The pharmacokinetic and biological activity profile of Dexamethasone targeted to sinusoidal endothelial and Kupffer cells

Journal of Drug Targeting

Volumn 11, Issue 1, 2003, Pages 1-10

  Melgert, Barbro N ^a   Weert, Betty ^a   Schellekens, Huub ^b   Meijer, Dirk K F ^a   Poelstra, Klaas ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Cirrhosis; Dexamethasone; Drug targeting; Human serum albumin; Liver fibrosis; Neoglycoproteins

Indexed keywords

ANTIINFLAMMATORY AGENT; COLLAGEN TYPE 1; COLLAGEN TYPE 3; CYTOKINE; DEXAMETHASONE; HUMAN SERUM ALBUMIN; LIPOPOLYSACCHARIDE; REACTIVE OXYGEN METABOLITE; SCAVENGER RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BILE DUCT LIGATION; BLOOD FLOW; CELL ISOLATION; CELL SPECIFICITY; CHRONIC LIVER DISEASE; COLLAGEN SYNTHESIS; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG ACTIVITY; DRUG CLEARANCE; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG OVERDOSE; DRUG POTENCY; DRUG TARGETING; ENDOTHELIUM CELL; KUPFFER CELL; LETHAL DOSE; LIVER FIBROSIS; LIVER SINUSOID; LOW DRUG DOSE; MALE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RAT; SPLEEN WEIGHT; WEIGHT REDUCTION;

ANIMALS; CHOLESTASIS; DEXAMETHASONE; DRUG DELIVERY SYSTEMS; ENDOTHELIUM; HUMANS; KUPFFER CELLS; LIVER CIRRHOSIS; MALE; RATS; RATS, WISTAR; SERUM ALBUMIN;

EID: 0038746701     PISSN: 1061186X     EISSN: None     Source Type: Journal    
DOI: 10.1080/1061186031000072969     Document Type: Article

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