Do in situ forming PLG/NMP implants behave similar in vitro and in vivo? A non-invasive and quantitative EPR investigation on the mechanisms of the implant formation process

Journal of Controlled Release

Volumn 130, Issue 3, 2008, Pages 220-225

  Kempe, Sabine ^a   Metz, Hendrik ^a   Mäder, Karsten ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

EPR; ESR; In situ forming implants; In vitro in vivo correlation; Poly(lactide co glycolide)

Indexed keywords

ABS RESINS; ELECTRON RESONANCE; MECHANISMS; ORGANIC COMPOUNDS; ORGANIC SOLVENTS; PARAMAGNETIC RESONANCE; PARAMAGNETISM; POLYMER SOLUTIONS; POLYMERS; QUANTUM THEORY;

EPR; ESR; IN SITU FORMING IMPLANTS; IN VITRO-IN VIVO CORRELATION; POLY(LACTIDE-CO-GLYCOLIDE);

ELECTRON SPIN RESONANCE SPECTROSCOPY;

1 METHYL 2 PYRROLIDINONE; BENZOIC ACID DERIVATIVE; NITROXIDE; ORGANIC SOLVENT; PHOSPHATE; PIPERIDINE DERIVATIVE; POLYGLACTIN; POLYMER; TEMPOLBENZOATE; UNCLASSIFIED DRUG; WATER;

ANIMAL EXPERIMENT; ARTICLE; CHEMICAL REACTION KINETICS; CORRELATION ANALYSIS; DIFFUSION; ELECTRON SPIN RESONANCE; FEMALE; IMPLANT; MOUSE; NONHUMAN; PH MEASUREMENT; PRECIPITATION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SOLID;

ABSORBABLE IMPLANTS; ANIMALS; CYCLIC N-OXIDES; DRUG DELIVERY SYSTEMS; DRUG IMPLANTS; ELECTRON SPIN RESONANCE SPECTROSCOPY; FEMALE; IMPLANTS, EXPERIMENTAL; INJECTIONS, SUBCUTANEOUS; LACTIC ACID; MICE; MICE, INBRED BALB C; POLYGLYCOLIC ACID; PYRROLIDINONES; SOLVENTS; SPIN LABELS; WATER;

EID: 50949132230     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2008.06.006     Document Type: Article

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