Non-invasive in vivo characterization of release processes in biodegradable polymers by low-frequency electron paramagnetic resonance spectroscopy

Biomaterials

Volumn 17, Issue 4, 1996, Pages 457-461

  Mader K ^a   Gallez, B ^a,b   Liu, K J ^a   Swartz, H M ^a  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

^b UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

Drug delivery; Electron paramagnetic resonance spectroscopy; pH measurements; Poly(D,L lactide co glycolide)

Indexed keywords

BIODEGRADATION; CHARACTERIZATION; DRUG THERAPY; FREE RADICALS; HYDROLYSIS; PARAMAGNETIC RESONANCE; PH; SOLUBILITY; VISCOSITY;

BIODEGRADABLE POLYMERS; DRUG DELIVERY SYSTEMS; DRUG SOLUBILITY; DRUG STABILITY; LOW FREQUENCY ELECTRON PARAMAGNETIC RESONANCE SPECTROSCOPY; MICROVISCOSITY; NONINVASIVE IN VIVO CHARACTERIZATION;

ORGANIC POLYMERS;

POLYGLACTIN; POLYMER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOAVAILABILITY; BIODEGRADATION; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG SOLUBILITY; DRUG STABILITY; ELECTRON SPIN RESONANCE; HYDROLYSIS; IMPLANTATION; MOUSE; NONHUMAN; PH; PHARMACOKINETICS; PRIORITY JOURNAL; TIME; VISCOSITY;

ANIMALIA;

EID: 0041718431     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/0142-9612(96)89664-5     Document Type: Article

References (25)

1. El Nokaly MA, Piatt DM, Charpentier DA, eds. Polymeric Delivery Systems: Properties and Applications. ACS Symposium Series 520. Washington, DC: American Chemical Society, 1993.
2. Dunn RL, Ottenbrite RM, eds. Polymeric Drugs and Drug Delivery Systems. ACS Symposium Series 469. Washington, DC: American Chemical Society, 1991.
3. Ottenbrite RM, ed. Polymeric Drugs and Drug Administration. ACS Symposium Series 545. Washington, DC: American Chemical Society, 1994.
4. Robinson JR, Lee VHL, eds. Controlled Drug Delivery. Fundamentals and Applications. New York, NY: Marcel Dekker, 1987.
5. Tamada JA, Langer R. Erosion kinetics of hydrolytically degradable polymers. Proc Natl Acad Sci USA 1993; 90: 552-556.
6. Therin M, Christel P, Li S, Garreau H, Vert M. In vivo degradation of massive poly(alpha-hydroxy acids): validation of in vitro findings. Biomaterials 1992; 13: 594-600.
7. Domb AJ, Rock M, Schwartz J et al. Metabolic disposition and elimination studies of a radiolabelled biodegradable polymeric implant in the rat brain. Biomaterials 1994; 15: 681-688.
8. Mäder K, Stösser R, Borchert HH, Mank R, Nerlich B. ESR-untersuchungen zur wasserpenetration in polymerfolien und mikropartikeln auf der basis von biologisch abbaubaren polyestern. Pharmazie 1991; 46: 342-345.
9. Mäder K, Borchert HH, Stösser R, Groth N, Herrling T. Modelluntersuchungen zur lokalization und mobilität von arzneitstoffen in polymerfolien mit hilfe der ESR-tomographie. Pharmazie 1991; 46: 439-442.
10. Schmitt EA, Flanagan DR, Linhardt RJ. Degradation and release properties of pellets fabricated from three commercial poly(D,L-lactide-co-glycolide) biodegradable polymers. J Pharm Sci 1993; 82: 326-329.
11. Eaton GR, Eaton SS, Ohno K, eds. EPR Imaging and in vivo EPR. Boca Raton, FL: CRC Press, 1991.
12. Nilges MJ, Walczak T, Swartz HM. 1 Ghz in vivo ESR spectrometer operating with a surface probe. Phys Med 1989; 5: 195-201.
13. Bacic G, Nilges MJ, Walczak T, Swartz HM. The use of in vivo EPR to follow the pharmacokinetics of drugs. Phys Med 1989; 5: 307-313.
14. Khramtsov VV, Weiner LM, Grigoriev IA, Volodarsky LB. Proton exchange in stable nitroxyl radicals. EPR study of aqueous solutions. Chem Phys Lett 1982; 91: 69-72.
15. Khramtsov VV, Weiner LM. In Volodarsky LB, ed. Imidazoline Nitroxides, Vol. 2. Boca Raton, FL: CRC Press, 1988: 37-80.
16. Kroll C, Mäder K, Stösser R, Borchert HH. Eur J Pharm Sci (in press)
17. Domb A, Turovsky R, Nudelman R. Chemical interactions between drugs containing reactive amines with hydrolyzable insoluble biopolymers in aqueous solutions. Pharm Res 1994; 11: 865-868.
18. Göpferich A, Langer R. The effects of erosion on the microstructure of biodegradable polymers. J Polym Sci 1993; 31: 2445-2458.
19. Wu MP, Tamada JA, Brem H, Langer R. In vivo versus in vitro degradation of controlled release polymers for intracranial surgical therapy. J Biomed Mater Res 1994; 28: 387-395.
20. Mikos AG, Lyman MD, Freed LE, Langer R. Wetting of poly(L-lactic acid) and poly(DL-lactic-co-glycolic acid) foams for tissue culture. Biomaterials 1994; 15: 55-58.
21. Merck Index, 11th edn. Rahway, NJ: Merck & Co., 1989.
22. Cohen S, Yoshioka T, Lucarelli M, Hwang LH, Langer R. Controlled delivery systems for proteins based on poly(lactic/glycolic acid) microspheres. Pharm Res 1991; 8: 713-720.
23. Domb A, Bogdansky S. Controlled delivery of water-soluble and hydrolytically unstable anticancer drugs from polymeric implants. Polym Prepr 1991; 32: 219-220.
24. Lee KC, Lee YJ, Song HM, Chun CJ, DeLuca PP. Degradation of synthetic salmon calcitonin in aqueous solution. Pharm Res 1992; 9: 1521-1523.
25. Millest AJ, Evans JR, Young JJ, Johnstone D. Calcif Tissue Int 1993; 52: 361-364.