Secretory defects induced by immunosuppressive agents on human pancreatic β-cells

Acta Diabetologica

Volumn 39, Issue 4, 2002, Pages 229-233

  Polastri, L ^a   Galbiati, F ^a   Bertuzzi, F ^a   Fiorina, P ^a   Nano, R ^a   Gregori, S ^b   Aldrighetti, L ^a   Pozza, G ^c   Secchi, A ^a   Adorini, L ^b   Davalli, A M ^a  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b ROCHE MILANO RICERCHE   (Italy)

^c VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

Author keywords

Human islet; Immunosuppressive agents; Insulin gene; Insulin secretion

Indexed keywords

CYCLOSPORIN A; CYTOKINE; GLUCOSE; IMMUNOSUPPRESSIVE AGENT; INSULIN; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; TACROLIMUS; CYCLOSPORIN; DRUG DERIVATIVE; MESSENGER RNA; MYCOPHENOLIC ACID;

ARTICLE; CELL CULTURE; CONTROLLED STUDY; DIABETOGENESIS; GENE EXPRESSION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IMMUNOSUPPRESSIVE TREATMENT; INSULIN RELEASE; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL; PRIORITY JOURNAL; ADULT; DRUG EFFECT; GENETICS; IN VITRO STUDY; METABOLISM; MIDDLE AGED; PANCREAS ISLET; SECRETION;

ADULT; CYCLOSPORINE; GENE EXPRESSION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INSULIN; ISLETS OF LANGERHANS; MIDDLE AGED; MYCOPHENOLIC ACID; RNA, MESSENGER; TACROLIMUS;

EID: 0036905423     PISSN: 09405429     EISSN: None     Source Type: Journal    
DOI: 10.1007/s005920200039     Document Type: Article

References (16)

1. Cosio FG, Pesarento TE, Osei K, Henry ML, Ferguson RM (2001) Post-transplantation diabetes mellitus: Increasing incidence in renal allograft recipient transplantated in recent years. Kidney Int 59:732-737
2. Nam JH, Mun JI, Kim SI, Kang SW, Choi KH, Park K, Ahn CW, Cha BS, Song YD, Lim SK, Kim KR, Lee HC, Kuh KB (2001) Beta-cell dysfunction rather than insulin resistance is the main contributing factor for the development of post-renal transplantation diabetes mellitus. Transplantation 71:1417-1423
3. Dufer M, Krippei-Drews P, Lembert N, Idahl LA, Drews G (2001) Diabetogenic effects of cyclosporin A are mediated by interference with mitochondrial function of pancreatic beta-cells. Mol Pharmacol 60:873-879
4. Drachenberg CB, Klassen DK, Weir MR, Wiland A, Fink JC, Bartlett ST, Cangro CB, Blahut S, Papadimitriou JC (1999) Islet cell damage associated with tacrolimus and cyclosporine: Morphological features in pancreas allograft biopsies and clinical correlation. Transplantation 68:396-402
5. Van Duijnhoven EM, Christiaans MH, Boots JM, Nieman FH, Wolffenbuttel BH, Van Hoof JP (2002) Glucose metabolism in the first 3 years after renal transplantation in patients receiving tacrolimus versus cyclosporine-based immunosuppression. J Am Soc Nephrol 13:213-220
6. Kutkuhn B, Hollenbeck M, Heering P et al (1997) Development of insulin resistance and elevated blood pressure during therapy with CsA. Blood Press 6(1):7-13
7. Ricordi C, Lacy PE, Finke EH et al (1988) Automated method for human pancreatic islets isolation. Diabetes 37(4):413-420
8. Meoni F, Bertuzzi A, Pontiroli E, Falqui L, Monaco L, Soria M, Arcelloni C, Paroni R, Foglieni C, Polastri L, Galbiati F, Folli F, Davalli AM (2000) Development and characterization of pituitary GH3 cell clones stably transfected with a human proinsulin cDNA. Cell Transplantation 9:829-840
9. Eizirik DL, Pipeleeers DG, Ling Z et al (1994) Major species differences between humans and rodents in the susceptibility to pancreatic β-cell injury. Proc Natl Acad Sci USA 91(20):9253-9256
10. Shapiro AM, Lakey JR, Ryan EA, Korbutt GS, Toth E, Warnock GL, Kneteman NM, Rajotte RV (2000) Islet transplatation in seven patients with type I diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med 343(4):289-290
11. Eizirik DL, Sandler S, Welsh N et al (1994) Cytokines suppress human islets function irrespective of their effects on nitric oxide generation. J Clin Invest 93(5):1968-1974
12. Drachenberg CB, Klassen DK, Weir MR et al (1999) Islet cell damage associated with tacrolimus and cyclosporine: Morphological features in pancreas allograft biopsies and clinical correlation. Transplantation 68(3):396-402
13. Nielsen JH, Mandrup-Poulsen T, Nerup J (1986) Direct effects of cyclosporine A on human pancreatic beta-cells. Diabetes 35(9):1049-1052
14. Sandberg JO, Anderson A, Sandler S (1993) Exposure of rat pancreatic islets to RS-61143 inhibits β-cell function. Transplatation 56(5):1197-1201
15. Li G, Segu VB, Rabaglia ME et al (1998) Prolonged depletion of guanosine triphosphate induces death of insulin-secreting cells by apoptosis. Endocrinology 139(9):3752-3762
16. Beger C, Menger MD (1997) RS-61443 prevents microvascular rejection of pancreatic islet xenografts. Transplantation 6(4):577-582