Unique cellular and mitochondrial defects mediate FK506-induced islet β-cell dysfunction

Transplantation

Volumn 91, Issue 6, 2011, Pages 615-623

  Rostambeigi, Nassir ^a   Lanza, Ian R ^a   Dzeja, Petras P ^a   Deeds, Michael C ^a   Irving, Brian A ^a   Reddi, Honey V ^a   Madde, Pranathi ^a   Zhang, Song ^a   Asmann, Yan W ^a   Anderson, Jarett M ^a   Schimke, Jill M ^a   Nair, K Sreekumaran ^a   Eberhardt, Norman L ^a,b   Kudva, Yogish C ^a  

^a MAYO CLINIC   (United States)

^b MAYO GRADUATE SCHOOL   (United States)

Author keywords

FK506; Insulin secretion; Islet toxicity; Mitochondrial density; Mitochondrial DNA; MotifADE

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; CYCLOSPORIN A; INSULIN; MESSENGER RNA; MITOCHONDRIAL DNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; TACROLIMUS;

ANIMAL CELL; APOPTOSIS; ARTICLE; B LYMPHOCYTE; CELL DIVISION; CELL ISOLATION; CELL METABOLISM; CELL PROLIFERATION; CELL RESPIRATION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; CYTOSKELETON; DIABETES MELLITUS; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DOWN REGULATION; GENE DOSAGE; GENE EXPRESSION; INSULIN RELEASE; LYMPHOCYTE FUNCTION; MALE; MICROARRAY ANALYSIS; NONHUMAN; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; PANCREAS ISLET BETA CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RAT;

ADENOSINE TRIPHOSPHATE; ANIMALS; CELL LINE, TUMOR; CYCLOSPORINE; DNA, MITOCHONDRIAL; GENE EXPRESSION PROFILING; IMMUNOSUPPRESSIVE AGENTS; INSULIN; INSULIN-SECRETING CELLS; MITOCHONDRIA; RATS; TACROLIMUS;

EID: 79952772991     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e3182094a33     Document Type: Article

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