Ribavirin conjugated with lactosaminated poly-L-lysine. Selective delivery to the liver and increased antiviral activity in mice with viral hepatitis

Biochemical Pharmacology

Volumn 54, Issue 3, 1997, Pages 357-363

  Di Stefano, Giuseppina ^a   Colonna, Francesco P ^b   Bongini, Alessandro ^a   Busi, Corrado ^a   Mattioli, Alessandro ^a   Fiume, Luigi ^a,c  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b CNR   (Italy)

^c Dipartimento di Patologia Sperimentale   (Italy)

Author keywords

Antiviral chemotheapy; Asiaglycoprotein receptor; Drug targeting; Hepatitis C; Lactosaminated poly L lysine; Ribavirin

Indexed keywords

ALANINE AMINOTRANSFERASE; LACTOSE; POLYLYSINE; RIBAVIRIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CONJUGATION; DRUG DETERMINATION; DRUG DISTRIBUTION; DRUG LIVER LEVEL; DRUG STABILITY; DRUG TARGETING; DRUG TISSUE LEVEL; FEMALE; HEPATITIS; HUMAN; HUMAN TISSUE; INTESTINE; INTRAMUSCULAR DRUG ADMINISTRATION; KIDNEY; MOUSE; MURINE HEPATITIS CORONAVIRUS; NONHUMAN; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; SPLEEN; VIRUS REPLICATION;

AMINO SUGARS; ANIMALS; ANTIVIRAL AGENTS; CELLS, CULTURED; DRUG STABILITY; ERYTHROCYTES; FEMALE; HEPATITIS; HEPATITIS C; HUMANS; INJECTIONS, INTRAMUSCULAR; LIVER; MICE; MICE, INBRED BALB C; POLYLYSINE; RIBAVIRIN; TRITIUM;

EID: 0030868838     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(97)00223-2     Document Type: Article

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