Receptor-mediated hepatic uptake of M6P-BSA-conjugated triplex-forming oligonucleotides in rats

Bioconjugate Chemistry

Volumn 17, Issue 3, 2006, Pages 823-830

  Ye, Zhaoyang ^a   Cheng, Kun ^a   Guntaka, Ramareddy V ^a,c   Mahato, Ram I ^a,b  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b 101 Molecular Science Bldg ^*  (United States)

^c 101 Molecular Science Bldg   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BODY FLUIDS; COLLAGEN; OLIGONUCLEOTIDES;

BOVINE SERUM ALBUMINS; CELLULAR UPTAKE; EXTRACELLULAR MATRICES; HEPATIC STELLATE CELLS; LIVER FIBROSIS; MANNOSE 6 PHOSPHATES; SYNTHESISED; TRIPLEX FORMING OLIGONUCLEOTIDES; TYPE I COLLAGEN; TYPE-I COLLAGEN;

RATS;

COLLAGEN TYPE 1; MANNOSE 6 PHOSPHATE BOVINE SERUM ALBUMIN; MANNOSE 6 PHOSPHATE SOMATOMEDIN B; OLIGONUCLEOTIDE; SOMATOMEDIN B RECEPTOR; TRIPLEX FORMING OLIGONUCLEOTIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; DRUG CONJUGATION; ENDOCYTOSIS; EXTRACELLULAR MATRIX; FIBROGENESIS; LIVER FIBROSIS; NONHUMAN; RAT; STELLATE CELL; TIME;

BOS TAURUS;

EID: 33646933490     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc060006z     Document Type: Article

References (37)

1. Kochanek, K. D., Murphy, S. L., Anderson, R. N., and Scott, C. (2004) Deaths: final data for 2002. Natl. Vital Stat. Rep. 53, 1-115.
2. Friedman, S. L. (2000) Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J. Biol. Chem. 275, 2247-50.
3. Knittel, T., Kobold, D., Piscaglia, F., Saile, B., Neubauer, K., Mehde, M., Timpl, R., and Ramadori, G. (1999) Localization of liver myofibroblasts and hepatic stellate cells in normal and diseased rat livers: distinct roles of (myo-)fibroblast subpopulations in hepatic tissue repair. Histochem. Cell Biol. 112, 387-401.
4. Raghow, R. (1994) The role of extracellular matrix in postinflammatory wound healing and fibrosis. FASEB J. 8, 823-31.
5. Rockey, D. C. (2005) Antifibrotic therapy in chronic liver disease. Clin. Gastroenterol. Hepatol. 3, 95-107.
6. Maher, J. J. (2001) Interactions between hepatic stellate cells and the immune system. Semin. Liver Dis. 21, 417-26.
7. Wu, C. H., Walton, C. M., and Wu, G. Y. (2000) Targeted inhibition of type I procollagen synthesis by antisense DNA oligonucleotides. Gene Ther. Regul. 1, 193-205.
8. Stefanovic, B., Hellerbrand, C., Holcik, M., Briendl, M., Aliebhaber, S., and Brenner, D. A. (1997) Posttranscriptional regulation of collagen alphal(I) mRNA in hepatic stellate cells. Mol. Cell. Biol. 17, 5201-9.
9. Joseph, J., Kandala, J. C., Veerapanane, D., Weber, K. T., and Guntaka, R. V. (1997) Antiparallel polypurine phosphorothioate oligonucleotides form stable triplexes with the rat alphal(I) collagen gene promoter and inhibit transcription in cultured rat fibroblasts. Nucleic Acids Res. 25, 2182-8.
10. Sawai, K., Mahato, R. I., Oka, Y., Takakura, Y., and Hashida, M. (1996) Disposition of oligonucleotides in isolated perfused rat kidney: involvement of scavenger receptors in their renal uptake. J. Pharmacol. Exp. Ther. 279, 284-90.
11. Takakura, Y., Mahato, R. I., Yoshida, M., Kanamaru, T., and Hashida, M. (1996) Uptake characteristics of oligonucleotides in the isolated rat liver perfusion system. Antisense Nucleic Acid Drug Dev. 6, 177-83.
12. Agrawal, S., Temsamani, J., and Tang, J. Y. (1991) Pharmacokinetics, biodistribution, and stability of oligodeoxynucleotide phosphorothioates in mice. Proc. Natl. Acad. Sci. U.S.A. 88, 7595-9.
13. Mahato, R. I., Takemura, S., Akamatsu, K., Nishikawa, M., Takakura, Y., and Hashida, M. (1997) Physicochemical and disposition characteristics of antisense oligonucleotides complexed with glycosylated poly(L-lysine). Biochem. Pharmacol. 53, 887-95.
14. Bijsterbosch, M. K., Manoharan, M., Dorland, R., Waarlo, I. H., Biessen, E. A., and van Berkel, T. J. (2001) Delivery of cholesteryl-conjugated phosphorothioate oligodeoxynucleotides to Kupffer cells by lactosylated low-density lipoprotein. Biochem. Pharmacol. 62, 627-33.
15. Bijsterbosch, M. K., Manoharan, M., Dorland, R., Van Veghel, R., Biessen, E. A., and Van Berkel, T. J. (2002) bis-Cholesteryl-conjugated phosphorothioate oligodeoxynucleotides are highly selectively taken up by the liver. J. Pharmacol. Exp. Ther. 302, 619-26.
16. Cheng, K., Ye, Z., Guntaka, R. V., and Mahato, R. I. (2005) Biodistribution and hepatic uptake of triplex-forming oligonucleotides against type alphal(I) collagen gene promoter in normal and fibrotic rats. Mol. Pharm. 2, 206-17.
17. Beljaars, L., Olinga, P., Molema, G., de Bleser, P., Geerts, A., Groothuis, G. M., Meijer, D. K., and Poelstra, K. (2001) Characteristics of the hepatic stellate cell-selective carrier mannose 6-phosphate modified albumin (M6P(28)-HSA). Liver 21, 320-8.
18. de Bleser, P. J., Jannes, P., van Buul-Offers, S. C., Hoogerbrugge, C. M., van Schravendijk, C. F., Niki, T., Rogiers, V., van den Brande, J. L., Wisse, E., and Geerts, A. (1995) Insulinlike growth factor-II/ mannose 6-phosphate receptor is expressed on CC14-exposed rat fat-storing cells and facilitates activation of latent transforming growth factor-beta in cocultures with sinusoidal endothelial cells. Hepatology 21, 1429-37.
19. Weiner, J. A., Chen, A., and Davis, B. H. (1998) E-box-binding repressor is down-regulated in hepatic stellate cells during upregulation of mannose 6-phosphate/insulin-like growth factor-II receptor expression in early hepatic fibrogenesis. J. Biol. Chem. 273, 15913-9.
20. Jenkins, S. A., Grandison, A., Baxter, J. N., Day, D. W., Taylor, I., and Shields, R. (1985) A dimethylnitrosamine-induced model of cirrhosis and portal hypertension in the rat. J. Hepatol. 1, 489-99.
21. Jamall, I. S., Finelli, V. N., and Que Hee, S. S. (1981) A simple method to determine nanogram levels of 4-hydroxyproline in biological tissues. Anal. Biochem. 112, 70-5.
22. Stull, R. A., and Szoka, F. C., Jr. (1995) Antigene, ribozyme and aptamer nucleic acid drugs: progress and prospects. Pharm. Res. 12, 465-83.
23. Laptev, A. V., Lu, Z., Colige, A., and Prockop, D. J. (1994) Specific inhibition of expression of a human collagen gene (COL1A1) with modified antisense oligonucleotides. The most effective target sites are clustered in double-stranded regions of the predicted secondary structure for the mRNA. Biochemistry 33, 11033-9.
24. Stefanovic, B., Schnabl, B., and Brenner, D. A. (2002) Inhibition of collagen alpha 1(1) expression by the 5′ stem-loop as a molecular decoy. J. Biol. Chem. 277, 18229-37.
25. Lindquist, J. N., Parsons, C. J., Stefanovic, B., and Brenner, D. A. (2004) Regulation of alpha 1(I) collagen messenger RNA decay by interactions with alphaCP at the 3′-untranslated region. J. Biol. Chem. 279, 23822-9.
26. Song, E., Lee, S. K., Wang, J., Ince, N., Ouyang, N., Min, J., Chen, J., Shankar, P., and Lieberman, J. (2003) RNA interference targeting Fas protects mice from fulminant hepatitis. Nat. Med. 9, 347-51.
27. Zender, L., Hutker, S., Liedtke, C., Tillmann, H. L., Zender, S., Mundt, B., Waltemathe, M., Gosling, T., Flemming, P., Malek, N. P., Trautwein, C., Manns, M. P., Kuhnel, F., and Kubicka, S. (2003) Caspase 8 small interfering RNA prevents acute liver failure in mice. Proc. Natl. Acad. Sci. U.S.A. 100, 7797-802.
28. Rajur, S. B., Roth, C. M., Morgan, J. R., and Yarmush, M. L. (1997) Covalent protein-oligonucleotide conjugates for efficient delivery of antisense molecules. Bioconjugate Chem. 8, 935-40.
29. Nakanishi, M., Weber, K. T., and Guntaka, R. V. (1998) Triple helix formation with the promoter of human alpha 1(I) procollagen gene by an antiparallel triplex-forming oligodeoxyribonucleotide. Nucleic Acids Res. 26, 5218-22.
30. Beljaars, L., Molema, G., Weert, B., Bonnema, H., Olinga, P., Groothuis, G. M., Meijer, D. K., and Poeistra, K. (1999) Albumin modified with mannose 6-phosphate: A potential carrier for selective delivery of antifibrotic drugs to rat and human hepatic stellate cells. Hepatology 29, 1486-93.
31. Vogel, S., Piantedosi, R., Frank, J., Lalazar, A., Rockey, D. C., Friedman, S. L., and Blaner, W. S. (2000) An immortalized rat liver stellate cell line (HSC-T6): a new cell model for the study of retinoid metabolism in vitro. J. Lipid Res. 41, 882-93.
32. Bonfils, E., Depierreux, C., Midoux, P., Thuong, N. T., Monsigny, M., and Roche, A. C. (1992) Drug targeting: synthesis and endocytosis of oligonucleotide-neoglycoprotein conjugates. Nucleic Acids Res. 20, 4621-9.
33. Cho, J. G., Kim, M. K., Oh, E. J., Yoon, E. J., Sohn, J., Park, M. K., and Park, G. H. (2002) Pharmacokinetics of (111)In-labeled triplex-forming oligonucleotide targeting human N-myc gene. Mol. Cells 14, 93-100.
34. Sato, M., Suzuki, S., and Senoo, H. (2003) Hepatic stellate cells: unique characteristics in cell biology and phenotype. Cell Struct. Funct. 28, 105-12.
35. Staud, F., Nishikawa, M., Takakura, Y., and Hashida, M. (1999) Liver uptake and hepato-biliary transfer of galactosylated proteins in rats are determined by the extent of galactosylation. Biochim. Biophys. Acta 1427, 183-92.
36. Rachmawati, H. (2005) Chemically modified IL-10 with a liver-specific ligand: a new strategy for the treatment of liver fibrosis with a therapeutic cytokine. Ph.D. Thesis, 106-28.
37. Ye, Z., Cheng, K., Guntaka, R. V., and Mahato, R. I. (2005) Targeted Delivery of a Triplex-Forming Oligonucleotide to Hepatic Stellate Cells. Biochemistry 44, 4466-76.