In vivo efficacy of an intratumorally injected in situ-forming doxorubicin/poly(ethylene glycol)-b-polycaprolactone diblock copolymer

Biomaterials

Volumn 32, Issue 20, 2011, Pages 4556-4564

  Kang, Yun Mi ^a   Kim, Gyeong Hae ^a   Kim, Jae Il ^a   Kim, Da Yeon ^a   Lee, Bit Na ^a   Yoon, So Mi ^a   Kim, Jae Ho ^a   Kim, Moon Suk ^a  

^a Ajou University   (South Korea)

Author keywords

Doxorubicin; Injectable in situ gel; Intratumoral injection; Tumors

Indexed keywords

ANTI-PROLIFERATIVE; ANTICANCER TREATMENT; APOPTOSIS; BIODISTRIBUTIONS; BODY TEMPERATURE; CANCER CELLS; DIBLOCK COPOLYMER; DOXORUBICIN; DRUG-DELIVERY SYSTEMS; IN-SITU; IN-VITRO; IN-VIVO; IN-VIVO EXPERIMENTS; INTRATUMORAL INJECTION; NORMAL TISSUE; ROOM TEMPERATURE; SIDE EFFECT; SINGLE-DOSE; SOL STATE; THERAPEUTIC DOSE; TUMOR CELLS; TUMOR GROWTH;

BLOCK COPOLYMERS; CELL DEATH; DISEASES; EMULSIFICATION; ETHYLENE; ETHYLENE GLYCOL; MOTION PICTURE EXPERTS GROUP STANDARDS; POLYCAPROLACTONE; TUMORS;

GELS;

DOXORUBICIN; MACROGOL; POLYCAPROLACTONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG EFFICACY; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR XENOGRAFT;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; BIOCOMPATIBLE MATERIALS; DOXORUBICIN; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; GELS; HUMANS; INJECTIONS; MATERIALS TESTING; MICE; MICE, INBRED C57BL; NEOPLASM TRANSPLANTATION; NEOPLASMS; POLYESTERS; POLYETHYLENE GLYCOLS; POLYMERS; TISSUE DISTRIBUTION; TRANSPLANTATION, HETEROLOGOUS;

MUS;

EID: 79955521271     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2011.03.007     Document Type: Article

References (33)

1. Pockaj B.A., Gray R.J. Current surgery for breast cancer. Future Oncol 2009, 5:465-479.
2. Niibe Y., Hayakawa K. Oligometastases and oligo-recurrence: the new era of cancer therapy. Jpn J Clin Oncol 2010, 40:107-111.
3. Bouchard P., Efron J. Management of recurrent rectal cancer. Ann Surg Oncol 2010, 17:1343-1356.
4. Omay S.B., Vogelbaum M.A. Current concepts and newer developments in the treatment of malignant gliomas. Indian J Cancer 2009, 46:88-95.
5. Chari R.V. Targeted cancer therapy: conferring specificity to cytotoxic drugs. Acc Chem Res 2008, 41:98-107.
6. Murakami T., Tsuchida K., Hashida M., Imahori H. Size control of lipid-based drug carrier by drug loading. Mol BioSyst 2010, 6:789-791.
7. Laginha K.M. Determination of doxorubicin levels in whole tumor and tumor nuclei in murine breast cancer tumors. Clin Cancer Res 2005, 11:6944-6949.
8. Herzog T.J. Recurrent ovarian cancer: how important is it to treat to disease progression?. Clin Cancer Res 2004, 10:7439-7449.
9. Jones W.G. Is there a place for chemotherapy in advanced prostatic cancer?. Am J Clin Oncol 1988, 11(Suppl. 2):S98-S100.
10. Bachur N.R., Gee M. Daunorubicin metabolism by rat tissue preparations. J Pharmacol Exp Ther 1971, 177:567-572.
11. Kim T.H., Mount C.W., Gombotz W.R., Pun S.H. The delivery of doxorubicin to 3-D multicellular spheroids and tumors in a murine xenograft model using tumor-penetrating triblock polymeric micelles. Biomaterials 2010, 31:7386-7397.
12. Napier M.E., DeSimone J.M. Nanoparticle drug delivery platform. Polym Rev 2007, 47:321-327.
13. Lee H., Fonge H., Hoang B., Reilly R.M., Allen C. The effects of particle size and molecular targeting on the intratumoral and subcellular distribution of polymeric nanoparticles. Mol Pharmaceutics 2010, 7:1195-1208.
14. Park J.H., Eom S., Ahn S.I., Hong H.H., Kim C.M., Lee D., et al. Dextran/PLGA double-layered microspheres for sustained release of doxorubicin. Tissue Eng Regen Med 2009, 6:588-594.
15. Chun C.J., Lee S.M., Kim C.W., Hong K.Y., Kim S.Y., Yang S.C., et al. Doxorubicin-polyphosphazene conjugate hydrogels for locally controlled delivery of cancer therapeutics. Biomaterials 2009, 30:4752-4762.
16. Cai H., Yang H., Xiang B., Li S., Liu S., Wan L., et al. Selective apoptotic killing of solid and hematologic tumor cells by bombesin-targeted delivery of mitochondria-disrupting peptides. Mol Pharmaceutics 2010, 7:586-596.
17. Springate C.M., Jackson J.K., Gleave M.E., Burt H.M. Clusterin antisense complexed with chitosan for controlled intratumoral delivery. Int J Pharm 2008, 350:53-64.
18. Tong R., Cheng J. Anticancer polymeric nanomedicines. Polym Rev 2007, 47:345-381.
19. Karathanasis E., Chan L., Balusu S.R., D'Orsi C.J., Annapragada A.V., Sechopoulos I., et al. Multifunctional nanocarriers for mammographic quantification of tumor dosing and prognosis of breast cancer therapy. Biomaterials 2008, 29:4815-4822.
20. Liu F., Urban M.W. Recent advances and challenges in designing stimuli-responsive polymers. Prog Polym Sci 2010, 35:3-23.
21. Kang Y.M., Lee S.H., Lee J.Y., Son J.S., Kim B.S., Lee B., et al. A biodegradable, injectable gel system based on MPEG-b-(PCL-ran-PLLA) diblock copolymers with an adjustable therapeutic window. Biomaterials 2010, 31:2453-2460.
22. Lee J.Y., Kim K.S., Kang Y.M., Kim E.S., Hwang S.J., Lee H.B., et al. In vivo efficacy of paclitaxel-loaded injectable in situ-forming gel against subcutaneous tumor growth. Int J Pharm 2010, 392:51-56.
23. Ahn H.H., Kim K.S., Lee J.H., Lee J.Y., Lee I.W., Chun H.J., et al. In vivo osteogenic differentiation of human adipose-derived stem cells in an injectable in situ-forming gel scaffold. Tissue Eng Part A 2009, 15:1821-1832.
24. Hyun H., Kim Y.H., Song I.B., Lee J.W., Kim M.S., Khang G., et al. In vitro and in vivo release of albumin using biodegradable MPEG-PCL diblock copolymer as an in situ gel forming carrier. Biomacromol 2007, 8:1093-1100.
25. Kim M.S., Kim S.K., Kim S.H., Hyun H., Khang G., Park K., et al. In vivo osteogenic differentiation of rat bone marrow stromal cells in thermosensitive MPEG-PCL diblock copolymer gel. Tissue Eng 2006, 12:2863-2873.
26. Devalapally H., Duan Z., Seiden M.V., Amiji M.M. Paclitaxel and ceramide coadministration in biodegradable polymeric nanoparticulate delivery system to overcome drug resistance in ovarian cancer. Int J Cancer 2007, 121:1830-1838.
27. Smith J.P., Kanekal S., Patawaran M.B., Chen J.Y., Jones R.E., Orenberg E.K., et al. Drug retention and distribution after intratumoral chemotherapy with fluorouracil/epinephrine injectable gel in human pancreatic cancer xenografts. Cancer Chemother Pharmacol 1999, 44:267-274.
28. Joo M.K., Park M.H., Choi B.G., Jeong B. Reverse thermogelling biodegradable polymer aqueous solutions. J Mater Chem 2009, 19:5891-5905.
29. Le Renard P.E., Jordan O., Faes A., Petri-Fink A., Hofmann H., Rüfenacht D., et al. The in vivo performance of magnetic particle-loaded injectable, in situ gelling, carriers for the delivery of local hyperthermia. Biomaterials 2010, 31:691-705.
30. Lippens E., Vertenten G., Gironès J., Declercq H., Saunders J., Luyten J., et al. Evaluation of bone regeneration with an injectable, in situ polymerizable Pluronic F127 hydrogel derivative combined with autologous mesenchymal stem cells in a goat tibia defect model. Tissue Eng Part A 2010, 16:617-627.
31. Arcamone F., Cassinelli G., Fantini G., Grein A., Orezzi P., Pol C., et al. Adriamycin, 1,4-hydroxydaunomycin, a new antitumor antibiotic from S. peucetius var. caesius. Biotechnol Bioeng 1969, 11:1101-1110.
32. Patil R.R., Guhagarkar S.A., Devarajan P.V. Engineered nanocarriers of doxorubicin: a current update. Crit Rev Ther Drug Carrier Syst 2008, 25:1-61.
33. Kataoka K., Matsumoto T., Yokoyama M., Okano T., Sakurai Y., Fukushima S., et al. Doxorubicin-loaded poly(ethylene glycol)-poly(beta-benzyl-L-aspartate) copolymer micelles: their pharmaceutical characteristics and biological significance. J Control Release 2000, 64:143-153.