (1993) Liver , vol.13 , pp. 80-85
    • Hyodo, I.1    Mizuno, M.2    Yamada, G.3    Tsuji, T.4
  • 145
    • 0025809808 scopus 로고
    • N-(2- Hydroxypropyl)methacrylamide copolymers targeted to the hepatocyte galactose-receptor: Pharmacokinetics in DBA2 mice
    • L.W. Seymour, K. Ulbrich, S.R. Wedge, I.C. Hume, J. Strohalm, R. Duncan, N-(2- hydroxypropyl)methacrylamide copolymers targeted to the hepatocyte galactose-receptor: pharmacokinetics in DBA2 mice, Br. J. Cancer 63 (1991) 859-866.
    • (1991) Br. J. Cancer , vol.63 , pp. 859-866
    • Seymour, L.W.1    Ulbrich, K.2    Wedge, S.R.3    Hume, I.C.4    Strohalm, J.5    Duncan, R.6
  • 147
    • 77955684788 scopus 로고    scopus 로고
    • Lactosaminated human albumin, a hepatotropic carrier of drugs
    • L. Fiume, G. Di Stefano, Lactosaminated human albumin, a hepatotropic carrier of drugs, Eur. J. Pharm. Sci. 40 (2010) 253-262.
    • (2010) Eur. J. Pharm. Sci. , vol.40 , pp. 253-262
    • Fiume, L.1    Di Stefano, G.2
  • 148
    • 67449113545 scopus 로고    scopus 로고
    • The enhancement of interstitial transport of a doxorubicin-lactosaminated albumin conjugate by imatinib: In rat hepatocellular carcinoma it is not preferentially higher than that in liver and bone marrow
    • L. Fiume, M. Baglioni, C. Busi, M. Manerba, G. Di Stefano, The enhancement of interstitial transport of a doxorubicin-lactosaminated albumin conjugate by imatinib: in rat hepatocellular carcinoma it is not preferentially higher than that in liver and bone marrow, Eur. J. Pharm. Biopharm. 72 (2009) 630-631.
    • (2009) Eur. J. Pharm. Biopharm. , vol.72 , pp. 630-631
    • Fiume, L.1    Baglioni, M.2    Busi, C.3    Manerba, M.4    Di Stefano, G.5
  • 152
    • 7044270989 scopus 로고    scopus 로고
    • Antibody-directed therapy for human hepatocellular carcinoma
    • L. Mohr, A. Yeung, C. Aloman, D. Wittrup, J.R. Wands, Antibody-directed therapy for human hepatocellular carcinoma, Gastroenterology 127 (5, Suppl. 1) (2004) S225-S231.
    • (2004) Gastroenterology , vol.127 , Issue.5 SUPPL. 1
    • Mohr, L.1    Yeung, A.2    Aloman, C.3    Wittrup, D.4    Wands, J.R.5
  • 154
    • 0347906012 scopus 로고    scopus 로고
    • A liver-specific nitric oxide donor improves the intra-hepatic vascular response to both portal blood flow increase and methoxamine in cirrhotic rats
    • M.R. Loureiro-Silva, G.W. Cadelina, Y. Iwakiri, R.J. Groszmann, A liver-specific nitric oxide donor improves the intra-hepatic vascular response to both portal blood flow increase and methoxamine in cirrhotic rats, J. Hepatol. 39 (2003) 940-946.
    • (2003) J. Hepatol. , vol.39 , pp. 940-946
    • Loureiro-Silva, M.R.1    Cadelina, G.W.2    Iwakiri, Y.3    Groszmann, R.J.4
  • 155
    • 0034856044 scopus 로고    scopus 로고
    • Cellular pathophysiology of portal hypertension and prospects for management with gene therapy
    • D.C. Rockey, Cellular pathophysiology of portal hypertension and prospects for management with gene therapy, Clin. Liver Dis. 5 (2001) 851-865.
    • (2001) Clin. Liver Dis. , vol.5 , pp. 851-865
    • Rockey, D.C.1
  • 156
    • 0036719232 scopus 로고    scopus 로고
    • In vivo gene transfer of endothelial nitric oxide synthase decreases portal pressure in anaesthetised carbon tetrachloride cirrhotic rats
    • M. Van de Casteele, A. Omasta, S. Janssens, T. Roskams, V. Desmet, F. Nevens, J. Fevery, In vivo gene transfer of endothelial nitric oxide synthase decreases portal pressure in anaesthetised carbon tetrachloride cirrhotic rats, Gut 51 (2002) 440-445.
    • (2002) Gut , vol.51 , pp. 440-445
    • Van De Casteele, M.1    Omasta, A.2    Janssens, S.3    Roskams, T.4    Desmet, V.5    Nevens, F.6    Fevery, J.7
  • 158
    • 46049097410 scopus 로고    scopus 로고
    • Gemcitabine plus oxaliplatin (GEMOX) combined with cetuximab in patients with progressive advanced stage hepatocellular carcinoma. Results of a multicenter phase 2 study
    • A. Asnacios, L. Fartoux, O. Romano, C. Tesmoingt, S.S. Louafi, T. Mansoubakht, P. Artru, T. Poynard, O. Rosmorduc, M. Hebbar, J. Taieb, Gemcitabine plus oxaliplatin (GEMOX) combined with cetuximab in patients with progressive advanced stage hepatocellular carcinoma. Results of a multicenter phase 2 study, Cancer 112 (2008) 2733-2739.
    • (2008) Cancer , vol.112 , pp. 2733-2739
    • Asnacios, A.1    Fartoux, L.2    Romano, O.3    Tesmoingt, C.4    Louafi, S.S.5    Mansoubakht, T.6    Artru, P.7    Poynard, T.8    Rosmorduc, O.9    Hebbar, M.10    Taieb, J.11
  • 159
    • 85047699262 scopus 로고    scopus 로고
    • Enhanced antitumor effect of EGF R-targeted p21WAF-1 and GM-CSF gene transfer in the established murine hepatoma by peritumoral injection
    • X. Liu, P. Tian, Y. Yu, M. Yao, X. Cao, J. Gu, Enhanced antitumor effect of EGF R-targeted p21WAF-1 and GM-CSF gene transfer in the established murine hepatoma by peritumoral injection, Cancer Gene Ther. 9 (2002) 100-108.
    • (2002) Cancer Gene Ther. , vol.9 , pp. 100-108
    • Liu, X.1    Tian, P.2    Yu, Y.3    Yao, M.4    Cao, X.5    Gu, J.6
  • 160
    • 0035426950 scopus 로고    scopus 로고
    • Gene delivery using a receptor-mediated gene transfer system targeted to hepatocellular carcinoma cells
    • T.K.W. Lee, J.-S. Han, S.-T. Fan, Z.-D. Liang, P.-K. Tian, J.-R. Gu, I.O.L. Ng, Gene delivery using a receptor-mediated gene transfer system targeted to hepatocellular carcinoma cells, Int. J. Cancer 93 (2001) 393-400.
    • (2001) Int. J. Cancer , vol.93 , pp. 393-400
    • Lee, T.K.W.1    Han, J.-S.2    Fan, S.-T.3    Liang, Z.-D.4    Tian, P.-K.5    Gu, J.-R.6    Ng, I.O.L.7
  • 162
    • 0038494570 scopus 로고    scopus 로고
    • Systemic genetic transfer of p21WAF-1 and GM-CSF utilizing of a novel oligopeptide-based EGF receptor targeting polyplex
    • X. Liu, P.-K. Tian, D.-W. Ju, M.-H. Zhang, M. Yao, X.-T. Cao, J.-R. Gu, Systemic genetic transfer of p21WAF-1 and GM-CSF utilizing of a novel oligopeptide-based EGF receptor targeting polyplex, Cancer Gene Ther. 10 (2003) 529-539.
    • (2003) Cancer Gene Ther. , vol.10 , pp. 529-539
    • Liu, X.1    Tian, P.-K.2    Ju, D.-W.3    Zhang, M.-H.4    Yao, M.5    Cao, X.-T.6    Gu, J.-R.7
  • 163
    • 0028848241 scopus 로고
    • Epirubicin-Lipiodol chemotherapy versus 131iodine-Lipiodol radiotherapy in the treatment of unresectable hepatocellular carcinoma
    • S. Bhattacharya, J.R. Novell, G.M. Dusheiko, A.J. Hilson, R. Dick, K.E. Hobbs, Epirubicin-Lipiodol chemotherapy versus 131iodine-Lipiodol radiotherapy in the treatment of unresectable hepatocellular carcinoma, Cancer 76 (1995) 2202-2210.
    • (1995) Cancer , vol.76 , pp. 2202-2210
    • Bhattacharya, S.1    Novell, J.R.2    Dusheiko, G.M.3    Hilson, A.J.4    Dick, R.5    Hobbs, K.E.6
  • 164
    • 74949104582 scopus 로고    scopus 로고
    • Treatment of hepatocellular carcinoma with intra-arterial injection of radionuclides
    • J.-L. Raoul, E. Boucher, Y. Rolland, E. Garin, Treatment of hepatocellular carcinoma with intra-arterial injection of radionuclides, Nat. Rev. Gastroenterol. Hepatol. 7 (2010) 41-49.
    • (2010) Nat. Rev. Gastroenterol. Hepatol. , vol.7 , pp. 41-49
    • Raoul, J.-L.1    Boucher, E.2    Rolland, Y.3    Garin, E.4
  • 165
    • 70349578955 scopus 로고    scopus 로고
    • Rhenium-188 based radiopharmaceuticals for treatment of liver tumours
    • B. Lambert, K. Bacher, L. Defreyne, Rhenium-188 based radiopharmaceuticals for treatment of liver tumours, Q. J. Nucl. Med. Mol. Imaging 53 (2009) 305-310.
    • (2009) Q. J. Nucl. Med. Mol. Imaging , vol.53 , pp. 305-310
    • Lambert, B.1    Bacher, K.2    Defreyne, L.3
  • 166
    • 60749108001 scopus 로고    scopus 로고
    • Polymeric drugs for efficient tumor-targeted drug delivery based on EPR-effect
    • H. Maeda, G.Y. Bharate, J. Daruwalla, Polymeric drugs for efficient tumor-targeted drug delivery based on EPR-effect, Eur. J. Pharm. Biopharm. 71 (2009) 409-419.
    • (2009) Eur. J. Pharm. Biopharm. , vol.71 , pp. 409-419
    • Maeda, H.1    Bharate, G.Y.2    Daruwalla, J.3
  • 169
    • 0032538432 scopus 로고    scopus 로고
    • Platelet-derived growth factor-BB and thrombin generate positive and negative signals for human hepatic stellate cell proliferation. Role of a prostaglandin/ cyclic AMP pathway and cross-talk with endothelin receptors
    • A. Mallat, C. Gallois, J. Tao, A. Habib, J. Maclouf, P. Mavier, A.-M. Préaux, S. Lotersztajn, Platelet-derived growth factor-BB and thrombin generate positive and negative signals for human hepatic stellate cell proliferation. Role of a prostaglandin/ cyclic AMP pathway and cross-talk with endothelin receptors, J. Biol. Chem. 273 (1998) 27300-27305.
    • (1998) J. Biol. Chem. , vol.273 , pp. 27300-27305
    • Mallat, A.1    Gallois, C.2    Tao, J.3    Habib, A.4    Maclouf, J.5    Mavier, P.6    Préaux, A.-M.7    Lotersztajn, S.8
  • 171
    • 77957193052 scopus 로고    scopus 로고
    • Serum fibrosis markers to predict clinical and histological progression in hepatitis C non-responders
    • R. Malik, D. Schuppan, Serum fibrosis markers to predict clinical and histological progression in hepatitis C non-responders, Gut 59 (2010) 1312-1313.
    • (2010) Gut , vol.59 , pp. 1312-1313
    • Malik, R.1    Schuppan, D.2
  • 172
    • 70350077449 scopus 로고    scopus 로고
    • Targeting liver fibrosis: Strategies for development and validation of antifibrotic therapies
    • Y. Popov, D. Schuppan, Targeting liver fibrosis: strategies for development and validation of antifibrotic therapies, Hepatology 50 (2009) 1294-1306.
    • (2009) Hepatology , vol.50 , pp. 1294-1306
    • Popov, Y.1    Schuppan, D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.