The preferential homing of a platelet derived growth factor receptor-recognizing macromolecule to fibroblast-like cells in fibrotic tissue

Biochemical Pharmacology

Volumn 66, Issue 7, 2003, Pages 1307-1317

  Beljaars, Leonie ^a   Weert, Betty ^a   Geerts, Albert ^b   Meijer, Dirk K F ^a   Poelstra, Klaas ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

Author keywords

Drug targeting; Fibroblast; Glomerulosclerosis; Hepatic stellate cells (HSC); Liver fibrosis; PDGF

Indexed keywords

ALBUMIN; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE DUCT LIGATION; BINDING AFFINITY; CELL ACTIVITY; CELL PROLIFERATION; CELL STRAIN; CONTROLLED STUDY; DENSITY; EMBRYO; FIBROBLAST; GLOMERULUS; IN VITRO STUDY; IN VIVO STUDY; KIDNEY FIBROSIS; LIVER CELL; LIVER FIBROSIS; MACROMOLECULE; MALE; MESANGIUM CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN TARGETING; RAT; STELLATE CELL;

EID: 0141740706     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(03)00445-3     Document Type: Article

References (41)

1. Powell D.W., Mifflin R.C., Valentich J.D., Crowe S.E., Saada J.I., West A.B. Myofibroblasts. I. Paracrine cells important in health and disease. Am. J. Physiol. 277:1999;C1-C19.
2. Heldin C.-H. Simultaneous induction of stimulatory and inhibitory signals by PDGF. FEBS Lett. 410:1997;17-21.
3. Claesson-Welsh L. Signal transduction by the PDGF receptors. Progr. Growth Factor Res. 5:1994;37-54.
4. Pinzani M., Marra F. Cytokine receptors and signaling in hepatic stellate cells. Semin. Liver Dis. 21:2001;397-416.
5. Li X., Ponten A., Aase K., Karlsson L., Abramsson A., Uutela M., Backstrom G., Hellstrom M., Bostrom H., Li H., Soriano P., Betsholtz C., Heldin C.H., Alitalo K., Ostman A., Eriksson U. PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor. Nat. Cell Biol. 2:2000;302-309.
6. Gilbertson D.G., Duff M.E., West J.W., Kelly J.D., Sheppard P.O., Hofstrand P.D., Gao Z., Shoemaker K., Bukowski T.R., Moore M., Feldhaus A.L., Humes J.M., Palmer T.E., Hart C.E. Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds to PDGF alpha and beta receptor. J. Biol. Chem. 276:2001;27406-27414.
7. Bergsten E., Uutela M., Li X., Pietras K., Ostman A., Heldin C.H., Alitalo K., Eriksson U. PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor. Nat. Cell Biol. 3:2001;512-516.
8. Larochelle W.J., Jeffers M., McDonald W.F., Chillakuru R.A., Giese N.A., Lokker N.A., Sullivan C., Boldog F.L., Yang M., Vernet C., Burgess C.E., Fernandes E., Deegler L.L., Rittman B., Shimkets J., Shimkets R.A., Rothberg J.M., Lichenstein H.S. PDGF-D, a new protease-activated growth factor. Nat. Cell Biol. 3:2001;517-521.
9. Friedman S.L. The virtuosity of hepatic stellate cells. Gastroenterology. 117:1999;1244-1246.
10. Win K.M., Charlotte F., Mallat A., Cherqui D., Martin N., Mavier P., Preaux A.M., Dhumeaux D., Rosenbaum J. Mitogenic effect of transforming growth factor-β1 on human Ito cells in culture - evidence for mediation by endogenous platelet-derived growth factor. Hepatology. 18:1993;137-145.
11. Wong L., Yamasaki G., Johnson R.J., Friedman S.L. Induction of β-platelet-derived growth factor receptor in rat hepatic lipocytes during cellular activation in vivo and in culture. J. Clin. Invest. 94:1994;1563-1569.
12. Pinzani M., Milani S., Herbst H., DeFranco R., Grappone C., Gentilini A., Caligiuri A., Pellegrini G., Ngo D.V., Romanelli R.G., Gentilini P. Expression of platelet-derived growth factor and its receptors in normal human liver and during active hepatic fibrogenesis. Am. J. Pathol. 148:1996;785-800.
13. Johnson R.J., Floege J., Yoshimura A., Iida H., Couser W.G., Alpers C.E. The activated mesangial cell: a glomerular "myofibroblast"? J. Am. Soc. Nephrol. 2:1992;S190-S197.
14. Iida H., Seifert R., Alpers C.E., Gronwald R.G.K., Phillips P.E., Pritzl P., Gordon K., Gown A.M., Ross R., Bowen-Pope D.F., Johnson R.J. Platelet-derived growth factor (PDGF) and PDGF receptor are induced in mesangial proliferative nephritis in the rat. Proc. Natl. Acad. Sci. U.S.A. 88:1991;6560-6564.
15. Matsuda M., Shikata K., Makino H., Sugimoto H., Ota K., Akiyama K., Hirata K., Ota Z. Gene expression of PDGF and PDGF receptor in various forms of glomerulonephritis. Am. J. Nephrol. 17:1997;25-31.
16. Kliem V., Johnson R.J., Alpers C.E., Yoshimura A., Couser W.G., Koch K.M., Floege J. Mechanisms involved in the pathogenesis of tubulointerstitial fibrosis in 5/6-nephrectomized rats. Kidney Int. 49:1996;666-678.
17. Clements J.M., Bawden L.J., Bloxidge R.E., Catlin G., Cook A.L., Craig S., Drummond A.H., Edwards R.M., Fallon A., Green D.R., Hellewell P.G., Kirwin P.M., Nayee P.D., Richardson S.J., Brown D., Chahwala S.B., Snary M., Winslow D. Two PDGF-B chain residues, arginine 27 and isoleucine 30, mediate receptor binding and activation. EMBO J. 10:1991;4113-4120.
18. Koivunen E., Wang B., Ruoslahti E. Phage libraries displaying cyclic peptides with different ring sizes: ligand specificities of the RGD-directed integrins. Biotechnology (N.Y.). 13:1995;265-270.
19. Marcelino J., McDevitt C.A. Attachment of articular cartilage chondrocytes to the tissue form of type VI collagen. Biochim. Biophys. Acta. 1249:1995;180-188.
20. Kok R.J., Schraa A.J., Bos E.J., Moorlag H.E., Asgeirsdottir S.A., Everts M.E., Meijer D.K.F., Molema G. Preparation and functional evaluation of RGD-modified proteins as alpha(v)beta(3) integrin directed therapeutics. Bioconjug. Chem. 13:2002;128-135.
21. Beljaars L., Molema G., Schuppan D., Geerts A., De Bleser P.J., Weert B., Meijer D.K.F., Poelstra K. Successful targeting of albumin to rat hepatic stellate cells using albumin modified with cyclic peptides that recognize the collagen type VI receptor. J. Biol. Chem. 275:2000;12743-12751.
22. Mather S.J., Ward B.C. High efficiency iodination of monoclonal antibodies for radiotherapy. J. Nucl. Med. 28:1987;1034-1036.
23. 125I -containing acylating agent Biochem. J. 133:1973;529-539.
24. Engström U., Engström A., Ernlund A., Westermark B., Heldin C.H. Identification of a peptide antagonist for platelet-derived growth factor. J. Biol. Chem. 267:1992;16581-16587.
25. Beljaars L., Olinga P., Molema G., De Bleser P., Geerts A., Groothuis G.M.M., Meijer D.K.F., Poelstra K. Characteristics of the hepatic stellate cell-selective carrier mannose 6-phosphate modified albumin (M6P(28)-HSA). Liver. 21:2001;320-328.
26. Heidaran M.A., Mahadevan D., Larochelle W.J. Beta PDGFR-IgG chimera demonstrates that human β PDGFR Ig-like domains 1 to 3 are sufficient for high affinity PDGF BB binding. FASEB J. 9:1995;140-145.
27. Gesualdo L., DiPaolo S., Ranieri E., Schena F.P. Trapidil inhibits human mesangial cell proliferation: effect on PDGF β-receptor binding and expression. Kidney Int. 46:1994;1002-1009.
28. Bagchus W.M., Hoedemaeker P.J., Rozing J., Bakker W.W. Glomerulonephritis induced by monoclonal anti-Thy1.1 antibodies. A sequential histological and ultrastructural study in the rat. Lab. Invest. 55:1986;680-687.
29. Poelstra K., Hardonk M.J., Koudstaal J., Bakker W.W. Intraglomerular platelet aggregation and experimental glomerulonephritis. Kidney Int. 37:1990;1500-1508.
30. Haas M., De Zeeuw D., Van Zanten A., Meijer D.K.F. Quantification of renal low-molecular-weight protein handling in the intact rat. Kidney Int. 43:1993;949-954.
31. Wright T.L., Roll F.J., Jones A.L., Weisiger R.A. Uptake and metabolism of polymerized albumin by rat liver. Gastroenterology. 94:1988;443-452.
32. Toth C.A., Thomas P. Liver endocytosis and Kupffer cells. Hepatology. 16:1992;255-266.
33. Yoshioka T., Yamamoto K., Kobashi H., Tomita M., Tsuji T. Receptor-mediated endocytosis of chemically modified albumins by sinusoidal endothelial cells and Kupffer Cells in rat and human liver. Liver. 14:1994;129-137.
34. 161) is required for receptor binding and mitogenic activity of the PDGF-AA homodimer. J. Biol. Chem. 268:1993; 10482-10489.
35. Fretto L.J., Snape A.J., Tominson J.E., Seroogy J.J., Wolf D.L., Larochelle W.J., Giese N.A. Mechanism of platelet-derived growth factor (PDGF) AA, AB, and BB binding to alpha and beta receptor. J. Biol. Chem. 268:1993;3625-3631.
36. Floege J., Ostendorf T. Platelet-derived growth factor: a new clinical target on the horizon. Kidney Int. 59:2001;1592-1593.
37. Cohen A.M., Soderberg C., Thomason A. Plasma clearance and tissue distribution of recombinant human platelet-derived growth factor (B-chain homodimer) in rats. J. Surg. Res. 49:1990;447-452.
38. Bowen-Pope D.F., Malpass T.W., Foster D.M., Ross R. Platelet-derived growth factor in vivo: levels, activity, and rate of clearance. Blood. 64:1984;458-469.
39. Lamarre J., Wollenberg G.K., Gonias S.L., Hayes M.A. Cytokine binding and clearance properties of proteinase-activated alpha 2-macroglobulins. Lab. Invest. 65:2000;3-14.
40. Soyez H., Schacht E., Van Der Kerken S. The crucial role of spacer groups in macromolecular prodrug design. Adv. Drug. Deliv. Rev. 21:1996;81-106.
41. Beljaars L., Meijer D.K.F., Poelstra K. Targeting hepatic stellate cells for cell-specific treatment of liver fibrosis. Front Biosci. 7:2002;E214-E222.