Massive and selective delivery of lipid-coated cationic lipoplexes of oligonucleotides targeted in vivo to hepatic endothelial cells

Pharmaceutical Research

Volumn 19, Issue 5, 2002, Pages 676-680

  Bartsch, M ^a   Weeke Klimp, A H ^a   Meijer, D K F ^a   Scherphof, G L ^a   Kamps, J A A M ^a,b  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

Aconitylated human serum albumin; Endothelial targeting; ISIS 9125; Rat liver endothelial cells; Scavenger receptor; Stabilized cationic lipoplexes

Indexed keywords

ALBUMIN; ANTISENSE OLIGONUCLEOTIDE; COATED CATIONIC LIPOPLEX; ETHER DERIVATIVE; INTERCELLULAR ADHESION MOLECULE 1; LIPID; MACROGOL; UNCLASSIFIED DRUG; ACONITIC ACID; DRUG CARRIER; DRUG DERIVATIVE; POLYACONITYLATED HUMAN SERUM ALBUMIN; SERUM ALBUMIN;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CATION TRANSPORT; CELL ISOLATION; CELLULAR DISTRIBUTION; COMPLEX FORMATION; CONTROLLED STUDY; DRUG ELIMINATION; ENDOTHELIUM CELL; GENE DELIVERY SYSTEM; GENE TARGETING; IN VIVO STUDY; MALE; NONHUMAN; ORGAN DISTRIBUTION; PRIORITY JOURNAL; RAT; SURFACE PROPERTY; ANIMAL; CHEMISTRY; CYTOLOGY; ENDOTHELIUM; GENETICS; INTRAVENOUS DRUG ADMINISTRATION; LIVER; METABOLISM; TISSUE DISTRIBUTION;

ACONITIC ACID; ANIMAL; DRUG CARRIERS; ENDOTHELIUM; INJECTIONS, INTRAVENOUS; INTERCELLULAR ADHESION MOLECULE-1; LIPIDS; LIVER; MALE; OLIGONUCLEOTIDES, ANTISENSE; RATS; SERUM ALBUMIN; SUPPORT, NON-U.S. GOV'T; TISSUE DISTRIBUTION; ANIMALS;

EID: 0036001401     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1015318415705     Document Type: Article

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