Myotoxicity studies of injectable biodegradable in-situ forming drug delivery systems

International Journal of Pharmaceutics

Volumn 212, Issue 1, 2001, Pages 11-18

  Kranz, H ^a   Brazeau, G A ^b   Napaporn, J ^b   Martin, R L ^b   Millard, W ^b   Bodmeier, R ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b UNIVERSITY OF FLORIDA   (United States)

Author keywords

Biodegradable polymers; Creatine kinase; Intramuscular injection; Microparticles; Muscle damage; Myotoxicity

Indexed keywords

2 PYRROLIDINONE; ARACHIS OIL; BUPIVACAINE; BUSERELIN ACETATE; CREATINE KINASE; DIMETHYL SULFOXIDE; METHYL 2 PYRROLIDONE; PHENYTOIN; POLYLACTIC ACID; POLYLACTIDE; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BIODEGRADABLE IMPLANT; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; ENZYME RELEASE; LABORATORY TEST; MALE; MUSCLE INJURY; NONHUMAN; PRIORITY JOURNAL; RAT; SKELETAL MUSCLE; STATISTICAL ANALYSIS;

ANIMALS; CREATINE KINASE; DRUG DELIVERY SYSTEMS; INJECTIONS, INTRAMUSCULAR; LACTIC ACID; MALE; MUSCLE, SKELETAL; POLYESTERS; POLYGLYCOLIC ACID; POLYMERS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0035808266     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(00)00568-8     Document Type: Article

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