Pulsatile drug release control using hydrogels

Advanced Drug Delivery Reviews

Volumn 54, Issue 1, 2002, Pages 53-77

  Kikuchi, Akihiko ^a   Okano, Teruo ^a  

^a TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

Author keywords

Hydrogel; Intelligent materials; Lag time control; Pulsed drug release; Regulated drug release; Release onset time; Stimuli responsive; Time programmed drug release

Indexed keywords

DRUG PRODUCTS; MICELLES; POLYAMIDES;

DRUG DELIVERY DEVICES;

HYDROGELS;

ANTIINFLAMMATORY AGENT; DEXTRAN; DOXORUBICIN; HYDROCORTISONE; M PROTEIN; PEPTIDE; POLY(N ISOPROPYLACRYLAMIDE); POLYLACTIC ACID;

DRUG ACTIVITY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; HYDROGEL; MICELLE; PRIORITY JOURNAL; PULSATILE DRUG RELEASE; REVIEW; THERMAL STIMULATION;

EID: 0037122787     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-409X(01)00243-5     Document Type: Article

References (96)

1. Formulation and delivery of proteins and peptides
2. Pulsatile patterns in hormone secretion
3. A strategy for oscillatory drug release. General scheme and simplified theory
4. Drug delivery using biodegradable microspheres
5. Biodegradable microspheres in drug delivery
6. Pulsatile transdermal delivery of LHRH using electroporation: Drug delivery and skin toxicology
7. Preparation and evaluation of a time-controlled release capsule made of ethylcellulose for colon delivery of drugs
8. Pulsed FSH release from an implantable capsule system
9. The TIME CLOCK system: A new oral dosage form for fast and complete of drug after a predetermined lag time
10. Sigmoidal-releasing system (SRS) as a novel oral controlled release formulation
11. Design and preparation of pulsatile release tablet as a new oral drug
12. Absorption of diltiazem in beagle dog from pulsatile release tablet
13. An organic acid-induced sigmoidal release system for oral controlled-release
14. Evaluation of low viscosity HPMC as retarding coating material in the preparation of a time-based oral colon specific delivery system
15. Enzymatically activated microencapsulated liposomes can provide pulsatile drug release
16. Optimization of a microencapsulated liposome system for enzymatically controlled release of macromolecules
17. Development of enzymatically degradable protective coatings for use in triggered drug delivery systems: Derivatized starch hydrogels
18. The effect of lipase on the release of naltrexone from triglyceride-coated cellulose acetate phthalate microspheres
19. Pulsatile peptide release from multi-layered hydrogel formulations consisting of poly(ethylene glycol)-grafted and ungrafted dextrans
20. Hyaluronic acid grafted with poly(ethylene glycol) as a novel peptide formulation
21. 'On-off' thermocontrol of solute transport. I. Temperature dependence of swelling of N-isopropylacrylamide networks modified with hydrophobic components in water
22. 'On-off' thermocontrol of solute transport. II. Solute release from thermosensitive hydrogels
23. Synthesis and application of thermally reversible heterogels for drug delivery
24. Thermally on-off switching polymers for drug permeation and release
25. Kinetics of discontinuous volume-phase transition of gels
26. Preparation and mechanical properties of thermo-responsive fibrous hydrogels made from poly(vinyl methyl ethers)
27. Synthesis of fast response, temperature-sensitive poly(N-isopropylacrylamide) gel
28. Synthesis and characterization of thermally reversible macroporous poly(N-isopropylacrylamide) hydrogels
29. Fast responsive poly(N-isopropylacrylamide) hydrogels prepared by γ-ray irradiation
30. Synthesis of superporous hydrogels: Hydrogels with fast swelling and superabsorbent properties
31. Comb-type grafted hydrogels with rapid temperature responses
32. Influence of freely mobile grafted chain length on dynamic properties of comb-type grafted poly(N-isopropylacrylamide) hydrogels
33. Fast swelling/deswelling kinetics of comb-type grafted poly(N-isopropylacrylamide) hydrogels
34. Rapid deswelling response of poly(N-isopropylacrylamide) hydrogels by the formation of water release channels using poly(ethylene oxide) graft chains
35. Block copolymer micelles for drug delivery: Design, characterization and biological significance
36. A new concept for macromolecular therapeutics in cancer chemotherapy: Mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs
37. Thermo-responsive drug delivery from polymeric micelles constructed using block copolymers of poly(N-isopropylacrylamide) and poly(butyl methacrylate)
38. Inner core segment design for drug delivery control of thermo-responsive polymeric micelles
39. Preparation and characterization of thermally responsive block copolymer micelles comprising poly(N-isopropylacrylamide-β-DL-lactide)
40. Control of adriamycin cytotoxic activity using thermally responsive polymeric micelles composed of poly(N-isopropylacrylamide-co-N,N-dimethylacrylamide)-β-poly(D,L- lactide)
41. Control of insulin permeation through a polymer membrane with responsive function for glucose
42. Glucose-sensitive membranes containing glucose oxidase: Activity, swelling, and permeability studies
43. Glucose sensitive membranes for controlled delivery of insulin: Insulin transport studies
44. Self-regulated glycosylated insulin delivery
45. A microcapsule self-regulating delivery system for insulin
46. Characterization of protein release through glucose-sensitive hydrogel membranes
47. Characterization of glucose dependent gel-sol phase transition of the polymeric glucose-concanavalin A hydrogel system
48. Effect of the incorporation of amino groups in a glucose-responsive polymer complex having phenylboronic acid moieties
49. Glucose-responsive complex formation between poly(vinyl alcohol) and poly(N-vinyl-2-pyrrolidone) with pendant phenylboronic acid moieties
50. A novel drug delivery system utilizing a glucose responsive polymer complex between poly(vinyl alcohol) and poly(N-vinyl-2-pyrrolidone) with a phenylboronic acid moiety
51. Preparation and characterization of a glucose-responsive insulin-releasing polymer device
52. A self-regulated insulin delivery system using boronic acid gel
53. Amine containing phenylboronic acid gel for glucose-responsive insulin release under physiological pH
54. Totally synthetic polymer gels responding to external glucose concentration: Their preparation and application to on-off regulation of insulin release
55. Inflammation responsive degradation of crosslinked hyaluronic acid gels
56. Regulated release of drug microspheres from inflammation responsive degradable matrices of crosslinked hyaluronic acid
57. A reversibly antigen-responsive hydrogel
58. Preparation of an antigen-sensitive hydrogel using antigen-antibody bindings
59. Electronically assisted drug delivery: An overview
60. Conversion of chemical into mechanical energy by synthetic polymer gels (chemomechanical system)
61. Stimuli sensitive polymers for drug delivery systems
62. Electrically erodible polymer gel for controlled release of drugs
63. Drug release from electric current sensitive polymers
64. Heparin release from polymer complex
65. Feedback controlled drug delivery using an electro-diffusion pump
66. Effect of ultrasound on transdermal drug delivery to rats and guinea pigs
67. Ultrasound for controlled delivery of therapeutics
68. Ultrasonically enhanced transdermal drug delivery. Experimental approaches to elucidate the mechanism
69. Ultrasound-mediated transdermal protein delivery
70. Transdermal drug delivery using low-frequency sonophoresis
71. The use of ultrasound as an enhancer for transcutaneous drug delivery: Phonophoresis
72. Synergistic effect of enhancers for transdermal drug delivery
73. Ultrasound-enhanced polymer degradation and release of incorporated substances
74. An investigation of the effects of ultrasound on degradable polyanhydride matrices
75. Performed porous microspheres for controlled and pulsed release of macromolecules
76. Surface modification of polymers with self-assembled molecular structures: Multitechnique surface characterization
77. Self-assembled molecular structures as ultrasonically-responsive barrier membranes for pulsatile drug delivery
78. Regulation of drug release from polymer matrices by oscillating magnetic fields
79. Magnetically controlled release systems: Effect of polymer composition
80. Magnetically enhanced insulin release in diabetic rats
81. Biological interactions between polysaccharides and divalent cations: The egg-box model
82. Molecular interactions in polysaccharide gelation
83. Molecular basis for some physical properties of alginates in gel state
84. Alginates
85. Microencapsulated islets as bioartificial endocrine pancreas
86. Microencapsulation of living cells - A long-term delivery system
87. Prolonged reversal of diabetic state in NOD mice by xenografts of microencapsulated rat islets
88. The controlled release of blue dextran from alginate beads
89. 2+-alginate gel dissolution on release of dextran with different molecular weights
90. Pulsed dextran release from calcium-alginate gel beads
91. Colorimetric determination of alginates and fragments thereof as the 2-nitrophenylhydrazides
92. Acid-induced and calcium-induced gelation of alginic acid: Bead formation and pH-dependent swelling