Increased liver uptake and reduced hepatic stellate cell activation with a cell-specific conjugate of the rho-kinase inhibitor Y27632

Pharmaceutical Research

Volumn 28, Issue 8, 2011, Pages 2045-2054

  Van Beuge, Marike Marjolijn ^a   Prakash, Jai ^a   Lacombe, Marie ^b   Post, Eduard ^a   Reker Smit, Catharina ^a   Beljaars, Leonie ^a   Poelstra, Klaas ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b Kreatech Diagnostics   (Netherlands)

Author keywords

drug targeting; insulin like growth factor II receptor; kinase inhibitor; liver fibrosis; Rho kinase

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; 4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE MANNOSE 6 PHOSPHATE HUMAN SERUM ALBUMIN CONJUGATE; ALBUMIN CONJUGATE; RHO KINASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG EFFECT; DRUG LIVER LEVEL; DRUG UPTAKE; FIBROBLAST; IN VITRO STUDY; IN VIVO STUDY; LIVER; LIVER HOMOGENATE; LIVER INJURY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; SINGLE DRUG DOSE; STELLATE CELL; TISSUE DISTRIBUTION;

AMIDES; ANIMALS; CARBON TETRACHLORIDE POISONING; CELLS, CULTURED; DRUG CARRIERS; ENZYME INHIBITORS; HEPATIC STELLATE CELLS; HUMANS; LIVER; LIVER CIRRHOSIS; MALE; MANNOSEPHOSPHATES; MICE; MICE, INBRED C57BL; NIH 3T3 CELLS; PYRIDINES; RATS; RATS, WISTAR; RECEPTOR, IGF TYPE 2; RHO-ASSOCIATED KINASES; SERUM ALBUMIN; TISSUE DISTRIBUTION;

EID: 79961166830     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-011-0430-9     Document Type: Article

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