In vitro hypoxia and excitotoxicity in human brain induce calcineurin-Bcl-2 interactions

Neuroscience

Volumn 117, Issue 3, 2003, Pages 557-565

  Erin, N ^a   Lehman, R A W ^a   Boyer, P J ^a   Billingsley, M L ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

Aglycia; Bcl 2; Calcineurin; Hypoxia; Ischemia

Indexed keywords

ASCOMYCIN; CALCINEURIN; CASPASE 3; INOSITOL TRISPHOSPHATE; PROTEIN BCL 2; RECEPTOR;

ADULT; ARTICLE; BRAIN INJURY; BRAIN ISCHEMIA; CLINICAL ARTICLE; CYTOTOXICITY; DATA ANALYSIS; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN TISSUE; HYPOXIA; IN VITRO STUDY; MALE; MODULATION; MOUSE; NERVE CELL LESION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION;

EID: 0344091560     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(02)00934-X     Document Type: Article

References (50)

1. Asai A., Qiu J., Narita Y., Chi S., Saito N., Shinoura N., Hamada H., Kuchino Y., Kirino T. High level of calcineurin activity predisposes neuronal cells to apoptosis. J Biol Chem. 274:1999;34450-34458.
2. Berman F.W., Murray T.F. Domoic acid neurotoxicity in cultured cerebellar granule neurons is mediated predominantly by NMDA receptors that are activated as a consequence of excitatory amino acid release. J Neurochem. 69:1997;693-703.
3. 2+ flux. Cell. 83:1995;463-472.
4. Cohen P. The structures and regulation of protein phosphatases. Annu Rev Biochem. 58:1989;453-508. [review].
5. Endres M., Namura S., Shimizu-Sasamata M., Waeber C., Zhang L., Gomez-Isla T., Hyman B.T., Moskowitz M.A. Attenuation of delayed neuronal death after mild focal ischemia in mice by inhibition of the caspase family. J Cereb Blood Flow Metab. 18:1998;238-247.
6. Erin N, Bronson SK, Billingsley ML (2003) Calcium-dependent interaction of calcineurin with Bcl-2 in neuronal tissue. Neurosci 117:541-555.
7. 2+ dysregulation with brain aging. J Neurosci. 21:2001;4066-4073.
8. Garcia I., Martinou I., Tsujimoto Y., Martinou J.C. Prevention of programmed cell death of sympathetic neurons by the Bcl-2 protooncogene. Science. 258:1992;302-304.
9. Griffith J.P., Kim J.L., Kim E.E., Sintchak M.D., Thomson J.A., Fitzgibbon M.J., Fleming M.A., Caron P.R., Hsiao K., Navia M.A. X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP-12-FK-506 complex. Cell. 82:1995;507-522.
10. Guglielmo M.A., Chan P.T., Cortez S., Stopa E.G., McMillan P., Johanson C.E., Epstein M., Doberstein C.E. The temporal profile and morphological features of neuronal death in human stroke resemble those observed in experimental forebrain ischemia the potential role of apoptosis . Neurological Res. 20:1998;283-296.
11. Hata R., Gillardon F., Michaelidis T.M., Hossmann K.A. Targeted disruption of the bcl-2 gene in mice exacerbates focal ischemic brain injury. Metab Brain Dis. 14:1999;117-124.
12. He H., Lam M., McCormick T.S., Distelhorst C.W. Maintenance of calcium homeostasis in the endoplasmic reticulum by Bcl-2. J Cell Biol. 38:1997;219-228.
13. Henshal D.C., Clark R.S., Adelson P.D., Chen M., Watkins S.C., Simon R.P. Alterations in bcl-2 and caspase gene family protein expression in human temporal lobe epilepsy. Neurology. 55:2000;250-257.
14. Idilman R., DeMaria N., Kugelmas M., Colantoni A., Van Thiel D.H. Immunosuppressive drug-induced leukoencephalopathy in patients with liver transplant. Eur J Gastroenterol Hepat. 10:1998;433-436.
15. Klee C.B., Draetta G.F., Hubbard M.J. Calcineurin. Adv Enzymol. 61:1988;149-200. [review].
16. Krajewski S., Tanaka S., Takayama M.J., Schibler W., Fenton W., Reed J.C. Investigation of the subcellular distribution of the Bcl-2 oncoprotein residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membrane . Cancer Res. 53:1993;4701-4714.
17. Lee S.T., Hoeflich K.P., Wasfy G.W., Woodgett J.R., Leber B., Andrews D.W., Hedley D.W., Penn L.Z. Bcl-2 targeted to the endoplasmic reticulum can inhibit apoptosis induced by Myc but not etopside in Rat-1 fibroblasts. Oncogene. 18:1999;3520-3528.
18. Lee J.M., Zipfel G.J., Choi D.W. The changing landscape of ischemic brain injury mechanisms. Nature. 399:1999;A7-A14.
19. Linnik M.D., Zobrist R.H., Hatfield M.D. Evidence supporting a role for programmed cell death in focal cerebral ischemia in rats. Stroke. 24:1993;2002-2008.
20. Liu J., Farmer J.D. Jr, Lane W.S., Friedman J., Weissman I., Schreiber S.L. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Trends Pharmacol Sci. 14:1991;182-188.
21. Mah S.P., Zhong L.T., Liu Y., Roghani A., Edwards R.H., Bredesen D.E. The protooncogene Bcl-2 inhibits apoptosis in PC12 cells. J Neurochem. 60:1993;1183-1186.
22. Martin L.J., Al-Abdulla N.A., Brambrink A.M., Kirsch J.R., Sieber F.E., Prtera-Cailliau C. Neurodegeneration in exitotoxicity, global cerebral ischemia and target deprivation a perspective on the contribution of apoptosis and necrosis . Brain Res Bull. 46:1998;281-309.
23. Martinou J.C., Dubois-Dauphin M., Stable J.K., Rodriguez I., Frankowski H., Missotten M., Albertini P., Talabot D., Catsicas S., Pietra C. Overexpression of Bcl-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia. Neuron. 13:1994;1017-1030.
24. Motamedi H., Shafiee A., Cai S.J., Streicher S.L., Arison B.H., Miller R.R. Characterization of methytransferase and hdrolase genes involved in the biosynthesis of the immunosuppressants FK506 and FK520. J Bacteriol. 178:1996;5243-5248.
25. Nath R., Raser K.J., Stafford D., Hajimohammadreza I., Posner A., Allen H., Talanian R.V., Yuen P., Gilbertsen R.B., Wang K.K. Nonerytroid alpha-spectrin breakdown by calpain and ICE- like protease(s) in apoptotic cells contributory roles of both protease families in neuronal apoptosis . Biochem J. 319:1996;683-690.
26. Nunez G., London L., Hockenbery D., Alexander M., McKearn J.P., Korsmeyer S.J. Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines. J Immunol. 144:1990;3602-3610.
27. 2+ channel activation and resultant nitric oxide synthesis in glutamate-mediated hypoxic injury in rat cerebrocortical slices. Life Sci. 67:2000;2331-2343.
28. + channel blocker with neuroprotective effects in models of in vitro and in vivo cerebral ischemia. Brain Res. 888:2001;138-149.
29. Perl M.T., Bedard M.S.N., Kotasky T., Hockin J.C., Todd E.C., Remis R.S. An outbreak of toxic encephalopathy caused by eating mussels contaminated with domoic acid. N Engl J Med. 322:1990;1775-1780.
30. Polischuk T.M., Andrew D. Real-time imaging of intrinsic optical signals during early excitotoxicity evoked by domoic acid in rat hippocampal slice. Can J Phsiol Pharmacol. 74:1996;712-722.
31. Reed J.C. Double identity for proteins of the Bcl-2 family. Nature. 387:1997;773-776. [review].
32. Robertson G.S., Crocker S.J., Nicholson D.W., Schulz J.B. Neuroprotection by the inhibition of apoptosis. Brain Pathol. 10:2000;283-292.
33. Sabatini D.M., Lai M.M., Snyder S.H. Neuronal roles of immunophilins and their ligands. Mol Neurobiol. 15:1997;223-239. [review].
34. Sasaki T., Senda M., Ohno T., Kojima S., Kubodera A. Effect of in vitro ischemic or hypoxic treatment on mitochondrial electron transfer activity in rat brain slices assessed by using gas-tissue autoradiography. Brain Res. 890:2001;100-119.
35. Schurr A., Rigor B.M. Cerebral ischemia revisited new insights as revealed using in vitro brain slice preparations . Experientia. 45:1989;648-695. [review].
36. Sharkey J., Butcher S.P. Immunophilins mediate the neuroprotective effects of FK506 in focal cerebral ischemia. Nature. 371:1994;336-339.
37. Shibasaki F., Kondo E., Akagi T., McKeon F. Suppression of signaling through transcription factor NF-AT by interactions between calcineurin and Bcl-2. Nature. 386:1997;728-731.
38. Shibasaki F., McKeon F. Calcineurin functions in Ca (2+)-activated cell death in mammalian cells. J Cell Biol. 131:1995;735-743.
39. Siesjo B.K., Zhao Q., Pahlmark K., Siesjo P., Katsura K., Folbergrova J. Glutamate, calcium and free radicals as mediators of ischemic brain damage. Ann Thorac Surg. 59:1995;1316-1320.
40. Springer J.E., Azbill R.D., Nottingham S.A., Kennedy S.E. Calcineurin-mediated BAD dephosphorylation activates the caspase-3 apoptotic cascade in traumatic spinal cord injury. J Neurosci. 20:2000;7246-7251.
41. Steg R.E., Kessinger A., Wszolek Z.K. Cortical blindness and seizures in patients receiving FK506 after bone marrow transplantation. Bone Marr Transp. 23:1999;959-962.
42. Steiner J.P., Connolly M.A., Valentine H.L., Hamilton G.S., Dawson T.M., Hester L., Snyder S.H. Neurotrophic actions of nonimmunosuppressive analogues of immunosuppressive drugs FK 506, rapamaycin and cyclosporin A. Nature Med. 3:1997;421-428.
43. Tong G., Shepherd D., Jahr C.E. Synaptic desensitization of NMDA receptors by calcineurin. Science. 267:1995;510-512.
44. Torocsik H.V., Curless R.G., Post J., Tzakis A.G., Pearse L. FK506-induced leukoencephalopathy in children with organ transplants. Neurology. 52:1999;1497-1500.
45. Wright J.L., Bird C.J., de Freitas A.S., Hampson D., McDonald J., Quilliam M.A. Chemistry, biology, and toxicology of domoic acid and its isomers. Can Dis Wkly Rep. 16:(Suppl 1E):1990;21-26.
46. Wood AM Bristow DR (1998) N-methyl-D-aspartate receptor desensitisation is neuroprotective by inhibiting glutamate-induced apoptotic-like death. J Neurochem 70:677-687.
47. Wolf P.A., Cobb J.L., D'Agostino R.B. Epidemiology of stroke. Barnett H.J., Stein B.M., Mohr J.P., Yatsu F.M. Stroke: pathophysiology, diagnosis, and managenement. 1992;3-27 Churchill Livingstone, New York.
48. Victor R.G., Thomas G.D., Marban E., O'Rourke B. Presynaptic modulation of cortical synaptic activity by calcineurin. Proc Natl Acad Sci USA. 92:1995;6269-6273.
49. Yagita Y., Kitagawa K., Matsushita K., Taguchi A., Mabuchi T., Ohtsuki T., Yanagihara T., Matsumoto M. Effect of immunosuppressant FK506 on ischemia-induced degeneration of hippocampal neurons in gerbils. Life Sci. 59:1996;1643-1650.
50. Yakel J.L. Calcineurin regulation of synaptic function from ion channels to transmitter release and gene transcription . Trends Pharmacol Sci. 18:1997;125-134. [review].