Pharmacokinetics of a hepatic stellate cell-targeted doxorubicin construct in bile duct-ligated rats

Biochemical Pharmacology

Volumn 73, Issue 9, 2007, Pages 1455-1462

  Greupink, Rick ^a   Reker Smit, Catharina ^a   Proost, Johannes H ^a   Weemaes, Anne miek van Loenen ^a   de Hooge, Marjolijn ^b   Poelstra, Klaas ^a   Beljaars, Leonie ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

Cytostatic drugs; Drug targeting; Hepatic stellate cell; Liver fibrosis; Mannose 6 phosphate insulin like growth factor II receptor; Selective delivery

Indexed keywords

DOXORUBICIN; HUMAN SERUM ALBUMIN; MANNOSE 6 PHOSPHATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DRUG CLEARANCE; DRUG CONJUGATION; DRUG DISPOSITION; DRUG DISTRIBUTION; DRUG LIVER LEVEL; DRUG RELEASE; DRUG SYNTHESIS; DRUG TARGETING; DRUG UPTAKE; GROWTH INHIBITION; IMMUNOHISTOCHEMISTRY; ISOTOPE LABELING; LIVER FIBROSIS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STELLATE CELL;

ANIMALS; ANTINEOPLASTIC AGENTS; BILE DUCTS; DISEASE MODELS, ANIMAL; DOXORUBICIN; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; HEPATOCYTES; LIGATION; LIVER; MALE; RATS; RATS, WISTAR; TISSUE DISTRIBUTION;

EID: 33947398872     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2006.12.017     Document Type: Article

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