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Volumn 161, Issue 2, 2012, Pages 668-679

In situ forming implants - An attractive formulation principle for parenteral depot formulations

Author keywords

Biodegradable; Controlled release; Implants; In situ; Parenteral; Polymer

Indexed keywords

BIODEGRADABLE; BURST RELEASE; CLINICAL TRIAL; CONTROLLED RELEASE; CONTROLLED RELEASE FORMULATIONS; DRUG RELEASE; IN-SITU; IN-SITU FORMING; IN-VIVO; MICRO-PARTICLES; ORGANOGELS; PARENTERAL; TISSUE RESPONSE; USED PRODUCT; VISCOUS SOLUTION;

EID: 84862652505     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.04.016     Document Type: Review
Times cited : (265)

References (154)
  • 1
    • 0025937865 scopus 로고
    • Parenterale Depotarzneiformen auf der Basis von biologisch abbaubaren Polymeren
    • R. Mank, G. Rafler, B. Nerlich, Parenterale Depotarzneiformen auf der Basis von biologisch abbaubaren Polymeren, Phamazie 46 (1991) 9-17.
    • (1991) Phamazie , vol.46 , pp. 9-17
    • Mank, R.1    Rafler, G.2    Nerlich, B.3
  • 2
    • 7444224004 scopus 로고    scopus 로고
    • Oil-in-water lipid emulsions: Implications for parenteral and ocular delivering systems
    • S. Tamilvanan, Oil-in-water lipid emulsions: implications for parenteral and ocular delivering systems, Prog. Lipid Res. 43 (2004) 489-533.
    • (2004) Prog. Lipid Res. , vol.43 , pp. 489-533
    • Tamilvanan, S.1
  • 3
    • 0030795298 scopus 로고    scopus 로고
    • Liposomes in drug delivery: Progress and limitations
    • A. Sharma, U.S. Sharma, Liposomes in drug delivery: progress and limitations, Int. J. Pharm. 154 (1997) 123-140.
    • (1997) Int. J. Pharm. , vol.154 , pp. 123-140
    • Sharma, A.1    Sharma, U.S.2
  • 4
    • 1942486331 scopus 로고    scopus 로고
    • Micelles from lipid derivatives of water-soluble polymers as delivery systems for poorly soluble drugs
    • A.N. Lukyanov, V.P. Torchilin, Micelles from lipid derivatives of water-soluble polymers as delivery systems for poorly soluble drugs, Adv. Drug Deliv. Rev. 56 (2004) 1273-1289.
    • (2004) Adv. Drug Deliv. Rev. , vol.56 , pp. 1273-1289
    • Lukyanov, A.N.1    Torchilin, V.P.2
  • 5
    • 27844589689 scopus 로고    scopus 로고
    • Perspectives on: Polymeric drugs and drug delivery systems
    • S. Thatte, K. Datar, R.M. Ottenbrite, Perspectives on: polymeric drugs and drug delivery systems, J. Bioact. Compat. Polym. 20 (2005) 585-601.
    • (2005) J. Bioact. Compat. Polym. , vol.20 , pp. 585-601
    • Thatte, S.1    Datar, K.2    Ottenbrite, R.M.3
  • 6
    • 4444246813 scopus 로고    scopus 로고
    • Polymer microspheres for controlled drug release
    • S. Freiberg, X.X. Zhu, Polymer microspheres for controlled drug release, Int. J. Pharm. 282 (2004) 1-18.
    • (2004) Int. J. Pharm. , vol.282 , pp. 1-18
    • Freiberg, S.1    Zhu, X.X.2
  • 7
    • 33745605771 scopus 로고    scopus 로고
    • Nanotechnology: Intelligent design to treat complex disease
    • P. Couvreur, C. Vauthier, Nanotechnology: intelligent design to treat complex disease, Pharm. Res. 23 (2006) 1-34.
    • (2006) Pharm. Res. , vol.23 , pp. 1-34
    • Couvreur, P.1    Vauthier, C.2
  • 9
    • 77957340876 scopus 로고    scopus 로고
    • Biodegradable implants for sustained drug release in the eye
    • S.S. Lee, P. Hughes, A.D. Ross, M.R. Robinson, Biodegradable implants for sustained drug release in the eye, Pharm. Res. 27 (2010) 2043-2053.
    • (2010) Pharm. Res. , vol.27 , pp. 2043-2053
    • Lee, S.S.1    Hughes, P.2    Ross, A.D.3    Robinson, M.R.4
  • 10
    • 55649104973 scopus 로고    scopus 로고
    • Principles of encapsulating hydrophobic drugs in PLA/PLGA microparticles
    • C. Wischke, S.P. Schwendeman, Principles of encapsulating hydrophobic drugs in PLA/PLGA microparticles, Int. J. Pharm. 364 (2008) 298-327.
    • (2008) Int. J. Pharm. , vol.364 , pp. 298-327
    • Wischke, C.1    Schwendeman, S.P.2
  • 11
    • 3843071010 scopus 로고    scopus 로고
    • In situ-forming hydrogels - Review of temperature-sensitive systems
    • E. Ruel-Gariepy, J.C. Leroux, In situ-forming hydrogels - review of temperature-sensitive systems, Eur. J. Pharm. Biopharm. 58 (2004) 409-426.
    • (2004) Eur. J. Pharm. Biopharm. , vol.58 , pp. 409-426
    • Ruel-Gariepy, E.1    Leroux, J.C.2
  • 12
    • 0037161339 scopus 로고    scopus 로고
    • Biodegradable injectable in situ forming drug delivery systems
    • A. Hatefi, B. Amsden, Biodegradable injectable in situ forming drug delivery systems, J. Control. Release 80 (2002) 9-28.
    • (2002) J. Control. Release , vol.80 , pp. 9-28
    • Hatefi, A.1    Amsden, B.2
  • 14
    • 0035423762 scopus 로고    scopus 로고
    • Injectable gels for tissue engineering
    • A. Gutowska, B. Jeong, M. Jasionowski, Injectable gels for tissue engineering, Anat. Rec. 263 (2001) 342-349.
    • (2001) Anat. Rec. , vol.263 , pp. 342-349
    • Gutowska, A.1    Jeong, B.2    Jasionowski, M.3
  • 15
    • 68749094066 scopus 로고    scopus 로고
    • Reverse thermogelling biodegradable polymer aqueous solutions
    • M.K. Joo, M.H. Park, B.G. Choi, B. Jeong, Reverse thermogelling biodegradable polymer aqueous solutions, J. Mater. Chem. 19 (2009) 5891-5905.
    • (2009) J. Mater. Chem. , vol.19 , pp. 5891-5905
    • Joo, M.K.1    Park, M.H.2    Choi, B.G.3    Jeong, B.4
  • 16
    • 0034580370 scopus 로고    scopus 로고
    • A review of photocrosslinked polyanhydrides: In situ forming degradable networks
    • A.K. Burkoth, K.S. Anseth, A review of photocrosslinked polyanhydrides: in situ forming degradable networks, Biomaterials 21 (2000) 2395-2404.
    • (2000) Biomaterials , vol.21 , pp. 2395-2404
    • Burkoth, A.K.1    Anseth, K.S.2
  • 17
    • 34248632529 scopus 로고    scopus 로고
    • Formulation and in vitro characterization of an in situ gelable, photo-polymerizable Pluronic hydrogel suitable for injection
    • S.Y. Lee, G. Tae, Formulation and in vitro characterization of an in situ gelable, photo-polymerizable Pluronic hydrogel suitable for injection, J. Control. Release 119 (2007) 313-319.
    • (2007) J. Control. Release , vol.119 , pp. 313-319
    • Lee, S.Y.1    Tae, G.2
  • 18
    • 0346094228 scopus 로고    scopus 로고
    • Structure and interactions in covalently and ionically crosslinked chitosan hydrogels for biomedical applications
    • J. Berger, M. Reist, J.M. Mayer, O. Felt, N.A. Peppas, R. Gurny, Structure and interactions in covalently and ionically crosslinked chitosan hydrogels for biomedical applications, Eur. J. Pharm. Biopharm. 57 (2004) 19-34.
    • (2004) Eur. J. Pharm. Biopharm. , vol.57 , pp. 19-34
    • Berger, J.1    Reist, M.2    Mayer, J.M.3    Felt, O.4    Peppas, N.A.5    Gurny, R.6
  • 19
    • 0032661368 scopus 로고    scopus 로고
    • Chitosan-polyelectrolyte complexation for the preparation of gel beads and controlled release of anticaner drug. II. Effect of pH-dependent ionic crosslinking or interpolymer complex using triphosphate or polyphosphate as reagent
    • F.L. Mi, S.S. Shyu, T.B. Wong, S.F. Jang, S.T. Lee, K.T. Lu, Chitosan-polyelectrolyte complexation for the preparation of gel beads and controlled release of anticaner drug. II. Effect of pH-dependent ionic crosslinking or interpolymer complex using triphosphate or polyphosphate as reagent, J. Appl. Polym. Sci. 74 (1999) 1093-1107.
    • (1999) J. Appl. Polym. Sci. , vol.74 , pp. 1093-1107
    • Mi, F.L.1    Shyu, S.S.2    Wong, T.B.3    Jang, S.F.4    Lee, S.T.5    Lu, K.T.6
  • 20
    • 0000806961 scopus 로고
    • Polymeric dental composites: Properties and reaction behavior of multimethacrylate dental restorations
    • K.S. Anseth, S.M. Newman, C.N. Bowman, Polymeric dental composites: properties and reaction behavior of multimethacrylate dental restorations, Biopolymers 122 (1995) 177-217.
    • (1995) Biopolymers , vol.122 , pp. 177-217
    • Anseth, K.S.1    Newman, S.M.2    Bowman, C.N.3
  • 21
    • 0035282397 scopus 로고    scopus 로고
    • Synthesis and characterization of tetrafunctional lactic acid oligomers: A potential in situ forming degradable orthopaedic biomaterial
    • J.A. Burdick, L.M. Philpott, K.S. Anseth, Synthesis and characterization of tetrafunctional lactic acid oligomers: a potential in situ forming degradable orthopaedic biomaterial, J. Polym. Sci. A Polym. Chem. 39 (2001) 683-692.
    • (2001) J. Polym. Sci. A Polym. Chem. , vol.39 , pp. 683-692
    • Burdick, J.A.1    Philpott, L.M.2    Anseth, K.S.3
  • 22
    • 0036379190 scopus 로고    scopus 로고
    • An investigation of the cytotoxicity and histocompartibility of in situ forming lactic acid based orthopedic biomaterials
    • J.A. Burdick, R.F. Padera, J.V. Huang, K.S. Anseth, An investigation of the cytotoxicity and histocompartibility of in situ forming lactic acid based orthopedic biomaterials, J. Biomed. Mater. Res. 63 (2002) 484-491.
    • (2002) J. Biomed. Mater. Res. , vol.63 , pp. 484-491
    • Burdick, J.A.1    Padera, R.F.2    Huang, J.V.3    Anseth, K.S.4
  • 24
    • 0030088049 scopus 로고    scopus 로고
    • Characterization of the formation of interfacially photopolymerized thin hydrogels in contact with arterial tissue
    • M.D. Lyman, D. Melanson, A.S. Sawhney, Characterization of the formation of interfacially photopolymerized thin hydrogels in contact with arterial tissue, Biomaterials 17 (1996) 359-364.
    • (1996) Biomaterials , vol.17 , pp. 359-364
    • Lyman, M.D.1    Melanson, D.2    Sawhney, A.S.3
  • 25
    • 11144344915 scopus 로고    scopus 로고
    • Self-cross-linking biopolymers as injectable in situ forming biodegradable scaffolds
    • B. Balakrishnan, A. Jayakrishnan, Self-cross-linking biopolymers as injectable in situ forming biodegradable scaffolds, Biomaterials 26 (2005) 3941-3951.
    • (2005) Biomaterials , vol.26 , pp. 3941-3951
    • Balakrishnan, B.1    Jayakrishnan, A.2
  • 27
    • 2942748422 scopus 로고    scopus 로고
    • Characterization of protein release from photocrosslinkable hyaluronic acid-polyethylene glycol hydrogel tissue engineering scaffolds
    • J.B. Leach, C.E. Schmidt, Characterization of protein release from photocrosslinkable hyaluronic acid-polyethylene glycol hydrogel tissue engineering scaffolds, Biomaterials 26 (2005) 125-135.
    • (2005) Biomaterials , vol.26 , pp. 125-135
    • Leach, J.B.1    Schmidt, C.E.2
  • 31
    • 0035808267 scopus 로고    scopus 로고
    • Novel pH-sensitive citrate cross-linked chitosan film for drug controlled release
    • X.Z. Shu, K.J. Zhu, W. Song, Novel pH-sensitive citrate cross-linked chitosan film for drug controlled release, Int. J. Pharm. 212 (2001) 19-28.
    • (2001) Int. J. Pharm. , vol.212 , pp. 19-28
    • Shu, X.Z.1    Zhu, K.J.2    Song, W.3
  • 32
    • 33745871131 scopus 로고    scopus 로고
    • Viscoelastic properties of phosphoric and oxalic acid-based chitosan hydrogels
    • M. Hamdine, M.C. Heuzey, A. Begin, Viscoelastic properties of phosphoric and oxalic acid-based chitosan hydrogels, Rheologica Acta 45 (2006) 659-675.
    • (2006) Rheologica Acta , vol.45 , pp. 659-675
    • Hamdine, M.1    Heuzey, M.C.2    Begin, A.3
  • 33
    • 0346724871 scopus 로고    scopus 로고
    • Structure and interactions in chitosan hydrogels formed by complexation or aggregation for biomedical applications
    • J. Berger, M. Reist, O. Felt, R. Gurny, Structure and interactions in chitosan hydrogels formed by complexation or aggregation for biomedical applications, Eur. J. Pharm. Biopharm. 57 (2004) 35-52.
    • (2004) Eur. J. Pharm. Biopharm. , vol.57 , pp. 35-52
    • Berger, J.1    Reist, M.2    Felt, O.3    Gurny, R.4
  • 34
  • 35
    • 41549148288 scopus 로고    scopus 로고
    • Hydrogels in drug delivery
    • T.R. Hoare, D.S. Kohane, Hydrogels in drug delivery, Polymer 49 (2008) 1993-2007.
    • (2008) Polymer , vol.49 , pp. 1993-2007
    • Hoare, T.R.1    Kohane, D.S.2
  • 36
    • 0038460837 scopus 로고    scopus 로고
    • Thiolated polymers-thiomers: Synthesis and in vitro evaluation of chitosan-2-iminothiolane conjugates
    • A. Bernkop-Schurch, M. Hornof, T. Zoidl, Thiolated polymers-thiomers: synthesis and in vitro evaluation of chitosan-2-iminothiolane conjugates, Int. J. Pharm. 260 (2003) 229-237.
    • (2003) Int. J. Pharm. , vol.260 , pp. 229-237
    • Bernkop-Schurch, A.1    Hornof, M.2    Zoidl, T.3
  • 37
    • 0038282932 scopus 로고    scopus 로고
    • Improvement of the in situ gelling properties of deacytylated gellan gum by the immobilization of thiol groups
    • A.H. Krauland, V.M. Leitner, A. Bernkop-Schurch, Improvement of the in situ gelling properties of deacytylated gellan gum by the immobilization of thiol groups, J. Pharm. Sci. 92 (2003) 1234-1241.
    • (2003) J. Pharm. Sci. , vol.92 , pp. 1234-1241
    • Krauland, A.H.1    Leitner, V.M.2    Bernkop-Schurch, A.3
  • 38
    • 3843126497 scopus 로고    scopus 로고
    • Thiomers: Potential excipients for non-invasive peptide delivery systems
    • A. Bernkop-Schurch, A.H. Krauland, V.M. Leitner, Thiomers: potential excipients for non-invasive peptide delivery systems, Eur. J. Pharm. Biopharm. 58 (2004) 253-263.
    • (2004) Eur. J. Pharm. Biopharm. , vol.58 , pp. 253-263
    • Bernkop-Schurch, A.1    Krauland, A.H.2    Leitner, V.M.3
  • 40
    • 0037209905 scopus 로고    scopus 로고
    • A hydrogel prepared by in situ cross-linking of a thio-containing poly(ethylene glycol)-based copolymer: A newbiomaterial for protein drug delivery
    • B. Qui, S. Stefanos, J. Ma, A. Lalloo, B.A. Perry, M.J. Leibowitz, P.J. Sinko, S. Stein, A hydrogel prepared by in situ cross-linking of a thio-containing poly(ethylene glycol)-based copolymer: a newbiomaterial for protein drug delivery, Biomaterials 24 (2002) 11-18.
    • (2002) Biomaterials , vol.24 , pp. 11-18
    • Qui, B.1    Stefanos, S.2    Ma, J.3    Lalloo, A.4    Perry, B.A.5    Leibowitz, M.J.6    Sinko, P.J.7    Stein, S.8
  • 41
    • 20444501659 scopus 로고    scopus 로고
    • Evaluation of an in situ forming hydrogel wound dressing based on oxidized alginate and gelatin
    • B. Balakrishnan, M. Mohanty, P.R. Umashankar, A. Jayakrishnan, Evaluation of an in situ forming hydrogel wound dressing based on oxidized alginate and gelatin, Biomaterials 26 (2005) 6335-6342.
    • (2005) Biomaterials , vol.26 , pp. 6335-6342
    • Balakrishnan, B.1    Mohanty, M.2    Umashankar, P.R.3    Jayakrishnan, A.4
  • 42
    • 38349188632 scopus 로고    scopus 로고
    • Organogels and their use in drug delivery - A review
    • A. Vintiloui, J.C. Leroux, Organogels and their use in drug delivery - a review, J. Control. Release 125 (2008) 179-192.
    • (2008) J. Control. Release , vol.125 , pp. 179-192
    • Vintiloui, A.1    Leroux, J.C.2
  • 43
    • 43349089561 scopus 로고    scopus 로고
    • In situ-forming oleogel implant for rivastigmine delivery
    • A. Vintiloui, M. Lafleur, G. Bastiat, J.C. Leroux, In situ-forming oleogel implant for rivastigmine delivery, Pharm. Res. 25 (2008) 845-852.
    • (2008) Pharm. Res. , vol.25 , pp. 845-852
    • Vintiloui, A.1    Lafleur, M.2    Bastiat, G.3    Leroux, J.C.4
  • 44
    • 27744446202 scopus 로고    scopus 로고
    • First report on the efficacy of L-alanine-based in situ-forming implants for the long-term parenteral delivery of drugs
    • F. Plourde, A. Motulsky, A.C. Couffin-Hoarau, D. Hoarau, H. Ong, J.C. Leroux, First report on the efficacy of L-alanine-based in situ-forming implants for the long-term parenteral delivery of drugs, J. Control. Release 108 (2005) 433-441.
    • (2005) J. Control. Release , vol.108 , pp. 433-441
    • Plourde, F.1    Motulsky, A.2    Couffin-Hoarau, A.C.3    Hoarau, D.4    Ong, H.5    Leroux, J.C.6
  • 45
    • 0029009390 scopus 로고
    • Controlled release of contraceptive steroids from biodegradable and injectable gel formulation - In vivo evaluation
    • Z.H. Gao, A.J. Shukla, J.R. Johnson, W.R. Crowley, Controlled release of contraceptive steroids from biodegradable and injectable gel formulation - in vivo evaluation, Pharm. Res. 12 (1995) 864-868.
    • (1995) Pharm. Res. , vol.12 , pp. 864-868
    • Gao, Z.H.1    Shukla, A.J.2    Johnson, J.R.3    Crowley, W.R.4
  • 46
    • 77954538778 scopus 로고    scopus 로고
    • Drug release form and sterilization of in situ cubic phase forming monoglyceride drug delivery systems
    • A.R. Ahmed, A. Dashevsky, R. Bodmeier, Drug release form and sterilization of in situ cubic phase forming monoglyceride drug delivery systems, Eur. J. Pharm. Biopharm. 75 (2010) 375-380.
    • (2010) Eur. J. Pharm. Biopharm. , vol.75 , pp. 375-380
    • Ahmed, A.R.1    Dashevsky, A.2    Bodmeier, R.3
  • 48
    • 0032699051 scopus 로고    scopus 로고
    • In vitro properties of an in situ forming gel for the parenteral delivery of macromolecular drugs
    • R. Joshi, D.H. Robinson, K.J. Himmelstein, In vitro properties of an in situ forming gel for the parenteral delivery of macromolecular drugs, Pharm. Dev. Technol. 4 (1999) 515-522.
    • (1999) Pharm. Dev. Technol. , vol.4 , pp. 515-522
    • Joshi, R.1    Robinson, D.H.2    Himmelstein, K.J.3
  • 49
    • 0027390570 scopus 로고
    • Pain-temperature relation in the application of local anaesthesia
    • P.E. Alonso, L.A. Perula, L.F. Rioja, Pain-temperature relation in the application of local anaesthesia, Br. J. Plast. Surg. 46 (1993) 76-78.
    • (1993) Br. J. Plast. Surg. , vol.46 , pp. 76-78
    • Alonso, P.E.1    Perula, L.A.2    Rioja, L.F.3
  • 51
    • 0035649058 scopus 로고    scopus 로고
    • Poly(ortho esters): Recent developments for biomedical applications
    • S. Einmahl, K. Schwach-Abdellaoui, J. Heller, R. Gurny, Poly(ortho esters): recent developments for biomedical applications, Chimia 55 (2001) 218-222.
    • (2001) Chimia , vol.55 , pp. 218-222
    • Einmahl, S.1    Schwach-Abdellaoui, K.2    Heller, J.3    Gurny, R.4
  • 53
    • 4243957642 scopus 로고    scopus 로고
    • Liquid absorbable copolymers for parenteral applications
    • Patent [5653992], 5-8-1997
    • R.S. Bezwada, S.C. Arnold, Liquid absorbable copolymers for parenteral applications, Patent [5653992], 5-8-1997.
    • Bezwada, R.S.1    Arnold, S.C.2
  • 54
    • 33846818951 scopus 로고    scopus 로고
    • Controlled delivery of recombinant hirudin based on thermo-sensitive Pluronic® F127 hydrogel for subcutaneous administration: In vitro and in vivo characterization
    • Y. Liu, W.L. Lu, J.C. Wang, X. Zhang, H. Zhang, X.Q. Wang, T.Y. Zhou, Q. Zhang, Controlled delivery of recombinant hirudin based on thermo-sensitive Pluronic® F127 hydrogel for subcutaneous administration: in vitro and in vivo characterization, J. Control. Release 117 (2007) 387-395.
    • (2007) J. Control. Release , vol.117 , pp. 387-395
    • Liu, Y.1    Lu, W.L.2    Wang, J.C.3    Zhang, X.4    Zhang, H.5    Wang, X.Q.6    Zhou, T.Y.7    Zhang, Q.8
  • 55
    • 0037258654 scopus 로고    scopus 로고
    • Crosslinkable PEO-PPO-PEO-based reverse thermo-responsive gels as potentially injectable materials
    • A. Sosnik, D. Cohn, J.S. San Roman, G.A. Abraham, Crosslinkable PEO-PPO-PEO-based reverse thermo-responsive gels as potentially injectable materials, J. Biomater. Sci. Polym. Ed. 14 (2003) 227-239.
    • (2003) J. Biomater. Sci. Polym. Ed. , vol.14 , pp. 227-239
    • Sosnik, A.1    Cohn, D.2    San Roman, J.S.3    Abraham, G.A.4
  • 56
    • 3242668912 scopus 로고    scopus 로고
    • Reverse thermo-responsive poly(ethylene oxide) and poly(propylene oxide) multiblock copolymers
    • A. Sosnik, D. Cohn, Reverse thermo-responsive poly(ethylene oxide) and poly(propylene oxide) multiblock copolymers, Biomaterials 26 (2005) 349-357.
    • (2005) Biomaterials , vol.26 , pp. 349-357
    • Sosnik, A.1    Cohn, D.2
  • 57
    • 22644443288 scopus 로고    scopus 로고
    • Rheological, mucoadhesive and release properties of Pluronic F-127 gel and Pluronic F-127/polycarbophil mixed gel systems
    • F. Tirnaksiz, J.R. Robinson, Rheological, mucoadhesive and release properties of Pluronic F-127 gel and Pluronic F-127/polycarbophil mixed gel systems, Pharmazie 60 (2005) 518-523.
    • (2005) Pharmazie , vol.60 , pp. 518-523
    • Tirnaksiz, F.1    Robinson, J.R.2
  • 58
    • 33645327112 scopus 로고    scopus 로고
    • Drug-polymer interactions and their effect on thermoresponsive poly(N-isopropylacrylamide) drug delivery systems
    • D.C. Coughlan, O.I. Corrigan, Drug-polymer interactions and their effect on thermoresponsive poly(N-isopropylacrylamide) drug delivery systems, Int. J. Pharm. 313 (2006) 163-174.
    • (2006) Int. J. Pharm. , vol.313 , pp. 163-174
    • Coughlan, D.C.1    Corrigan, O.I.2
  • 59
    • 0037122786 scopus 로고    scopus 로고
    • Thermosensitive sol-gel reversible hydrogels
    • B. Jeong, S.W. Kim, Y.H. Bae, Thermosensitive sol-gel reversible hydrogels, Adv. Drug Deliv. Rev. 54 (2002) 37-51.
    • (2002) Adv. Drug Deliv. Rev. , vol.54 , pp. 37-51
    • Jeong, B.1    Kim, S.W.2    Bae, Y.H.3
  • 60
    • 0036629185 scopus 로고    scopus 로고
    • Lessons from nature: Stimuli-responsive polymers and their biomedical applications
    • B. Jeong, A. Gutowska, Lessons from nature: stimuli-responsive polymers and their biomedical applications, Trends Biotechnol. 20 (2002) 305-311.
    • (2002) Trends Biotechnol. , vol.20 , pp. 305-311
    • Jeong, B.1    Gutowska, A.2
  • 61
    • 34247618686 scopus 로고    scopus 로고
    • In vitro and in vivo release of albumin using a biodegradableMPEG-PCL diblock copolymer as an in situ gel-forming carrier
    • H. Hyun, Y.H. Kim, I.B. Song, J.W. Lee, M.S. Kim, G. Khang, K. Park, H.B. Lee, In vitro and in vivo release of albumin using a biodegradableMPEG-PCL diblock copolymer as an in situ gel-forming carrier, Biomacromolecules 8 (2007) 1093-1100.
    • (2007) Biomacromolecules , vol.8 , pp. 1093-1100
    • Hyun, H.1    Kim, Y.H.2    Song, I.B.3    Lee, J.W.4    Kim, M.S.5    Khang, G.6    Park, K.7    Lee, H.B.8
  • 63
    • 84862674795 scopus 로고    scopus 로고
    • assessed 20. January 2012, A. Burrows, 05-04-2011, London (UK)
    • http://www.btgplc.com/page/12921/btg-plc-close-period-update: assessed 20. January 2012, A. Burrows, BTG Press Release - Close period update, 05-04-2011, London (UK).
    • BTG Press Release - Close Period Update
  • 64
    • 0036258319 scopus 로고    scopus 로고
    • Sol-gel transition temperature of PLGA-g-PEG aqueous solutions
    • Y.M. Chung, K.L. Simmons, A. Gutowska, B. Jeong, Sol-gel transition temperature of PLGA-g-PEG aqueous solutions, Biomacromolecules 3 (2002) 511-516.
    • (2002) Biomacromolecules , vol.3 , pp. 511-516
    • Chung, Y.M.1    Simmons, K.L.2    Gutowska, A.3    Jeong, B.4
  • 65
    • 0035928697 scopus 로고    scopus 로고
    • Biodegradable thermoreversible gelling PLGA-g-PEG copolymers
    • B. Jeong, L.Q. Wang, A. Gutowska, Biodegradable thermoreversible gelling PLGA-g-PEG copolymers, Chem. Commun. (2001) 1516-1517.
    • (2001) Chem. Commun. , pp. 1516-1517
    • Jeong, B.1    Wang, L.Q.2    Gutowska, A.3
  • 66
    • 0041718431 scopus 로고    scopus 로고
    • Non-invasive in vivo characterization of release processes in biodegradable polymers by low-frequency electron paramagnetic resonance spectroscopy
    • K. Mäder, B. Gallez, K.J. Liu, H.M. Swartz, Non-invasive in vivo characterization of release processes in biodegradable polymers by low-frequency electron paramagnetic resonance spectroscopy, Biomaterials 17 (1996) 457-461.
    • (1996) Biomaterials , vol.17 , pp. 457-461
    • Mäder, K.1    Gallez, B.2    Liu, K.J.3    Swartz, H.M.4
  • 67
    • 33646443088 scopus 로고    scopus 로고
    • Prediction of microclimate pH in poly(lactic-co-glycolic acid) films
    • A.G. Ding, A. Shenderova, S.P. Schwendeman, Prediction of microclimate pH in poly(lactic-co-glycolic acid) films, J. Am. Chem. Soc. 128 (2006) 5384-5390.
    • (2006) J. Am. Chem. Soc. , vol.128 , pp. 5384-5390
    • Ding, A.G.1    Shenderova, A.2    Schwendeman, S.P.3
  • 69
    • 79955521271 scopus 로고    scopus 로고
    • In vivo efficacy of an intratumorally injected in situ-forming doxorubicin/poly-(ethylene glycol)-b-polycaprolactone diblock copolymer
    • Y.M. Kang, G.H. Kim, J.I. Kim, D.Y. Kim, B.N. Lee, S.M. Yoon, J.H. Kim, M.S. Kim, In vivo efficacy of an intratumorally injected in situ-forming doxorubicin/poly-(ethylene glycol)-b-polycaprolactone diblock copolymer, Biomaterials 32 (2011) 4556-4564.
    • (2011) Biomaterials , vol.32 , pp. 4556-4564
    • Kang, Y.M.1    Kim, G.H.2    Kim, J.I.3    Kim, D.Y.4    Lee, B.N.5    Yoon, S.M.6    Kim, J.H.7    Kim, M.S.8
  • 70
    • 0033204936 scopus 로고    scopus 로고
    • Thermoreversible gelation of aqueous methylcellulose solutions
    • K. Kobayashi, C. Huang, T.P. Lodge, Thermoreversible gelation of aqueous methylcellulose solutions, Macromolecules 32 (1999) 7070-7077.
    • (1999) Macromolecules , vol.32 , pp. 7070-7077
    • Kobayashi, K.1    Huang, C.2    Lodge, T.P.3
  • 71
    • 29244439335 scopus 로고    scopus 로고
    • Fast-gelling injectable blend of hyaluronan and methylcellulose for intrathecal, localized delivery to the injured spinal cord
    • D. Gupta, C.H. Tator, M.S. Shoichet, Fast-gelling injectable blend of hyaluronan and methylcellulose for intrathecal, localized delivery to the injured spinal cord, Biomaterials 27 (2006) 2370-2379.
    • (2006) Biomaterials , vol.27 , pp. 2370-2379
    • Gupta, D.1    Tator, C.H.2    Shoichet, M.S.3
  • 73
    • 0034255170 scopus 로고    scopus 로고
    • Characterization of thermosensitive chitosan gels for the sustained delivery of drugs
    • E. Ruel-Gariepy, A. Chenite, C. Chaput, S. Guirguis, J.C. Leroux, Characterization of thermosensitive chitosan gels for the sustained delivery of drugs, Int. J. Pharm. 203 (2000) 89-98.
    • (2000) Int. J. Pharm. , vol.203 , pp. 89-98
    • Ruel-Gariepy, E.1    Chenite, A.2    Chaput, C.3    Guirguis, S.4    Leroux, J.C.5
  • 75
    • 0037151326 scopus 로고    scopus 로고
    • Thermosensitive chitosan-based hydrogel containing liposomes for the delivery of hydrophilic molecules
    • E. Ruel-Gariepy, G. Leclair, P. Hildgen, A. Gupta, J.C. Leroux, Thermosensitive chitosan-based hydrogel containing liposomes for the delivery of hydrophilic molecules, J. Control. Release 82 (2002) 373-383.
    • (2002) J. Control. Release , vol.82 , pp. 373-383
    • Ruel-Gariepy, E.1    Leclair, G.2    Hildgen, P.3    Gupta, A.4    Leroux, J.C.5
  • 76
    • 40649110564 scopus 로고    scopus 로고
    • Ultrastructure of hybrid chitosan-glycerolphosphate blood clots by environmental scanning electron microscopy
    • M. Iliescu, C.D. Hoemann, M.S. Shive, A. Chenite, M.D. Buschmann, Ultrastructure of hybrid chitosan-glycerolphosphate blood clots by environmental scanning electron microscopy, Microsc. Res. Tech. 71 (2008) 236-247.
    • (2008) Microsc. Res. Tech. , vol.71 , pp. 236-247
    • Iliescu, M.1    Hoemann, C.D.2    Shive, M.S.3    Chenite, A.4    Buschmann, M.D.5
  • 78
    • 0033430983 scopus 로고    scopus 로고
    • Dental drug delivery devices: Local and sustained release applications
    • D. Steinberg, M. Friedman, Dental drug delivery devices: local and sustained release applications, Crit. Rev. Ther. Drug Carrier Syst. 16 (1999) 425-459.
    • (1999) Crit. Rev. Ther. Drug Carrier Syst. , vol.16 , pp. 425-459
    • Steinberg, D.1    Friedman, M.2
  • 79
    • 0043125533 scopus 로고    scopus 로고
    • An eight-month clinical study of LA-2575 30.0 mg: A new 4-month, subcutaneous delivery system for leuprolide acetate in the treatment of prostate cancer
    • O. Sator, M.K. Dineen, R. Perez-Marreno, F.M. Chu, G.J. Carron, R.C. Tyler, An eight-month clinical study of LA-2575 30.0 mg: a new 4-month, subcutaneous delivery system for leuprolide acetate in the treatment of prostate cancer, Urology 62 (2003) 319-323.
    • (2003) Urology , vol.62 , pp. 319-323
    • Sator, O.1    Dineen, M.K.2    Perez-Marreno, R.3    Chu, F.M.4    Carron, G.J.5    Tyler, R.C.6
  • 81
    • 0029789140 scopus 로고    scopus 로고
    • Biodegradable injectable implant system for long term drug delivery using poly (lactic-co-glycolic) acid copolymers
    • G. Chandrashekar, N. Udupa, Biodegradable injectable implant system for long term drug delivery using poly (lactic-co-glycolic) acid copolymers, J. Pharm. Pharmacol. 48 (1996) 669-674.
    • (1996) J. Pharm. Pharmacol. , vol.48 , pp. 669-674
    • Chandrashekar, G.1    Udupa, N.2
  • 82
    • 43049180016 scopus 로고    scopus 로고
    • Controlled delivery of aspirin: Effect of aspirin on polymer degradation an in vitro release from PLGA based phase sensitive systems
    • Y. Tang, J. Singh, Controlled delivery of aspirin: effect of aspirin on polymer degradation an in vitro release from PLGA based phase sensitive systems, Int. J. Pharm. 357 (2008) 119-125.
    • (2008) Int. J. Pharm. , vol.357 , pp. 119-125
    • Tang, Y.1    Singh, J.2
  • 83
    • 23144456487 scopus 로고    scopus 로고
    • Sustained activity and release of leuprolide acetate from an situ forming polymeric implant
    • article 1
    • H.B. Ravivarapu, K.L. Moyer, R.L. Dunn, Sustained activity and release of leuprolide acetate from an situ forming polymeric implant, AAPS Pharm. Sci. Technol. 1 (2000) article 1.
    • (2000) AAPS Pharm. Sci. Technol. , vol.1
    • Ravivarapu, H.B.1    Moyer, K.L.2    Dunn, R.L.3
  • 84
    • 0028858961 scopus 로고
    • Development of an in situ forming biodegradable polylactide-co-glycolide system for the controlled release of proteins
    • W.J. Lambert, K.D. Peck, Development of an in situ forming biodegradable polylactide-co-glycolide system for the controlled release of proteins, J. Control. Release 33 (1995) 189-195.
    • (1995) J. Control. Release , vol.33 , pp. 189-195
    • Lambert, W.J.1    Peck, K.D.2
  • 85
    • 0033403807 scopus 로고    scopus 로고
    • Sustained release of human growth hormone from PLGA solution depots
    • K.J. Brodbeck, S. Pushpala, A.J. Mchugh, Sustained release of human growth hormone from PLGA solution depots, Pharm. Res. 16 (1999) 1825-1829.
    • (1999) Pharm. Res. , vol.16 , pp. 1825-1829
    • Brodbeck, K.J.1    Pushpala, S.2    Mchugh, A.J.3
  • 86
    • 0034110737 scopus 로고    scopus 로고
    • Characterization of a polymeric PLGA-injectable implant delivery system for the controlled release of proteins
    • R. Eliaz, J. Kost, Characterization of a polymeric PLGA-injectable implant delivery system for the controlled release of proteins, J. Biomed. Mater. Res. 50 (2000) 388-396.
    • (2000) J. Biomed. Mater. Res. , vol.50 , pp. 388-396
    • Eliaz, R.1    Kost, J.2
  • 88
    • 28444499002 scopus 로고    scopus 로고
    • The role of polymer membrane formation in sustained release drug delivery systems
    • A. McHugh, The role of polymer membrane formation in sustained release drug delivery systems, J. Control. Release 109 (2005) 211-221.
    • (2005) J. Control. Release , vol.109 , pp. 211-221
    • McHugh, A.1
  • 89
    • 33749555615 scopus 로고    scopus 로고
    • Stability of poly(D, L-lactide-co-glycolide) and leuprolide acetate in-situ forming drug delivery systems
    • W.Y. Dong, M. Körber, V. Lopez Esguerra, R. Bodmeier, Stability of poly(D, L-lactide-co-glycolide) and leuprolide acetate in-situ forming drug delivery systems, J. Control. Release 115 (2006) 158-167.
    • (2006) J. Control. Release , vol.115 , pp. 158-167
    • Dong, W.Y.1    Körber, M.2    Lopez Esguerra, V.3    Bodmeier, R.4
  • 90
    • 29244460647 scopus 로고    scopus 로고
    • Influence of the poly(lactide-co-glycolide) type on the leuprolide release from in situ forming microparticle systems
    • X. Luan, R. Bodmeier, Influence of the poly(lactide-co-glycolide) type on the leuprolide release from in situ forming microparticle systems, J. Control. Release 110 (2006) 266-272.
    • (2006) J. Control. Release , vol.110 , pp. 266-272
    • Luan, X.1    Bodmeier, R.2
  • 91
    • 0033032661 scopus 로고    scopus 로고
    • Phase inversion dynamics of PLGA solutions related to drug delivery
    • P.D. Graham, K.J. Brodbeck, A.J. McHugh, Phase inversion dynamics of PLGA solutions related to drug delivery, J. Control. Release 58 (1999) 233-245.
    • (1999) J. Control. Release , vol.58 , pp. 233-245
    • Graham, P.D.1    Brodbeck, K.J.2    McHugh, A.J.3
  • 92
    • 0032866354 scopus 로고    scopus 로고
    • Phase inversion dynamics of PLGA solutions related to drug delivery - Part II. The role of solution thermodynamics and bath-side mass transfer
    • K.J. Brodbeck, J.R. DesNoyer, A.J. McHugh, Phase inversion dynamics of PLGA solutions related to drug delivery - part II. The role of solution thermodynamics and bath-side mass transfer, J. Control. Release 62 (1999) 333-344.
    • (1999) J. Control. Release , vol.62 , pp. 333-344
    • Brodbeck, K.J.1    DesNoyer, J.R.2    McHugh, A.J.3
  • 94
    • 26444565321 scopus 로고    scopus 로고
    • In vitro release of insulin and biocompatibility of in situ forming gel systems
    • F. Kang, J. Singh, In vitro release of insulin and biocompatibility of in situ forming gel systems, Int. J. Pharm. 304 (2005) 83-90.
    • (2005) Int. J. Pharm. , vol.304 , pp. 83-90
    • Kang, F.1    Singh, J.2
  • 95
    • 38149135712 scopus 로고    scopus 로고
    • Sucrose acetate isobutyrate as an in situ forming system for sustained risperidone release
    • Y. Lu, Y. Yu, X. Tang, Sucrose acetate isobutyrate as an in situ forming system for sustained risperidone release, J. Pharm. Sci. 96 (2007) 3252-3262.
    • (2007) J. Pharm. Sci. , vol.96 , pp. 3252-3262
    • Lu, Y.1    Yu, Y.2    Tang, X.3
  • 96
  • 100
    • 33846859117 scopus 로고    scopus 로고
    • A novel in situ forming drug delivery system for controlled parenteral drug delivery
    • H. Kranz, R. Bodmeier, A novel in situ forming drug delivery system for controlled parenteral drug delivery, Int. J. Pharm. 332 (2007) 107-114.
    • (2007) Int. J. Pharm. , vol.332 , pp. 107-114
    • Kranz, H.1    Bodmeier, R.2
  • 102
    • 70449134629 scopus 로고    scopus 로고
    • Poly(ethyleneglycol) 500 dimethylether as novel solvent for injectable in situ forming depots
    • K. Schoenhammer, H. Petersen, F. Guethlein, A. Goepferich, Poly(ethyleneglycol) 500 dimethylether as novel solvent for injectable in situ forming depots, Pharm. Res. 26 (2009) 2568-2577.
    • (2009) Pharm. Res. , vol.26 , pp. 2568-2577
    • Schoenhammer, K.1    Petersen, H.2    Guethlein, F.3    Goepferich, A.4
  • 104
    • 41149151684 scopus 로고    scopus 로고
    • In vitro and in vivo degradation of poly(l-lactide-co-glycolide) films and scaffolds
    • E. Pamula, E. Menaszek, In vitro and in vivo degradation of poly(l-lactide-co-glycolide) films and scaffolds, J. Mater. Sci. Mater. Med. 19 (2008) 2063-2070.
    • (2008) J. Mater. Sci. Mater. Med. , vol.19 , pp. 2063-2070
    • Pamula, E.1    Menaszek, E.2
  • 105
    • 84862688155 scopus 로고    scopus 로고
    • Applicability testing of in situ forming implants with incorporated microspheres: In vivo monitoring of calcification
    • A. Lochmann, H. Nitzsche, A. Schädlich, S. von Einem, E. Schwarz, K. Mäder, Applicability testing of in situ forming implants with incorporated microspheres: in vivo monitoring of calcification, Regen. Med. 4 (2009) 5218-5219.
    • (2009) Regen. Med. , vol.4 , pp. 5218-5219
    • Lochmann, A.1    Nitzsche, H.2    Schädlich, A.3    Von Einem, S.4    Schwarz, E.5    Mäder, K.6
  • 106
    • 78649499043 scopus 로고    scopus 로고
    • Chitosan hydrogel containing capsaicinoids-loaded nanocapsules: An innovative formulation for topical delivery
    • R.V. Contri, T. Katzer, A.R. Pohlmann, S.S. Guterres, Chitosan hydrogel containing capsaicinoids-loaded nanocapsules: an innovative formulation for topical delivery, Soft Mater. 8 (4) (2010) 370-385.
    • (2010) Soft Mater. , vol.8 , Issue.4 , pp. 370-385
    • Contri, R.V.1    Katzer, T.2    Pohlmann, A.R.3    Guterres, S.S.4
  • 107
    • 79959226051 scopus 로고    scopus 로고
    • An in situ-forming, solid lipid/PLGA hybrid implant for long-acting antipsychotics
    • S. Dong, S. Wang, C. Zheng, W. Liang, Y. Hunag, An in situ-forming, solid lipid/PLGA hybrid implant for long-acting antipsychotics, Soft Matter 7 (2011) 5873-5878.
    • (2011) Soft Matter , vol.7 , pp. 5873-5878
    • Dong, S.1    Wang, S.2    Zheng, C.3    Liang, W.4    Hunag, Y.5
  • 108
    • 84862678080 scopus 로고    scopus 로고
    • Cosolvent effects on the drug release and depot swelling in injectable in situ depot-forming systems
    • H. Liu, S.S. Venkatraman, Cosolvent effects on the drug release and depot swelling in injectable in situ depot-forming systems, J. Pharm. Sci. 101 (2012) 1783-1793.
    • (2012) J. Pharm. Sci. , vol.101 , pp. 1783-1793
    • Liu, H.1    Venkatraman, S.S.2
  • 109
    • 84857789097 scopus 로고    scopus 로고
    • In situ forming implant for controlled delivery of an anti-HIV fusion inhibitor
    • D. Kapoor, O.P. Katare, S. Dhawan, In situ forming implant for controlled delivery of an anti-HIV fusion inhibitor, Int. J. Pharm. 426 (2012) 132-143.
    • (2012) Int. J. Pharm. , vol.426 , pp. 132-143
    • Kapoor, D.1    Katare, O.P.2    Dhawan, S.3
  • 110
    • 79958132622 scopus 로고    scopus 로고
    • The effect of aliphatic esters on the formation and degradation behaviour of PLGA-based in situ forming systems
    • A. Mashak, H. Mobedi, F. Ziaee, M. Nekoomanesh, The effect of aliphatic esters on the formation and degradation behaviour of PLGA-based in situ forming systems, Polym. Bull. 66 (2011) 1063-1073.
    • (2011) Polym. Bull. , vol.66 , pp. 1063-1073
    • Mashak, A.1    Mobedi, H.2    Ziaee, F.3    Nekoomanesh, M.4
  • 111
    • 84862653239 scopus 로고    scopus 로고
    • A novel risperidone-loaded SAIB-PLGA mixtures matrix depot with a reduced burst release: Effect of solvents and PLGA on drug release behaviors in vitro/in vivo
    • X. Lin, S. Yang, J. Gou, M. Zhao, Y. Zhang, N. Qi, H. He, C. Cai, X. Tang, P. Guo, A novel risperidone-loaded SAIB-PLGA mixtures matrix depot with a reduced burst release: effect of solvents and PLGA on drug release behaviors in vitro/in vivo, J. Mater. Sci. Mater. Med. 23 (2012) 443-455.
    • (2012) J. Mater. Sci. Mater. Med. , vol.23 , pp. 443-455
    • Lin, X.1    Yang, S.2    Gou, J.3    Zhao, M.4    Zhang, Y.5    Qi, N.6    He, H.7    Cai, C.8    Tang, X.9    Guo, P.10
  • 112
    • 77957281434 scopus 로고    scopus 로고
    • Poly(ethylene carbonate) as a surface-eroding biomaterial for in situ forming parenteral drug delivery systems: A feasibility study
    • Y. Liu, A. Kemmer, K. Keim, C. Curdy, H. Petersen, T. Kissel, Poly(ethylene carbonate) as a surface-eroding biomaterial for in situ forming parenteral drug delivery systems: a feasibility study, Eur. J. Pharm. Biopharm. 76 (2010) 222-229.
    • (2010) Eur. J. Pharm. Biopharm. , vol.76 , pp. 222-229
    • Liu, Y.1    Kemmer, A.2    Keim, K.3    Curdy, C.4    Petersen, H.5    Kissel, T.6
  • 113
    • 4544224331 scopus 로고    scopus 로고
    • Drug release from injectable depots: Two different in vitro mechanisms
    • L.W. Wang, S. Venkatraman, L. Kleiner, Drug release from injectable depots: two different in vitro mechanisms, J. Control. Release 99 (2004) 207-216.
    • (2004) J. Control. Release , vol.99 , pp. 207-216
    • Wang, L.W.1    Venkatraman, S.2    Kleiner, L.3
  • 114
    • 58149252069 scopus 로고    scopus 로고
    • Changes in morphology of in situ forming PLGA implant prepared by different polymer molecular weight and its effect on release behaviour
    • R. Astaneh, M. Erfan, H. Moghimi, H. Mobedi, Changes in morphology of in situ forming PLGA implant prepared by different polymer molecular weight and its effect on release behaviour, J. Pharm. Sci. 98 (2009) 135-145.
    • (2009) J. Pharm. Sci. , vol.98 , pp. 135-145
    • Astaneh, R.1    Erfan, M.2    Moghimi, H.3    Mobedi, H.4
  • 115
    • 78650680292 scopus 로고    scopus 로고
    • A novel, simple method to simulate gelling process of injectable biodegradable in situ forming drug delivery system based on determination of electrical conductivity
    • K. Wang, Q. Jia, J. Yuan, S. Li, A novel, simple method to simulate gelling process of injectable biodegradable in situ forming drug delivery system based on determination of electrical conductivity, Int. J. Pharm. 404 (2011) 176-179.
    • (2011) Int. J. Pharm. , vol.404 , pp. 176-179
    • Wang, K.1    Jia, Q.2    Yuan, J.3    Li, S.4
  • 116
    • 72149125040 scopus 로고    scopus 로고
    • Application of electron paramagnetic resonance (EPR) spectroscopy and imaging in drug delivery research - Chances and challenges
    • S. Kempe, H. Metz, K. Mäder, Application of electron paramagnetic resonance (EPR) spectroscopy and imaging in drug delivery research - chances and challenges, Eur. J. Pharm. Biopharm. 74 (2010) 55-66.
    • (2010) Eur. J. Pharm. Biopharm. , vol.74 , pp. 55-66
    • Kempe, S.1    Metz, H.2    Mäder, K.3
  • 117
    • 72149087444 scopus 로고    scopus 로고
    • Non-invasive in vivo evaluation of in situ forming PLGA implants by benchtop magnetic resonance imaging (BT-MRI) and EPR spectroscopy
    • S. Kempe, H. Metz, P.G.C. Pereira, K. Mäder, Non-invasive in vivo evaluation of in situ forming PLGA implants by benchtop magnetic resonance imaging (BT-MRI) and EPR spectroscopy, Eur. J. Pharm. Biopharm. 74 (2010) 102-108.
    • (2010) Eur. J. Pharm. Biopharm. , vol.74 , pp. 102-108
    • Kempe, S.1    Metz, H.2    Pereira, P.G.C.3    Mäder, K.4
  • 118
    • 50949132230 scopus 로고    scopus 로고
    • Do in situ forming PLG/NMP implants behave similar in vitro and in vivo? A noninvasive and quantitative EPR investigation on the mechanism of the implant formation process
    • S. Kempe, H. Metz, K. Mäder, Do in situ forming PLG/NMP implants behave similar in vitro and in vivo? A noninvasive and quantitative EPR investigation on the mechanism of the implant formation process, J. Control. Release 130 (2008) 220-225.
    • (2008) J. Control. Release , vol.130 , pp. 220-225
    • Kempe, S.1    Metz, H.2    Mäder, K.3
  • 119
    • 36549067196 scopus 로고    scopus 로고
    • Characterisation of thermosensitive chitosan-based hydrogels by rheology and electron paramagnetic resonance spectroscopy
    • S. Kempe, H. Metz, M. Bastrop, A. Hvilsom, R.V. Contri, K. Mäder, Characterisation of thermosensitive chitosan-based hydrogels by rheology and electron paramagnetic resonance spectroscopy, Eur. J. Pharm. Biopharm. 68 (2008) 26-33.
    • (2008) Eur. J. Pharm. Biopharm. , vol.68 , pp. 26-33
    • Kempe, S.1    Metz, H.2    Bastrop, M.3    Hvilsom, A.4    Contri, R.V.5    Mäder, K.6
  • 120
    • 6444244487 scopus 로고    scopus 로고
    • A novel evaluation of subcutaneous formulations by in vivo magnetic resonance imaging (MRI)
    • B. Madhu, I. Elmroth, A. Lundgren, B. Abrahamsson, B. Soussi, A novel evaluation of subcutaneous formulations by in vivo magnetic resonance imaging (MRI), Pharm. Res. 45 (2002) 207-212.
    • (2002) Pharm. Res. , vol.45 , pp. 207-212
    • Madhu, B.1    Elmroth, I.2    Lundgren, A.3    Abrahamsson, B.4    Soussi, B.5
  • 121
    • 77950341560 scopus 로고    scopus 로고
    • Noninvasive characterization of in situ forming implants using diagnostic ultrasound
    • L. Solorio, B.M. Babin, R.B. Patel, J. Mach, N. Azar, A.A. Exner, Noninvasive characterization of in situ forming implants using diagnostic ultrasound, J. Control. Release 143 (2010) 183-190.
    • (2010) J. Control. Release , vol.143 , pp. 183-190
    • Solorio, L.1    Babin, B.M.2    Patel, R.B.3    Mach, J.4    Azar, N.5    Exner, A.A.6
  • 122
    • 78049456852 scopus 로고    scopus 로고
    • Effect of injection site on in situ implant formation and drug release in vivo
    • R.B. Patel, L. Solorio, H. Wu, T. Krupka, A.A. Exner, Effect of injection site on in situ implant formation and drug release in vivo, J. Control. Release 147 (2010) 350-358.
    • (2010) J. Control. Release , vol.147 , pp. 350-358
    • Patel, R.B.1    Solorio, L.2    Wu, H.3    Krupka, T.4    Exner, A.A.5
  • 123
    • 0041718431 scopus 로고    scopus 로고
    • Non-invasive in vivo characterization of release processes in biodegradable polymers by low-frequency electron paramagnetic resonance spectroscopy
    • K. Mäder, B. Gallez, K.J. Liu, H.M. Swartz, Non-invasive in vivo characterization of release processes in biodegradable polymers by low-frequency electron paramagnetic resonance spectroscopy, Biomaterials 17 (4) (1996) 457-461.
    • (1996) Biomaterials , vol.17 , Issue.4 , pp. 457-461
    • Mäder, K.1    Gallez, B.2    Liu, K.J.3    Swartz, H.M.4
  • 124
    • 43049097877 scopus 로고    scopus 로고
    • In vitro and in vivo drug release from a novel in situ forming drug delivery system
    • H. Kranz, E. Yilmaz, G.A. Brazeau, R. Bodmeier, In vitro and in vivo drug release from a novel in situ forming drug delivery system, Pharm. Res. 25 (2008) 1347-1354.
    • (2008) Pharm. Res. , vol.25 , pp. 1347-1354
    • Kranz, H.1    Yilmaz, E.2    Brazeau, G.A.3    Bodmeier, R.4
  • 125
    • 40949133332 scopus 로고    scopus 로고
    • PLGA-based drug delivery systems: Importance of the type of drug and device geometry
    • D. Klose, F. Siepmann, K. Elkharraz, J. Siepmann, PLGA-based drug delivery systems: importance of the type of drug and device geometry, Int. J. Pharm. 354 (2011) 95-103.
    • (2011) Int. J. Pharm. , vol.354 , pp. 95-103
    • Klose, D.1    Siepmann, F.2    Elkharraz, K.3    Siepmann, J.4
  • 126
    • 33646188402 scopus 로고    scopus 로고
    • Effects of the type of release medium on drug release from PLGA-based microparticles: Experiment and theory
    • N. Faisant, J. Akiki, F. Siepmann, J.P. Benoit, J. Siepmann, Effects of the type of release medium on drug release from PLGA-based microparticles: experiment and theory, Int. J. Pharm. 314 (2006) 189-197.
    • (2006) Int. J. Pharm. , vol.314 , pp. 189-197
    • Faisant, N.1    Akiki, J.2    Siepmann, F.3    Benoit, J.P.4    Siepmann, J.5
  • 127
    • 78650678085 scopus 로고    scopus 로고
    • Unintended potential of perfect sink conditions on PLGA degradation in microparticles
    • D. Klose, C. Delplace, J. Siepmann, Unintended potential of perfect sink conditions on PLGA degradation in microparticles, Int. J. Pharm. 404 (2011) 75-82.
    • (2011) Int. J. Pharm. , vol.404 , pp. 75-82
    • Klose, D.1    Delplace, C.2    Siepmann, J.3
  • 128
    • 62749195118 scopus 로고    scopus 로고
    • Injectable in situ forming depot systems: PEG-DAE as novel solvent for improved PLGA storage stability
    • K. Schoenhammer, H. Petersen, F. Guethlein, A. Goepferich, Injectable in situ forming depot systems: PEG-DAE as novel solvent for improved PLGA storage stability, Int. J. Pharm. 371 (2009) 33-39.
    • (2009) Int. J. Pharm. , vol.371 , pp. 33-39
    • Schoenhammer, K.1    Petersen, H.2    Guethlein, F.3    Goepferich, A.4
  • 129
    • 33845499458 scopus 로고    scopus 로고
    • Poly(hexyl-substituted lactides): Novel injectable hydrophobic drug delivery systems
    • T. Trimaille, R. Gurny, M. Möller, Poly(hexyl-substituted lactides): novel injectable hydrophobic drug delivery systems, J. Biomed. Mater. Res. A 80A (2007) 55-65.
    • (2007) J. Biomed. Mater. Res. A , vol.80 A , pp. 55-65
    • Trimaille, T.1    Gurny, R.2    Möller, M.3
  • 130
    • 80053932589 scopus 로고    scopus 로고
    • Solutions as solutions - Synthesis and use of a liquid polyester excipient to dissolve lipophilic drugs and formulate sustained-release parenterals
    • L.R. Asmus, R. Gurny, M. Moller, Solutions as solutions - synthesis and use of a liquid polyester excipient to dissolve lipophilic drugs and formulate sustained-release parenterals, Eur. J. Pharm. Biopharm. 79 (2011) 584-591.
    • (2011) Eur. J. Pharm. Biopharm. , vol.79 , pp. 584-591
    • Asmus, L.R.1    Gurny, R.2    Moller, M.3
  • 131
    • 79953706299 scopus 로고    scopus 로고
    • Solutions for lipophilic drugs: A biodegradable polymer acting as solvent, matrix, and carrier to solve drug delivery issues
    • L.R. Asmus, R. Gurny, M. Moller, Solutions for lipophilic drugs: a biodegradable polymer acting as solvent, matrix, and carrier to solve drug delivery issues, Int. J. Artif. Organs 34 (2011) 238-242.
    • (2011) Int. J. Artif. Organs , vol.34 , pp. 238-242
    • Asmus, L.R.1    Gurny, R.2    Moller, M.3
  • 132
    • 36549073613 scopus 로고    scopus 로고
    • Thermoresponsive hydrogels in biomedical applications
    • L. Klouda, A.G. Mikos, Thermoresponsive hydrogels in biomedical applications, Eur. J. Pharm. Biopharm. 68 (2008) 34-45.
    • (2008) Eur. J. Pharm. Biopharm. , vol.68 , pp. 34-45
    • Klouda, L.1    Mikos, A.G.2
  • 133
    • 18144413904 scopus 로고    scopus 로고
    • In vitro and in vivo characterization of a novel biocompatible polymer-lipid implant system for the sustained delivery of paclitaxel
    • E.A. Ho, V. Vassileva, C. Allen, M. Piquette-Miller, In vitro and in vivo characterization of a novel biocompatible polymer-lipid implant system for the sustained delivery of paclitaxel, J. Control. Release 104 (2005) 181-191.
    • (2005) J. Control. Release , vol.104 , pp. 181-191
    • Ho, E.A.1    Vassileva, V.2    Allen, C.3    Piquette-Miller, M.4
  • 134
    • 0037122787 scopus 로고    scopus 로고
    • Pulsatile drug release control using hydrogels
    • A. Kikuchi, T. Okano, Pulsatile drug release control using hydrogels, Adv. Drug Deliv. Rev. 54 (2002) 53-77.
    • (2002) Adv. Drug Deliv. Rev. , vol.54 , pp. 53-77
    • Kikuchi, A.1    Okano, T.2
  • 136
    • 0036498038 scopus 로고    scopus 로고
    • Study of a chitin-based gel as injectable material in periodontal surgery
    • P. Gerentes, L. Vachoud, J. Doury, A. Domard, Study of a chitin-based gel as injectable material in periodontal surgery, Biomaterials 23 (2002) 1295-1302.
    • (2002) Biomaterials , vol.23 , pp. 1295-1302
    • Gerentes, P.1    Vachoud, L.2    Doury, J.3    Domard, A.4
  • 137
    • 26844568977 scopus 로고    scopus 로고
    • The potential of chitosan-based gels containing intervertebral disc cells for nucleus pulposus supplementation
    • P. Roughley, C. Hoemann, E. Desrosiers, F. Mwale, J. Antoniou, M. Alini, The potential of chitosan-based gels containing intervertebral disc cells for nucleus pulposus supplementation, Biomaterials 27 (2006) 388-396.
    • (2006) Biomaterials , vol.27 , pp. 388-396
    • Roughley, P.1    Hoemann, C.2    Desrosiers, E.3    Mwale, F.4    Antoniou, J.5    Alini, M.6
  • 138
    • 33847228434 scopus 로고    scopus 로고
    • Gelation time and degradation rate of chitosan-based injectable hydrogel
    • F. Ganji, M.J. Abdekhodaie, A. Ramazani, Gelation time and degradation rate of chitosan-based injectable hydrogel, J. Sol-Gel Sci. Technol. 42 (2007) 47-53.
    • (2007) J. Sol-Gel Sci. Technol. , vol.42 , pp. 47-53
    • Ganji, F.1    Abdekhodaie, M.J.2    Ramazani, A.3
  • 139
    • 0035998953 scopus 로고    scopus 로고
    • Physical characterization of a chitosan-based hydrogel delivery system
    • J. Li, Z. Xu, Physical characterization of a chitosan-based hydrogel delivery system, J. Pharm. Sci. 91 (2007) 1669-1677.
    • (2007) J. Pharm. Sci. , vol.91 , pp. 1669-1677
    • Li, J.1    Xu, Z.2
  • 142
    • 0035452921 scopus 로고    scopus 로고
    • Rheological characterisation of thermogelling chitosan/glycerol-phosphate solutions
    • A. Chenite, M. Buschmann, D. Wang, C. Chaput, N. Kandani, Rheological characterisation of thermogelling chitosan/glycerol-phosphate solutions, Carbohydr. Polym. 46 (2001) 39-47.
    • (2001) Carbohydr. Polym. , vol.46 , pp. 39-47
    • Chenite, A.1    Buschmann, M.2    Wang, D.3    Chaput, C.4    Kandani, N.5
  • 143
    • 49149096671 scopus 로고    scopus 로고
    • Biocompatibility and gelation of chitosan-glycerolphosphate hydrogels
    • R. Ahmadi, J.D. deBruijn, Biocompatibility and gelation of chitosan-glycerolphosphate hydrogels, J. Biomed. Mater. Res. A 86 (2008) 824-832.
    • (2008) J. Biomed. Mater. Res. A , vol.86 , pp. 824-832
    • Ahmadi, R.1    DeBruijn, J.D.2
  • 145
    • 78449296782 scopus 로고    scopus 로고
    • Injectable chitosan-based hydrogel for implantable drug delivery: Body response and induced variations of structure and composition
    • J. Sun, G. Jiang, T. Qui, Y. Wang, K. Zhang, F. Ding, Injectable chitosan-based hydrogel for implantable drug delivery: body response and induced variations of structure and composition, J. Biomed. Mater. Res. A 95A (2010) 1019-1027.
    • (2010) J. Biomed. Mater. Res. A , vol.95 A , pp. 1019-1027
    • Sun, J.1    Jiang, G.2    Qui, T.3    Wang, Y.4    Zhang, K.5    Ding, F.6
  • 146
    • 80052771947 scopus 로고    scopus 로고
    • In situ forming chitosan hydrogels prepared via ionic/covalent co-cross-linking
    • J. Moura, H. Faneca, M.P. Lima, M.H. Gil, M.M. Figueiredo, In situ forming chitosan hydrogels prepared via ionic/covalent co-cross-linking, Biomacromolecules 12 (2011) 3275-3284.
    • (2011) Biomacromolecules , vol.12 , pp. 3275-3284
    • Moura, J.1    Faneca, H.2    Lima, M.P.3    Gil, M.H.4    Figueiredo, M.M.5
  • 147
  • 148
    • 56749183581 scopus 로고    scopus 로고
    • Chitosan-based thermosensitive hydrogel containing liposomes for sustained delivery of cytarabine
    • R. Mulik, V. KulKarni, R.S.R. Murthy, Chitosan-based thermosensitive hydrogel containing liposomes for sustained delivery of cytarabine, Drug Dev. Ind. Pharm. 35 (2009) 49-56.
    • (2009) Drug Dev. Ind. Pharm. , vol.35 , pp. 49-56
    • Mulik, R.1    KulKarni, V.2    Murthy, R.S.R.3
  • 149
    • 45549095243 scopus 로고    scopus 로고
    • Chitosan gel as an in situ-forming scaffold for rat bone marrow mesenchymal stem cells in vivo
    • M.H. Cho, K.S. Kim, H.H. Ahn, M.S. Kim, S.H. Kim, G. Khang, B. Lee, H.B. Lee, Chitosan gel as an in situ-forming scaffold for rat bone marrow mesenchymal stem cells in vivo, Tissue Eng. Part A 14 (2008) 1099-1108.
    • (2008) Tissue Eng. Part A , vol.14 , pp. 1099-1108
    • Cho, M.H.1    Kim, K.S.2    Ahn, H.H.3    Kim, M.S.4    Kim, S.H.5    Khang, G.6    Lee, B.7    Lee, H.B.8
  • 150
    • 14944380686 scopus 로고    scopus 로고
    • Tissue engineering of cartilage using an injectable and adhesive chitosan-based cell-delivery vehicle
    • C. Hoemann, J. Sun, A. Légaré, M.D. McKee, M. Buschmann, Tissue engineering of cartilage using an injectable and adhesive chitosan-based cell-delivery vehicle, Osteoarthritis Cartilage 13 (2005) 318-329.
    • (2005) Osteoarthritis Cartilage , vol.13 , pp. 318-329
    • Hoemann, C.1    Sun, J.2    Légaré, A.3    McKee, M.D.4    Buschmann, M.5
  • 151
    • 75149147526 scopus 로고    scopus 로고
    • Biodegradation, biodistribution and toxicity of chitosan
    • T. Kean, M. Thanou, Biodegradation, biodistribution and toxicity of chitosan, Adv. Drug Deliv. Rev. 62 (2010) 3-11.
    • (2010) Adv. Drug Deliv. Rev. , vol.62 , pp. 3-11
    • Kean, T.1    Thanou, M.2
  • 152
    • 0036770156 scopus 로고    scopus 로고
    • Reporting degree of deacetylation values of chitosan: The influence of analytical methods
    • T.A. Khan, K.K. Peh, H.S. Ch'ng, Reporting degree of deacetylation values of chitosan: the influence of analytical methods, J. Pharm. Sci. 5 (2002) 205-212.
    • (2002) J. Pharm. Sci. , vol.5 , pp. 205-212
    • Khan, T.A.1    Peh, K.K.2    Ch'ng, H.S.3
  • 153
    • 38749109283 scopus 로고    scopus 로고
    • Characterizing molar mass distributions and molecule structures of different chitosans using asymmetrical flow field-flow fractionation combined with multi-angle light scattering
    • C. Augsten, K. Mäder, Characterizing molar mass distributions and molecule structures of different chitosans using asymmetrical flow field-flow fractionation combined with multi-angle light scattering, Int. J. Pharm. 351 (2008) 23-30.
    • (2008) Int. J. Pharm. , vol.351 , pp. 23-30
    • Augsten, C.1    Mäder, K.2
  • 154
    • 84862908086 scopus 로고    scopus 로고
    • Controlled thermal gelation of poly(ε-caprolactone)/poly(ethylene glycol) block copolymers by modifying cyclic ether pedant groups on poly(ε-caprolactone)
    • W. Wang, L. Chang, X. Li, Y. Wu, J. Xing, L. Deng, A. Dong, Controlled thermal gelation of poly(ε-caprolactone)/poly(ethylene glycol) block copolymers by modifying cyclic ether pedant groups on poly(ε-caprolactone), Soft Matter 8 (2012) 1575-1583.
    • (2012) Soft Matter , vol.8 , pp. 1575-1583
    • Wang, W.1    Chang, L.2    Li, X.3    Wu, Y.4    Xing, J.5    Deng, L.6    Dong, A.7


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