Albumin modified with mannose 6-phosphate: A potential carrier for selective delivery of antifibrotic drugs to rat and human hepatic stellate cells

Hepatology

Volumn 29, Issue 5, 1999, Pages 1486-1493

  Beljaars, Leonie ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; ANTIFIBROTIC AGENT; DRUG CARRIER; MANNOSE 6 PHOSPHATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ACTIVATION; CELLULAR DISTRIBUTION; DRUG DELIVERY SYSTEM; DRUG DISPOSITION; IMMUNOHISTOCHEMISTRY; INTRAVENOUS DRUG ADMINISTRATION; ISOTOPE LABELING; LIVER CELL; LIVER FIBROSIS; MALE; NONHUMAN; ORGAN DISTRIBUTION; PRIORITY JOURNAL; RAT; STELLATE CELL; TARGET CELL;

ANIMALS; DRUG CARRIERS; HUMANS; IMMUNOHISTOCHEMISTRY; LIVER; LIVER CIRRHOSIS; LIVER CIRRHOSIS, EXPERIMENTAL; MALE; MANNOSEPHOSPHATES; RATS; RATS, WISTAR; REFERENCE VALUES; SERUM ALBUMIN; SERUM ALBUMIN, BOVINE; TISSUE DISTRIBUTION;

EID: 0032899156     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.510290526     Document Type: Article

References (6)

1. Pinzani M. Novel insights into the biology and physiology of the Ito cell. Pharmacol Ther 1995;66:387-412.
2. Mathew J, Geerts A, Burt AD. Pathobiology of hepatic stellate cells. Hepatogastroenterology 1996;43:72-91.
3. Maher JJ, McGuire RF. Extracellular matrix gene expression increases preferentially in rat lipocytes and sinusoidal endothelial cells during hepatic fibrosis in vivo. J Clin Invest 1990;86:1641-1648.
4. Gressner AM. Perisinusoidal lipocytes and fibrogenesis. Gut 1994;35: 1331-1333.
5. Hautekeete ML, Geerts A. The hepatic stellate (Ito) cell: its role in human liver disease. Virchows Arch 1997;430:195-207.
6. Wu J, Danielsson A. Inhibition of hepatic fibrogenesis: a review of pharmacologic candidates. Scand J Gastroenterol 1994;29:385-391.