Hepatic stellate cell-targeted delivery of M6P-HSA-glycyrrhetinic acid attenuates hepatic fibrogenesis in a bile duct ligation rat model

Liver International

Volumn 27, Issue 4, 2007, Pages 548-557

  Luk, John M ^a   Zhang, Qi Sheng ^a,b   Lee, Nikki P ^a   Wo, Jana Y ^a   Leung, Pauline P ^a   Liu, Ling Xiao ^a,c   Hu, Mei Yu ^c   Cheung, Kwok Fan ^d   Hui, Chee Kin ^d   Lau, George K ^d   Fan, Sheung Tat ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b SHANGHAI FIRST PEOPLE S HOSPITAL   (China)

^c FUDAN UNIVERSITY   (China)

^d QUEEN MARY HOSPITAL   (Hong Kong)

Author keywords

Glycyrrhetinic acid; Hepatic stellate cells; Liver fibrosis; M6P26 HSA; Type I collagen

Indexed keywords

18ALPHA GLYCYRRHETINIC ACID; COLLAGEN; DRUG CARRIER; HUMAN SERUM ALBUMIN; MANNOSE 6 PHOSPHATE; PROCOLLAGEN; SMOOTH MUSCLE ACTIN; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE DUCT LIGATION; CELL SURFACE; CONTROLLED STUDY; CYTOPLASM; DRUG DELIVERY SYSTEM; DRUG UPTAKE; FIBROGENESIS; GENE EXPRESSION PROFILING; IMMUNOCYTOCHEMISTRY; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; IN VITRO STUDY; LIVER CELL; LIVER FIBROSIS; LIVER INJURY; MALE; NONHUMAN; POLYMERASE CHAIN REACTION; QUANTITATIVE ANALYSIS; RAT; STELLATE CELL; TARGET CELL;

ANIMALS; ANTI-INFLAMMATORY AGENTS; DISEASE MODELS, ANIMAL; DRUG DELIVERY SYSTEMS; DRUG MONITORING; GENE EXPRESSION PROFILING; GLYCYRRHETINIC ACID; LIVER; LIVER CIRRHOSIS; PERICYTES; RATS;

EID: 34047200700     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/j.1478-3231.2007.01452.x     Document Type: Article

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