Implication of mitochondrial cytoprotection in human islet isolation and transplantation

Biochemistry Research International

Volumn , Issue , 2012, Pages

  Wang, Yong ^a   Mendoza Elias, Joshua E ^a   Qi, Meirigeng ^a   Harvat, Tricia A ^a   Ahn, Sang Joon ^a   Lee, Dongyoung ^a   Gutierrez, Diana ^a   Jeon, Hyojin ^a   Paushter, Daniel ^a   Oberholzer, José ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84862275960     PISSN: 20902247     EISSN: 20902255     Source Type: Journal    
DOI: 10.1155/2012/395974     Document Type: Review

References (163)

1. Shapiro A. M. J., Lakey J. R. T., Ryan E. A., Korbutt G. S., Toth E., Warnock G. L., Kneteman N. M., Rajotte R. V., Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen New England Journal of Medicine 2000 343 4 230 238 (Pubitemid 30490390)
2. Alejandro R., Barton F. B., Hering B. J., Wease S., 2008 Update from the collaborative islet transplant r Transplantation 2008 86 12 1783 1788
3. Bellin M. D., Kandaswamy R., Parkey J., Zhang H. J., Liu B., Ihm S. H., Ansite J. D., Witson J., Bansal-Pakala P., Balamurugan A. N., Papas K., Sutherland D. E. R., Moran A., Hering B. J., Prolonged insulin independence after islet allotransplants in recipients with type 1 diabetes American Journal of Transplantation 2008 8 11 2463 2470
4. Gangemi A., Salehi P., Hatipoglu B., Martellotto J., Barbaro B., Kuechle J. B., Qi M., Wang Y., Pallan P., Owens C., Bui J., West D., Kaplan B., Benedetti E., Oberholzer J., Islet transplantation for brittle type 1 diabetes: the UIC protocol American Journal of Transplantation 2008 8 6 1250 1261 (Pubitemid 351763686)
5. Ryan E. A., Paty B. W., Senior P. A., Bigam D., Alfadhli E., Kneteman N. M., Lakey J. R. T., Shapiro A. M. J., Five-year follow-up after clinical islet transplantation Diabetes 2005 54 7 2060 2069 (Pubitemid 40911269)
6. Wiederkehr A., Wollheim C. B., Minireview: implication of mitochondria in insulin secretion and action Endocrinology 2006 147 6 2643 2649 (Pubitemid 43764598)
7. Henquin J. C., Triggering and amplifying pathways of regulation of insulin secretion by glucose Diabetes 2000 49 11 1751 1760
8. Sekine N., Fasolato C., Pralong W. F., Theler J. M., Wollheim C. B., Glucose-induced insulin secretion in INS-1 cells depends on factors present in fetal calf serum and rat islet-conditioned medium Diabetes 1997 46 9 1424 1433 (Pubitemid 27369079)
9. Rorsman P., The pancreatic beta-cell as a fuel sensor: an electrophysiologist's viewpoint Diabetologia 1997 40 5 487 495 (Pubitemid 27186783)
10. Lakey J. R. T., Tsujimura T., Shapiro A. M. J., Kuroda Y., Preservation of the human pancreas before islet isolation using a two-layer (UW solution-perfluorochemical) cold storage method Transplantation 2002 74 12 1809 1811 (Pubitemid 36019343)
11. Tsujimura T., Kuroda Y., Avila J. G., Kin T., Oberholzer J., Shapiro A. M. J., Lakey J. R. T., Influence of pancreas preservation on human islet isolation outcomes: impact of the two-layer method Transplantation 2004 78 1 96 100
12. Tsujimura T., Kuroda Y., Avila J. G., Kin T., Churchill T. A., Shapiro A. M. J., Lakey J. R. T., Resuscitation of the ischemically damaged human pancreas by the two-layer method prior to islet isolation Transplantation Proceedings 2003 35 7 2461 2462 (Pubitemid 37378032)
13. Eckhoff D. E., Smyth C. A., Eckstein C., Bilbao G., Young C. J., Thompson J. A., Contreras J. L., Suppression of the c-Jun N-terminal kinase pathway by 17 -estradiol can preserve human islet functional mass from proinflammatory cytokine-induced destruction Surgery 2003 134 2 169 179 (Pubitemid 37070336)
14. Abdelli S., Ansite J., Roduit R., Borsello T., Matsumoto I., Sawada T., Allaman-Pillet N., Henry H., Beckmann J. S., Hering B. J., Bonny C., Intracellular stress signaling pathways activated during human islet preparation and following acute cytokine exposure Diabetes 2004 53 11 2815 2823 (Pubitemid 39425906)
15. Paraskevas S., Aikin R., Maysinger D., Lakey J. R. T., Cavanagh T. J., Hering B., Wang R., Rosenberg L., Activation and expression of ERK, JNK, and p38 MAP-kinases in isolated islets of Langerhans: implications for cultured islet survival FEBS Letters 1999 455 3 203 208 (Pubitemid 29333036)
16. Potdar S., Malek S., Eghtesad B., Shapiro R., Basu A., Patel K., Broznick B., Fung J. J., Initial experience using histidine-tryptophan-ketoglutarate solution in clinical pancreas transplantation Clinical Transplantation 2004 18 6 661 665 (Pubitemid 39496978)
17. Fridell J. A., Agarwal A., Milgrom M. L., Goggins W. C., Murdock P., Pescovitz M. D., Comparison of histidine-tryptophan-ketoglutarate solution and University of Wisconsin solution for organ preservation in clinical pancreas transplantation Transplantation 2004 77 8 1304 1306 (Pubitemid 38580316)
18. Canelo R., Hakim N. S., Ringe B., Experience with hystidine tryptophan ketoglutarate versus University Wisconsin preservation solutions in transplantation International Surgery 2003 88 3 145 151 (Pubitemid 39625496)
19. Kuroda Y., Fujino Y., Morita A., Tanioka Y., Ku Y., Saitoh Y., Oxygenation of the human pancreas during preservation by a two-layer (University of Wisconsin solution/perfluorochemical) cold-storage method Transplantation 1992 54 3 561 562
20. Kuroda Y., Kawamura T., Suzuki Y., Fujiwara H., Yamamoto K., Saitoh Y., A new, simple method for cold storage of the pancreas using perfluorochemical Transplantation 1988 46 3 457 460
21. Fujino Y., Kuroda Y., Suzuki Y., Fujiwara H., Kawamura T., Morita A., Ku Y., Saitoh Y., Preservation of canine pancreas for 96 hours by a modified two-layer (UW solution/perfluorochemical) cold storage method Transplantation 1991 51 5 1133 1135
22. Merani S., Shapiro A. M. J., Current status of pancreatic islet transplantation Clinical Science 2006 110 6 611 625 (Pubitemid 43844731)
23. Matsumoto S., Kuroda Y., Perfluorocarbon for organ preservation before transplantation Transplantation 2002 74 12 1804 1809 (Pubitemid 36019342)
24. Hering B. J., Matsumoto I., Sawada T., Nakano M., Sakai T., Kandaswamy R., Sutherland D. E. R., Impact of two-layer pancreas preservation on islet isolation and transplantation Transplantation 2002 74 12 1813 1816 (Pubitemid 36019345)
25. Baertschiger R. M., Berney T., Morel P., Organ preservation in pancreas and islet transplantation Current Opinion in Organ Transplantation 2008 13 1 59 66
26. Iwanaga Y., Sutherland D. E. R., Harmon J. V., Papas K. K., Pancreas preservation for pancreas and islet transplantation Current Opinion in Organ Transplantation 2008 13 2 135 141 (Pubitemid 351374250)
27. Noguchi H., Levy M. F., Kobayashi N., Matsumoto S., Pancreas preservation by the two-layer method: does it have a beneficial effect compared with simple preservation in University of Wisconsin solution? Cell Transplantation 2009 18 5-6 497 503
28. Matsumoto S., Qualley S. A., Goel S., Hagman D. K., Sweet I. R., Poitout V., Strong D. M., Robertson R. P., Reems J. A., Effect of the two-layer (University of Wisconsin solution-perfluorochemical plus O2) method of pancreas preservation on human islet isolation, as assessed by the edmonton isolation protocol Transplantation 2002 74 10 1414 1419 (Pubitemid 35379548)
29. Matsumoto S., Rigley T. H., Qualley S. A., Kuroda Y., Reems J. A., Stevens R. B., Efficacy of the oxygen-charged static two-layer method for short-term pancreas preservation and islet isolation from nonhuman primate and human pancreata Cell Transplantation 2002 11 8 769 777 (Pubitemid 36176788)
30. Hiraoka K., Kuroda Y., Suzuki Y., Fujino Y., Tanioka Y., Matsumoto S., Sakai T., Kandaswamy R., Sutherland D. E. R., Outcomes in clinical pancreas transplantation with the two-layer cold storage method versus simple storage in University of Wisconsin solution Transplantation Proceedings 2002 34 7 2688 2689 (Pubitemid 35304884)
31. Ricordi C., Fraker C., Szust J., Al-Abdullah I., Poggioli R., Kirlew T., Khan A., Alejandro R., Improved human islet isolation outcome from marginal donors following addition of oxygenated perfluorocarbon to the cold-storage solution Transplantation 2003 75 9 1524 1527 (Pubitemid 36597289)
32. Tsujimura T., Kuroda Y., Kin T., Avila J. G., Rajotte R. V., Korbutt G. S., Ryan E. A., Shapiro A. M. J., Lakey J. R. T., Human islet transplantation from pancreases with prolonged cold ischemia using additional preservation by the two-layer (UW solution/perfluorochemical) cold-storage method Transplantation 2002 74 12 1687 1691 (Pubitemid 36019319)
33. Hering B. J., Kandaswamy R., Harmon J. V., Ansite J. D., Clemmings S. M., Sakai T., Paraskevas S., Eckman P. M., Sageshima J., Nakanoa M., Sawada T., Matsumotoa I., Zhang H. J., Sutherland D. E. R., Bluestone J. A., Transplantation of cultured islets from two-layer preserved pancreases in type 1 diabetes with anti-CD3 antibody American Journal of Transplantation 2004 4 3 390 401 (Pubitemid 38282295)
34. Zhang G., Matsumoto S., Newman H., Strong D. M., Robertson R. P., Reems J. A., Improve islet yields and quality when clinical grade pancreata are preserved by the two-layer method Cell and Tissue Banking 2006 7 3 195 201 (Pubitemid 44288482)
35. Witkowski P., Liu Z., Guo Q., Poumian-Ruiz E., Cernea S., Herold K., Hardy M. A., Two-layer method in short-term pancreas preservation for successful islet isolation Transplantation Proceedings 2005 37 8 3398 3401 (Pubitemid 41659898)
36. Salehi P., Mirbolooki M., Kin T., Tsujimura T., Shapiro A. M. J., Churchill T. A., Lakey J. R. T., Ameliorating injury during preservation and isolation of human islets using the two-layer method with perfluorocarbon and UW solution Cell Transplantation 2006 15 2 187 194 (Pubitemid 43726194)
37. Ramachandran S., Desai N. M., Goers T. A., Benshoff N., Olack B., Shenoy S., Jendrisak M. D., Chapman W. C., Mohanakumar T., Improved islet yields from pancreas preserved in perflurocarbon is via inhibition of apoptosis mediated by mitochondrial pathway American Journal of Transplantation 2006 6 7 1696 1703 (Pubitemid 43945812)
38. Papas K. K., Hering B. J., Gunther L., Rappel M. J., Colton C. K., Avgoustiniatos E. S., Pancreas oxygenation is limited during preservation with the two-layer method Transplantation Proceedings 2005 37 8 3501 3504 (Pubitemid 41659934)
39. Kin T., Mirbolooki M., Salehi P., Tsukada M., O'Gorman D., Imes S., Ryan E. A., Shapiro A. M. J., Lakey J. R. T., Islet isolation and transplantation outcomes of pancreas preserved with University of Wisconsin solution versus two-layer method using preoxygenated perfluorocarbon Transplantation 2006 82 10 1286 1290 (Pubitemid 44832910)
40. Caballero-Corbaln J., Eich T., Lundgren T., Foss A., Felldin M., Kllen R., Salmela K., Tibell A., Tufveson G., Korsgren O., Brandhorst D., No beneficial effect of two-layer storage compared with UW-storage on human islet isolation and transplantation Transplantation 2007 84 7 864 869 (Pubitemid 351338947)
41. Nano R., Clissi B., Melzi R., Calori G., Maffi P., Antonioli B., Marzorati S., Aldrighetti L., Freschi M., Grochowiecki T., Socci C., Secchi A., Di Carlo V., Bonifacio E., Bertuzzi F., Islet isolation for allotransplantation: variables associated with successful islet yield and graft function Diabetologia 2005 48 5 906 912 (Pubitemid 40767984)
42. Qin H., Matsumoto S., Klintmalm G. B., de vol E. B., A meta-analysis for comparison of the two-layer and university of Wisconsin pancreas preservation methods in islet transplantation Cell Transplantation 2011 20 7 1127 1137
43. Iken M., Brandhorst H., Korsgren O., Brandhorst D., Pig pancreas oxygenation at 20C increases islet ATP generation but deteriorates islet function Cell Transplantation 2009 18 7 745 751
44. Brandhorst H., Asif S., Andersson K., Theisinger B., Andersson H. H., Felldin M., Foss A., Salmela K., Tibell A., Tufveson G., Korsgren O., Brandhorst D., A new oxygen carrier for improved long-term storage of human pancreata before islet isolation Transplantation 2010 89 2 155 160
45. Avila J. G., Wang Y., Barbaro B., Gangemi A., Qi M., Kuechle J., Doubleday N., Doubleday M., Churchill T., Salehi P., Shapiro J., Philipson L. H., Benedetti E., Lakey J. R. T., Oberholzer J., Improved outcomes in islet isolation and transplantation by the use of a novel hemoglobin-based O2 carrier American Journal of Transplantation 2006 6 12 2861 2870
46. Kwon Y. S., Foley J. D., Murphy C. J., McAnulty J. F., The effect of trophic factor supplementation on cold ischemia-induced early apoptotic changes Transplantation 2007 83 1 91 94 (Pubitemid 46104980)
47. Desurmont T., Giraud S., Cau J., Goujon J.-M., Scepi M., Roumy J., Chatauret N., Thuillier R., Hauet T., Trophic factor and FR167653 supplementation during cold storage rescue chronic renal injury Journal of Urology 2011 185 3 1139 1146
48. Mitchell T., Rotaru D., Saba H., Smith R. A. J., Murphy M. P., MacMillan-Crow L. A., The mitochondria-targeted antioxidant mitoquinone protects against cold storage injury of renal tubular cells and rat kidneys Journal of Pharmacology and Experimental Therapeutics 2011 336 3 682 692
49. Mosbah I. B., Rosell-Catafau J., Alfany-Fernandez I., Rimola A., Parellada P. P., Mitjavila M. T., Lojek A., Abdennebi H. B., Boillot O., Rodés J., Peralta C., Addition of carvedilol to University Wisconsin solution improves rat steatotic and nonsteatotic liver preservation Liver Transplantation 2010 16 2 163 171
50. Zaouali M. A., Ben Mosbah I., Padrissa-Alts S., Calvo M., Ben Abdennebi H., Saidane-Mosbahi D., Bjaoui M., Garcia-Gil F. A., Panisello A., Rosello-Catafau J., Relevance of epidermal growth factor to improve steatotic liver preservation in IGL-1 solution Transplantation Proceedings 2010 42 8 3070 3075
51. Zaouali M. A., Padrissa-Altés S., Mosbah I. B., Alfany-Fernandez I., Massip-Salcedo M., Casillas-Ramirez A., Bintanel-Morcillo M., Boillot O., Serafin A., Rimola A., Rodés J., Rosell-Catafau J., Peralta C., Improved rat steatotic and nonsteatotic liver preservation by the addition of epidermal growth factor and insulin-like growth factor-I to University of Wisconsin solution Liver Transplantation 2010 16 9 1098 1111
52. White S. A., Djaballah H., Hughes D. P., Roberts D. L., Contractor H. H., Pathak S., London N. J. M., A preliminary study of the activation of endogenous pancreatic exocrine enzymes during automated porcine islet isolation Cell Transplantation 1999 8 3 265 276 (Pubitemid 29350222)
53. Heiser A., Ulrichs K., Muller-Ruchholtz W., Isolation of porcine pancreatic islets: low trypsin activity during the isolation procedure guarantees reproducible high islet yields Journal of Clinical Laboratory Analysis 1994 8 6 407 411 (Pubitemid 24376803)
54. Matsumoto S., Lawrence O., Rigley T. H., Lakey J. R. T., Stevens R. B., Strong D. M., University of Wisconsin solution with trypsin inhibitor Pefabloc improves survival of viable human and primate impure islets during storage Cell and Tissue Banking 2001 2 1 15 21 (Pubitemid 32771675)
55. Lakey J. R. T., Helms L. M. H., Kin T., Korbutt G. S., Rajotte R. V., James Shapiro A. M., Warnock G. L., Serine-protease inhibition during islet isolation increases islet yield from human pancreases with prolonged ischemia Transplantation 2001 72 4 565 570 (Pubitemid 32802735)
56. Matsumoto S., Rigley T. H., Reems J. A., Kuroda Y., Stevens R. B., Improved islet yields from Macaca nemestrina and marginal human pancreata after two-layer method preservation and endogenous trypsin inhibition American Journal of Transplantation 2003 3 1 53 63 (Pubitemid 36306824)
57. Al-Abdullah I. H., Bentsi-Barnes K., Valiente L., Omori K., Iglesias I., Orr C., Umeadi C., Ferreri K., Todorov I., Al-Sayed M., Kandeel F., Testing combinations of protease inhibitor and preservation solution to improve islet quality and yield Transplantation Proceedings 2008 40 2 390 392 (Pubitemid 351406426)
58. Bottino R., Balamurugan A. N., Tse H., Thirunavukkarasu C., Ge X., Profozich J., Milton M., Ziegenfuss A., Trucco M., Piganelli J. D., Response of human islets to isolation stress and the effect of antioxidant treatment Diabetes 2004 53 10 2559 2568 (Pubitemid 39299262)
59. Bottino R., Balamurugan A. N., Bertera S., Pietropaolo M., Trucco M., Piganelli J. D., Preservation of human islet cell functional mass by anti-oxidative action of a novel SOD mimic compound Diabetes 2002 51 8 2561 2567 (Pubitemid 34827407)
60. Eagle H., Oyama V. I., Levy M., Horton C. L., Fleischman R., The growth response of mammalian cells in tissue culture to L-glutamine and L-glutamic acid Journal of Biological Chemistry 1956 218 2 607 616
61. Evans M. E., Jones D. P., Ziegler T. R., Glutamine inhibits cytokine-induced apoptosis in human colonic epithelial cells via the pyrimidine pathway American Journal of Physiology 2005 289 3 G388 G396
62. Newsholme P., Procopio J., Ramos Lima M. M., Pithon-Curi T. C., Curi R., Glutamine and glutamatetheir central role in cell metabolism and function Cell Biochemistry and Function 2003 21 1 1 9 (Pubitemid 36227820)
63. Li C., Buettger C., Kwagh J., Matter A., Daikhin Y., Nissim I. B., Collins H. W., Yudkoff M., Stanley C. A., Matschinsky F. M., A signaling role of glutamine in insulin secretion Journal of Biological Chemistry 2004 279 14 13393 13401 (Pubitemid 38468862)
64. Carobbio S., Ishihara H., Fernandez-Pascual S., Bartley C., Martin-Del-Rio R., Maechler P., Insulin secretion profiles are modified by overexpression of glutamate dehydrogenase in pancreatic islets Diabetologia 2004 47 2 266 276 (Pubitemid 38315363)
65. Avila J. G., Tsujimura T., Oberholzer J., Churchill T., Salehi P., Shapiro A. M. J., Lakey J. R. T., Improvement of pancreatic islet isolation outcomes using glutamine perfusion during isolation procedure Cell Transplantation 2004 12 8 877 881 (Pubitemid 38044652)
66. Avila J., Barbaro B., Gangemi A., Romagnoli T., Kuechle J., Hansen M., Shapiro J., Testa G., Sankary H., Benedetti E., Lakey J., Oberholzer J., Intra-ductal glutamine administration reduces oxidative injury during human pancreatic islet isolation American Journal of Transplantation 2005 5 12 2830 2837 (Pubitemid 43923943)
67. Thomas D. A., Stauffer C., Zhao K., Yang H., Sharma V. K., Szeto H. H., Suthanthiran M., Mitochondrial targeting with antioxidant peptide SS-31 prevents mitochondrial depolarization, reduces islet cell apoptosis, increases islet cell yield, and improves posttransplantation function Journal of the American Society of Nephrology 2007 18 1 213 222 (Pubitemid 46053434)
68. Zhao K., Luo G., Giannelli S., Szeto H. H., Mitochondria-targeted peptide prevents mitochondrial depolarization and apoptosis induced by tert-butyl hydroperoxide in neuronal cell lines Biochemical Pharmacology 2005 70 12 1796 1806 (Pubitemid 41612010)
69. Eizirik D. L., Darville M. I., -cell apoptosis and defense mechanisms: lessons from type 1 diabetes Diabetes 2001 50 1 S64 S69
70. Scarim A. L., Arnush M., Hill J. R., Marshall C. A., Baldwin A., McDaniel M. L., Corbett J. A., Evidence for the presence of type IL-1 receptors on -cells of islets of Langerhans Biochimica et Biophysica Acta 1997 1361 3 313 320 (Pubitemid 27475310)
71. Steer S. A., Scarim A. L., Chambers K. T., Corbett J. A., Interleukin-1 stimulates -cell necrosis and release of the immunological adjuvant HMGB1 PLoS Medicine 2006 3 2, article e17
72. Cnop M., Welsh N., Jonas J. -C., Jrns A., Lenzen S., Eizirik D. L., Mechanisms of pancreatic -cell death in type 1 and type 2 diabetes: many differences, few similarities Diabetes 2005 54 supplement 2 S97 S107
73. Corbett J. A., Wang J. L., Misko T. P., Zhao W., Hickey W. F., McDaniel M. L., Nitric oxide mediates IL-1 -induced islet dysfunction and destruction: prevention by dexamethasone Autoimmunity 1993 15 2 145 153 (Pubitemid 23276009)
74. Kaneto H., Kajimoto Y., Fujitani Y., Matsuoka T., Sakamoto K., Matsuhisa M., Yamasaki Y., Hori M., Oxidative stress induces p21 expression in pancreatic islet cells: possible implication in beta-cell dysfunction Diabetologia 1999 42 9 1093 1097 (Pubitemid 29408807)
75. Tanaka Y., Tran P. O. T., Harmon J., Robertson R. P., A role for glutathione peroxidase in protecting pancreatic cells against oxidative stress in a model of glucose toxicity Proceedings of the National Academy of Sciences of the United States of America 2002 99 19 12363 12368
76. Monfared S. S.M.S., Larijani B., Abdollahi M., Islet transplantation and antioxidant management: a comprehensive review World Journal of Gastroenterology 2009 15 10 1153 1161
77. Botsios C., Sfriso P., Ostuni P. A., Todesco S., Punzi L., Efficacy of the IL-1 receptor antagonist, anakinra, for the treatment of diffuse anterior scleritis in rheumatoid arthritis. Report of two cases [8] Rheumatology 2007 46 6 1042 1043 (Pubitemid 47062524)
78. Larsen C. M., Faulenbach M., Vaag A., Vlund A., Ehses J. A., Seifert B., Mandrup-Poulsen T., Donath M. Y., Interleukin-1-receptor antagonist in type 2 diabetes mellitus New England Journal of Medicine 2007 356 15 1517 1526 (Pubitemid 46588416)
79. Schwarznau A., Hanson M. S., Sperger J. M., Schram B. R., Danobeitia J. S., Greenwood K. K., Vijayan A., Fernandez L. A., IL-1 receptor blockade protects islets against pro-inflammatory cytokine induced necrosis and apoptosis Journal of Cellular Physiology 2009 220 2 341 347
80. Hsu B. R., Fu S. H., Hsu S., Chen S. T., Interleukin-1 receptor antagonist enhances islet engraftment without impacting serum levels of nitrite or osteopontin Transplantation Proceedings 2009 41 5 1781 1785
81. Westwell-Roper C., Dai D. L., Soukhatcheva G., Potter K. J., Van Rooijen N., Ehses J. A., Verchere C. B., IL-1 blockade attenuates islet amyloid polypeptide-induced proinflammatory cytokine release and pancreatic islet graft dysfunction Journal of Immunology 2011 187 5 2755 2765
82. Emamaullee J. A., Stanton L., Schur C., Shapiro A. M. J., Caspase inhibitor therapy enhances marginal mass islet graft survival and preserves long-term function in islet transplantation Diabetes 2007 56 5 1289 1298 (Pubitemid 46715609)
83. Emamaullee J. A., Davis J., Pawlick R., Toso C., Merani S., Cai S. X., Tseng B., Shapiro A. M. J., The caspase selective inhibitor EP1013 augments human islet graft function and longevity in marginal mass islet transplantation in mice Diabetes 2008 57 6 1556 1566
84. Montolio M., Téllez N., Biarnés M., Soler J., Montanya E., Short-term culture with the caspase inhibitor z-VAD.fmk reduces beta cell apoptosis in transplanted islets and improves the metabolic outcome of the graft Cell Transplantation 2005 14 1 59 65 (Pubitemid 40387679)
85. Johansson M., Olerud J., Jansson L., Carlsson P. O., Prolactin treatment improves engraftment and function of transplanted pancreatic islets Endocrinology 2009 150 4 1646 1653
86. Yamamoto T., Mita A., Ricordi C., Messinger S., Miki A., Sakuma Y., Timoneri F., Barker S., Fornoni A., Molano R. D., Inverardi L., Pileggi A., Ichii H., Prolactin supplementation to culture medium improves -cell survival Transplantation 2010 89 11 1328 1335
87. Labriola L., Ferreira G. B., Montor W. R., Demasi M. A. A., Pimenta D. C., Lojudice F. H., Genzini T., Goldberg A. C., Eliaschewitz F. G., Sogayar M. C., Prolactin-induced changes in protein expression in human pancreatic islets Molecular and Cellular Endocrinology 2007 264 1-2 16 27 (Pubitemid 46099066)
88. Terra L. F., Garay-Malpartida M. H., Wailemann R. A., Sogayar M. C., Labriola L., Recombinant human prolactin promotes human beta cell survival via inhibition of extrinsic and intrinsic apoptosis pathways Diabetologia 2011 54 6 1388 1397
89. Kaneto H., Nakatani Y., Miyatsuka T., Kawamori D., Matsuoka T. A., Matsuhisa M., Kajimoto Y., Ichijo H., Yamasaki Y., Hori M., Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide Nature Medicine 2004 10 10 1128 1132 (Pubitemid 39424876)
90. Contreras J. L., Eckstein C., Smyth C. A., Sellers M. T., Vilatoba M., Bilbao G., Rahemtulla F. G., Young C. J., Thompson J. A., Chaudry I. H., Eckhoff D. E., Brain Death Significantly Reduces Isolated Pancreatic Islet Yields and Functionality In Vitro and In Vivo after Transplantation in Rats Diabetes 2003 52 12 2935 2942 (Pubitemid 37466863)
91. Noguchi H., Nakai Y., Ueda M., Masui Y., Futaki S., Kobayashi N., Hayashi S., Matsumoto S., Activation of c-Jun NH2-terminal kinase (JNK) pathway during islet transplantation and prevention of islet graft loss by intraportal injection of JNK inhibitor Diabetologia 2007 50 3 612 619 (Pubitemid 46215505)
92. Noguchi H., Nakai Y., Matsumoto S., Kawaguchi M., Ueda M., Okitsu T., Iwanaga Y., Yonekawa Y., Nagata H., Minami K., Masui Y., Futaki S., Tanaka K., Cell permeable peptide of JNK inhibitor prevents islet apoptosis immediately after isolation and improves islet graft function American Journal of Transplantation 2005 5 8 1848 1855 (Pubitemid 41039857)
93. Noguchi H., Matsumoto S., Onaca N., Naziruddin B., Jackson A., Ikemoto T., Shimoda M., Fujita Y., Chujo D., Iwanaga Y., Nagata H., Okitsu T., Kobayashi N., Ueno H., Chaussabel D., Grayburn P., Banchereau J., Levy M. F., Ductal injection of JNK inhibitors before pancreas preservation prevents islet apoptosis and improves islet graft function Human Gene Therapy 2009 20 1 73 85
94. Rose N. L., Palcic M. M., Helms L. M. H., Lakey J. R. T., Evaluation of pefabloc as a serine protease inhibitor during human-islet isolation Transplantation 2003 75 4 462 466 (Pubitemid 36241139)
95. Wang W., Upshaw L., Zhang G., Strong M. D., Reems J. A., Adjustment of digestion enzyme composition improves islet isolation outcome from marginal grade human donor pancreata Cell and Tissue Banking 2007 8 3 187 194 (Pubitemid 47202288)
96. Rose N. L., Palcic M. M., Shapiro A. M. J., Lakey J. R. T., An evaluation of the activation of endogenous pancreatic enzymes during human islet isolations Transplantation Proceedings 2003 35 7 2455 2457 (Pubitemid 37378030)
97. Umeadi C., Bentsi-Barnes K., Kandeel F., Al-Abdullah I. H., Endogenous pancreatic protease activity and methods for impeding their function Transplantation Proceedings 2008 40 2 355 357 (Pubitemid 351406424)
98. Nduaguibe C. C., Bentsi-Barnes K., Mullen Y., Kandeel F., Al-Abdullah I. H., Serine protease inhibitors suppress pancreatic endogenous proteases and modulate bacterial neutral proteases Islets 2010 2 3 200 206
99. Dionne K. E., Colton C. K., Yarmush M. L., Effect of hypoxia on insulin secretion by isolated rat and canine islets of Langerhans Diabetes 1993 42 1 12 21 (Pubitemid 23013790)
100. Lehmann R., Zuellig R. A., Kugelmeier P., Baenninger P. B., Moritz W., Perren A., Clavien P. A., Weber M., Spinas G. A., Superiority of small islets in human islet transplantation Diabetes 2007 56 3 594 603 (Pubitemid 46348450)
101. Ricordi C., Lakey J. R. T., Hering B. J., Challenges toward standardization of islet isolation technology Transplantation Proceedings 2001 33 1-2 1709 (Pubitemid 32238032)
102. Carvalho C. P. F., Barbosa H. C. L., Britan A., Santos-Silva J. C. R., Boschero A. C., Meda P., Collares-Buzato C. B., Beta cell coupling and connexin expression change during the functional maturation of rat pancreatic islets Diabetologia 2010 53 7 1428 1437
103. London N. J. M., Thirdborough S. M., Swift S. M., Bell P. R. F., James R. F. L., The diabetic human reconstituted severe combined immunodeficient (SCID-hu) mouse: a model for isogeneic, allogeneic, and xenogeneic human islet transplantation Transplantation Proceedings 1991 23 1 749
104. Wang W., Upshaw L., Strong D. M., Robertson R. P., Reems J., Increased oxygen consumption rates in response to high glucose detected by a novel oxygen biosensor system in non-human primate and human islets Journal of Endocrinology 2005 185 3 445 455 (Pubitemid 40883390)
105. Goto M., Holgersson J., Kumagai-Braesch M., Korsgren O., The ADP/ATP ratio: a novel predictive assay for quality assessment of isolated pancreatic islets American Journal of Transplantation 2006 6 10 2483 2487 (Pubitemid 44359438)
106. Miwa I., Ichimura N., Sugiura M., Hamada Y., Taniguchi S., Inhibition of glucose-induced insulin secretion by 4-hydroxy-2-nonenal and other lipid peroxidation products Endocrinology 2000 141 8 2767 2772 (Pubitemid 32250437)
107. Hennige A. M., Lembert N., Wahl M. A., Ammon H. P. T., Oxidative stress increases potassium efflux from pancreatic islets by depletion of intracellular calcium stores Free Radical Research 2000 33 5 507 516 (Pubitemid 32103693)
108. Wolff S. P., Diabetes mellitus and free radicals. Free radicals, transition metals and oxidative stress in the aetiology of diabetes mellitus and complications British Medical Bulletin 1993 49 3 642 652 (Pubitemid 23243836)
109. Vega R. A., Wang Y., Harvat T., Wang S., Qi M., Adewola A. F., Lee D., Benedetti E., Oberholzer J., Modified gold nanoparticle vectors: a biocompatible intracellular delivery system for pancreatic islet cell transplantation Surgery 2010 148 4 858 866
110. Rink J. S., McMahon K. M., Chen X., Mirkin C. A., Thaxton C. S., Kaufman D. B., Transfection of pancreatic islets using polyvalent DNA-functionalized gold nanoparticles Surgery 2010 148 2 335 345
111. Nakano M., Matsumoto I., Sawada T., Ansite J., Oberbroeckling J., Zhang H. J., Kirchhof N., Shearer J., Sutherland D. E. R., Hering B. J., Caspase-3 inhibitor prevents apoptosis of human islets immediately after isolation and improves islet graft function Pancreas 2004 29 2 104 109 (Pubitemid 38971799)
112. Street C. N., Lakey J. R. T., Shapiro A. M. J., Imes S., Rajotte R. V., Ryan E. A., Lyon J. G., Kin T., Avila J., Tsujimura T., Korbutt G. S., Islet graft assessment in the Edmonton Protocol: implications for predicting long-term clinical outcome Diabetes 2004 53 12 3107 3114 (Pubitemid 39564485)
113. Papas K. K., Suszynski T. M., Colton C. K., Islet assessment for transplantation Current Opinion in Organ Transplantation 2009 14 6 674 682
114. Papas K. K., Colton C. K., Nelson R. A., Rozak P. R., Avgoustiniatos E. S., Scott W. E., Wildey G. M., Pisania A., Weir G. C., Hering B. J., Human islet oxygen consumption rate and DNA measurements predict diabetes reversal in nude mice American Journal of Transplantation 2007 7 3 707 713 (Pubitemid 46376439)
115. Sweet I. R., Gilbert M., Scott S., Todorov I., Jensen R., Nair I., Al-Abdullah I., Rawson J., Kandeel F., Ferreri K., Glucose-stimulated increment in oxygen consumption rate as a standardized test of human islet quality American Journal of Transplantation 2008 8 1 183 192
116. Armann B., Hanson M. S., Hatch E., Steffen A., Fernandez L. A., Quantification of basal and stimulated ROS levels as predictors of islet potency and function American Journal of Transplantation 2007 7 1 38 47 (Pubitemid 44952854)
117. Nam K. H., Yong W., Harvat T., Adewola A., Wang S., Oberholzer J., Eddington D. T., Size-based separation and collection of mouse pancreatic islets for functional analysis Biomedical Microdevices 2010 12 5 865 874
118. Bertuzzi F., Ricordi C., Prediction of clinical outcome in islet allotransplantation Diabetes Care 2007 30 2 410 417 (Pubitemid 46201652)
119. Ricordi C., Scharp D. W., Lacy P. E., Reversal of diabetes in nude mice after transplantation of fresh and 7-day-cultured (24C) human pancreatic islets Transplantation 1988 45 5 994 996
120. Papas K. K., Pisania A., Wu H., Weir G. C., Colton C. K., A stirred microchamber for oxygen consumption rate measurements with pancreatic islets Biotechnology and Bioengineering 2007 98 5 1071 1082 (Pubitemid 350205583)
121. Sweet I. R., Gilbert M., Contribution of calcium influx in mediating glucose-stimulated oxygen consumption in pancreatic islets Diabetes 2006 55 12 3509 3519 (Pubitemid 44923612)
122. Kim J. H., Park S. G., Lee H. N., Lee Y. Y., Park H. S., Kim H. I., Yu J. E., Kim S. H., Park C. G., Ha J., Kim S. J., Park K. S., ATP measurement predicts porcine islet transplantation outcome in nude mice Transplantation 2009 87 2 166 169
123. Lee Y., Wang M.-Y., Du X. Q., Charron M. J., Unger R. H., Glucagon receptor knockout prevents insulin-deficient type 1 diabetes in mice Diabetes 2011 60 2 391 397
124. Spigelman A. F., Dai X., MacDonald P. E., Voltage-dependent K+ channels are positive regulators of alpha cell action potential generation and glucagon secretion in mice and humans Diabetologia 2010 53 9 1917 1926
125. Lukowiak B., Vandewalle B., Riachy R., Kerr-Conte J., Gmyr V., Belaich S., Lefebvre J., Pattou F., Identification and purification of functional human -cells by a new specific zinc-fluorescent probe Journal of Histochemistry and Cytochemistry 2001 49 4 519 527 (Pubitemid 32295174)
126. Ichii H., Inverardi L., Pileggi A., Molano R. D., Cabrera O., Caicedo A., Messinger S., Kuroda Y., Berggren P. O., Ricordi C., A novel method for the assessment of cellular composition and beta-cell viability in human islet preparations American Journal of Transplantation 2005 5 7 1635 1645 (Pubitemid 40910445)
127. Iglesias I., Bentsi-Barnes K., Umeadi C., Brown L., Kandeel F., Al-Abdullah I. H., Comprehensive analysis of human pancreatic islets using flow and laser scanning cytometry Transplantation Proceedings 2008 40 2 351 354 (Pubitemid 351406428)
128. Jayaraman S., Assessment of beta cell viability Current Protocols in Cytometry 2011 supplement 55, article 6.27
129. Jayaraman S., A novel method for the detection of viable human pancreatic beta cells by flow cytometry using fluorophores that selectively detect labile zinc, mitochondrial membrane potential and protein thiols Cytometry Part A 2008 73 7 615 625 (Pubitemid 351930748)
130. Hanson M. S., Park E. E., Sears M. L., Greenwood K. K., Danobeitia J. S., Hullett D. A., Fernandez L. A., A simplified approach to human islet quality assessment Transplantation 2010 89 10 1178 1188
131. Roper M. G., Shackman J. G., Dahlgren G. M., Kennedy R. T., Microfluidic chip for continuous monitoring of hormone secretion from live cells using an electrophoresis-based immunoassay Analytical Chemistry 2003 75 18 4711 4717 (Pubitemid 37139769)
132. Rocheleau J. V., Walker G. M., Head S. S., McGuinness O. P., Piston D. W., Microfluidic glucose stimulation reveals limited coordination of intracellular Ca2 + activity oscillations in pancreatic islets Proceedings of the National Academy of Sciences of the United States of America 2004 101 35 12899 12903 (Pubitemid 39167555)
133. Chen D., Du W., Liu Y., Liu W., Kuznetsov A., Mendez F. E., Philipson L. H., Ismagilov R. F., The chemistrode: a droplet-based microfluidic device for stimulation and recording with high temporal, spatial, and chemical resolution Proceedings of the National Academy of Sciences of the United States of America 2008 105 44 16843 16848
134. Mohammed J. S., Wang Y., Harvat T. A., Oberholzer J., Eddington D. T., Microfluidic device for multimodal characterization of pancreatic islets Lab on a Chip 2009 9 1 97 106
135. Adewola A. F., Lee D., Harvat T., Mohammed J., Eddington D. T., Oberholzer J., Wang Y., Microfluidic perifusion and imaging device for multi-parametric islet function assessment Biomedical Microdevices 2010 12 3 409 417
136. Robertson R. P., Davis C., Larsen J., Stratta R., Sutherland D. E. R., Pancreas and islet transplantation for patients with diabetes Diabetes Care 2000 23 1 112 116 (Pubitemid 30022905)
137. Schieke S. M., Phillips D., McCoy J. P., Aponte A. M., Shen R. F., Balaban R. S., Finkel T., The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity Journal of Biological Chemistry 2006 281 37 27643 27652 (Pubitemid 44401789)
138. Chen C., Liu Y., Liu R., Ikenoue T., Guan K. L., Liu Y., Zheng P., TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species Journal of Experimental Medicine 2008 205 10 2397 2408
139. Hotamisligil G. S., Endoplasmic reticulum stress and the inflammatory basis of metabolic disease Cell 2010 140 6 900 917
140. Tanemura M., Saga A., Kawamoto K., Machida T., Deguchi T., Nishida T., Sawa Y., Doki Y., Mori M., Ito T., Rapamycin induces autophagy in islets: relevance in islet transplantation Transplantation Proceedings 2009 41 1 334 338
141. Li J. Y., Furuichi Y., Matsuoka N., Mutoh S., Yanagihara T., Tacrolimus (FK506) attenuates biphasic cytochrome c release and Bad phosphorylation following transient cerebral ischemia in mice Neuroscience 2006 142 3 789 797 (Pubitemid 44485917)
142. Erin N., Lehman R. A. W., Boyer P. J., Billingsley M. L., In vitro hypoxia and excitotoxicity in human brain induce calcineurin-Bcl-2 interactions Neuroscience 2003 117 3 557 565 (Pubitemid 36263151)
143. Marcelli-Tourvieille S., Hubert T., Moerman E., Gmyr V., Kerr-Conte J., Nunes B., Dherbomez M., Vandewalle B., Pattou F., Vantyghem M. C., In vivo and in vitro effect of sirolimus on insulin secretion Transplantation 2007 83 5 532 538 (Pubitemid 46440238)
144. Mita A., Ricordi C., Miki A., Barker S., Haertter R., Hashikura Y., Miyagawa S. I., Burke G. W., Inverardi L., Ichii H., Anti-proinflammatory effects of sirolimus on human islet preparations Transplantation 2008 86 1 46 53
145. Piemonti L., Maffi P., Monti L., Lampasona V., Perseghin G., Magistretti P., Secchi A., Bonifacio E., Beta cell function during rapamycin monotherapy in long-term type 1 diabetes Diabetologia 2011 54 2 433 439
146. Melzi R., Maffi P., Nano R., Sordi V., Mercalli A., Scavini M., Secchi A., Bonifacio E., Piemonti L., Rapamycin does not adversely affect intrahepatic islet engraftment in mice and improves early islet engraftment in humans Islets 2009 1 1 42 49
147. Shimodahira M., Fujimoto S., Mukai E., Nakamura Y., Nishi Y., Sasaki M., Sato Y., Sato H., Hosokawa M., Nagashima K., Seino Y., Inagaki N., Rapamycin impairs metabolism-secretion coupling in rat pancreatic islets by suppressing carbohydrate metabolism Journal of Endocrinology 2010 204 1 37 46
148. Laugharne M., Cross S., Richards S., Dawson C., Ilchyshyn L., Saleem M., Mathieson P., Smith R., Sirolimus toxicity and vascular endothelial growth factor release from islet and renal cell lines Transplantation 2007 83 12 1635 1638 (Pubitemid 46987917)
149. Bussiere C. T., Lakey J. R. T., Shapiro A. M. J., Korbutt G. S., The impact of the mTOR inhibitor sirolimus on the proliferation and function of pancreatic islets and ductal cells Diabetologia 2006 49 10 2341 2349 (Pubitemid 44359095)
150. Paty B. W., Harmon J. S., Marsh C. L., Robertson R. P., Inhibitory effects of immunosuppressive drugs on insulin secretion from HIT-T15 cells and Wistar rat islets Transplantation 2002 73 3 353 357 (Pubitemid 34174283)
151. Polastri L., Galbiati F., Bertuzzi F., Fiorina P., Nano R., Gregori S., Aldrighetti L., Pozza G., Secchi A., Adorini L., Davalli A. M., Secretory defects induced by immunosuppressive agents on human pancreatic -cells Acta Diabetologica 2002 39 4 229 233 (Pubitemid 35470538)
152. Redmon J. B., Olson L. K., Armstrong M. B., Greene M. J., Robertson R. P., Effects of tacrolimus (FK506) on human insulin gene expression, insulin mRNA levels, and insulin secretion in HIT-T15 cells Journal of Clinical Investigation 1996 98 12 2786 2793 (Pubitemid 26427406)
153. Montori V. M., Basu A., Erwin P. J., Velosa J. A., Gabriel S. E., Kudva Y. C., Posttransplantation diabetes: a systematic review of the literature Diabetes Care 2002 25 3 583 592
154. Radu R. G., Fujimoto S., Mukai E., Takehiro M., Shimono D., Nabe K., Shimodahira M., Kominato R., Aramaki Y., Nishi Y., Funakoshi S., Yamada Y., Seino Y., Tacrolimus suppresses glucose-induced insulin release from pancreatic islets by reducing glucokinase activity American Journal of Physiology 2005 288 2 E365 E371
155. Rostambeigi N., Lanza I. R., Dzeja P. P., Deeds M. C., Irving B. A., Reddi H. V., Madde P., Zhang S., Asmann Y. W., Anderson J. M., Schimke J. M., Nair K. S., Eberhardt N. L., Kudva Y. C., Unique cellular and mitochondrial defects mediate FK506-induced islet -cell dysfunction Transplantation 2011 91 6 615 623
156. Johnson J. D., Ao Z., Ao P., Li H., Dai L. J., He Z., Tee M., Potter K. J., Klimek A. M., Meloche R. M., Thompson D. M., Verchere C. B., Warnock G. L., Different effects of FK506, rapamycin, and mycophenolate mofetil on glucose-stimulated insulin release and apoptosis in human islets Cell Transplantation 2009 18 8 833 845
157. Song H. K., Han D. H., Song J. H., Ghee J. Y., Piao S. G., Kim S. H., Yoon H. E., Li C., Kim J., Yang C. W., Influence of sirolimus on cyclosporine-induced pancreas islet dysfunction in rats American Journal of Transplantation 2009 9 9 2024 2033
158. Kaplan B., West P., Neeley H., Martellotto J., Iqbal R., Gangemi A., Hatipoglu B., Benedetti E., Oberholzer J., Use of low dose tacrolimus, mycophenolate mofetil and maintenance IL-2 receptor blockade in an islet transplant recipient Clinical Transplantation 2008 22 2 250 253 (Pubitemid 351420022)
159. Barshes N. R., Wyllie S., Goss J. A., Inflammation-mediated dysfunction and apoptosis in pancreatic islet transplantation: implications for intrahepatic grafts Journal of Leukocyte Biology 2005 77 5 587 597 (Pubitemid 40628740)
160. Gleason C. E., Gonzalez M., Harmon J. S., Paul Robertson R., Determinants of glucose toxicity and its reversibility in the pancreatic islet -cell line, HIT-T15 American Journal of Physiology 2000 279 5 E997 E1002
161. Poitout V., Robertson R. P., Minireview: decondary -cell failure in type 2 diabetesa convergence of glucotoxicity and lipotoxicity Endocrinology 2002 143 2 339 342 (Pubitemid 34107184)
162. Rajab A., Islet transplantation: alternative sites Current Diabetes Reports 2010 10 5 332 337
163. Merani S., Toso C., Emamaullee J., Shapiro A. M. J., Optimal implantation site for pancreatic islet transplantation British Journal of Surgery 2008 95 12 1449 1461