-
1
-
-
0036865991
-
Mitochondria as the conductor of metabolic signals for insulin exocytosis in pancreatic β-cells
-
Maechler P 2002 Mitochondria as the conductor of metabolic signals for insulin exocytosis in pancreatic β-cells. Cell Mol Life Sci 59:1803-1818
-
(2002)
Cell Mol Life Sci
, vol.59
, pp. 1803-1818
-
-
Maechler, P.1
-
2
-
-
4043086952
-
Mitochondria in health and disease: Perspectives on a new mitochondrial biology
-
Duchen MR 2004 Mitochondria in health and disease: perspectives on a new mitochondrial biology. Mol Aspects Med 25:365-451
-
(2004)
Mol Aspects Med
, vol.25
, pp. 365-451
-
-
Duchen, M.R.1
-
3
-
-
12344305124
-
Mitochondrial dysfunction and type 2 diabetes
-
Lowell BB, Shulman GI 2005 Mitochondrial dysfunction and type 2 diabetes. Science 307:384-387
-
(2005)
Science
, vol.307
, pp. 384-387
-
-
Lowell, B.B.1
Shulman, G.I.2
-
4
-
-
0036311080
-
β-Cell mitochondria and insulin secretion: Messenger role of nucleotides and metabolites
-
Wollheim CB, Maechler P 2002 β-Cell mitochondria and insulin secretion: messenger role of nucleotides and metabolites. Diabetes 51(Suppl 1):S37-S42
-
(2002)
Diabetes
, vol.51
, Issue.1 SUPPL.
-
-
Wollheim, C.B.1
Maechler, P.2
-
5
-
-
9444259786
-
Pathways in β-cell stimulus-secretion coupling as targets for therapeutic insulin secretagogues
-
Henquin JC 2004 Pathways in β-cell stimulus-secretion coupling as targets for therapeutic insulin secretagogues. Diabetes 53(Suppl 3):S48-S58
-
(2004)
Diabetes
, vol.53
, Issue.3 SUPPL.
-
-
Henquin, J.C.1
-
6
-
-
33644872401
-
In β-cells, mitochondria integrate and generate metabolic signals controlling insulin secretion
-
Maechler P, Carobbio S, Rubi B 2006 In β-cells, mitochondria integrate and generate metabolic signals controlling insulin secretion. Int J Biochem Cell Biol 38(5-6):696-709
-
(2006)
Int J Biochem Cell Biol
, vol.38
, Issue.5-6
, pp. 696-709
-
-
Maechler, P.1
Carobbio, S.2
Rubi, B.3
-
7
-
-
0036896635
-
Regulation of pancreatic β-cell glucokinase: From basics to therapeutics
-
Matschinsky FM 2002 Regulation of pancreatic β-cell glucokinase: from basics to therapeutics. Diabetes 51(Suppl 3):S394-S404
-
(2002)
Diabetes
, vol.51
, Issue.3 SUPPL.
-
-
Matschinsky, F.M.1
-
8
-
-
12044255619
-
Low lactate dehydrogenase and high mitochondrial glycerol phosphate dehydrogenase in pancreatic β-cells. Potential role in nutrient sensing
-
Sekine N, Cirulli V, Regazzi R, Brown LJ, Gine E, Tamarit-Rodriguez J, Girotti M, Marie S, MacDonald MJ, Wollheim CB 1994 Low lactate dehydrogenase and high mitochondrial glycerol phosphate dehydrogenase in pancreatic β-cells. Potential role in nutrient sensing. J Biol Chem 269:4895-4902
-
(1994)
J Biol Chem
, vol.269
, pp. 4895-4902
-
-
Sekine, N.1
Cirulli, V.2
Regazzi, R.3
Brown, L.J.4
Gine, E.5
Tamarit-Rodriguez, J.6
Girotti, M.7
Marie, S.8
MacDonald, M.J.9
Wollheim, C.B.10
-
9
-
-
0030810982
-
Metabolic fate of glucose in purified islet cells. Glucose-regulated anaplerosis in β cells
-
Schuit F, De Vos A, Farfari S, Moens K, Pipeleers D, Brun T, Prentki M 1997 Metabolic fate of glucose in purified islet cells. Glucose-regulated anaplerosis in β cells. J Biol Chem 272:18572-18579
-
(1997)
J Biol Chem
, vol.272
, pp. 18572-18579
-
-
Schuit, F.1
De Vos, A.2
Farfari, S.3
Moens, K.4
Pipeleers, D.5
Brun, T.6
Prentki, M.7
-
11
-
-
0037022527
-
13C NMR isotopomer analysis reveals a connection between pyruvate cycling and glucose-stimulated insulin secretion (GSIS)
-
USA
-
13C NMR isotopomer analysis reveals a connection between pyruvate cycling and glucose-stimulated insulin secretion (GSIS). Proc Natl Acad Sci USA 99:2708-2713
-
(2002)
Proc Natl Acad Sci
, vol.99
, pp. 2708-2713
-
-
Lu, D.1
Mulder, H.2
Zhao, P.3
Burgess, S.C.4
Jensen, M.V.5
Kamzolova, S.6
Newgard, C.B.7
Sherry, A.D.8
-
12
-
-
27144525581
-
New mitochondrial carriers: An overview
-
Arco AD, Satrustegui J 2005 New mitochondrial carriers: an overview. Cell Mol Life Sci 62:2204-2227
-
(2005)
Cell Mol Life Sci
, vol.62
, pp. 2204-2227
-
-
Arco, A.D.1
Satrustegui, J.2
-
13
-
-
11244318158
-
The malate-aspartate NADH shuttle member aralar1 determines glucose metabolic fate, mitochondrial activity, and insulin secretion in β cells
-
Rubi B, del Arco A, Bartley C, Satrustegui J, Maechler P 2004 The malate-aspartate NADH shuttle member aralar1 determines glucose metabolic fate, mitochondrial activity, and insulin secretion in β cells. J Biol Chem 279:55659-55666
-
(2004)
J Biol Chem
, vol.279
, pp. 55659-55666
-
-
Rubi, B.1
Del Arco, A.2
Bartley, C.3
Satrustegui, J.4
Maechler, P.5
-
14
-
-
0036829678
-
Switch to anaerobic glucose metabolism with NADH accumulation in the β-cell model of mitochondrial diabetes. Characteristics of βHC9 cells deficient in mitochondrial DNA transcription
-
Noda M, Yamashita S, Takahashi N, Eto K, Shen LM, Izumi K, Daniel S, Tsubamoto Y, Nemoto T, Iino M, Kasai H, Sharp GW, Kadowaki T 2002 Switch to anaerobic glucose metabolism with NADH accumulation in the β-cell model of mitochondrial diabetes. Characteristics of βHC9 cells deficient in mitochondrial DNA transcription. J Biol Chem 277:41817-41826
-
(2002)
J Biol Chem
, vol.277
, pp. 41817-41826
-
-
Noda, M.1
Yamashita, S.2
Takahashi, N.3
Eto, K.4
Shen, L.M.5
Izumi, K.6
Daniel, S.7
Tsubamoto, Y.8
Nemoto, T.9
Iino, M.10
Kasai, H.11
Sharp, G.W.12
Kadowaki, T.13
-
15
-
-
0033548138
-
Role of NADH shuttle system in glucose-induced activation of mitochondrial metabolism and insulin secretion
-
Eto K, Tsubamoto Y, Terauchi Y, Sugiyama T, Kishimoto T, Takahashi N, Yamauchi N, Kubota N, Murayama S, Aizawa T, Akanuma Y, Aizawa S, Kasai H, Yazaki Y, Kadowaki T 1999 Role of NADH shuttle system in glucose-induced activation of mitochondrial metabolism and insulin secretion. Science 283:981-985
-
(1999)
Science
, vol.283
, pp. 981-985
-
-
Eto, K.1
Tsubamoto, Y.2
Terauchi, Y.3
Sugiyama, T.4
Kishimoto, T.5
Takahashi, N.6
Yamauchi, N.7
Kubota, N.8
Murayama, S.9
Aizawa, T.10
Akanuma, Y.11
Aizawa, S.12
Kasai, H.13
Yazaki, Y.14
Kadowaki, T.15
-
16
-
-
0031892856
-
Effects of depletion of mitochondrial DNA in metabolism secretion coupling in INS-1 cells
-
Kennedy ED, Maechler P, Wollheim CB 1998 Effects of depletion of mitochondrial DNA in metabolism secretion coupling in INS-1 cells. Diabetes 47:374-380
-
(1998)
Diabetes
, vol.47
, pp. 374-380
-
-
Kennedy, E.D.1
Maechler, P.2
Wollheim, C.B.3
-
17
-
-
0037385959
-
Islet β-cell secretion determines glucagon release from neighbouring α-cells
-
Ishihara H, Maechler P, Gjinovci A, Herrera PL, Wollheim CB 2003 Islet β-cell secretion determines glucagon release from neighbouring α-cells. Nat Cell Biol 5:330-335
-
(2003)
Nat Cell Biol
, vol.5
, pp. 330-335
-
-
Ishihara, H.1
Maechler, P.2
Gjinovci, A.3
Herrera, P.L.4
Wollheim, C.B.5
-
18
-
-
0037023692
-
Mitochondrial metabolism sets the maximal limit of fuel-stimulated insulin secretion in a model pancreatic β cell: A survey of four fuel secretagogues
-
Antinozzi PA, Ishihara H, Newgard CB, Wollheim CB 2002 Mitochondrial metabolism sets the maximal limit of fuel-stimulated insulin secretion in a model pancreatic β cell: a survey of four fuel secretagogues. J Biol Chem 277:11746-11755
-
(2002)
J Biol Chem
, vol.277
, pp. 11746-11755
-
-
Antinozzi, P.A.1
Ishihara, H.2
Newgard, C.B.3
Wollheim, C.B.4
-
20
-
-
0042879951
-
Insulin granule dynamics in pancreatic β cells
-
Rorsman P, Renstrom E 2003 Insulin granule dynamics in pancreatic β cells. Diabetologia 46:1029-1045
-
(2003)
Diabetologia
, vol.46
, pp. 1029-1045
-
-
Rorsman, P.1
Renstrom, E.2
-
23
-
-
0034064334
-
β-Cell mitochondria in the regulation of insulin secretion: A new culprit in type II diabetes
-
Wollheim CB 2000 β-Cell mitochondria in the regulation of insulin secretion: a new culprit in type II diabetes. Diabetologia 43:265-277
-
(2000)
Diabetologia
, vol.43
, pp. 265-277
-
-
Wollheim, C.B.1
-
24
-
-
33644868754
-
+ signals to neuronal mitochondria
-
+ signals to neuronal mitochondria. J Biol Chem 281:1039-1047
-
(2006)
J Biol Chem
, vol.281
, pp. 1039-1047
-
-
Pardo, B.1
Contreras, L.2
Serrano, A.3
Ramos, M.4
Kobayashi, K.5
Iijima, M.6
Saheki, T.7
Satrustegui, J.8
-
25
-
-
0345074100
-
2+ exchanger increases mitochondrial metabolism and potentiates glucose-stimulated insulin secretion in rat pancreatic islets
-
2+ exchanger increases mitochondrial metabolism and potentiates glucose-stimulated insulin secretion in rat pancreatic islets. Diabetes 52:965-973
-
(2003)
Diabetes
, vol.52
, pp. 965-973
-
-
Lee, B.1
Miles, P.D.2
Vargas, L.3
Luan, P.4
Glasco, S.5
Kushnareva, Y.6
Kornbrust, E.S.7
Grako, K.A.8
Wollheim, C.B.9
Maechler, P.10
Olefsky, J.M.11
Anderson, C.M.12
-
26
-
-
4644326685
-
2+ handling in human complex I deficiency
-
2+ handling in human complex I deficiency. J Biol Chem 279:40328-40336
-
(2004)
J Biol Chem
, vol.279
, pp. 40328-40336
-
-
Visch, H.J.1
Rutter, G.A.2
Koopman, W.J.3
Koenderink, J.B.4
Verkaart, S.5
De Groot, T.6
Varadi, A.7
Mitchell, K.J.8
Van Den Heuvel, L.P.9
Smeitink, J.A.10
Willems, P.H.11
-
27
-
-
0026632641
-
Evidence that glucose can control insulin release independently from its action on ATP-sensitive K+ channels in mouse B cells
-
Gembal M, Gilon P, Henquin JC 1992 Evidence that glucose can control insulin release independently from its action on ATP-sensitive K+ channels in mouse B cells. J Clin Invest 89:1288-1295
-
(1992)
J Clin Invest
, vol.89
, pp. 1288-1295
-
-
Gembal, M.1
Gilon, P.2
Henquin, J.C.3
-
28
-
-
0030926003
-
Mitochondrial activation directly triggers the exocytosis of insulin in permeabilized pancreatic β-cells
-
Maechler P, Kennedy ED, Pozzan T, Wollheim CB 1997 Mitochondrial activation directly triggers the exocytosis of insulin in permeabilized pancreatic β-cells. EMBO J 16:3833-3841
-
(1997)
EMBO J
, vol.16
, pp. 3833-3841
-
-
Maechler, P.1
Kennedy, E.D.2
Pozzan, T.3
Wollheim, C.B.4
-
29
-
-
0033540037
-
Mitochondrial glutamate acts as a messenger in glucose-induced insulin exocytosis
-
Maechler P, Wollheim CB 1999 Mitochondrial glutamate acts as a messenger in glucose-induced insulin exocytosis. Nature 402:685-689
-
(1999)
Nature
, vol.402
, pp. 685-689
-
-
Maechler, P.1
Wollheim, C.B.2
-
30
-
-
0034072556
-
Glucose-regulated anaplerosis and cataplerosis in pancreatic β-cells: Possible implication of a pyruvate/ citrate shuttle in insulin secretion
-
Farfari S, Schulz V, Corkey B, Prentki M 2000 Glucose-regulated anaplerosis and cataplerosis in pancreatic β-cells: possible implication of a pyruvate/ citrate shuttle in insulin secretion. Diabetes 49:718-726
-
(2000)
Diabetes
, vol.49
, pp. 718-726
-
-
Farfari, S.1
Schulz, V.2
Corkey, B.3
Prentki, M.4
-
32
-
-
0034737731
-
Acute stimulation with long chain acyl-CoA enhances exocytosis in insulin-secreting cells (HIT T-15 and NMRI β-cells)
-
Deeney JT, Gromada J, Hoy M, Olsen HL, Rhodes CJ, Prentki M, Berggren PO, Corkey BE 2000 Acute stimulation with long chain acyl-CoA enhances exocytosis in insulin-secreting cells (HIT T-15 and NMRI β-cells). J Biol Chem 275:9363-9368
-
(2000)
J Biol Chem
, vol.275
, pp. 9363-9368
-
-
Deeney, J.T.1
Gromada, J.2
Hoy, M.3
Olsen, H.L.4
Rhodes, C.J.5
Prentki, M.6
Berggren, P.O.7
Corkey, B.E.8
-
33
-
-
0141755328
-
A sustained increase in plasma free fatty acids impairs insulin secretion in nondiabetic subjects genetically predisposed to develop type 2 diabetes
-
Kashyap S, Belfort R, Gastaldelli A, Pratipanawatr T, Berria R, Pratipanawatr W, Bajaj M, Mandarino L, DeFronzo R, Cusi K 2003 A sustained increase in plasma free fatty acids impairs insulin secretion in nondiabetic subjects genetically predisposed to develop type 2 diabetes. Diabetes 52:2461-2474
-
(2003)
Diabetes
, vol.52
, pp. 2461-2474
-
-
Kashyap, S.1
Belfort, R.2
Gastaldelli, A.3
Pratipanawatr, T.4
Berria, R.5
Pratipanawatr, W.6
Bajaj, M.7
Mandarino, L.8
Defronzo, R.9
Cusi, K.10
-
34
-
-
3042591440
-
Biochemical mechanism of lipid-induced impairment of glucose-stimulated insulin secretion and reversal with a malate analogue
-
Boucher A, Lu D, Burgess SC, Telemaque-Potts S, Jensen MV, Mulder H, Wang MY, Unger RH, Sherry AD, Newgard CB 2004 Biochemical mechanism of lipid-induced impairment of glucose-stimulated insulin secretion and reversal with a malate analogue. J Biol Chem 279:27263-27271
-
(2004)
J Biol Chem
, vol.279
, pp. 27263-27271
-
-
Boucher, A.1
Lu, D.2
Burgess, S.C.3
Telemaque-Potts, S.4
Jensen, M.V.5
Mulder, H.6
Wang, M.Y.7
Unger, R.H.8
Sherry, A.D.9
Newgard, C.B.10
-
35
-
-
21344456969
-
Redox control of exocytosis: Regulatory role of NADPH, thioredoxin, and glutaredoxin
-
Ivarsson R, Quintens R, Dejonghe S, Tsukamoto K, in 't Veld P, Renstrom E, Schuit FC 2005 Redox control of exocytosis: regulatory role of NADPH, thioredoxin, and glutaredoxin. Diabetes 54:2132-2142
-
(2005)
Diabetes
, vol.54
, pp. 2132-2142
-
-
Ivarsson, R.1
Quintens, R.2
Dejonghe, S.3
Tsukamoto, K.4
In 't Veld, P.5
Renstrom, E.6
Schuit, F.C.7
-
36
-
-
0037031896
-
The elevation of glutamate content and the amplification of insulin secretion in glucose-stimulated pancreatic islets are not causally related
-
Bertrand G, Ishiyama N, Nenquin M, Ravier MA, Henquin JC 2002 The elevation of glutamate content and the amplification of insulin secretion in glucose-stimulated pancreatic islets are not causally related. J Biol Chem 277:32883-32891
-
(2002)
J Biol Chem
, vol.277
, pp. 32883-32891
-
-
Bertrand, G.1
Ishiyama, N.2
Nenquin, M.3
Ravier, M.A.4
Henquin, J.C.5
-
37
-
-
0038540613
-
Mitochondria-derived glutamate at the interplay between branched-chain amino acid and glucose-induced insulin secretion
-
Broca C, Brennan L, Petit P, Newsholme P, Maechler P 2003 Mitochondria-derived glutamate at the interplay between branched-chain amino acid and glucose-induced insulin secretion. FEBS Lett 545:167-172
-
(2003)
FEBS Lett
, vol.545
, pp. 167-172
-
-
Broca, C.1
Brennan, L.2
Petit, P.3
Newsholme, P.4
Maechler, P.5
-
38
-
-
0037032447
-
Increase in cellular glutamate levels stimulates exocytosis in pancreatic β-cells
-
Hoy M, Maechler P, Efanov AM, Wollheim CB, Berggren PO, Gromada J 2002 Increase in cellular glutamate levels stimulates exocytosis in pancreatic β-cells. FEBS Lett 531:199-203
-
(2002)
FEBS Lett
, vol.531
, pp. 199-203
-
-
Hoy, M.1
Maechler, P.2
Efanov, A.M.3
Wollheim, C.B.4
Berggren, P.O.5
Gromada, J.6
-
39
-
-
0036894314
-
Glutaminolysis and insulin secretion: From bedside to bench and back
-
Kelly A, Li C, Gao Z, Stanley CA, Matschinsky FM 2002 Glutaminolysis and insulin secretion: from bedside to bench and back. Diabetes 51(Suppl 3):S421-S426
-
(2002)
Diabetes
, vol.51
, Issue.3 SUPPL.
-
-
Kelly, A.1
Li, C.2
Gao, Z.3
Stanley, C.A.4
Matschinsky, F.M.5
-
40
-
-
0035856942
-
Mitochondrial function in normal and diabetic β-cells
-
Maechler P, Wollheim CB 2001 Mitochondrial function in normal and diabetic β-cells. Nature 414:807-812
-
(2001)
Nature
, vol.414
, pp. 807-812
-
-
Maechler, P.1
Wollheim, C.B.2
-
41
-
-
20344378241
-
Molecular mechanisms of mitochondrial diabetes (MIDD)
-
Maassen JA, Janssen GM, t Hart LM 2005 Molecular mechanisms of mitochondrial diabetes (MIDD). Ann Med 37:213-221
-
(2005)
Ann Med
, vol.37
, pp. 213-221
-
-
Maassen, J.A.1
Janssen, G.M.2
T Hart, L.M.3
-
42
-
-
0030747209
-
In situ characterization of islets in diabetes with a mitochondrial DNA mutation at nucleotide position 3243
-
Kobayashi T, Nakanishi K, Nakase H, Kajio H, Okubo M, Murase T, Kosaka K 1997 In situ characterization of islets in diabetes with a mitochondrial DNA mutation at nucleotide position 3243. Diabetes 46:1567-1571
-
(1997)
Diabetes
, vol.46
, pp. 1567-1571
-
-
Kobayashi, T.1
Nakanishi, K.2
Nakase, H.3
Kajio, H.4
Okubo, M.5
Murase, T.6
Kosaka, K.7
-
43
-
-
9444242665
-
Five stages of evolving β-cell dysfunction during progression to diabetes
-
Weir GC, Bonner-Weir S 2004 Five stages of evolving β-cell dysfunction during progression to diabetes. Diabetes 53(Suppl 3):S16-S21
-
(2004)
Diabetes
, vol.53
, Issue.3 SUPPL.
-
-
Weir, G.C.1
Bonner-Weir, S.2
-
44
-
-
13944278132
-
Mitochondria, oxidants, and aging
-
Balaban RS, Nemoto S, Finkel T 2005 Mitochondria, oxidants, and aging. Cell 120:483-495
-
(2005)
Cell
, vol.120
, pp. 483-495
-
-
Balaban, R.S.1
Nemoto, S.2
Finkel, T.3
-
45
-
-
2642580016
-
Premature ageing in mice expressing defective mitochondrial DNA polymerase
-
Trifunovic A, Wredenberg A, Falkenberg M, Spelbrink JN, Rovio AT, Bruder CE, Bohlooly YM, Gidlof S, Oldfors A, Wibom R, Tornell J, Jacobs HT, Larsson NG 2004 Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature 429:417-423
-
(2004)
Nature
, vol.429
, pp. 417-423
-
-
Trifunovic, A.1
Wredenberg, A.2
Falkenberg, M.3
Spelbrink, J.N.4
Rovio, A.T.5
Bruder, C.E.6
Bohlooly, Y.M.7
Gidlof, S.8
Oldfors, A.9
Wibom, R.10
Tornell, J.11
Jacobs, H.T.12
Larsson, N.G.13
-
46
-
-
0033595684
-
Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication
-
Michikawa Y, Mazzucchelli F, Bresolin N, Scarlato G, Attardi G 1999 Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication. Science 286:774-779
-
(1999)
Science
, vol.286
, pp. 774-779
-
-
Michikawa, Y.1
Mazzucchelli, F.2
Bresolin, N.3
Scarlato, G.4
Attardi, G.5
-
47
-
-
85047690706
-
Frataxin deficiency in pancreatic islets causes diabetes due to loss of β cell mass
-
Ristow M, Mulder H, Pomplun D, Schulz TJ, Muller-Schmehl K, Krause A, Fex M, Puccio H, Muller J, Isken F, Spranger J, Muller-Wieland D, Magnuson MA, Mohlig M, Koenig M, Pfeiffer AF 2003 Frataxin deficiency in pancreatic islets causes diabetes due to loss of β cell mass. J Clin Invest 112:527-534
-
(2003)
J Clin Invest
, vol.112
, pp. 527-534
-
-
Ristow, M.1
Mulder, H.2
Pomplun, D.3
Schulz, T.J.4
Muller-Schmehl, K.5
Krause, A.6
Fex, M.7
Puccio, H.8
Muller, J.9
Isken, F.10
Spranger, J.11
Muller-Wieland, D.12
Magnuson, M.A.13
Mohlig, M.14
Koenig, M.15
Pfeiffer, A.F.16
-
48
-
-
0037984371
-
Visualizing superoxide production in normal and diabetic rat islets of Langerhans
-
Bindokas VP, Kuznetsov A, Sreenan S, Polonsky KS, Roe MW, Philipson LH 2003 Visualizing superoxide production in normal and diabetic rat islets of Langerhans. J Biol Chem 278:9796-9801
-
(2003)
J Biol Chem
, vol.278
, pp. 9796-9801
-
-
Bindokas, V.P.1
Kuznetsov, A.2
Sreenan, S.3
Polonsky, K.S.4
Roe, M.W.5
Philipson, L.H.6
-
49
-
-
0346340042
-
Superoxide-mediated activation of uncoupling protein 2 causes pancreatic β cell dysfunction
-
Krauss S, Zhang CY, Scorrano L, Dalgaard LT, St-Pierre J, Grey ST, Lowell BB 2003 Superoxide-mediated activation of uncoupling protein 2 causes pancreatic β cell dysfunction. J Clin Invest 112:1831-1842
-
(2003)
J Clin Invest
, vol.112
, pp. 1831-1842
-
-
Krauss, S.1
Zhang, C.Y.2
Scorrano, L.3
Dalgaard, L.T.4
St-Pierre, J.5
Grey, S.T.6
Lowell, B.B.7
-
50
-
-
20144364947
-
Glucose suppresses superoxide generation in metabolically responsive pancreatic β cells
-
Martens GA, Cai Y, Hinke S, Stange G, Van de Casteele M, Pipeleers D 2005 Glucose suppresses superoxide generation in metabolically responsive pancreatic β cells. J Biol Chem 280:20389-20396
-
(2005)
J Biol Chem
, vol.280
, pp. 20389-20396
-
-
Martens, G.A.1
Cai, Y.2
Hinke, S.3
Stange, G.4
Van De Casteele, M.5
Pipeleers, D.6
-
51
-
-
0030689041
-
Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells
-
Tiedge M, Lortz S, Drinkgern J, Lenzen S 1997 Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells. Diabetes 46:1733-1742
-
(1997)
Diabetes
, vol.46
, pp. 1733-1742
-
-
Tiedge, M.1
Lortz, S.2
Drinkgern, J.3
Lenzen, S.4
-
52
-
-
10044219818
-
Five cysteine-containing compounds delay diabetic deterioration in BALB/cA mice
-
Hsu CC, Yen HF, Yin MC, Tsai CM, Hsieh CH 2004 Five cysteine-containing compounds delay diabetic deterioration in BALB/cA mice. J Nutr 134:3245-3249
-
(2004)
J Nutr
, vol.134
, pp. 3245-3249
-
-
Hsu, C.C.1
Yen, H.F.2
Yin, M.C.3
Tsai, C.M.4
Hsieh, C.H.5
-
53
-
-
0037219411
-
β-Cell deficit and increased β-cell apoptosis in humans with type 2 diabetes
-
Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC 2003 β-Cell deficit and increased β-cell apoptosis in humans with type 2 diabetes. Diabetes 52:102-110
-
(2003)
Diabetes
, vol.52
, pp. 102-110
-
-
Butler, A.E.1
Janson, J.2
Bonner-Weir, S.3
Ritzel, R.4
Rizza, R.A.5
Butler, P.C.6
-
54
-
-
33644747390
-
Mechanisms of β-cell death in type 2 diabetes
-
Donath MY, Ehses JA, Maedler K, Schumann DM, Ellingsgaard H, Eppler E, Reinecke M 2005 Mechanisms of β-cell death in type 2 diabetes. Diabetes 54(Suppl 2):S108-S113
-
(2005)
Diabetes
, vol.54
, Issue.2 SUPPL.
-
-
Donath, M.Y.1
Ehses, J.A.2
Maedler, K.3
Schumann, D.M.4
Ellingsgaard, H.5
Eppler, E.6
Reinecke, M.7
-
55
-
-
12444292715
-
A common polymorphism in the promoter of UCP2 contributes to the variation in insulin secretion in glucose-tolerant subjects
-
Sesti G, Cardellini M, Marini MA, Frontoni S, D'Adamo M, Del Guerra S, Lauro D, De Nicolais P, Sbraccia P, Del Prato S, Gambardella S, Federici M, Marchetti P, Lauro R 2003 A common polymorphism in the promoter of UCP2 contributes to the variation in insulin secretion in glucose-tolerant subjects. Diabetes 52:1280-1283
-
(2003)
Diabetes
, vol.52
, pp. 1280-1283
-
-
Sesti, G.1
Cardellini, M.2
Marini, M.A.3
Frontoni, S.4
D'Adamo, M.5
Del Guerra, S.6
Lauro, D.7
De Nicolais, P.8
Sbraccia, P.9
Del Prato, S.10
Gambardella, S.11
Federici, M.12
Marchetti, P.13
Lauro, R.14
-
56
-
-
0035875087
-
Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, β cell dysfunction, and type 2 diabetes
-
Zhang CY, Baffy G, Perret P, Krauss S, Peroni O, Grujic D, Hagen T, Vidal-Puig AJ, Boss O, Kim YB, Zheng XX, Wheeler MB, Shulman GI, Chan CB, Lowell BB 2001 Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, β cell dysfunction, and type 2 diabetes. Cell 105:745-755
-
(2001)
Cell
, vol.105
, pp. 745-755
-
-
Zhang, C.Y.1
Baffy, G.2
Perret, P.3
Krauss, S.4
Peroni, O.5
Grujic, D.6
Hagen, T.7
Vidal-Puig, A.J.8
Boss, O.9
Kim, Y.B.10
Zheng, X.X.11
Wheeler, M.B.12
Shulman, G.I.13
Chan, C.B.14
Lowell, B.B.15
-
57
-
-
33644868208
-
Uncoupling protein 2 overexpression prevents cytokine-induced reactive oxygen species production and apoptosis in pancreatic β cells
-
Zengaffinen N, Perreten H, Lameloise N, Keller P, Muzzin P, Assimacopoulos-Jeannet F 2005 Uncoupling protein 2 overexpression prevents cytokine-induced reactive oxygen species production and apoptosis in pancreatic β cells. Diabetologia 48:A38
-
(2005)
Diabetologia
, vol.48
-
-
Zengaffinen, N.1
Perreten, H.2
Lameloise, N.3
Keller, P.4
Muzzin, P.5
Assimacopoulos-Jeannet, F.6
-
58
-
-
2442431673
-
Mitochondrial transcription factor a regulates mtDNA copy number in mammals
-
Ekstrand MI, Falkenberg M, Rantanen A, Park CB, Gaspari M, Hultenby K, Rustin P, Gustafsson CM, Larsson NG 2004 Mitochondrial transcription factor A regulates mtDNA copy number in mammals. Hum Mol Genet 13:935-944
-
(2004)
Hum Mol Genet
, vol.13
, pp. 935-944
-
-
Ekstrand, M.I.1
Falkenberg, M.2
Rantanen, A.3
Park, C.B.4
Gaspari, M.5
Hultenby, K.6
Rustin, P.7
Gustafsson, C.M.8
Larsson, N.G.9
-
59
-
-
0033762782
-
Impaired insulin secretion and β-cell loss in tissue-specific knockout mice with mitochondrial diabetes
-
Silva JP, Kohler M, Graff C, Oldfors A, Magnuson MA, Berggren PO, Larsson NG 2000 Impaired insulin secretion and β-cell loss in tissue-specific knockout mice with mitochondrial diabetes. Nat Genet 26:336-340
-
(2000)
Nat Genet
, vol.26
, pp. 336-340
-
-
Silva, J.P.1
Kohler, M.2
Graff, C.3
Oldfors, A.4
Magnuson, M.A.5
Berggren, P.O.6
Larsson, N.G.7
-
60
-
-
3843101644
-
Oligonucleotide microarray analysis reveals PDX1 as an essential regulator of mitochondrial metabolism in rat islets
-
Gauthier BR, Brun T, Sarret EJ, Ishihara H, Schaad O, Descombes P, Wollheim CB 2004 Oligonucleotide microarray analysis reveals PDX1 as an essential regulator of mitochondrial metabolism in rat islets. J Biol Chem 279:31121-31130
-
(2004)
J Biol Chem
, vol.279
, pp. 31121-31130
-
-
Gauthier, B.R.1
Brun, T.2
Sarret, E.J.3
Ishihara, H.4
Schaad, O.5
Descombes, P.6
Wollheim, C.B.7
-
61
-
-
0242584873
-
+/- mice
-
+/- mice. J Clin Invest 111:1147-1160
-
(2003)
J Clin Invest
, vol.111
, pp. 1147-1160
-
-
Johnson, J.D.1
Ahmed, N.T.2
Luciani, D.S.3
Han, Z.4
Tran, H.5
Fujita, J.6
Misler, S.7
Edlund, H.8
Polonsky, K.S.9
-
62
-
-
33645982255
-
From mice to men: Insights into the insulin resistance syndromes
-
Biddinger SB, Kahn CR 2005 From mice to men: insights into the insulin resistance syndromes. Annu Rev Physiol 68:123-158
-
(2005)
Annu Rev Physiol
, vol.68
, pp. 123-158
-
-
Biddinger, S.B.1
Kahn, C.R.2
-
63
-
-
2542593338
-
Oxidative capacity, lipotoxicity, and mitochondrial damage in type 2 diabetes
-
Schrauwen P, Hesselink MK 2004 Oxidative capacity, lipotoxicity, and mitochondrial damage in type 2 diabetes. Diabetes 53:1412-1417
-
(2004)
Diabetes
, vol.53
, pp. 1412-1417
-
-
Schrauwen, P.1
Hesselink, M.K.2
-
64
-
-
1642367438
-
Dissociation between fat-induced in vivo insulin resistance and proximal insulin signaling in skeletal muscle in men at risk for type 2 diabetes
-
Storgaard H, Jensen CB, Bjornholm M, Song XM, Madsbad S, Zierath JR, Vaag AA 2004 Dissociation between fat-induced in vivo insulin resistance and proximal insulin signaling in skeletal muscle in men at risk for type 2 diabetes. J Clin Endocrinol Metab 89:1301-1311
-
(2004)
J Clin Endocrinol Metab
, vol.89
, pp. 1301-1311
-
-
Storgaard, H.1
Jensen, C.B.2
Bjornholm, M.3
Song, X.M.4
Madsbad, S.5
Zierath, J.R.6
Vaag, A.A.7
-
65
-
-
0038025371
-
Mitochondrial dysfunction in the elderly: Possible role in insulin resistance
-
Petersen KF, Befroy D, Dufour S, Dziura J, Ariyan C, Rothman DL, DiPietro L, Cline GW, Shulman GI 2003 Mitochondrial dysfunction in the elderly: possible role in insulin resistance. Science 300:1140-1142
-
(2003)
Science
, vol.300
, pp. 1140-1142
-
-
Petersen, K.F.1
Befroy, D.2
Dufour, S.3
Dziura, J.4
Ariyan, C.5
Rothman, D.L.6
Dipietro, L.7
Cline, G.W.8
Shulman, G.I.9
-
66
-
-
1642377274
-
Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes
-
Petersen KF, Dufour S, Befroy D, Garcia R, Shulman GI 2004 Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes. N Engl J Med 350:664-671
-
(2004)
N Engl J Med
, vol.350
, pp. 664-671
-
-
Petersen, K.F.1
Dufour, S.2
Befroy, D.3
Garcia, R.4
Shulman, G.I.5
-
67
-
-
0038271638
-
Effect of insulin on human skeletal muscle mitochondrial ATP production, protein synthesis, and mRNA transcripts
-
USA
-
Stump CS, Short KR, Bigelow ML, Schimke JM, Nair KS 2003 Effect of insulin on human skeletal muscle mitochondrial ATP production, protein synthesis, and mRNA transcripts. Proc Natl Acad Sci USA 100:7996-8001
-
(2003)
Proc Natl Acad Sci
, vol.100
, pp. 7996-8001
-
-
Stump, C.S.1
Short, K.R.2
Bigelow, M.L.3
Schimke, J.M.4
Nair, K.S.5
-
68
-
-
3843061592
-
AMP kinase and malonyl-CoA: Targets for therapy of the metabolic syndrome
-
Ruderman N, Prentki M 2004 AMP kinase and malonyl-CoA: targets for therapy of the metabolic syndrome. Nat Rev Drug Discov 3:340-351
-
(2004)
Nat Rev Drug Discov
, vol.3
, pp. 340-351
-
-
Ruderman, N.1
Prentki, M.2
-
69
-
-
2442691889
-
Metformin, but not leptin, regulates AMP-activated protein kinase in pancreatic islets: Impact on glucose-stimulated insulin secretion
-
Leclerc I, Woltersdorf WW, da Silva Xavier G, Rowe RL, Cross SE, Korbutt GS, Rajotte RV, Smith R, Rutter GA 2004 Metformin, but not leptin, regulates AMP-activated protein kinase in pancreatic islets: impact on glucose-stimulated insulin secretion. Am J Physiol 286:E1023-E1031
-
(2004)
Am J Physiol
, vol.286
-
-
Leclerc, I.1
Woltersdorf, W.W.2
Da Silva Xavier, G.3
Rowe, R.L.4
Cross, S.E.5
Korbutt, G.S.6
Rajotte, R.V.7
Smith, R.8
Rutter, G.A.9
-
70
-
-
0038054341
-
PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
-
Mootha VK, Lindgren CM, Eriksson KF, Subramanian A, Sihag S, Lehar J, Puigserver P, Carlsson E, Ridderstrale M, Laurila E, Houstis N, Daly MJ, Patterson N, Mesirov JP, Golub TR, Tamayo P, Spiegelman B, Lander ES, Hirschhorn JN, Altshuler D, Groop LC 2003 PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet 34:267-273
-
(2003)
Nat Genet
, vol.34
, pp. 267-273
-
-
Mootha, V.K.1
Lindgren, C.M.2
Eriksson, K.F.3
Subramanian, A.4
Sihag, S.5
Lehar, J.6
Puigserver, P.7
Carlsson, E.8
Ridderstrale, M.9
Laurila, E.10
Houstis, N.11
Daly, M.J.12
Patterson, N.13
Mesirov, J.P.14
Golub, T.R.15
Tamayo, P.16
Spiegelman, B.17
Lander, E.S.18
Hirschhorn, J.N.19
Altshuler, D.20
Groop, L.C.21
more..
-
71
-
-
0038686576
-
Suppression of β cell energy metabolism and insulin release by PGC-1α
-
Yoon JC, Xu G, Deeney JT, Yang SN, Rhee J, Puigserver P, Levens AR, Yang R, Zhang CY, Lowell BB, Berggren PO, Newgard CB, Bonner-Weir S, Weir G, Spiegelman BM 2003 Suppression of β cell energy metabolism and insulin release by PGC-1α. Dev Cell 5:73-83
-
(2003)
Dev Cell
, vol.5
, pp. 73-83
-
-
Yoon, J.C.1
Xu, G.2
Deeney, J.T.3
Yang, S.N.4
Rhee, J.5
Puigserver, P.6
Levens, A.R.7
Yang, R.8
Zhang, C.Y.9
Lowell, B.B.10
Berggren, P.O.11
Newgard, C.B.12
Bonner-Weir, S.13
Weir, G.14
Spiegelman, B.M.15
-
72
-
-
28844433549
-
A role for hypothalamic malonyl-CoA in the control of food intake
-
Hu Z, Dai Y, Prentki M, Chohnan S, Lane MD 2005 A role for hypothalamic malonyl-CoA in the control of food intake. J Biol Chem 280:39681-39683
-
(2005)
J Biol Chem
, vol.280
, pp. 39681-39683
-
-
Hu, Z.1
Dai, Y.2
Prentki, M.3
Chohnan, S.4
Lane, M.D.5
|