Caspase Induction by IgA Antimitochondrial Antibody: IgA-Mediated Biliary Injury in Primary Biliary Cirrhosis

Hepatology

Volumn 39, Issue 5, 2004, Pages 1415-1422

  Matsumura, Shuji ^a,b   Van De Water, Judy ^a   Leung, Patrick ^a   Odin, Joseph A ^b   Yamamoto, Kazuhide ^c   Gores, Gregory J ^d   Mostov, Keith ^e   Ansari, Aftab A ^f   Coppel, Ross L ^g   Shiratori, Yasushi ^c   Gershwin, M Eric ^a,h  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c OKAYAMA UNIVERSITY   (Japan)

^d MAYO CLINIC   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g MONASH UNIVERSITY   (Australia)

^h UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 OXOACID DEHYDROGENASE; BENZYLOXYCARBONYLASPARTYLGLUTAMYLVALYLASPARTYL FLUOROMETHYL KETONE; CARBOXYFLUORESCEIN; CASPASE; DIMER; IMMUNOGLOBULIN A; IMMUNOGLOBULIN RECEPTOR; MITOCHONDRION ANTIBODY; MONOMER;

ANIMAL CELL; ANTIBODY TITER; ANTIGEN SPECIFICITY; APOPTOSIS; ARTICLE; BILE DUCT INJURY; BILE SECRETION; BILIARY CIRRHOSIS; CELL STRAIN; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INDUCTION; FLOW CYTOMETRY; GENETIC TRANSFECTION; HUMAN; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; SEROLOGY; STREPTOCOCCUS GROUP A; TRANSCYTOSIS;

ANIMALS; ANTIBODY SPECIFICITY; CASPASES; CELL LINE; ENZYME ACTIVATION; HUMANS; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; LIVER CIRRHOSIS, BILIARY; MITOCHONDRIA, LIVER;

EID: 2342541212     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.20175     Document Type: Article

References (43)

1. Kaplan MM. Primary biliary cirrhosis. N Engl J Med 1996;335:1570-1580.
2. Gershwin ME, Ansari AA, Mackay IR, Nakanuma Y, Nishio A, Rowley MJ, et al. Primary biliary cirrhosis: an orchestrated immune response against epithelial cells. Immunol Rev 2000;174:210-225.
3. Metcalf JV, Mitchison HC, Palmer JM, Jones DE, Bassendine MF, James OF. Natural history of early primary biliary cirrhosis. Lancet 1996;348:1399-1402.
4. Nishio A, Keeffe EB, Gershwin ME. Immunopathogenesis of primary biliary cirrhosis. Semin Liver Dis 2002;22:1291-302.
5. Epstein O, Thomas HC, Sherlock S. Primary biliary cirrhosis is a dry gland syndrome with features of chronic graft-versus-host disease. Lancet 1980;1:1166-1168.
6. Nishio A, Van de Water J, Leung PS, Joplin R, Neuberger JM, Lake J, et al. Comparative studies of antimitochondrial autoantibodies in sera and bile in primary biliary cirrhosis. HEPATOLOGY 1997;25:1085-1089.
7. Reynoso-Paz S, Leung PS, Van De Water J, Tanaka A, Munoz S, Bass N, et al. Evidence for a locally driven mucosal response and the presence of mitochondrial antigens in saliva in primary biliary cirrhosis. HEPATOLOGY 2000;31:24-29.
8. Tanaka A, Nalbandian G, Leung PS, Benson GD, Munoz S, Findor JA, et al. Mucosal immunity and primary biliary cirrhosis: presence of antimitochondrial antibodies in urine. HEPATOLOGY 2000;32:910-915.
9. Malmborg AC, Shultz DB, Luton F, Mostov KE, Richly E, Leung PS, et al. Penetration and colocalization in MDCK cell mitochondria of IgA derived from patients with primary biliary cirrhosis. J Autoimmun 1998;11:573-580.
10. Fukushima N, Nalbandian G, Van De Water J, White K, Ansari AA, Leung P, et al. Characterization of recombinant monodonal IgA anti-PDC-E2 autoantibodies derived from patients with PBC. HEPATOLOGY 2002;36:1383-1392.
11. Sandin C, Linse S, Areschoug T, Woof JM, Reinholdt J, Lindahl G. Isolation and detection of human IgA using a streptococcal IgA-binding peptide. J Immunol 2002;169:1357-1364.
12. Navarre WW, Schneewind O. Surface proteins of gram-positive bacteria and mechanisms of their targeting to the cell wall envelope. Microbiol Mol Biol Rev 1999;63:174-229.
13. Johnsson E, Andersson G, Lindahl G, Heden LO. Identification of the IgA-binding region in streptococcal protein Arp. J Immunol 1994;153:3557-3564.
14. Bessen DE. Localization of immunoglobutin A-binding sites within M or M-like proteins of group A streptococci. Infect Immun 1994;62:1968-1974.
15. Moteki S, Leung PS, Coppel RL, Dickson ER, Kaplan MM, Munoz S, Gershwin ME. Use of a designer triple expression hybrid clone for three different lipoyl domain for the detection of antimitochondrial autoantibodies. HEPATOLOGY 1996;24:97-103.
16. Fregeau DR, Davis PA, Danner DJ, Ansari A, Coppel RL, Dickson ER, et al. Antimitochondrial antibodies of primary biliary cirrhosis recognize dihydrolipoamide acyltransferase and inhibit enzyme function of the branched chain alpha-ketoacid dehydrogenase complex. J Immunol 1989;142:3815-3820.
17. Bomsel M, Heyman M, Hocini H, Lagaye S, Belec L, Dupont C, et al. Intracellular neutralization of HIV transcytosis across tight epithelial barriers by anti-HIV envelope protein dIgA or IgM. Immunity 1998;9:277-287.
18. Burns JW, Siadat-Pajouh M, Krishnaney AA, Greenberg HB. Protective effect of rotavirus VP6-specific ISA monoclonal antibodies that lack neutralizing activity. Science 1996;272:104-107.
19. Mazanec MB, Kaetzel CS, Lamm ME, Fletcher D, Nedrud JG. Intracellular neutralization of virus by immunoglobulin A antibodies. Proc Natl Acad Sci U S A 1992;89:6901-6905.
20. Kinoshita H, Omagari K, Whittingham S, Kato Y, Ishibashi H, Sugi K, et al. Autoimmune cholangitis and primary biliary cirrhosis - an autoimmune enigma. Liver 1999;19:122-128.
21. James SP, Jones EA, Schafer DF, Hoofnagle JH, Varma RR, Strober W. Selective immunoglobulin A deficiency associated with primary biliary cirrhosis in a family with liver disease. Gastroenterology 1986;90:283-288.
22. Shimoda S, Van de Water J, Ansari A, Nakamura M, Ishibashi H, Coppel RL, et al. Identification and precursor frequency analysis of a common T cell epitope motif in mitochondrial autoantigens in primary biliary cirrhosis. J Clin Invest 1998;102:1831-1840.
23. Kita H, Lian ZX, Van de Water J, He XS, Matsumura S, Kaplan M, et al. Identification of HLA-A2-restriaed CD8(+) cytotoxic T cell responses in primary biliary cirrhosis: T cell activation is augmented by immune complexes cross-presented by dendritic cells. J Exp Med 2002;195:113-123.
24. Kita H, Matsumura S, He XS, Ansari AA, Lian ZX, Van de Water J, et al. Quantitative and functional analysis of PDC-E2-specific autoreactive cytotoxic T lymphocytes in primary biliary cirrhosis. J Clin Invest 2002;109:1231-1240.
25. Van de Water J, Shimoda S, Niho Y, Coppel R, Ansari A, Gershwin ME. The role of T cells in primary biliary cirrhosis. Semin Liver Dis 1997;17:105-113.
26. Odin JA, Huebert RC, Casciola-Rosen L, LaRusso NF, Rosen A. Bd-2-dependent oxidation of pyruvate dehydrogenase-E2, a primary biliary cirrhosis autoantigen, during apoptosis. J Clin Invest 2001;108:223-232.
27. Bai J, Odin JA. Apoptosis and the liver: relation to autoimmunity and related conditions. Autoimmun Rev 2003;2:36-42.
28. Saulsbury FT. Henoch-Schonlein purpura in children. Report of 100 patients and review of the literature. Medicine (Baltimore) 1999;78:395-409.
29. Endo Y. IgA nephropathy - human disease and animal model. Ren Fail 1997;19:347-371.
30. Abu-Ghazaleh RI, Fujisawa T, Mestecky J, Kyle RA, Gleich GJ. IgA induced eosinophil degranulation. J Immunol 1989;142:2393-2400.
31. Sancho J, Gonzalez E, Egido J. The importance of the Fc receptors for IgA in the recognition of IgA by mouse liver cells: its comparison with carbohydrate and secretory component receptors. Immunology 1986;57:37-42.
32. Singer KL, Mostov KE. Dimerization of the polymeric immunoglobulin receptor controls its transcytotic trafficking. Mol Biol Cell 1998;9:901-915.
33. Luton F, Mostov KE. Transduction of basolateral-to-apical signals across epithelial cells: ligand-stimulated transcytosis of the polymeric immunoglobulin receptor requires two signals. Mol Biol Cell 1999;10:1409-1427.
34. Monteiro RC, Kubagawa H, Cooper MD. Cellular distribution, regulation, and biochemical nature of an Fc alpha receptor in humans. J Exp Med 1990;171:597-613.
35. Tomana M, Zikan J, Moldoveanu Z, Kulhavy R, Bennett JC, Mestecky J. Interactions of cell-surface galactosyltransferase with immunoglobulins. Mol Immunol 1993;30:265-275.
36. Diven SC, Caflisch CR, Hammond DK, Weigel PH, Oka JA, Goldblum RM. IgA induced activation of human mesangial cells: independent of FcalphaRl (CD 89). Kidney Int 1998;54:837-847.
37. Kitamura T, Garofalo RP, Kamijo A, Hammond DK, Oka JA, Caflisch CR, et al. Human intestinal epithelial cells express a novel receptor for IgA. J Immunol 2000;164:5029-5034.
38. Weisbart RH, Baldwin R, Huh B, Zack DJ, Nishimura R. Novel protein transfection of primary rat cortical neurons using an antibody that penetrates living cells. J Immunol 2000;164:6020-6026.
39. Koscec M, Koren E, Wolfson-Reichlin M, Fugate RD, Trieu E, Targoff IN,et al. Autoantibodies to ribosomal P proteins penetrate into live hepatocytes and cause cellular dysfunction in culture. J Immunol 1997;159:2033-2041
40. Yanase K, Smith RM, Puccetti A, Jarert L, Madaio MP. Receptor-mediated cellular entry of nuclear localizing anti-DNA antibodies via myosin 1. J Clin Invest 1997;100:25-31.
41. Reichlin M. Cellular dysfunction induced by penetration of autoantibodies into living cells: cellular damage and dysfunction mediated by antibodies to dsDNA and ribosomal P proteins. J Autoimmun 1998;11:57-561.
42. Reynoso-Paz S, Coppel RL, Mackay IR, Bass NM, Ansari AA, Gershwin ME. The immunobiology of bile and biliary epithelium. HEPATOLOGY 1999;30:351-357.
43. Reynoso-Paz S, Coppel RL, AnsariAA, Gershwin ME. Vanishing bile duct syndromes: considerations of the immunobiology of autoimmune biliary diseases. Isr Med Assoc J 1999;1:37-44.