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Paraskevas, S.1
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Maysinger, D.3
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55
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0141481948
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Pancreas preservation by the 2-layer cold storage method before islet isolation protects isolated islets against apoptosis through the mitochondrial pathway
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Matsuda T, Suzuki Y, Tanioka Y, et al. Pancreas preservation by the 2-layer cold storage method before islet isolation protects isolated islets against apoptosis through the mitochondrial pathway. Surgery 2003; 134:437-445.
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(2003)
Surgery
, vol.134
, pp. 437-445
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Matsuda, T.1
Suzuki, Y.2
Tanioka, Y.3
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56
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33745410720
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Improved islet yields from pancreas preserved in perflurocarbon is via inhibition of apoptosis mediated by mitochondrial pathway
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Ramachandran S, Desai NM, Goers TA, et al. Improved islet yields from pancreas preserved in perflurocarbon is via inhibition of apoptosis mediated by mitochondrial pathway. Am J Transplant 2006; 6:1696-1703.
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(2006)
Am J Transplant
, vol.6
, pp. 1696-1703
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Ramachandran, S.1
Desai, N.M.2
Goers, T.A.3
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57
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33644927502
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Modified two-layer preservation method (M-Kyoto/PFC) improves islet yields in islet isolation
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Noguchi H, Ueda M, Nakai Y, et al. Modified two-layer preservation method (M-Kyoto/PFC) improves islet yields in islet isolation. Am J Transplant 2006; 6:496-504.
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(2006)
Am J Transplant
, vol.6
, pp. 496-504
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Noguchi, H.1
Ueda, M.2
Nakai, Y.3
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58
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34548736060
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Noguchi H, Ueda M, Hayashi S, et al. Comparison of M-Kyoto solution and histidine-tryptophan-ketoglutarate solution with a trypsin inhibitor for pancreas preservation in islet transplantation. Transplantation 2007; 84:655-658. This study attempts to explain the mechanism by which TLM may improve islet yields. It suggests that TLM improvements are via the inhibition of apoptosis mediated by the mitochondrial pathway. Of note is that the comparisons were conducted between oxygen saturated perfluorocarbon in TLM and air saturated UWS. Perhaps an additional comparison of interest would be between oxygen saturated perfluorocarbon in TLM and oxygen saturated UWS.
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Noguchi H, Ueda M, Hayashi S, et al. Comparison of M-Kyoto solution and histidine-tryptophan-ketoglutarate solution with a trypsin inhibitor for pancreas preservation in islet transplantation. Transplantation 2007; 84:655-658. This study attempts to explain the mechanism by which TLM may improve islet yields. It suggests that TLM improvements are via the inhibition of apoptosis mediated by the mitochondrial pathway. Of note is that the comparisons were conducted between oxygen saturated perfluorocarbon in TLM and air saturated UWS. Perhaps an additional comparison of interest would be between oxygen saturated perfluorocarbon in TLM and oxygen saturated UWS.
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59
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0038451599
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Improved islet yield and function with ductal injection of University of Wisconsin solution before pancreas preservation
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This article suggests that TLM using M-Kyoto Solution significantly improves islet yields compared with TLM using University of Wisconsin solution
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Sawada T, Matsumoto I, Nakano M, et al. Improved islet yield and function with ductal injection of University of Wisconsin solution before pancreas preservation. Transplantation 2003; 75:1965-1969. This article suggests that TLM using M-Kyoto Solution significantly improves islet yields compared with TLM using University of Wisconsin solution.
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(2003)
Transplantation
, vol.75
, pp. 1965-1969
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Sawada, T.1
Matsumoto, I.2
Nakano, M.3
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60
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0028874753
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The effect of UW solution and its components on the collagenase digestion of human and porcine pancreas
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This study suggests that for pancreas preservation for islet isolation and transplantation, M-Kyoto solution may be better than HTK when used in conjunction with TLM
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Contractor HH, Johnson PR, Chadwick DR, et al. The effect of UW solution and its components on the collagenase digestion of human and porcine pancreas. Cell Transplant 1995; 4:615-619. This study suggests that for pancreas preservation for islet isolation and transplantation, M-Kyoto solution may be better than HTK when used in conjunction with TLM.
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(1995)
Cell Transplant
, vol.4
, pp. 615-619
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Contractor, H.H.1
Johnson, P.R.2
Chadwick, D.R.3
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61
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14044251522
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Successful pancreas preservation by a perfluorocarbon-based one-layer method for subsequent pig islet isolation
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Brandhorst D, Iken M, Bretzel RG, et al. Successful pancreas preservation by a perfluorocarbon-based one-layer method for subsequent pig islet isolation. Transplantation 2005; 79:433-437.
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(2005)
Transplantation
, vol.79
, pp. 433-437
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Brandhorst, D.1
Iken, M.2
Bretzel, R.G.3
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62
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33747615715
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Pancreas storage in oxygenated perfluorodecalin does not restore posttransplant function of isolated pig islets predamaged by warm ischemia
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Brandhorst D, Iken M, Bretzel RG, Brandhorst H. Pancreas storage in oxygenated perfluorodecalin does not restore posttransplant function of isolated pig islets predamaged by warm ischemia. Xenotransplantation 2006; 13:465-470.
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(2006)
Xenotransplantation
, vol.13
, pp. 465-470
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Brandhorst, D.1
Iken, M.2
Bretzel, R.G.3
Brandhorst, H.4
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63
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26644473407
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Possibility of islet transplantation from a nonheartbeating donor pancreas resuscitated by the two-layer method
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Tanaka T, Suzuki Y, Tanioka Y, et al. Possibility of islet transplantation from a nonheartbeating donor pancreas resuscitated by the two-layer method. Transplantation 2005; 80:738-742.
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(2005)
Transplantation
, vol.80
, pp. 738-742
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Tanaka, T.1
Suzuki, Y.2
Tanioka, Y.3
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64
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33744936551
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The rat pancreas is not an appropriate model for testing the preservation of the human pancreas with the two-layer method
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This study reports that short-term storage of pancreases in preoxygenated perfluorodecalin improves the in-vitro but not the in-vivo function of ischemically-damaged islets
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Avgoustiniatos ES, Hering BJ, Papas KK. The rat pancreas is not an appropriate model for testing the preservation of the human pancreas with the two-layer method. Transplantation 2006; 81:1471-1472. This study reports that short-term storage of pancreases in preoxygenated perfluorodecalin improves the in-vitro but not the in-vivo function of ischemically-damaged islets.
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(2006)
Transplantation
, vol.81
, pp. 1471-1472
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Avgoustiniatos, E.S.1
Hering, B.J.2
Papas, K.K.3
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65
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27844544711
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Pancreas oxygenation is limited during preservation with thetwo-layer method
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Papas KK, Hering BJ, Guenther L, et al. Pancreas oxygenation is limited during preservation with thetwo-layer method. Transplant Proc 2005;37:3501-3504.
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(2005)
Transplant Proc
, vol.37
, pp. 3501-3504
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Papas, K.K.1
Hering, B.J.2
Guenther, L.3
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66
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33751501716
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Kin T, Mirbolooki M, Salehi P, et al. Islet isolation and transplantation outcomes of pancreas preserved with University of Wisconsin solution versus two-layer method using preoxygenated perfluorocarbon. Transplantation 2006; 82:1286-1290. This report alerts the community to issues related to the effect of pancreas size on pancreas oxygenation by diffusion during cold storage and notes that results obtained with pancreases from small animals (rodents) are not directly translatable to thicker porcine and human pancreases.
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Kin T, Mirbolooki M, Salehi P, et al. Islet isolation and transplantation outcomes of pancreas preserved with University of Wisconsin solution versus two-layer method using preoxygenated perfluorocarbon. Transplantation 2006; 82:1286-1290. This report alerts the community to issues related to the effect of pancreas size on pancreas oxygenation by diffusion during cold storage and notes that results obtained with pancreases from small animals (rodents) are not directly translatable to thicker porcine and human pancreases.
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67
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38449089799
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No beneficial effect of two-layer storage compared with UW-storage on human islet isolation and transplantation
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Caballero-Corbalan J, Eich T, Lundgren T, et al. No beneficial effect of two-layer storage compared with UW-storage on human islet isolation and transplantation. Transplantation 2007; 84:864-869.
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(2007)
Transplantation
, vol.84
, pp. 864-869
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Caballero-Corbalan, J.1
Eich, T.2
Lundgren, T.3
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68
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40649089477
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Collaborative Islet Transplant Registry (CITR) Annual Report. Rockville, MD: The EMMES Corporation; Aug 2007. This article demonstrates that there is no beneficial effect of TLM with preoxygenated PFC on islet isolation and transplantation outcomes based on a large-scale clinical study.
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Collaborative Islet Transplant Registry (CITR) Annual Report. Rockville, MD: The EMMES Corporation; Aug 2007. This article demonstrates that there is no beneficial effect of TLM with preoxygenated PFC on islet isolation and transplantation outcomes based on a large-scale clinical study.
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69
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33847704983
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Human islet oxygen consumption rate and DNA measurements predict diabetes reversal in nude mice
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This report suggests that there is no beneficial effect of TLM with preoxygenated perfluorocarbon on islet isolation and transplantation outcomes based on results with 200 human pancreases
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Papas KK, Colton CK, Nelson RA, et al. Human islet oxygen consumption rate and DNA measurements predict diabetes reversal in nude mice. Am J Transplant 2007; 7:707-713. This report suggests that there is no beneficial effect of TLM with preoxygenated perfluorocarbon on islet isolation and transplantation outcomes based on results with 200 human pancreases.
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(2007)
Am J Transplant
, vol.7
, pp. 707-713
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Papas, K.K.1
Colton, C.K.2
Nelson, R.A.3
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70
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40649101555
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Real-time noninvasive assessment of pancreatic ATP levels during preservation
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Scott W, Matsumoto S, Tanaka T, et al. Real-time noninvasive assessment of pancreatic ATP levels during preservation. Xenotransplantation 2007; 14:501-502.
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(2007)
Xenotransplantation
, vol.14
, pp. 501-502
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Scott, W.1
Matsumoto, S.2
Tanaka, T.3
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71
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1242293170
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Beyond the red cell: Pegylation of other blood cells and tissues
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Scott MD, Chen AM. Beyond the red cell: pegylation of other blood cells and tissues. Transfus Clin Biol 2004; 11:40-46.
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(2004)
Transfus Clin Biol
, vol.11
, pp. 40-46
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Scott, M.D.1
Chen, A.M.2
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72
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34249053456
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A new preservation solution increases islet yield and reduces graft immunogenicity in pancreatic islet transplantation
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This study reports on the effectiveness of SCOT solution in reducing islet immunogenicity when used in islet isolation and culture
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Giraud S, Claire B, Eugene M, et al. A new preservation solution increases islet yield and reduces graft immunogenicity in pancreatic islet transplantation. Transplantation 2007; 83:1397-1400. This study reports on the effectiveness of SCOT solution in reducing islet immunogenicity when used in islet isolation and culture.
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(2007)
Transplantation
, vol.83
, pp. 1397-1400
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Giraud, S.1
Claire, B.2
Eugene, M.3
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73
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40649084399
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Twenty-four hour hypothermic machine perfusion preservation of porcine pancreas facilitates processing for islet isolation
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This study suggests that machine perfusion may facilitate islet processing and improve islet yields when compared with fresh as well as cold-stored porcine pancreases, even after 24 h of preservation
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Taylor MJ, Baicu S, Leman B, et al. Twenty-four hour hypothermic machine perfusion preservation of porcine pancreas facilitates processing for islet isolation. Xenotransplantation 2007; 14:418-419. This study suggests that machine perfusion may facilitate islet processing and improve islet yields when compared with fresh as well as cold-stored porcine pancreases, even after 24 h of preservation.
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(2007)
Xenotransplantation
, vol.14
, pp. 418-419
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Taylor, M.J.1
Baicu, S.2
Leman, B.3
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74
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33645335487
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Intermittent capillary perfusion in rat pancreas grafts following short- and long-term preservation in University of Wisconsin solution
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Preissler G, Massberg S, Waldner H, Messmer K. Intermittent capillary perfusion in rat pancreas grafts following short- and long-term preservation in University of Wisconsin solution. Transpl Int 2006; 19:325-332.
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(2006)
Transpl Int
, vol.19
, pp. 325-332
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Preissler, G.1
Massberg, S.2
Waldner, H.3
Messmer, K.4
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75
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34147135145
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Goto T, Tanioka Y, Sakai T, et al. Application of the two-layer method on pancreas digestion results in improved islet yield and maintained viability of isolated islets. Transplantation 2007; 83:754-758. This study suggests that improvement of oxygenation by the addition of perfluorocarbon during islet digestion may have a beneficial effect on islet yield. This study suggests that hypoxia during islet processing may be negatively affecting islet isolation outcomes and that ways to improve oxygenation may be necessary to further improve islet yield and isolated islet quality.
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Goto T, Tanioka Y, Sakai T, et al. Application of the two-layer method on pancreas digestion results in improved islet yield and maintained viability of isolated islets. Transplantation 2007; 83:754-758. This study suggests that improvement of oxygenation by the addition of perfluorocarbon during islet digestion may have a beneficial effect on islet yield. This study suggests that hypoxia during islet processing may be negatively affecting islet isolation outcomes and that ways to improve oxygenation may be necessary to further improve islet yield and isolated islet quality.
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76
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33746930848
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Improved human islet isolation using nicotinamide
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This study reports that nicotinamide supplementation of the processing medium reduces the production of tissue tactor and macrophage chemoattractant protein from islet preparations
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Ichii H, Wang X, Messinger S, et al. Improved human islet isolation using nicotinamide. Am J Transplant 2006; 6:2060-2068. This study reports that nicotinamide supplementation of the processing medium reduces the production of tissue tactor and macrophage chemoattractant protein from islet preparations.
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(2006)
Am J Transplant
, vol.6
, pp. 2060-2068
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Ichii, H.1
Wang, X.2
Messinger, S.3
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77
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10744233687
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Nicotinamide inhibits tissue factor expression in isolated human pancreatic islets: Implications for clinical islet transplantation
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Moberg L, Olsson A, Berne C, et al. Nicotinamide inhibits tissue factor expression in isolated human pancreatic islets: implications for clinical islet transplantation. Transplantation 2003; 76:1285-1288.
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(2003)
Transplantation
, vol.76
, pp. 1285-1288
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Moberg, L.1
Olsson, A.2
Berne, C.3
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78
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22844439230
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Cell permeable peptide of JNK inhibitor prevents islet apoptosis immediately after isolation and improves islet graft function
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Noguchi H, Nakai Y, Matsumoto S, et al. Cell permeable peptide of JNK inhibitor prevents islet apoptosis immediately after isolation and improves islet graft function. Am J Transplant 2005; 5:1848-1855.
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(2005)
Am J Transplant
, vol.5
, pp. 1848-1855
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Noguchi, H.1
Nakai, Y.2
Matsumoto, S.3
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79
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40649127986
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Pancreas preservation with JNK inhibitor protects isolated islets against apoptosis and improves islet graft function
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Noguchi H, Matsumoto S, Kobayashi N, et al. Pancreas preservation with JNK inhibitor protects isolated islets against apoptosis and improves islet graft function. Xenotransplantation 2007; 14:480-481.
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(2007)
Xenotransplantation
, vol.14
, pp. 480-481
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Noguchi, H.1
Matsumoto, S.2
Kobayashi, N.3
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80
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40649098066
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Increased islet yield by p38 mitogen-activated protein kinase (MAPD) inhibitor infusion of the canine pancreas prior to overnight cold preservation
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Ito T, Omori K, Rawson J, et al. Increased islet yield by p38 mitogen-activated protein kinase (MAPD) inhibitor infusion of the canine pancreas prior to overnight cold preservation. Xenotransplantation 2007; 14:388.
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(2007)
Xenotransplantation
, vol.14
, pp. 388
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Ito, T.1
Omori, K.2
Rawson, J.3
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