A novel in situ forming drug delivery system for controlled parenteral drug delivery

International Journal of Pharmaceutics

Volumn 332, Issue 1-2, 2007, Pages 107-114

  Kranz, H ^a   Bodmeier, R ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

Biodegradable polymers; In situ; Microparticles; Peptide; Poly(d,l lactide); Poly(d,l lactide co glycolide); Sustained release depot

Indexed keywords

1 METHYL 2 PYRROLIDINONE; 2 PYRROLIDINONE; BUSERELIN ACETATE; DILTIAZEM; DIMETHYL SULFOXIDE; POLYGLACTIN; POLYLACTIDE; POLYMER;

ARTICLE; CONTROLLED DRUG RELEASE; DEGRADATION; DRUG DELIVERY SYSTEM; DRUG IMPLANT; DRUG SOLUBILITY; EVAPORATION; GEL PERMEATION CHROMATOGRAPHY; GRINDING; INTERMETHOD COMPARISON; MOLECULAR WEIGHT; PARTICLE SIZE; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPE;

BUSERELIN; CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; DILTIAZEM; DIMETHYL SULFOXIDE; DRUG CARRIERS; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; DRUG IMPLANTS; EMULSIONS; KINETICS; LACTIC ACID; MODELS, CHEMICAL; MOLECULAR WEIGHT; PARTICLE SIZE; PHARMACEUTICAL SOLUTIONS; POLYGLACTIN 910; POLYMERS; POROSITY; PYRROLIDINONES; SOLUBILITY; SOLVENTS; TECHNOLOGY, PHARMACEUTICAL;

EID: 33846859117     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2006.09.033     Document Type: Article

References (24)

1. Benoit J.P., Marchais H., Rolland H., and Vande-Velde V. Biodegradable microspheres: advances in production technology. In: Benita S. (Ed). Microencapsulation Methods and Industrial Applications (1996), Dekker, New York 35-72
2. Bodmeier, R., 1997. Verfahren zur in-situ Herstellung von Partikeln. Offenlegungsschrift DE Patent 197,24,784.
3. Brannon-Peppas L. Recent advances on the use of biodegradable microparticles and nanoparticles in controlled drug delivery. Int. J. Pharm. 116 (1995) 1-9
4. Brodbeck K.J., DesNoyer J.R., and McHugh A.J. Phase inversion dynamics of PLGA solutions related to drug delivery. Part II: The role of solution thermodynamics and bath-side mass transfer. J. Control. Release 62 (1999) 333-344
5. Dunn, R.L., English, J.P., Cowsar, D.R., Vanderbilt, D.P., 1990. Biodegradable in situ forming implants and methods of producing the same. US Patent 4,938,763.
6. Duysen E.G., Yewey G.L., Southard J.L., Dunn R.L., and Huffer W. Release of bioactive growth factors from the Atrigel delivery system in tibial defect and dermal wound models. Pharm. Res. 10 (1993) 83
7. El-Kharraz K., Dashevsky A., and Bodmeier R. Microparticles prepared by grinding of films. Proceedings of the Second World Meeting APGI/APV. Paris (1998) 555-556
8. Graham P.D., Brodbeck K.J., and McHugh A.J. Phase inversion dynamics of PLGA solutions related to drug delivery. J. Control. Release 58 (1999) 233-245
9. Hatefi A., and Amsden B. Biodegradable injectable in situ forming drug delivery systems. J. Control. Release 80 (2002) 9-28
10. Jain R.A., Rhodes C.T., Railkar A.M., Malick A.W., and Shah N.H. Controlled release of drugs from a novel injectable in situ formed biodegradable PLGA microsphere system. Pharm. Sci. Suppl. 1 (1998) 298
11. Jalil R., and Nixon J.R. Biodegradable poly(lactide acid) and poly(lactide-co-glycolide) microcapsules: problems associated with preparative techniques and release properties. J. Microencapsul. 7 (1990) 297-325
12. Kranz H., Brazeau G.A., Napaporn J., Martin R.L., Millard W., and Bodmeier R. Myotoxicity studies of injectable biodegradable in situ forming drug delivery systems. Int. J. Pharm. 212 (2001) 11-18
13. Kranz H., and Bodmeier R. A biodegradable in situ forming system for controlled drug release. Pharm. Sci. Suppl. 1 (1998) 414
14. Lambert W.J., and Peck K.D. Development of an in situ forming biodegradable poly-lactide-co-glycolide system for the controlled release of proteins. J. Control. Release 33 (1995) 189-195
15. Li S., and McCarthy S. Further investigations on the hydrolytic degradation of poly(d,l-lactide). Biomaterials 20 (1999) 35-44
16. Merck Index. An Encyclopedia of Chemicals, Drugs and Biologics (1996), Merck and Co. Inc., Whitehouse Station, NJ
17. Packhaeuser C.B., Schnieders J., Oster C.G., and Kissel T. In situ forming parenteral drug delivery systems: an overview. Eur. J. Pharm. Biopharm. 58 (2004) 445-455
18. Ravivarapu H.B., Moyer K.L., and Dunn R.L. Sustained suppression of pituitary-gonadal axis with an injectable, in situ forming implant of leuprolide acetate. J. Pharm. Sci. 89 (2000) 732-741
19. Rothen-Weinhold A., Besseghir K., De Zelicourt Y., and Gurny R. Development and evaluation in vivo of a long-term delivery system for vapreotide, a somatostatin analogue. J. Control. Release 52 (1998) 205-213
20. Rothen-Weinhold A., Besseghir K., Vuaridel E., Sublet E., Oudry N., Kubel F., and Gurny R. Injection-molding versus extrusion as manufacturing technique for the preparation of biodegradable implants. Eur. J. Pharm. Biopharm. 48 (1999) 113-121
21. Royals M.A., Fujita S.M., Yewey G.L., Rodriguez J., Schultheiss P.C., and Dunn R.L. Biocompatibility of a biodegradable in situ forming implant system in rhesus monkeys. J. Biomed. Mater. Res. 45 (1999) 231-239
22. Shah N.H., Railkar A.S., Chen F.C., Tarantino R., Kumar S., Murjani M., Palmer D., Infeld M.H., and Malick A.W. A biodegradable injectable implant for delivering micro and macromolecules using poly(lactic-co-glycolic) acid (PLGA) copolymers. J. Control. Release 27 (1993) 139-147
23. Wang L., Kleiner L., and Venkatraman S. Structure formation in injectable poly(lactide-co-glycolide) depots. J. Control. Release 90 (2003) 345-354
24. Zuidema J., Kadir F., Titulaer H.A.C., and Oussoren C. Release and absorption rates of intramuscularly and subcutaneously injected pharmaceuticals (II). Int. J. Pharm. 105 (1994) 189-207