메뉴 건너뛰기




Volumn 47, Issue 2, 2004, Pages 266-276

Insulin secretion profiles are modified by overexpression of glutamate dehydrogenase in pancreatic islets

Author keywords

BCH; Beta cell; GDH; Glutamate dehydrogenase; Glutamine; Insulin secretion; Pancreatic islets

Indexed keywords

2 AMINOBICYCLO[2.2.1]HEPTANE 2 CARBOXYLIC ACID; AMINO ACID; GLUCOSE; GLUTAMATE DEHYDROGENASE; GLUTAMINE; INSULIN;

EID: 1542374749     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-003-1306-2     Document Type: Article
Times cited : (82)

References (65)
  • 1
    • 0027167547 scopus 로고
    • The human glutamate dehydrogenase gene family: Gene organization and structural characterization
    • Michaelidis TM, Tzimagiorgis G, Moschonas NK, Papamatheakis J (1993) The human glutamate dehydrogenase gene family: gene organization and structural characterization. Genomics 16:150-160
    • (1993) Genomics , vol.16 , pp. 150-160
    • Michaelidis, T.M.1    Tzimagiorgis, G.2    Moschonas, N.K.3    Papamatheakis, J.4
  • 2
    • 0027333040 scopus 로고
    • L-glutamate dehydrogenases: Distribution, properties and mechanism
    • Hudson RC, Daniel RM (1993) L-glutamate dehydrogenases: distribution, properties and mechanism. Comp Biochem Physiol B 106:767-792
    • (1993) Comp Biochem Physiol B , vol.106 , pp. 767-792
    • Hudson, R.C.1    Daniel, R.M.2
  • 3
    • 0033779559 scopus 로고    scopus 로고
    • Astrocyte glutamate transport: Review of properties, regulation, and physiological functions
    • Anderson CM, Swanson RA (2000) Astrocyte glutamate transport: review of properties, regulation, and physiological functions. Glia 32:1-14
    • (2000) Glia , vol.32 , pp. 1-14
    • Anderson, C.M.1    Swanson, R.A.2
  • 4
    • 0032698449 scopus 로고    scopus 로고
    • Newer aspects of glutamine/glutamate metabolism: The role of acute pH changes
    • Nissim I (1999) Newer aspects of glutamine/glutamate metabolism: the role of acute pH changes. Am J Physiol 277: F493-F497
    • (1999) Am J Physiol , vol.277
    • Nissim, I.1
  • 5
    • 0019133275 scopus 로고
    • L-leucine and a nonmetabolized analogue activate pancreatic islet glutamate dehydrogenase
    • Sener A, Malaisse WJ (1980) L-leucine and a nonmetabolized analogue activate pancreatic islet glutamate dehydrogenase. Nature 288:187-189
    • (1980) Nature , vol.288 , pp. 187-189
    • Sener, A.1    Malaisse, W.J.2
  • 6
    • 0028106823 scopus 로고
    • Regulation of the glutamate dehydrogenase activity in rat islets of Langerhans and its consequence on insulin release
    • Bryla J, Michalik M, Nelson J, Erecinska M (1994) Regulation of the glutamate dehydrogenase activity in rat islets of Langerhans and its consequence on insulin release. Metabolism 43:1187-1195
    • (1994) Metabolism , vol.43 , pp. 1187-1195
    • Bryla, J.1    Michalik, M.2    Nelson, J.3    Erecinska, M.4
  • 7
    • 0038422184 scopus 로고    scopus 로고
    • Regulatory effects of 5′-deoxypyridoxal on glutamate dehydrogenase activity and insulin secretion in pancreatic islets
    • Yang SJ, Huh JW, Kim MJ et al. (2003) Regulatory effects of 5′-deoxypyridoxal on glutamate dehydrogenase activity and insulin secretion in pancreatic islets. Biochimie 85:581-586
    • (2003) Biochimie , vol.85 , pp. 581-586
    • Yang, S.J.1    Huh, J.W.2    Kim, M.J.3
  • 8
    • 0032493123 scopus 로고    scopus 로고
    • Hyperinsulinism and hyperammonemia in infants with regulatory mutations of the glutamate dehydrogenase gene
    • Stanley CA, Lieu YK, Hsu BY et al. (1998) Hyperinsulinism and hyperammonemia in infants with regulatory mutations of the glutamate dehydrogenase gene. N Engl J Med 338:1352-1357
    • (1998) N Engl J Med , vol.338 , pp. 1352-1357
    • Stanley, C.A.1    Lieu, Y.K.2    Hsu, B.Y.3
  • 9
    • 0032777882 scopus 로고    scopus 로고
    • Hyperinsulinism-hyperammonemia syndrome caused by mutant glutamate dehydrogenase accompanied by novel enzyme kinetics
    • Yorifuji T, Muroi J, Uematsu A, Hiramatsu H, Momoi T (1999) Hyperinsulinism-hyperammonemia syndrome caused by mutant glutamate dehydrogenase accompanied by novel enzyme kinetics. Hum Genet 104:476-479
    • (1999) Hum Genet , vol.104 , pp. 476-479
    • Yorifuji, T.1    Muroi, J.2    Uematsu, A.3    Hiramatsu, H.4    Momoi, T.5
  • 10
    • 0022272444 scopus 로고
    • L-Glutamate dehydrogenase from bovine liver
    • Fisher HF (1985) L-Glutamate dehydrogenase from bovine liver. Methods Enzymol 113:16-27
    • (1985) Methods Enzymol , vol.113 , pp. 16-27
    • Fisher, H.F.1
  • 11
    • 0035937256 scopus 로고    scopus 로고
    • Structures of bovine glutamate dehydrogenase complexes elucidate the mechanism of purine regulation
    • Smith TJ, Peterson PE, Schmidt T, Fang J, Stanley CA (2001) Structures of bovine glutamate dehydrogenase complexes elucidate the mechanism of purine regulation. J Mol Biol 307:707-720
    • (2001) J Mol Biol , vol.307 , pp. 707-720
    • Smith, T.J.1    Peterson, P.E.2    Schmidt, T.3    Fang, J.4    Stanley, C.A.5
  • 12
    • 0034029974 scopus 로고    scopus 로고
    • Molecular basis and characterization of the hyperinsulinism/ hyperammonemia syndrome: Predominance of mutations in exons 11 and 12 of the glutamate dehydrogenase gene. HI/HA Contributing Investigators
    • Stanley CA, Fang J, Kutyna K et al. (2000) Molecular basis and characterization of the hyperinsulinism/hyperammonemia syndrome: predominance of mutations in exons 11 and 12 of the glutamate dehydrogenase gene. HI/HA Contributing Investigators. Diabetes 49:667-673
    • (2000) Diabetes , vol.49 , pp. 667-673
    • Stanley, C.A.1    Fang, J.2    Kutyna, K.3
  • 13
    • 0033540037 scopus 로고    scopus 로고
    • Mitochondrial glutamate acts as a messenger in glucose-induced insulin exocytosis
    • Maechler P, Wollheim CB (1999) Mitochondrial glutamate acts as a messenger in glucose-induced insulin exocytosis. Nature 402:685-689
    • (1999) Nature , vol.402 , pp. 685-689
    • Maechler, P.1    Wollheim, C.B.2
  • 14
    • 0034602141 scopus 로고    scopus 로고
    • Glutamate is not a messenger in insulin secretion
    • MacDonald MJ, Fahien LA (2000) Glutamate is not a messenger in insulin secretion. J Biol Chem 275:34025-34027
    • (2000) J Biol Chem , vol.275 , pp. 34025-34027
    • MacDonald, M.J.1    Fahien, L.A.2
  • 15
    • 0035965364 scopus 로고    scopus 로고
    • GAD65-mediated glutamate decarboxylation reduces glucose-stimulated insulin secretion in pancreatic beta cells
    • Rubi B, Ishihara H, Hegardt FG, Wollheim CB, Maechler P (2001) GAD65-mediated glutamate decarboxylation reduces glucose-stimulated insulin secretion in pancreatic beta cells. J Biol Chem 276:36391-36396
    • (2001) J Biol Chem , vol.276 , pp. 36391-36396
    • Rubi, B.1    Ishihara, H.2    Hegardt, F.G.3    Wollheim, C.B.4    Maechler, P.5
  • 16
    • 0037031896 scopus 로고    scopus 로고
    • The elevation of glutamate content and the amplification of insulin secretion in glucose-stimulated pancreatic islets are not causally related
    • Bertrand G, Ishiyama N, Nenquin M, Ravier MA, Henquin JC (2002) The elevation of glutamate content and the amplification of insulin secretion in glucose-stimulated pancreatic islets are not causally related. J Biol Chem 277:32883-32891
    • (2002) J Biol Chem , vol.277 , pp. 32883-32891
    • Bertrand, G.1    Ishiyama, N.2    Nenquin, M.3    Ravier, M.A.4    Henquin, J.C.5
  • 17
  • 19
    • 0033760442 scopus 로고    scopus 로고
    • Triggering and amplifying pathways of regulation of insulin secretion by glucose
    • Henquin JC (2000) Triggering and amplifying pathways of regulation of insulin secretion by glucose. Diabetes 49: 1751-1760
    • (2000) Diabetes , vol.49 , pp. 1751-1760
    • Henquin, J.C.1
  • 20
    • 0035856942 scopus 로고    scopus 로고
    • Mitochondrial function in normal and diabetic beta-cells
    • Maechler P, Wollheim CB (2001) Mitochondrial function in normal and diabetic beta-cells. Nature 414:807-812
    • (2001) Nature , vol.414 , pp. 807-812
    • Maechler, P.1    Wollheim, C.B.2
  • 21
    • 0032933339 scopus 로고    scopus 로고
    • The structure and function of the ATP-sensitive K+ channel in insulin-secreting pancreatic beta-cells
    • Miki T, Nagashima K, Seino S (1999) The structure and function of the ATP-sensitive K+ channel in insulin-secreting pancreatic beta-cells. J Mol Endocrinol 22:113-123
    • (1999) J Mol Endocrinol , vol.22 , pp. 113-123
    • Miki, T.1    Nagashima, K.2    Seino, S.3
  • 22
    • 0030894850 scopus 로고    scopus 로고
    • The pancreatic beta-cell as a fuel sensor: An electrophysiologist's viewpoint
    • Rorsman P (1997) The pancreatic beta-cell as a fuel sensor: an electrophysiologist's viewpoint. Diabetologia 40:487-495
    • (1997) Diabetologia , vol.40 , pp. 487-495
    • Rorsman, P.1
  • 23
    • 0033556082 scopus 로고    scopus 로고
    • Molecular mechanisms and regulation of insulin exocytosis as a paradigm of endocrine secretion
    • Lang J (1999) Molecular mechanisms and regulation of insulin exocytosis as a paradigm of endocrine secretion. Eur J Biochem 259:3-17
    • (1999) Eur J Biochem , vol.259 , pp. 3-17
    • Lang, J.1
  • 24
    • 0018975576 scopus 로고
    • The stimulus-secretion coupling of glucose-induced insulin release. XLVI. Physiological role of L-glutamine as a fuel for pancreatic islets
    • Malaisse WJ, Sener A, Carpinelli AR et al. (1980) The stimulus-secretion coupling of glucose-induced insulin release. XLVI. Physiological role of L-glutamine as a fuel for pancreatic islets. Mol Cell Endocrinol 20:171-189
    • (1980) Mol Cell Endocrinol , vol.20 , pp. 171-189
    • Malaisse, W.J.1    Sener, A.2    Carpinelli, A.R.3
  • 25
    • 0021320053 scopus 로고
    • Regulation of insulin secretion by energy metabolism in pancreatic B-cell mitochondria. Studies with a nonmetabolizable leucine analogue
    • Panten U, Zielmann S, Langer J, Zunkler BJ, Lenzen S (1984) Regulation of insulin secretion by energy metabolism in pancreatic B-cell mitochondria. Studies with a nonmetabolizable leucine analogue. Biochem J 219:189-196
    • (1984) Biochem J , vol.219 , pp. 189-196
    • Panten, U.1    Zielmann, S.2    Langer, J.3    Zunkler, B.J.4    Lenzen, S.5
  • 26
    • 0027203345 scopus 로고
    • Heterogeneity in glucose sensitivity among pancreatic beta-cells is correlated to differences in glucose phosphorylation rather than glucose transport
    • Heimberg H, De Vos A, Vandercammen A, Schaftingen E van, Pipeleers D, Schuit F (1993) Heterogeneity in glucose sensitivity among pancreatic beta-cells is correlated to differences in glucose phosphorylation rather than glucose transport. EMBO J 12:2873-2879
    • (1993) EMBO J , vol.12 , pp. 2873-2879
    • Heimberg, H.1    De Vos, A.2    Vandercammen, A.3    Van Schaftingen, E.4    Pipeleers, D.5    Schuit, F.6
  • 27
    • 77955093164 scopus 로고
    • Stimulation of pancreatic islet metabolism and insulin release by a nonmetabolizable amino acid
    • Sener A, Malaisse-Lagae F, Malaisse WJ (1981) Stimulation of pancreatic islet metabolism and insulin release by a nonmetabolizable amino acid. Proc Natl Acad Sci USA 78: 5460-5464
    • (1981) Proc Natl Acad Sci USA , vol.78 , pp. 5460-5464
    • Sener, A.1    Malaisse-Lagae, F.2    Malaisse, W.J.3
  • 28
    • 0032806183 scopus 로고    scopus 로고
    • Glucose regulation of glutaminolysis and its role in insulin secretion
    • Gao ZY, Li G, Najafi H, Wolf BA, Matschinsky FM (1999) Glucose regulation of glutaminolysis and its role in insulin secretion. Diabetes 48:1535-1542
    • (1999) Diabetes , vol.48 , pp. 1535-1542
    • Gao, Z.Y.1    Li, G.2    Najafi, H.3    Wolf, B.A.4    Matschinsky, F.M.5
  • 29
    • 0037474212 scopus 로고    scopus 로고
    • Regulation of leucine-stimulated insulin secretion and glutamine metabolism in isolated rat islets
    • Li C, Najafi H, Daikhin Y et al. (2003) Regulation of leucine-stimulated insulin secretion and glutamine metabolism in isolated rat islets. J Biol Chem 278:2853-2858
    • (2003) J Biol Chem , vol.278 , pp. 2853-2858
    • Li, C.1    Najafi, H.2    Daikhin, Y.3
  • 30
    • 0036865991 scopus 로고    scopus 로고
    • Mitochondria as the conductor of metabolic signals for insulin exocytosis in pancreatic beta-cells
    • Maechler P (2002) Mitochondria as the conductor of metabolic signals for insulin exocytosis in pancreatic beta-cells. Cell Mol Life Sci 59:1803-1818
    • (2002) Cell Mol Life Sci , vol.59 , pp. 1803-1818
    • Maechler, P.1
  • 31
    • 0038540613 scopus 로고    scopus 로고
    • Mitochondria-derived glutamate at the interplay between branched-chain amino acid and glucose-induced insulin secretion
    • Broca C, Brennan L, Petit P, Newsholme P, Maechler P (2003) Mitochondria-derived glutamate at the interplay between branched-chain amino acid and glucose-induced insulin secretion. FEBS Lett 545:167-172
    • (2003) FEBS Lett , vol.545 , pp. 167-172
    • Broca, C.1    Brennan, L.2    Petit, P.3    Newsholme, P.4    Maechler, P.5
  • 32
    • 0023695196 scopus 로고
    • Regulation of insulin release by factors that also modify glutamate dehydrogenase
    • Fahien LA, MacDonald MJ, Kmiotek EH, Mertz RJ, Fahien CM (1988) Regulation of insulin release by factors that also modify glutamate dehydrogenase. J Biol Chem 263:13610-13614
    • (1988) J Biol Chem , vol.263 , pp. 13610-13614
    • Fahien, L.A.1    MacDonald, M.J.2    Kmiotek, E.H.3    Mertz, R.J.4    Fahien, C.M.5
  • 33
    • 0020317782 scopus 로고
    • The stimulus-secretion coupling of amino acid-induced insulin release. Influence of a nonmetabolized analog of leucine on the metabolism of glutamine in pancreatic islets
    • Malaisse-Lagae F, Sener A, Garcia-Morales P, Valverde I, Malaisse WJ (1982) The stimulus-secretion coupling of amino acid-induced insulin release. Influence of a nonmetabolized analog of leucine on the metabolism of glutamine in pancreatic islets. J Biol Chem 257:3754-3758
    • (1982) J Biol Chem , vol.257 , pp. 3754-3758
    • Malaisse-Lagae, F.1    Sener, A.2    Garcia-Morales, P.3    Valverde, I.4    Malaisse, W.J.5
  • 34
    • 1542263385 scopus 로고    scopus 로고
    • Glucose sensitivity and metabolism-secretion coupling studied during two-year continuous culture in INS-1E insulinoma cells
    • in press
    • Merglen A, Theander S, Rubi B, Chaffard G, Wollheim CB, Maechler P (2003) Glucose sensitivity and metabolism-secretion coupling studied during two-year continuous culture in INS-1E insulinoma cells. Endocrinology (in press)
    • (2003) Endocrinology
    • Merglen, A.1    Theander, S.2    Rubi, B.3    Chaffard, G.4    Wollheim, C.B.5    Maechler, P.6
  • 35
    • 0026550830 scopus 로고
    • Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines
    • Asfari M, Janjic D, Meda P, Li G, Halban PA, Wollheim CB (1992) Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines. Endocrinology 130:167-178
    • (1992) Endocrinology , vol.130 , pp. 167-178
    • Asfari, M.1    Janjic, D.2    Meda, P.3    Li, G.4    Halban, P.A.5    Wollheim, C.B.6
  • 36
    • 0027943837 scopus 로고
    • Dynamic pacing of cell metabolism by intracellular Ca2+ transients
    • Pralong WF, Spat A, Wollheim CB (1994) Dynamic pacing of cell metabolism by intracellular Ca2+ transients. J Biol Chem 269:27310-27314
    • (1994) J Biol Chem , vol.269 , pp. 27310-27314
    • Pralong, W.F.1    Spat, A.2    Wollheim, C.B.3
  • 37
    • 0025884056 scopus 로고
    • Efficient selection for high-expression transfectants with a novel eukaryotic vector
    • Niwa H, Yamamura K, Miyazaki J (1991) Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene 108:193-199
    • (1991) Gene , vol.108 , pp. 193-199
    • Niwa, H.1    Yamamura, K.2    Miyazaki, J.3
  • 38
    • 0030070724 scopus 로고    scopus 로고
    • Efficient generation of recombinant adenoviruses using adenovirus DNA-terminal protein complex and a cosmid bearing the full-length virus genome
    • Miyake S, Makimura M, Kanegae Y (1996) Efficient generation of recombinant adenoviruses using adenovirus DNA-terminal protein complex and a cosmid bearing the full-length virus genome. Proc Natl Acad Sci USA 93: 1320-1324
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 1320-1324
    • Miyake, S.1    Makimura, M.2    Kanegae, Y.3
  • 39
    • 0036311083 scopus 로고    scopus 로고
    • Implication of glutamate in the kinetics of insulin secretion in rat and mouse perfused pancreas
    • Maechler P, Gjinovci A, Wollheim CB (2002) Implication of glutamate in the kinetics of insulin secretion in rat and mouse perfused pancreas. Diabetes 51 [Suppl 1]:S99-S102
    • (2002) Diabetes , vol.51 , Issue.1 SUPPL.
    • Maechler, P.1    Gjinovci, A.2    Wollheim, C.B.3
  • 40
    • 0033600762 scopus 로고    scopus 로고
    • Hydrogen peroxide alters mitochondrial activation and insulin secretion in pancreatic beta cells
    • Maechler P, Jornot L, Wollheim CB (1999) Hydrogen peroxide alters mitochondrial activation and insulin secretion in pancreatic beta cells. J Biol Chem 274:27905-27913
    • (1999) J Biol Chem , vol.274 , pp. 27905-27913
    • Maechler, P.1    Jornot, L.2    Wollheim, C.B.3
  • 41
    • 0035662149 scopus 로고    scopus 로고
    • An osmotic-sensitive taurine pool is localized in rat pancreatic islet cells containing glucagon and somatostatin
    • Bustamante J, Lobo MV, Alonso FJ et al. (2001) An osmotic-sensitive taurine pool is localized in rat pancreatic islet cells containing glucagon and somatostatin. Am J Physiol Endocrinol Metab 281:E1275-E1285
    • (2001) Am J Physiol Endocrinol Metab , vol.281
    • Bustamante, J.1    Lobo, M.V.2    Alonso, F.J.3
  • 42
    • 0030926003 scopus 로고    scopus 로고
    • Mitochondrial activation directly triggers the exocytosis of insulin in permeabilized pancreatic beta-cells
    • Maechler P, Kennedy ED, Pozzan T, Wollheim CB (1997) Mitochondrial activation directly triggers the exocytosis of insulin in permeabilized pancreatic beta-cells. EMBO J 16:3833-3841
    • (1997) EMBO J , vol.16 , pp. 3833-3841
    • Maechler, P.1    Kennedy, E.D.2    Pozzan, T.3    Wollheim, C.B.4
  • 43
    • 0032488880 scopus 로고    scopus 로고
    • Continuous monitoring of ATP levels in living insulin secreting cells expressing cytosolic firefly luciferase
    • Maechler P, Wang H, Wollheim CB (1998) Continuous monitoring of ATP levels in living insulin secreting cells expressing cytosolic firefly luciferase. FEBS Lett 422: 328-332
    • (1998) FEBS Lett , vol.422 , pp. 328-332
    • Maechler, P.1    Wang, H.2    Wollheim, C.B.3
  • 44
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
    • Mosmann T (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65:55-63
    • (1983) J Immunol Methods , vol.65 , pp. 55-63
    • Mosmann, T.1
  • 45
    • 0026581414 scopus 로고
    • Islet cell metabolism is reflected by the MTT (tetrazolium) colorimetric assay
    • Janjic D, Wollheim CB (1992) Islet cell metabolism is reflected by the MTT (tetrazolium) colorimetric assay. Diabetologia 35:482-485
    • (1992) Diabetologia , vol.35 , pp. 482-485
    • Janjic, D.1    Wollheim, C.B.2
  • 46
    • 0030810982 scopus 로고    scopus 로고
    • Metabolic fate of glucose in purified islet cells. Glucose-regulated anaplerosis in beta cells
    • Schuit F, De Vos A, Farfari S et al. (1997) Metabolic fate of glucose in purified islet cells. Glucose-regulated anaplerosis in beta cells. J Biol Chem 272:18572-18579
    • (1997) J Biol Chem , vol.272 , pp. 18572-18579
    • Schuit, F.1    De Vos, A.2    Farfari, S.3
  • 47
    • 0037022527 scopus 로고    scopus 로고
    • 13C NMR isotopomer analysis reveals a connection between pyruvate cycling and glucose-stimulated insulin secretion (GSIS)
    • Lu D, Mulder H, Zhao P et al. (2002) 13C NMR isotopomer analysis reveals a connection between pyruvate cycling and glucose-stimulated insulin secretion (GSIS). Proc Natl Acad Sci USA 99:2708-2713
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 2708-2713
    • Lu, D.1    Mulder, H.2    Zhao, P.3
  • 48
    • 0037163021 scopus 로고    scopus 로고
    • The key role of anaplerosis and cataplerosis for citric acid cycle function
    • Owen OE, Kalhan SC, Hanson RW (2002) The key role of anaplerosis and cataplerosis for citric acid cycle function. J Biol Chem 277:30409-30412
    • (2002) J Biol Chem , vol.277 , pp. 30409-30412
    • Owen, O.E.1    Kalhan, S.C.2    Hanson, R.W.3
  • 49
    • 0345700770 scopus 로고    scopus 로고
    • Characterization of vesicular glutamate transporter in pancreatic alpha- and beta-cells and its regulation by glucose
    • Bai L, Zhang X, Ghishan FK (2003) Characterization of vesicular glutamate transporter in pancreatic alpha-and beta-cells and its regulation by glucose. Am J Physiol Gastrointest Liver Physiol 284:G808-G814
    • (2003) Am J Physiol Gastrointest Liver Physiol , vol.284
    • Bai, L.1    Zhang, X.2    Ghishan, F.K.3
  • 50
    • 0041802735 scopus 로고    scopus 로고
    • Glucose metabolism and glutamate analog acutely alkalinize pH of insulin secretory vesicles of pancreatic beta-cells
    • Eto K, Yamashita T, Hirose K et al. (2003) Glucose metabolism and glutamate analog acutely alkalinize pH of insulin secretory vesicles of pancreatic beta-cells. Am J Physiol Endocrinol Metab 285:E262-E271
    • (2003) Am J Physiol Endocrinol Metab , vol.285
    • Eto, K.1    Yamashita, T.2    Hirose, K.3
  • 51
    • 0022663535 scopus 로고
    • 2-Ketoglutarate generation in pancreatic B-cell mitochondria regulates insulin secretory action of amino acids and 2-keto acids
    • Lenzen S, Schmidt W, Rustenbeck I, Panten U (1986) 2-ketoglutarate generation in pancreatic B-cell mitochondria regulates insulin secretory action of amino acids and 2-keto acids. Biosci Rep 6:163-169
    • (1986) Biosci Rep , vol.6 , pp. 163-169
    • Lenzen, S.1    Schmidt, W.2    Rustenbeck, I.3    Panten, U.4
  • 52
    • 0036894314 scopus 로고    scopus 로고
    • Glutaminolysis and insulin secretion: From bedside to bench and back
    • Kelly A, Li C, Gao Z, Stanley CA, Matschinsky FM (2002) Glutaminolysis and insulin secretion: from bedside to bench and back. Diabetes 51 [Suppl 3]:S421-S426
    • (2002) Diabetes , vol.51 , Issue.3 SUPPL.
    • Kelly, A.1    Li, C.2    Gao, Z.3    Stanley, C.A.4    Matschinsky, F.M.5
  • 53
    • 0033788473 scopus 로고    scopus 로고
    • Modulation of glutamate generation in mitochondria affects hormone secretion in INS-1E beta cells
    • Maechler P, Antinozzi PA, Wollheim CB (2000) Modulation of glutamate generation in mitochondria affects hormone secretion in INS-1E beta cells. IUBMB Life 50:27-31
    • (2000) IUBMB Life , vol.50 , pp. 27-31
    • Maechler, P.1    Antinozzi, P.A.2    Wollheim, C.B.3
  • 54
    • 0027975322 scopus 로고
    • Insulinotropic action of glutamic acid dimethyl ester
    • Sener A, Conget I, Rasschaert J et al. (1994) Insulinotropic action of glutamic acid dimethyl ester. Am J Physiol 267: E573-E584
    • (1994) Am J Physiol , vol.267
    • Sener, A.1    Conget, I.2    Rasschaert, J.3
  • 55
    • 0026688668 scopus 로고
    • Glutamate production in islets of Langerhans: Properties of phosphate-activated glutaminase
    • Michalik M, Nelson J, Erecinska M (1992) Glutamate production in islets of Langerhans: properties of phosphate-activated glutaminase. Metabolism 41:1319-1326
    • (1992) Metabolism , vol.41 , pp. 1319-1326
    • Michalik, M.1    Nelson, J.2    Erecinska, M.3
  • 56
    • 0019904523 scopus 로고
    • The stimulus-secretion coupling of amino acid-induced insulin release. Metabolic response of pancreatic islets of L-glutamine and L-leucine
    • Malaisse WJ, Sener A, Malaisse-Lagae F et al. (1982) The stimulus-secretion coupling of amino acid-induced insulin release. Metabolic response of pancreatic islets of L-glutamine and L-leucine. J Biol Chem 257:8731-8737
    • (1982) J Biol Chem , vol.257 , pp. 8731-8737
    • Malaisse, W.J.1    Sener, A.2    Malaisse-Lagae, F.3
  • 57
    • 0021368641 scopus 로고
    • Transamination of 3-phenylpyruvate in pancreatic B-cell mitochondria
    • Lenzen S, Rustenbeck I, Panten U (1984) Transamination of 3-phenylpyruvate in pancreatic B-cell mitochondria. J Biol Chem 259:2043-2046
    • (1984) J Biol Chem , vol.259 , pp. 2043-2046
    • Lenzen, S.1    Rustenbeck, I.2    Panten, U.3
  • 58
    • 0022347742 scopus 로고
    • Transamination of neutral amino acids and 2-keto acids in pancreatic B-cell mitochondria
    • Lenzen S, Schmidt W, Panten U (1985) Transamination of neutral amino acids and 2-keto acids in pancreatic B-cell mitochondria. J Biol Chem 260:12629-12634
    • (1985) J Biol Chem , vol.260 , pp. 12629-12634
    • Lenzen, S.1    Schmidt, W.2    Panten, U.3
  • 59
    • 0036263720 scopus 로고    scopus 로고
    • A nuclear magnetic resonance-based demonstration of substantial oxidative L-alanine metabolism and L-alanine-enhanced glucose metabolism in a clonal pancreatic beta-cell line: Metabolism of L-alanine is important to the regulation of insulin secretion
    • Brennan L, Shine A, Hewage C et al. (2002) A nuclear magnetic resonance-based demonstration of substantial oxidative L-alanine metabolism and L-alanine-enhanced glucose metabolism in a clonal pancreatic beta-cell line: metabolism of L-alanine is important to the regulation of insulin secretion. Diabetes 51:1714-1721
    • (2002) Diabetes , vol.51 , pp. 1714-1721
    • Brennan, L.1    Shine, A.2    Hewage, C.3
  • 60
    • 0345548707 scopus 로고    scopus 로고
    • 13C NMR analysis reveals a link between L-glutamine metabolism, D-glucose metabolism and gamma-glutamyl cycle activity in a clonal pancreatic beta-cell line
    • Brennan L, Corless M, Hewage C et al. (2003) 13C NMR analysis reveals a link between L-glutamine metabolism, D-glucose metabolism and gamma-glutamyl cycle activity in a clonal pancreatic beta-cell line. Diabetologia 46:1512-1521
    • (2003) Diabetologia , vol.46 , pp. 1512-1521
    • Brennan, L.1    Corless, M.2    Hewage, C.3
  • 61
    • 0036313624 scopus 로고    scopus 로고
    • Unregulated elevation of glutamate dehydrogenase activity induces glutamine-stimulated insulin secretion: Identification and characterization of a GLUD1 gene mutation and insulin secretion studies with MIN6 cells overexpressing the mutant glutamate dehydrogenase
    • Tanizawa Y, Nakai K, Sasaki T et al. (2002) Unregulated elevation of glutamate dehydrogenase activity induces glutamine-stimulated insulin secretion: identification and characterization of a GLUD1 gene mutation and insulin secretion studies with MIN6 cells overexpressing the mutant glutamate dehydrogenase. Diabetes 51:712-717
    • (2002) Diabetes , vol.51 , pp. 712-717
    • Tanizawa, Y.1    Nakai, K.2    Sasaki, T.3
  • 63
    • 0026236051 scopus 로고
    • Effect of exercise on amino acid concentrations in skeletal muscle and plasma
    • Henriksson J (1991) Effect of exercise on amino acid concentrations in skeletal muscle and plasma. J Exp Biol 160: 149-165
    • (1991) J Exp Biol , vol.160 , pp. 149-165
    • Henriksson, J.1
  • 64
    • 0033431775 scopus 로고    scopus 로고
    • Overexpression of monocarboxylate transporter and lactate dehydrogenase alters insulin secretory responses to pyruvate and lactate in beta cells
    • Ishihara H, Wang H, Drewes LR, Wollheim CB (1999) Overexpression of monocarboxylate transporter and lactate dehydrogenase alters insulin secretory responses to pyruvate and lactate in beta cells. J Clin Invest 104:1621-1629
    • (1999) J Clin Invest , vol.104 , pp. 1621-1629
    • Ishihara, H.1    Wang, H.2    Drewes, L.R.3    Wollheim, C.B.4
  • 65
    • 0037221769 scopus 로고    scopus 로고
    • Physical exercise-induced hyperinsulinemic hypoglycemia is an autosomal-dominant trait characterized by abnormal pyruvate-induced insulin release
    • Otonkoski T, Kaminen N, Ustinov J, Lapatto R, Meissner T, Mayatepek E, Kere J, Sipila I (2003) Physical exercise-induced hyperinsulinemic hypoglycemia is an autosomal-dominant trait characterized by abnormal pyruvate-induced insulin release. Diabetes 52:199-204
    • (2003) Diabetes , vol.52 , pp. 199-204
    • Otonkoski, T.1    Kaminen, N.2    Ustinov, J.3    Lapatto, R.4    Meissner, T.5    Mayatepek, E.6    Kere, J.7    Sipila, I.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.