In vitro and in vivo drug release from a novel in situ forming drug delivery system

Pharmaceutical Research

Volumn 25, Issue 6, 2008, Pages 1347-1354

  Kranz, Heiko ^a,c   Yilmaz, Erol ^a   Brazeau, Gayle A ^b   Bodmeier, Roland ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b UNIVERSITY OF FLORIDA   (United States)

^c BAYER PHARMA AG   (Germany)

Author keywords

Biodegradable polymers; In situ; Local anesthetic; Microparticles; Sustained release depot

Indexed keywords

2 PYRROLIDINONE; BUPIVACAINE; POLYGLACTIN; POLYMER; SOLUPHOR;

ARTICLE; BIODEGRADABLE IMPLANT; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; DRUG SYNTHESIS; IMPLANT; IN SITU FORMING MICROPARTICLE SYSTEM; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; SUSTAINED DRUG RELEASE;

ANIMALS; BUPIVACAINE; CHEMISTRY, PHARMACEUTICAL; DRUG DELIVERY SYSTEMS; LACTIC ACID; MALE; POLYGLYCOLIC ACID; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY;

EID: 43049097877     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-007-9478-y     Document Type: Article

References (30)

1. 1. D. B. Masters C. B. Berde S. K. Dutta C. T. Griggs D. Hu W. Kupsky R. Langer 1993 Prolonged regional nerve blockade by controlled release of local anesthetic from a biodegradable polymer matrix Anesthesiology 79 340 346 8342843 10.1097/00000542-199308000-00020 1:CAS:528:DyaK3sXmsFKgtbk%3D D. B. Masters, C. B. Berde, S. K. Dutta, C. T. Griggs, D. Hu, W. Kupsky, and R. Langer. Prolonged regional nerve blockade by controlled release of local anesthetic from a biodegradable polymer matrix. Anesthesiology 79:340–346 (1993).
2. 2. M. J. Cousins P. O. Bridenbaugh 1988 Neural blockade in clinical anesthesia and management of pain Lippincott Williams & Wilkins Philadelphia 719 735 M. J. Cousins and P. O. Bridenbaugh. Neural blockade in clinical anesthesia and management of pain. Lippincott Williams & Wilkins, Philadelphia, 1988, pp. 719–735.
3. 3. J. Curley J. Castillo J. Hotz M. Uezono S. Hernandez J. O. Lim J. Tigner M. Chasin R. Langer C. Berde 1996 Prolonged regional nerve blockade Anesthesiology 84 1401 1410 8669682 10.1097/00000542-199606000-00017 1:CAS:528:DyaK28Xkt1ems7c%3D J. Curley, J. Castillo, J. Hotz, M. Uezono, S. Hernandez, J. O. Lim, J. Tigner, M. Chasin, R. Langer, and C. Berde. Prolonged regional nerve blockade. Anesthesiology 84:1401–1410 (1996).
4. 4. L. Bonhomme D. Benhamou T. Beugre 1992 Slow release effect of pH-adjusted bupivacaine: in vitro demonstration Int. J. Pharm. 84 33 37 10.1016/0378-5173(92)90212-K 1:CAS:528:DyaK38XlvFygtb4%3D L. Bonhomme, D. Benhamou, and T. Beugre. Slow release effect of pH-adjusted bupivacaine: in vitro demonstration. Int. J. Pharm. 84:33–37 (1992).
5. 5. J. R. Mhando A. Li Wan Po 1990 Controlled release of local anaesthetic agents from liquid–solid emulsion gels Int. J. Pharm. 62 249 258 10.1016/0378-5173(90)90238-Y 1:CAS:528:DyaK3cXlslyitLY%3D J. R. Mhando, and A. Li Wan Po. Controlled release of local anesthetic agents from liquid–solid emulsion gels. Int. J. Pharm. 62:249–258 (1990).
6. 6. L. Langerman J. G. Gilbert M. Zakowski E. Golomb S. Ramanathan H. Turndorf 1992 Prolongation of epidural anesthesia using a lipid drug carrier with procaine, lidocaine, and tetracaine Anesth. Analg. 75 900 905 1443709 10.1213/00000539-199212000-00007 1:CAS:528:DyaK3sXoslGltw%3D%3D L. Langerman, J. G. Gilbert, M. Zakowski, E. Golomb, S. Ramanathan, and H. Turndorf. Prolongation of epidural anesthesia using a lipid drug carrier with procaine, lidocaine, and tetracaine. Anesth. Analg. 75:900–905 (1992).
7. 7. A. Gesztes M. Mezei 1988 Topical anesthesia of the skin by liposome encapsulated tetracaine Anesth. Analg. 67 1079 1081 3189897 1:STN:280:DyaL1M%2FkvVChtQ%3D%3D 10.1213/00000539-198867110-00010 A. Gesztes, and M. Mezei. Topical anesthesia of the skin by liposome encapsulated tetracaine. Anesth. Analg. 67:1079–1081 (1988).
8. 8. D. B. Masters C. B. Berde S. Dutta T. Turek R. Langer 1993 Sustained local anesthetic release from bioerodible polymer matrices: a potential method for prolonged regional anesthesia Pharm. Res. 10 1527 1532 8272418 10.1023/A:1018995913972 1:CAS:528:DyaK2cXhsVOntw%3D%3D D. B. Masters, C. B. Berde, S. Dutta, T. Turek, and R. Langer. Sustained local anesthetic release from bioerodible polymer matrices: a potential method for prolonged regional anesthesia. Pharm. Res. 10:1527–1532 (1993).
9. 9. J. P. Estebe P. Le Corre Y. Mallédant F. Chevanne R. Leverge 1995 Prolongation of spinal anesthesia with bupivacaine-loaded (d, l-lactide) microspheres Anesth. Analg. 81 99 103 7598291 10.1097/00000539-199507000-00020 1:STN:280:DyaK2MzitFGjsQ%3D%3D J. P. Estebe, P. Le Corre, Y. Mallédant, F. Chevanne, and R. Leverge. Prolongation of spinal anesthesia with bupivacaine-loaded (d, l-lactide) microspheres. Anesth. Analg. 81:99–103 (1995).
10. 10. J. M. Malinovsky J. M. Bernard P. Le Corre J. B. Dumand J. Y. Lepage R. Le Verge R. Souron 1995 Motor and blood pressure effects of epidural sustained-release bupivacaine from polymer microspheres: a dose-response study in rabbits Anesth. Analg. 81 519 524 7653815 10.1097/00000539-199509000-00016 1:CAS:528:DyaK2MXos1Gmtbs%3D J. M. Malinovsky, J. M. Bernard, P. Le Corre, J. B. Dumand, J. Y. Lepage, R. Le Verge, and R. Souron. Motor and blood pressure effects of epidural sustained-release bupivacaine from polymer microspheres: a dose-response study in rabbits. Anesth. Analg. 81:519–524 (1995).
11. 11. R. Jalil J. R. Nixon 1990 Biodegradable poly(lactide acid) and poly(lactide-co-glycolide) microcapsules: problems associated with preparative techniques and release properties J. Microencapsulation 7 297 325 2200861 10.3109/02652049009021842 1:CAS:528:DyaK3cXltlygtLo%3D R. Jalil, and J. R. Nixon. Biodegradable poly(lactide acid) and poly(lactide-co-glycolide) microcapsules: problems associated with preparative techniques and release properties. J. Microencapsulation 7:297–325 (1990).
12. 12. R. L. Dunn, J. P. English, D. R. Cowsar, and D. P. Vanderbilt. Biodegradable in situ forming implants and methods of producing the same. US Patent 4,938,763 (1990).
13. 13. N. H. Shah A. S. Railkar F. C. Chen R. Tarantino S. Kumar M. Murjani D. Palmer H. Infeld A. W. Malick 1993 A biodegradable injectable implant for delivering micro and macromolecules using poly(lactic-co-glycolic) acid (PLGA) copolymers J. Control. Release 27 139 147 10.1016/0168-3659(93)90217-S 1:CAS:528:DyaK2cXjvVSitQ%3D%3D N. H. Shah, A. S. Railkar, F. C. Chen, R. Tarantino, S. Kumar, M. Murjani, D. Palmer, M. H. Infeld, and A. W. Malick. A biodegradable injectable implant for delivering micro and macromolecules using poly(lactic-co-glycolic) acid (PLGA) copolymers. J. Control. Release 27:139–147 (1993).
14. 14. P. D. Graham K. J. Brodbeck A. J. McHugh 1999 Phase inversion dynamics of PLGA solutions related to drug delivery J. Control. Release 58 233 245 10053196 10.1016/S0168-3659(98)00158-8 1:CAS:528:DyaK1MXhsVentL8%3D P. D. Graham, K. J. Brodbeck, and A. J. McHugh. Phase inversion dynamics of PLGA solutions related to drug delivery. J. Control. Release 58:233–245 (1999).
15. 15. E. G. Duysen G. L. Yewey J. L. Southard R. L. Dunn W. Huffer 1993 Release of bioactive growth factors from the Atrigel delivery system in tibial defect and dermal wound models Pharm. Res. 10 83 E. G. Duysen, G. L. Yewey, J. L. Southard, R. L. Dunn, and W. Huffer. Release of bioactive growth factors from the Atrigel delivery system in tibial defect and dermal wound models. Pharm. Res. 10:83 (1993).
16. 16. A. Hatefi B. Amsden 2002 Biodegradable injectable in situ forming drug delivery systems J. Control. Release 80 9 28 11943384 10.1016/S0168-3659(02)00008-1 1:CAS:528:DC%2BD38XisFyrs7s%3D A. Hatefi, and B. Amsden. Biodegradable injectable in situ forming drug delivery systems. J. Control. Release 80:9–28 (2002).
17. 17. C. B. Packhaeuser J. Schnieders C. G. Oster T. Kissel 2004 In situ forming parenteral drug delivery systems: an overview Eur. J. Pharm. Biopharm. 58 445 455 15296966 10.1016/j.ejpb.2004.03.003 1:CAS:528:DC%2BD2cXmsVGnsL0%3D C. B. Packhaeuser, J. Schnieders, C. G. Oster, and T. Kissel. In situ forming parenteral drug delivery systems: an overview. Eur. J. Pharm. Biopharm. 58:445–455 (2004).
18. 18. D. Steinberg M. Friedman 1999 Dental drug delivery devices: local and sustained release applications Crit. Rev. Therapeutic Drug Carrier Systems 16 425 459 1:CAS:528:DC%2BD3cXjs1Sjsw%3D%3D D. Steinberg and M. Friedman. Dental drug delivery devices: local and sustained release applications. Crit. Rev. Therapeutic Drug Carrier Systems 16:425–459 (1999).
19. 19. H. Kranz R. Bodmeier 1998 A biodegradable in situ forming system for controlled drug release PharmSci. Supplement 1 414 H. Kranz and R. Bodmeier. A biodegradable in situ forming system for controlled drug release. PharmSci. Supplement 1:414 (1998).
20. 20. H. Kranz G. A. Brazeau J. Napaporn R. L. Martin W. Millard R. Bodmeier 2001 Myotoxicity studies of injectable biodegradable in situ forming drug delivery systems Int. J. Pharm. 212 11 18 11165816 10.1016/S0378-5173(00)00568-8 1:CAS:528:DC%2BD3MXovFWgtQ%3D%3D H. Kranz, G. A. Brazeau, J. Napaporn, R. L. Martin, W. Millard, and R. Bodmeier. Myotoxicity studies of injectable biodegradable in situ forming drug delivery systems. Int. J. Pharm. 212:11–18 (2001).
21. 21. R. Bodmeier. Multiphase system. Int. Patent Application WO 98/55100 (1998).
22. 22. W. J. Millard J. J. Martin J. Audet S. M. Sagar J. B. Martin 1982 Evidence that reduced growth hormone secretion observed in monosodium glutamate-treated rats is due to a deficiency in growth hormone-releasing factor Endocrinology 110 540 6120072 1:CAS:528:DyaL38XhtFKht7k%3D 10.1210/endo-110-2-540 W. J. Millard, J. J. Martin, J. Audet, S. M. Sagar, and J. B. Martin. Evidence that reduced growth hormone secretion observed in monosodium glutamate-treated rats is due to a deficiency in growth hormone-releasing factor. Endocrinology 110:540 (1982).
23. 23. P. Le Corre P. Le Guevello V. Gajan F. Chevanne R. Le Verge 1994 Preparation and characterization of bupivacaine loaded polylactide and poly-co-glycolide microspheres Int. J. Pharm. 107 41 49 10.1016/0378-5173(94)90300-X P. Le Corre, P. Le Guevello, V. Gajan, F. Chevanne, and R. Le Verge. Preparation and characterization of bupivacaine loaded polylactide and poly-co-glycolide microspheres. Int. J. Pharm. 107:41–49 (1994).
24. 24. X. J. Xu Z. Wiesenfeld-Hallin J. Hughes D. C. Horwell T. Hökfelt 1992 CI 1988, a selective antagonist of cholecystokinin B receptors, prevents morphine tolerance in the rat J. Pharmacol. 105 591 596 1:CAS:528:DyaK38XitVyiur8%3D X. J. Xu, Z. Wiesenfeld-Hallin, J. Hughes, D. C. Horwell, and T. Hökfelt. CI 1988, a selective antagonist of cholecystokinin B receptors, prevents morphine tolerance in the rat. J. Pharmacol. 105:591–596 (1992).
25. 25. D. H. Lewis 1990 Controlled release of bioactive agents from lactide/glycolide polymers M. Chasin R. Langer Biodegradable Polymers as Drug Delivery Systems Dekker New York 1 41 D. H. Lewis. Controlled release of bioactive agents from lactide/glycolide polymers. In M. Chasin and R. Langer (eds.), Biodegradable Polymers as Drug Delivery Systems, Dekker, New York, 1990, pp. 1–41.
26. 26. K. Schultz B. Mollgaard A. N. Fisher L. Illum C. Larsen 1998 Intramuscular rate of disappearance of oily vehicles in rabbits investigated by gamma-scintigraphy Int. J. Pharm. 169 121 126 10.1016/S0378-5173(98)00121-5 1:CAS:528:DyaK1cXksF2lsb4%3D K. Schultz, B. Mollgaard, A. N. Fisher, L. Illum, and C. Larsen. Intramuscular rate of disappearance of oily vehicles in rabbits investigated by gamma-scintigraphy. Int. J. Pharm. 169:121–126 (1998).
27. 27. A. Rothen-Weinhold K. Besseghir Y. De Zelicourt R. Gurny 1998 Development and evaluation in vivo of a long-term delivery system for vapreotide, a somatostatin analogue J. Control. Release 52 205 213 9685950 10.1016/S0168-3659(97)00216-2 1:CAS:528:DyaK1cXhtlars7o%3D A. Rothen-Weinhold, K. Besseghir, Y. De Zelicourt, and R. Gurny. Development and evaluation in vivo of a long-term delivery system for vapreotide, a somatostatin analogue. J. Control. Release 52:205–213 (1998).
28. 28. K. El-Kharraz, A. Dashevsky, and R. Bodmeier. Microparticles prepared by grinding of films. Proceedings of the 2nd World Meeting APGI/APV, Paris, pp. 555–556 (1998).
29. 29. H. Kranz R. Bodmeier 2007 A novel in situ forming drug delivery system for controlled parenteral drug delivery Int. J. Pharm. 332 107 114 17084049 10.1016/j.ijpharm.2006.09.033 1:CAS:528:DC%2BD2sXhvVSlu7w%3D H. Kranz, and R. Bodmeier. A novel in situ forming drug delivery system for controlled parenteral drug delivery. Int. J. Pharm. 332:107–114 (2007).
30. 30. L. Langerman G. Chaimsky E. Golomb M. Tverskoy A. Kook S. Benita 1990 A rabbit model for evaluation of spinal anesthesia: chronic cannulation of the subarachnoid space Anesth. Analg. 71 529 535 2221414 10.1213/00000539-199011000-00013 1:CAS:528:DyaK3MXhsFKnurw%3D L. Langerman, G. Chaimsky, E. Golomb, M. Tverskoy, A. Kook, and S. Benita. A rabbit model for evaluation of spinal anesthesia: chronic cannulation of the subarachnoid space. Anesth. Analg. 71:529–535 (1990).