Biocompatibility and gelation of chitosan-glycerol phosphate hydrogels

Journal of Biomedical Materials Research - Part A

Volumn 86, Issue 3, 2008, Pages 824-832

  Ahmadi, Raheleh ^a   De Bruijn, Joost D ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Bone tissue engineering; Chitosan; Glycerol phosphate; Injectable binder; Mesenchymal stem cells

Indexed keywords

BIOCOMPATIBILITY; BIOTECHNOLOGY; CELL CULTURE; CELL PROLIFERATION; CELLS; CHITIN; CHITOSAN; COAGULATION; COLLOIDS; CYTOLOGY; ENCAPSULATION; GELATION; GELS; GLYCEROL; HYDROGELS; TECHNOLOGY; TISSUE ENGINEERING;

BODY TEMPERATURES; BONE MARROW; BONE TISSUE ENGINEERING; CELL ENCAPSULATIONS; GELATION TIME; GLYCEROL PHOSPHATE; HYDROGEL; INJECTABLE BINDER; MESENCHYMAL STEM CELLS; OSMOLALITY; PHYSIOLOGICAL RANGE; PROLIFERATION RATE; SOL-GEL TRANSITIONS; WITH OR WITHOUT;

AMINES;

CHITOSAN; GLYCEROPHOSPHATE;

ANIMAL CELL; ARTICLE; BIOCOMPATIBILITY; BODY TEMPERATURE; BONE MARROW CELL; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; GELATION; GOAT; HEAT SENSITIVITY; HYDROGEL; MESENCHYME CELL; NONHUMAN; OSMOLALITY;

ANIMALS; BIOCOMPATIBLE MATERIALS; CELL PROLIFERATION; CHITOSAN; CULTURE MEDIA; GLYCEROPHOSPHATES; GOATS; HYDROGELS; HYDROGEN-ION CONCENTRATION; MATERIALS TESTING; MESENCHYMAL STEM CELLS; OSMOLAR CONCENTRATION; SOLUTIONS; TIME FACTORS;

EID: 49149096671     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.31676     Document Type: Article

References (33)

1. Chen G, Hoffman AS. Graft copolymers that exhibit temperature-induced phase transitions over a wide range of pH. Nature 1995;373:49-52.
2. Jeong B, Gutowska A. Lessons from nature: Stimuli-responsive polymers and their biomedical applications. Trends Biotechnol 2002;20:305-311.
3. Johnston TP, Miller SC. Inulin disposition following intramuscular administration of an inulin/poloxamer gel matrix. J Parenteral Sci Technol 1989;43:279-286.
4. Johnston TP, Punjabi MA, Froelich CJ. Sustained delivery of interleukin-2 from a poloxamer 407 gel matrix following intraperitoneal injection in mice. Pharm Res 1992;9:425-434.
5. Pec EA, Wout ZG, Johnston TP. Biological activity of urease formulated in poloxamer 407 after intraperitoneal injection in the rat. J Pharm Sci 1992;81:626-630.
6. Bhardwaj R, Blanchard J. Controlled-release delivery system for the α-MSH analog melanotan-I using poloxamer 407. J Pharm Sci 1996;85:915-919.
7. Pelletier A, Lemire I, Sygusch J. Chitin/chitosan transformation by thermo-mechano-chemical treatment including characterization by enzymatic depolymerization. Biotechnol Bioeng 1990;36:310-315.
8. Khor E, Lim LY. Implantable applications of chitin and chitosan. Biomaterials 2003;24:2339-2349.
9. Montembault A, Viton C, Domard A. Rheometric study of the gelation of chitosan in a hydroalcoholic medium. Biomaterials 2005;26:1633-1643.
10. Hirano S, Noishiki Y. The blood compatibility of chitosan and N-acylchitosans. J Biomed Mater Res 1985;19:413-417.
11. Muzzarelli RA. Human enzymatic activities related to the therapeutic administration of chitin derivatives. Cell Mol Life Sci 1997;53:131-140.
12. Ueno H, Mori T, Fujinaga T. Topical formulations and wound healing applications of chitosan. Adv Drug Deliv Rev 2001;52:105-115.
13. Felt O, Carrel A, Baehni P, Buri P, Gurny R. Chitosan as tear substitute: A wetting agent endowed with antimicrobial efficacy. J Ocul Pharmacol Ther 2000;16:261-270.
14. Li Z, Ramay HR, Hauch KD, Xiao D, Zhang M. Chitosan-alginate hybrid scaffolds for bone tissue engineering. Biomaterials 2005;26:3919-3928.
15. Suh JK, Matthew HW. Application of chitosan-based polysaccharide biomaterials in cartilage tissue engineering: A review. Biomaterials 2000;21:2589-2598.
16. Hutmacher DW, Goh JC, Teoh SH. An introduction to biodegradable materials for tissue engineering applications. Ann Acad Med Singapore 2001;30:183-191.
17. Chenite A, Chaput C, Wang D, Combes C, Buschmann MD, Hoemann CD, Leroux JC, Atkinson BL, Binette F, Selmani A. Novel injectable neutral solutions of chitosan form biodegradable gels in situ. Biomaterials 2000;21:2155-2161.
18. Ruel-Gariepy E, Chenite A, Chaput C, Guirguis S, Leroux J. Characterization of thermosensitive chitosan gels for the sustained delivery of drugs. Int J Pharm 2000;203:89-98.
19. Molinaro G, Leroux JC, Damas J, Adam A. Biocompatibility of thermosensitive chitosan-based hydrogels: An in vivo experimental approach to injectable biomaterials. Biomaterials 2002;23:2717-2722.
20. Cho J, Heuzey MC, Begin A, Carreau PJ. Chitosan and glycerophosphate concentration dependence of solution behaviour and gel point using small amplitude oscillatory rheometry. Food Hydrocoll 2006;20:936-945.
21. Zan J, Zhu D, Tan F, Jiang G, Lin Y, Ding F. Preparation of thermosensitive chitosan formulations containing 5-fluorouracil/poly-3- hydroxybutyrate microparticles used as injectable drug delivery system. Chin J Chem Eng 2006;14:235-241.
22. Wu J, Su Z, Ma GH. A thermo- and pH-sensitive hydrogel composed of quaternized chitosan/glycerophosphate. Int J Pharm 2006;315:1-11.
23. Kruyt MC, Dhert WJ, Oner C, van Blitterswijk CA, Verbout AJ, de Bruijn JD. Optimization of bone-tissue engineering in goats. J Biomed Mater Res B Appl Biomater 2004;69:113-120.
24. Lawson MA, Barralet JE, Wang L, Shelton RM, Triffitt JT. Adhesion and growth of bone marrow stromal cells on modified alginate hydrogels. Tissue Eng 2004;10:1480-1491.
25. Tung CYM, Dynes PJ. Relationship between visco-elastic properties and gelation in thermosetting systems. J Appl Polym Sci 1982;27:569-574.
26. Luginbuehl V, Wenk E, Koch A, Gander B, Merkle HP, Meinel L. Insulin-like growth factor I-releasing alginate-tricalcium-phosphate composites for bone regeneration. Pharm Res 2005;22:940-950.
27. Ganji F, Abdekhodaie MJ, Ramazani A. Gelation time and degradation rate of chitosan-based injectable hydrogel. J Sol-Gel Sci Technol 2007;42:47-53.
28. Chenite A, Buschmann M, Wang D, Chaput C, Kandani N. Rheological characterisation of thermogelling chitosan/glycerol-phosphate solutions. Carbohydr Polym 2001;46:39-47.
29. Chenite A, Chaput C, Combes C, Selmani A, Fayrouze J. Temperature-controlled pH-dependent formation of ionic polysaccharide gels. US Pat 6,344,488; 2002.
30. Davies A, Blakeley A, Kidd C. Human Physiology. Edinburgh: Churchill Livingstone; 2001; ISBN 0443 045593. 762 p.
31. Howling GI, Dettmar PW, Goddard PA, Hampson FC, Dornish M, Wood EJ. The effect of chitin and chitosan on the proliferation of human skin fibroblasts and keratinocytes in vitro. Biomaterials 2001;22:2959-2966.
32. Mori T, Okumura M, Matsuura M, Ueno K, Tokura S, Okamoto Y, Minami S, Fujinaga T. Effects of chitin and its derivatives on the proliferation and cytokine production of fibroblasts in vitro. Biomaterials 1997;18:947-951.
33. Inui H, Tsujikubo M, Hirano S. Low molecular weight chitosan stimulation of mitogenic response to platelet-derived growth factor in vascular smooth muscle cells. Biosci Biotechnol Biochem 1995;59:2111-2114.