CNS regulation of appetite

Neuropharmacology

Volumn 63, Issue 1, 2012, Pages 3-17

  Harrold, Joanne A ^a   Dovey, Terry M ^b   Blundell, John E ^c   Halford, Jason C G ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b LOUGHBOROUGH UNIVERSITY   (United Kingdom)

^c UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

Appetite; Central; Food intake; Hunger; Peripheral; Satiety

Indexed keywords

AMYLIN; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CHOLECYSTOKININ; COCAINE AND AMPHETAMINE REGULATED TRANSCRIPT PEPTIDE; GHRELIN; GLUCAGON LIKE PEPTIDE 1; LEPTIN; MELANIN CONCENTRATING HORMONE; MELANOCORTIN 3 RECEPTOR; MELANOCORTIN 4 RECEPTOR; NEUROPEPTIDE Y; OPIATE PEPTIDE; OREXIN 1 RECEPTOR; OREXIN 2 RECEPTOR; PEPTIDE YY [3-36];

BEHAVIOR CHANGE; CENTRAL NERVOUS SYSTEM FUNCTION; DISEASE ASSOCIATION; FEEDING BEHAVIOR; FOOD INTAKE; GENE EXPRESSION REGULATION; GENE MUTATION; HUMAN; HUNGER; NEUROMODULATION; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; REGULATORY MECHANISM; REVIEW; SATIETY; SIGNAL TRANSDUCTION; WEIGHT CONTROL;

ANIMALS; APPETITE; CENTRAL NERVOUS SYSTEM; EATING; HUMANS;

EID: 84862147114     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2012.01.007     Document Type: Review

References (209)

1. C.R. Abbott, M. Rossi, M. Kim, S.H. AlAhmed, G.M. Taylor, M.A. Ghatei, D.M. Smith, and S.,R. Bloom Investigation of the melanocyte stimulating hormones on food intake. Lack Of evidence to support a role for the melanocortin-3- receptor Brain Res. 869 2000 203 210
2. C.R. Abbott, M. Rossi, A.M. Wren, K.G. Murphy, A.R. Kennedy, S.A. Stanley, A.N. Zollner, D.G. Morgan, I. Morgan, M.A. Ghatei, D. Stephens, and S. Bloom Evidence of an orexigenic role for cocaine- and amphetamine-regulated transcript after administration into discrete hypothalamic nuclei Endocrinology 142 2001 3457 3463
3. C.R. Abbott, M. Monteiro, C.J. Small, A. Sajedi, K.L. Smith, J.R. Parkinson, M.A. Ghatei, and S.R. Bloom The inhibitory effects of peripheral administration of peptide YY(3-36) and glucagon-like peptide-1 on food intake are attenuated by ablation of the vagal-brainstem-hypothalamic pathway Brain Res. 1044 2005 127 131
4. R.A. Adan, and W.H. Gispen Brain melanocortin receptors: from cloning to function Peptides 18 1997 1279 1287
5. Y.S. Allen, T.E. Adrian, J.M. Allen, K. Tatemoto, T.J. Crow, S.R. Bloom, and J.M. Polak Neuropeptide Y distribution in rat brain Science 221 1983 877 879
6. U. Andersson, K. Filipsson, C.R. Abbott, A. Woods, K. Smith, S.R. Bloom, D. Carling, and C.J. Small AMP-activated protein kinase plays a role in the control of food intake J. Biol. Chem. 279 2004 12005 12008
7. M. Arnone, J. Maruani, F. Chaperon, M.H. Thiebot, M. Poncelet, P. Soubrie, and G. Le Fur Selective inhibition of sucrose and ethanol intake by SR 141716, an antagonist of central cannabinoid (CB1) receptors Psychopharmacology 132 1997 104 106
8. D. Atalayer, K.L. Robertson, C. Haskell-Luevano, A. Andreasen, and N.E. Rowland Food demand and meal size in mice with single or combined disruption of melanocortin type 3 and 4 receptors Am. J. Physiol. Regul. Integr. Comp. Physiol. 298 2010 R1667 R1674
9. B.W. Balleine, A.S. Killcross, and A. Dickinson The effect of lesions of the basolateral amygdala on instrumental conditioning J. Neurosci. 23 2003 666 675
10. M.F. Barbano, and M. Cador Opioids for hedonic experience and dopamine to get ready for it Psychopharmacology 191 2007 497 506
11. R.L. Batterham, M.A. Cowley, C.J. Small, H. Herzog, M.A. Cohen, C.L. Dakin, A.M. Wren, A.E. Brynes, M.J. Low, M.A. Ghatei, R.D. Cone, and S.R. Bloom Gut hormone PYY3-36 physiologically inhibits food intake Nature 418 2002 650 654
12. R.L. Batterham, M.A. Cohen, S.M. Ellis, C.W. Le Roux, D.J. Withers, G.S. Frost, M.A. Ghatei, and S.R. Bloom Inhibition of food intake in obese subjects by Peptide YY3-36 N. Eng. J. Med. 349 2003 914 918
13. R.L. Batterham, D.H. Ffytche, J.M. Rosenthal, F.O. Zelaya, G.J. Barker, D.J. Withers, and S.C. Williams PYY modulation of cortical and hypothalamic brain areas predicts feeding behaviour in humans Nature 450 2007 106 109
14. C. Becskei, V. Grabler, G.L. Edwards, T. Riediger, and T.A. Lutz Lesion of the lateral parabrachial nucleus attenuates the anorectic effect of peripheral amylin and CCK Brain Res. 1162 2007 76 84
15. C. Beglinger, L. Degen, D. Matzinger, M. D'Amoto, and J. Drewe Loxiglumide, a CCK-A receptor antagonist, stimulates calorie intake and hunger feelings in humans Am. J. Physiol. Regul. Integr. Comp. Physiol. 280 2001 R1149 R1154
16. H.R. Berthoud Multiple neural systems controlling food intake and body weight Neurosci. Biobehav. Rev. 26 2002 393 428
17. M.W. Bengtsson, K. Makela, M. Sjoblom, S. Uotila, K.E. Akerman, K.H. Herzig, and G. Flemstrom Food induced expression of orexin-receptors in rat duodenal mucosa regulates the bicarbonate secretory response to orexin-A Am. J. Physiol. Gastrointest. Liver Physiol. 293 2007 G501 G509
18. L.A. Blackshaw, and D. Grundy Effects of cholecystokinin (CCK-8) on two classes of gastroduodenal vagal afferent fibre J. Auton. Nerv Syst. 31 1990 191 201
19. J.E. Blevins, B.G. Stanley, and R.D. Reidelberger Brain regions where cholecystokinin suppresses feeding in rats Brain Res. 860 2000 1 10
20. J.E. Blevins, T.J. Eakin, J.A. Murphy, M.W. Schwartz, and D.G. Baskin Oxytocin innervation of caudal brainstem nuclei activated by cholecystokinin Brain Res. 993 2003 30 41
21. J.E. Blundell Pharmacological approaches to appetite suppression Trends Pharm. Sci. 12 1991 147 157
22. J.E. Blundell, and J.C.G. Halford Serotonin and appetite regulation: implications for the pharmacological treatment of obesity CNS Drugs 9 1998 473 495
23. J.E. Blundell, and C.J. Latham Pharmacological manipulation of feeding behaviour: possible influences of serotonin and dopamine on food intake S. Garattini, R. Samanin, Central Mechanisms of Anorectic Drugs 1978 Raven Press NY 83 109
24. J.E. Blundell, and C.J. Latham Characteristic adjustments to the structure of feeding behaviour following pharmacological treatments: effects of amphetamine and fenfluramine and the antagonism by pimozide and metergoline Pharmacol. Biochem. Behav. 12 1980 717 722
25. C. Bjorbaek, S. Uotani, B. da Silva, and J.S. Flier Divergent signaling capacities of the long and short isoforms of the leptin receptor J. Biol. Chem. 272 1997 32686 326895
26. S.L. Borgland, S. Taha, F. Sarti, H.L. Fields, and A. Bonci Orexin A signalling in dopamine neurones is critical for cocaine induced synaptic plasticity and behavioral sensitization Neuron 49 2006 589 601
27. S.L. Borgland, E. Storm, and A. Bonci OrexinB.hypocretin-2 increases glutamatergic synaptic transmission to ventral tegmental neurones Eur. J. Neurosci. 29 2008 1 12
28. B.P. Bullock, R.S. Heller, and J.F. Habener Tissue distribution of messenger ribonucleic acid encoding the rat glucagon-like peptide-1 receptor Endocrinology 137 1996 2968 2978
29. G. Burdyga, S. Lai, A. Varro, R. Dimaline, D.G. Thompson, and G.J. Dockray Expression of cannabinoid CB1 receptors by vagal afferent neurones is inhibited by cholecystokinin J. Neurosci. 24 2004 2708 2715
30. G. Burdyga, A. Varro, R. Dimaline, D.G. Thompson, and G.J. Dockray Feeding-dependent depression of melanin-concentrating hormone and melanin-concentrating hormone receptor-1 expression in vagal afferent neurones Neuroscience 137 2006 1405 1415
31. G. Burdyga, G. de Lartigue, H.E. Raybould, R. Morris, R. Dimaline, A. Varro, D.G. Thompson, and G.J. Dockray Cholecystokinin regulates expression of Y2 receptors in vagal afferent neurones serving the stomach J. Neurosci. 28 2008 11583 11592
32. B. Burton-Freeman, P.A. Davis, and B.O. Schneeman Plasma cholecystokinin is associated with subjective measures of satiety in women Am. J. Clin. Nutr. 76 2002 659 667
33. X.J. Cai, M.L. Evans, C.A. Lister, R.A. Leslie, J.R. Arch, S. Wilson, and G. Williams Hypoglycemia activates orexin neurons and selectively increases hypothalamic orexin-B levels: responses inhibited by feeding and possibly mediated by the nucleus of the solitary tract Diabetes 50 2001 105 112
34. X.J. Cai, P.S. Widdowson, J. Harrold, S. Wilson, R.E. Buckingham, J.R. Arch, M. Tadayyon, J.C. Clapham, J. Wilding, and G. Williams Hypothalamic orexin expression: modulation by blood glucose and feeding Diabetes 48 1999 2132 2137
35. H.S. Callahan, D.E. Cummings, M.S. Pepe, P.A. Breen, C.C. Matthys, and D.S. Weigle Postprandial suppression of plasma ghrelin level is proportional to ingested caloric load but does not predict intermeal interval in humans J. Clin. Endocrinol. Metab. 89 2004 1319 1324
36. L.A. Campfield, F.J. Smith, Y. Guisez, R. Devos, and P. Burn Recombinant mouse ob protein-evidence for a peripheral signal linking adiposity and central neural networks Science 269 1995 546 549
37. J.F. Caro, J.W. Kolaczynski, M.R. Nyce, J.P. Ohannesian, I. Opentanova, W.H. Goldman, R.B. Lynn, P.L. Zhang, M.K. Sinha, and R.V. Considine Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance Lancet 348 1996 159 161
38. I. Chapman, B. Parker, S. Doran, C. Feinle-Bisset, J. Wishart, S. Strobel, Y. Wang, C. Burns, C. Lush, C. Weyer, and M. Horowitz Effect of pramlintide on satiety and food intake in obese subjects and subjects with type 2 diabetes Diabetologia 48 2005 838 848
39. I. Chapman, B. Parker, S. Doran, C. Feinle-Bisset, J. Wishart, C.W. Lush, R. McKay, C. Weyer, and M. Horowitz Low-dose pramlintide reduced food intake and meal duration in healthy, normal-weight subjects Obesity (Silver Spring) 15 2007 1179 1186
40. R.M. Chemelli, J.T. Willie, C.M. Sinton, J.K. Elmquist, T. Scammell, C. Lee, J.A. Richardson, S.C. Williams, Y. Xiong, Y. Kisanuki, T.E. Fitch, M. Nakazato, R.E. Hammer, C.B. Saper, and M. Yanagisawa Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation Cell 98 1999 437 451
41. A.S. Chen, D.J. Marsh, M.E. Trumbauer, E.G. Frazier, X.M. Guan, H. Yu, C.I. Rosenblum, A. Vongs, Y. Feng, L. Cao, J.M. Metzger, A.M. Strack, R.E. Camacho, T.N. Mellin, C.N. Nunes, W. Min, J. Fisher, S. Gopal-Truter, D.E. MacIntyre, H.Y. Chen, and L.H. Van der Ploeg Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass Nat. Genet. 26 2000 97 102
42. C.C. Cheung, D.K. Clifton, and R.A. Steiner Proopiomelanocortin neurones are direct targets for leptin in the hypothalamus Endocrinology 138 1997 4489 4492
43. S.C. Chua Jr., W.K. Chung, X.S. Wu-Peng, Y. Zhang, S.M. Liu, L. Tartaglia, and R.L. Leibel Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor Science 271 1996 994 996
44. Cinti, S., Frederich, R.C., Zingaretti, M.C., De Matteis, R., Flier, J.S., Lowell, B.B., 1997. Immunohistochemical localization of leptin and uncoupling protein in white and brown adipose tissue. Endocrinology 138, 797-804.
45. S.J. Cooper Effects of opiate agonists and antagonists on fluid intake and saccharin choice in the rat Neuropharmacology 22 1983 323 328
46. D. Cota CB1 receptors: emerging evidence for central and peripheral mechanisms that regulate energy balance, metabolism and cardiovascular health Diabetes Metab. Res. Rev. 23 2007 507 517
47. D. Cota, M.H. Tschop, T.L. Horvath, and A.S. Levine Cannabinoids, opioids and eating behaviour: the molecular face of hedonism? Brain Res. Rev. 51 2006 85 107
48. D.E. Cummings, J.Q. Purnell, R.S. Frayo, K. Schmidova, B.E. Wisse, and D.S. Weigle A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans Diabetes 50 2001 1714 1719
49. D.E. Cummings Ghrelin and the short- and long-term regulation of appetite and body weight Physiol. Behav. 89 2006 71 84
50. P.J. Currie, N. Saxena, and A.Y. Tu 5-HT(2A/2C) receptor antagonists in the paraventricular nucleus attenuate the action of DOI on NPY-stimulated eating Neuroreport 10 1999 3033 3036
51. P.J. Currie, and D.V. Coscina Metergoline potentiates natural feeding and antagonizes the anorectic action of medical hypothalamic 5-hydroxytryptamine Pharmacol. Biochem. Behav. 53 1996 1023 1028
52. S. Dallvechia-Adams, M.J. Kuhar, and Y. Smith Cocaine- and amphetamine-regulated transcript peptide projections in the ventral midbrain: colocalization with gamma-aminobutyric acid, melanin-concentrating hormone, dynorphin, and synaptic interactions with dopamine neurones J. Comp. Neurol. 448 2002 360 372
53. G. de Lartigue, R. Dimaline, A. Varro, and G.J. Dockray Cocaine- and amphetamine-regulated transcript: stimulation of expression in rat vagal afferent neurones by cholecystokinin and suppression by ghrelin J. Neurosci. 27 2007 2876 2882
54. 7-36 amide reduce food intake and modulate brain activity in appetite centres in humans Cell Metab. 14 2011 1 7
55. J.P. Despres, A. Golay, L. Sjostrom, and Rimonabant in Obesity-Lipids Study Group Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia N. Engl. J. Med. 353 2005 2121 2134
56. S.L. Dickinson, E. Egecioglu, S. Landgren, K.P. Skibicka, J.A. Engel, and E. Jerlhag The role of the central ghrelin system in reward from food and chemical drugs Mol. Cell. Endocrinol. 340 2011 80 87
57. V. Di Marzo, and J.P. Despres CB1 antagonists for obesity - what lessons have we learnt from rimonabant? Nat. Rev. Endocrinol. 5 2009 633 638
58. V. Di Marzo, S.K. Goparaju, L. Wang, J. Liu, S. Bátkai, Z. Járai, F. Fezza, G.I. Miura, R.D. Palmiter, T. Sugiura, and G. Kunos Leptin-regulated endocannabinoids are involved in maintaining food intake Nature 410 2001 822 825
59. E. Disse, A.L. Bussier, C. Veyrat-Durebex, N. Deblon, P.T. Pfluger, M.H. Tschop, M. LAville, and F. Rohner-Jeanrenaud Peripheral ghrelin enhances sweet taste food consumption and preference, regardless of its caloric content Physiol. Behav. 101 2010 277 281
60. G. Dockray Cholecystokinin and gut-brain signalling Regul. Pept. 155 2009 6 10
61. A.M. Dossat, N. Lilly, K. Kay, and D.L. Williams Glucagon-like Peptide 1 receptors in nucleus accumbens affect food intake J. Neurosci. 31 2011 14453 14457
62. A. Drewnowski, D.D. Krahn, M.A. Demitrack, K. Nairn, and B.A. Gosnell Taste responses and preferences for sweet high-fat foods: evidence for opioid involvement Physiol. Behav. 51 1992 371 379
63. J. Dum, C. Gramsch, and A. Herz Activation of hypothalamic beta-endorphin pools by reward induced by highly palatable food Pharmacol. Biochem. Behav. 18 1983 443 447
64. Y. Dumont, D. Jacques, P. Bouchard, and R. Quirion Species differences in the expression and distribution of the neuropeptide Y Y1, Y2, Y4, and Y5 receptors in rodents, guinea pig, and primates brains J. Comp. Neurol. 402 1998 372 384
65. K. Ebihara, Y. Ogawa, G. Katsuura, Y. Numata, H. Masuzaki, N. Satoh, M. Tamaki, T. Yoshioka, M. Hayase, N. Matsuoka, M. Aizawa-Abe, Y. Yoshimasa, and K. Nakao Involvement of agouti-related protein, an endogenous antagonist at the hypothalamic melanocortin receptor; in leptin action Diabetes 48 1999 2028 2033
66. E. Egecioglu, E. Jerlhag, N. Salome, K.P. Skibicka, D. Haage, Y.M. Bohlooly, D. Andersson, M. Bjursell, D. Perrissoud, J. Engel, and S.L. Dickinson Ghrelin increases intake of rewarding food in rodents Addict. Biol. 15 2010 304 311
67. C.F. Elias, C.B. Saper, E. Maratos-Flier, N.A. Tritos, C. Lee, J. Kelly, J.B. Tatro, G.E. Hoffman, M.M. Ollmann, G.S. Barsh, T. Sakurai, M. Yanagisawa, and J.K. Elmquist Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area J. Comp. Neurol. 402 1998 442 459
68. J.K. Elmquist, C. Bjorbaek, R.S. Ahima, J.S. Flier, and C.B. Saper Distribution of leptin receptor mRNA isoforms in the rat brain J. Comp. Neurol. 395 1998 535 547
69. J.K. Elmquist, C. Elias, and C. Saper From lesions to leptin: hypothalamic control of food intake and body weight Neuron 22 1999 221 232
70. M. Emond, G.J. Schwartz, E.E. Ladenheim, and T.H. Moran Central leptin modulates behavioral and neural responsivity to CCK Am. J. Physiol. Regul. Integr. Comp. Physiol. 276 1999 R1545 R1549
71. P.J. English, M.A. Ghatei, I.A. Malik, S.R. Bloom, and J.P. Wilding Food fails to suppress ghrelin levels in obese humans J. Clin. Endocrinol. Metab. 87 2002 2984
72. J. Fadel, and A.Y. Deutch Anatomical substrates of orexin-dopamine interactions: lateral hypothalamic projections to the ventral tegmental area Neuroscience 111 2002 379 387
73. W. Fan, K.L. Ellacott, I.G. Halatchev, K. Takahashi, P. Yu, and R.D. Cone Cholecystokinin-mediated suppression of feeding involves the brainstem melanocortin system Nat. Neurosci. 7 2004 335 336
74. W. Fan, B.A. Boston, R.A. Kesterson, V.J. Hruby, and R.D. Cone Role of melanocortinergic neurones in feeding and the agouti obesity syndrome Nature 385 1997 119 120
75. D.P. Figlewicz, A.M. Nadzan, A.J. Sipols, P.K. Green, R.A. Liddle, D. Porte Jr., and S.C. Woods Intraventricular CCK-8 reduces single meal size in the baboon by interaction with type-A CCK receptors Am. J. Physiol. 263 1992 R863 R867
76. A. Flint, A. Raben, A. Astrup, and J.J. Holst Glucagon-like peptide-1 promotes satiety and suppresses energy intake in humans J. Clin. Invest. 101 1998 515 520
77. M. Fodor, A. Sluiter, A. FrankhuijzenSierevogel, V.M. Wiegant, P. Hoogerhout, D.J. DeWildt, and D.H.G. Versteeg Distribution of Lys-gamma(2)-melanocyte-stimulating hormone-(Lys-gamma(2)-MSH)-like immunoreactivity in neuronal elements in the brain and peripheral tissues of the rat Brain Res. 731 1996 182 189
78. G.S. Frost, A.E. Brynes, W.S. Dhillo, S.R. Bloom, and M.I. McBurney The effects of fiber enrichment of pasta and fat content on gastric emptying, GLP-1, glucose, and insulin responses to a meal Eur. J. Clin. Nutr. 57 2003 293 298
79. K.M. Gamber, H. Macarthur, and T.C. Westfall Cannabinoids augment the release of neuropeptide Y in the rat hypothalamus Neuropharmacology 49 2005 646 652
80. 6 receptor antagonist, reduces food intake and body weight in rats Proceedings of the Serotonin Club Sixth IUPHAR Satellite Meeting on Serotonin, Hokkaido 2006 P2 P17
81. J. Gibbs, R.C. Young, and G.P. Smith Cholecystokinin decreases food intake in rats J. Comp. Physiol. Psychol. 84 1973 488 495
82. F.L. Greenway, M.J. Whitehouse, M. Guttadauria, J.W. Anderson, R.L. Atkinson, K. Fujioka, K.M. Gadde, A.K. Gupta, P. O'Neil, D. Schumacher, D. Smith, E. Dunayevich, G.D. Tollefson, E. Weber, and M.A. Cowley Rational design of a combination medication for the treatment of obesity Obesity (Silver Spring) 17 2009 30 39
83. H.J. Grill, and J.M. Kaplan The neuroanatomical axis for control of energy balance Front. Neuroendocrinol. 23 2002 2 40
84. H.J. Grill, M.W. Schwartz, J.M. Kaplan, J.S. Foxhall, J. Breininger, and D.G. Baskin Evidence that the caudal brainstem is a target for the inhibitory effect of leptin on food intake Endocrinology 143 2002 239 246
85. B. Guesdon, E. Paradis, P. Samson, and D. Richard Effects of intracerebroventricular and intra-accumbens melanin-concentrating hormone agonism on food intake and energy expenditure Am. J. Physiol. Regul. Integr. Comp. Physiol. 296 2009 R469 R475
86. J.P. Gutzwiller, J. Drewe, S. Ketterer, P. Hildebrand, A. Krautheim, and C. Beglinger Interaction between CCK and a preload on reduction of food intake is mediated by CCK-A receptors in humans Am. J. Physiol. Regul. Integr. Comp. Physiol. 279 2000 R189 R195
87. J.P. Gutzwiller, L. Degen, L. Heuss, and C. Beglinger Glucagon-like peptide-1 (GLP-1) and eating Physiol. Behav. 82 2004 17 19
88. S. Haj-Dahmane, and R.Y. Shen The wake-promoting peptide orexin B inhibits glutamatergic transmission to dorsal raphe nucleus serotonin neurones through retrograde endocannabinoid signalling J. Neurosci. 25 2005 896 905
89. J.C.G. Halford, and J.E. Blundell Separate systems for serotonin and leptin in appetite control Ann. Med. 32 2000 222 232
90. J.C.G. Halford, G.D. Cooper, T.M. Dovey, Y. Ishii, R.J. Rodgers, and J.C.G. Blundell Pharmacological approaches to obesity treatment Curr. Med. Chem. Cent. Nerv Syst. Agents 3 2003 283 310
91. J.C.G. Halford, E.J. Boyland, J.E. Blundell, T.C. Kirkham, and J.E. Harrold Pharmacological management of human appetite expression: evaluating the effects of novel anti-obesity agents on eating behaviour Nat. Rev. Endocrinol. 6 2010 255 269
92. J.A. Harrold, T. Dovey, X.J. Cai, J.C. Halford, and J. Pinkney Autoradiographic analysis of ghrelin receptors in the rat hypothalamus Brain Res. 1196 2008 59 64
93. Y. Hirosue, A. Inui, A. Teranishi, M. Miura, M. Nakajima, M. Okita, Y. Nakajima, N. Himori, S. Baba, and M. Kasuga Cholecystokinin octapeptide analogues suppress food intake via central CCK-A receptors in mice Am. J. Physiol. 265 1993 R481 R486
94. J.J. Holst The physiology of glucagon-like peptide 1 Physiol. Rev. 87 2007 1409 1439
95. S.G. Holtzman Tolerance to the stimulant effects of morphine and pentazocine on avoidance responding in the rat Psychopharmacologia 39 1974 23 37
96. H. Huang, C. Acuna-Goycolea, Y. Li, H.M. Cheng, K. Obrietan, and A.N. van den Pol Cannabinoids excite hypothalamic melanocortin-concentrating hormone but inhibit hypocretin/orexin neurones: implications for cannabinoid actions on food intake and cognitive arousal J. Neurosci. 27 2007 4870 4881
97. D. Huszar, C.A. Lynch, V. Fairchild-Huntress, J.H. Dunmore, Q. Fang, L.R. Berkemeier, W. Gu, R.A. Kesterson, B.A. Boston, R.D. Cone, F.J. Smith, L.A. Campfield, P. Burn, and F. Lee Targeted disruption of the melanocortin-4 receptor results in obesity in mice Cell 88 1997 131 141
98. T.M. Hyde, and R.R. Miselis Effects of area postrema/caudal medial nucleus of solitary tract lesions on food intake and body weight Am. J. Physiol. 244 1983 R577 R587
99. N. Jamshidi, and D.A. Taylor Anandamide administration into the ventromedial hypothalamus stimulates appetite in rats Br. J. Pharmacol. 134 2001 1151 1154
100. D. Jones End of the line for cannabinoid receptor 1 as an anti-obesity target? Nat. Rev. Drug Discov. 7 2008 961 962
101. J.E. Kanoski, E.R. Hayes, H.S. Greenwald, S.M. Fortin, C.A. Gianessi, J.R. Gilbert, and H.J. Grill Hippocampal leptin signalling reduces food intake and modulates food-related memory processing Neuropsychopharmacology 36 2011 1859 1870
102. A.J. Kastin, V. Akerstrom, and W. Pan Interactions of glucagon-like peptide-1 (GLP-1) with the blood-brain barrier J. Mol. Neurosci. 18 2002 7 14
103. Y. Katsuura, J.A. Heckmann, and S.A. Taha Mu-Opioid receptor stimulation in the nucleus accumbens elevates fatty tastant intake by increasing palatability and suppressing satiety signals Am. J. Physiol. Regul. Integr. Comp. Physiol. 301 2011 244 254
104. A.E. Kelley, B.A. Baldo, and W.E. Pratt A proposed hypothalamic-thalamic- striatal axis for the integration of energy balance, arousal, and food reward J. Comp. Neurol. 493 2005 72 85
105. E.M. Kim, J.G. Quinn, A.S. Levine, and E. O'Hare A bi-directional mu-opioid connection between the nucleus of the accumbens shell and the central nucleus of the amygdale in the rat Brain Res. 1029 2004 135 139
106. B.J. Kim, O.D. Carlson, H.J. Jang, D. Elahi, C. Berry, and J.M. Egan Peptide YY is secreted after oral glucose administration in a gender-specific manner J. Clin. Endocrinol. Metab. 90 2005 6665 6671
107. D.H. Kim, D.A. D'Alessio, S.C. Woods, and R.J. Seeley The effects of GLP-1 infusion in the hepatic portal region on food intake Regul. Pept. 155 2009 110 114
108. H.L. Kimmel, W. Gong, S.D. Vechia, R.G. Hunter, and M.J. Kuhar Intra-ventral tegmental area injection of rat cocaine and amphetamine-regulated transcript peptide 55-102 induces locomotor activity and promotes conditioned place preference J. Pharmacol. Exp. Ther. 294 2000 7847 7892
109. S.J. King, A.M. Isaacs, E. O'Farrell, and A. Abizaid Motivation to obtain preferred foods is enhanced by ghrelin in the ventral tegmental area Horm. Behav. 19 2011 [Epub ahead of print]
110. T.C. Kirkham, and C.M. Williams Synergistic effects of opioid and cannabinoid antagonists on food intake Psychopharmacology (Berl) 153 2001 267 270
111. M. Kojima, H. Hosoda, Y. Date, M. Nakazato, H. Matsuo, and K. Kangawa Ghrelin is a growth-hormone-releasing acylated peptide from stomach Nature 402 1999 656 660
112. J.W. Kolaczynski, R.V. Considine, J. Ohannesian, C. Marco, I. Opentanova, M.R. Nyce, M. Myint, and J.F. Caro Responses of leptin to short-term fasting and refeeding in humans: a link with ketogenesis but not ketones themselves Diabetes 45 1996 1511 1515
113. T.M. Korotkova, K.S. Sergeeva, K.S. Eriksson, H.L. Haas, and R.E. Brown Excitation of ventral tegmental area dopaminergic and nondopaminergic neurones by orexins/hypocretins J. Neurosci. 23 2003 7 11
114. P. Kristensen, M.E. Judge, L. Thim, U. Ribel, K.N. Christjansen, B.S. Wulff, J.T. Clausen, P.B. Jensen, O.D. Madsen, N. Vrang, P.J. Larsen, and S. Hastrup Hypothalamic CART is a new anorectic peptide regulated by leptin Nature 393 1998 72 76
115. H. Krude, H. Biebermann, W. Luck, R. Horn, G. Brabant, and A. Gruters Severe early-onset obesity, adrenal insufficiency and read hair pigmentation caused by POMC mutations in humans Nat. Genet. 19 1998 155 157
116. M.J. Kuhar, and S.E. Dall Vechia CART peptides: novel addiction- and feeding-related neuropeptides Trends Neurosci. 22 1999 316 320
117. P.D. Lambert, P.R. Couceyro, E.O. Koylu, N.C. Ling, E.B. DeSouza, and M.J. Kuhar A role for novel CART peptide fragments in the central control of food intake Neuropeptides 31 1997 620 621
118. W. Langhans Metabolic and glucostatic control of feeding P Nutr. Soc. 55 1996 497 515
119. J.H. Lavin, G.A. Wittert, J. Andrews, B. Yeap, J.M. Wishart, H.A. Morris, J.E. Morley, M. Horowitz, and N.W. Read Interaction of insulin, glucagon-like peptide 1, gastric inhibitory polypeptide, and appetite in response to intraduodenal carbohydrate Am. J. Clin. Nutr. 68 1998 591 598
120. M. Lee, A. Kim, I.M. Conwell, V. Hruby, A. Mayorov, M. Cai, and S.L. Wardlaw Effects of selective modulation of the central melanocortin-3-receptor on food intake and hypothalamic POMC expression Peptides 29 2008 440 447
121. J. Lee, E. Martin, G. Paulino, G. de Lartigue, and H.E. Raybould Effect of ghrelin receptor antagonist on meal patterns in cholecystokinin type 1 receptor null mice Physiol. Behav. 103 2011 181 187
122. S.F. Leibowitz, G.F. Weiss, and J.S. Suh Medial hypothalamic nuclei mediate serotonin's inhibitory effect on feeding behavior Pharmacol. Biochem. Behav. 37 1990 735 742
123. B.E. Levin Metabolic sensors: viewing glucose neurones from a broader perspective Physiol. Behav. 76 2002 397 401
124. B.E. Levin Metabolic sensing neurones and the control of energy homeostasis Physiol. Behav. 89 2006 486 489
125. L. Lin, J. Faraco, R. Li, H. Kadotani, W. Rogers, X. Lin, X. Qiu, P.J. de Jong, S. Nishino, and E. Mignot The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene Cell 98 1999 365 376
126. S. Lin, D. Boey, M. Couzens, N. Lee, A. Sainsbury, and H. Herzog Compensatory changes in [125I]-PYY binding in Y receptor knockout mice suggest the potential existence of further Y receptor(s) Neuropeptides 39 2005 21 28
127. J. LouisSylvestre, and J. LeMagnen A fall in blood-glucose level precedes meal onset in free-feeding rats Neurosci. Biobehav. Rev. 4 1980 13 15
128. Lopez, C.A., Guesdon, B., Baraboi, E.-D., Roffarello, B.M., Hetu, M., Richard, D., 2011. Involvement of the opioid system in the orexigenic and hedonic effects of melanin concentrating hormone. Am. J. Physiol. Regul. Integr. Comp. Physiol. 301, R1105-R1111.
129. T.A. Lutz, A. Mollet, P.A. Rushing, T. Riediger, and E. Scharrer The anorectic effect of a chronic peripheral infusion of amylin is abolished in area postrema/nucleus of the solitary tract (AP/NTS) lesioned rats Int. J. Obes. Relat. Metab. Disord. 25 2001 1005 1011
130. S.V. Mahler, K.S. Smith, and K.C. Berridge Endocannabinoid hedonic hotspot for sensory pleasure: anandamide in nucleus accumbens shell enhances 'liking' of a sweet reward Neuropsychopharmacology 32 2007 2267 2278
131. S. Malik, F. McGlone, D. Bedrossian, and A. Dagher Ghrelin modulates brain activity in areas that control appetitive behaviour Cell Metab. 7 2008 400 409
132. V. Marks, L. Morgan, J. Oben, and R. Elliott Gut hormones in glucose homeostasis Proc. Nutr. Soc. 50 1991 545 552
133. S. Mashiko, R. Moriya, A. Ishihara, A. Gomori, H. Matsushita, S. Egashira, H. Iwaasa, T. Takahashi, Y. Haga, T. Fukami, and A. Kanatani Synergistic interaction between neuropeptide Y1 and Y5 receptor pathways in regulation of energy homeostasis Eur. J. Pharmacol. 615 2009 113 117
134. I. Matias, A.V. Vergoni, S. Petrosino, A. Ottani, A. Pocai, A. Bertolini, and V. Di Marzo Regulation of hypothalamic endocannabinoid levels by neuropeptides and hormones involved in food intake and metabolism: insulin and melanocortins Neuropharmacology 54 2008 206 212
135. M.H. Mei, and Q. Chen Interaction of vagal stimulation and duodenal acidification in the regulation of pancreatic secretion Sheng Li Xue Bao 37 1985 410 415
136. K.J. Melanson, M.S. Westerterp-Plantenga, L.A. Campfield, and W.H.M. Saris Blood glucose and meal patterns in time-blinded males, after aspartame, carbohydrate, and fat consumption, in relation to sweetness perception Brit. J. Nutr. 82 1999 437 446
137. T. Melis, S. Succu, F. Sanna, A. Boi, A. Argiolas, and M.R. Melis The cannabinoid antagonist SR 141716A (Rimonabant) reduces the increase of extra-cellular dopamine release in the rat nucleus accumbens induced by a novel highly palatable food Neurosci. Lett. 419 2007 231 235
138. J.G. Mercer, K.M. Moar, V.D. Rayner, P. Trayhurn, and N. Hoggard Regulation of leptin receptor and NPY gene expression in hypothalamus of leptin-treated obese (ob/ob) and cold-exposed lean mice FEBS Lett. 402 1997 185 188
139. Y. Minokoshi, T. Alquier, N. Furukawa, Y.B. Kim, A. Lee, B. Xue, J. Mu, F. Foufelle, P. Ferre, M.J. Birnbaum, B.J. Stuck, and B.B. Kahn AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus Nature 428 2004 569 574
140. V. Mohamed-Ali, J.H. Pinkney, and S.W. Coppack Adipose tissue as an endocrine and paracrine organ Int. J. Obes. Relat. Metab. Disord. 22 1998 1145 1158
141. C.T. Montague, I.S. Farooqi, J.P. Whitehead, M.A. Soos, H. Rau, N.J. Wareham, C.P. Sewter, J.E. Digby, S.N. Mohammed, J.A. Hurst, C.H. Cheetham, A.R. Earley, A.H. Barnett, J.B. Prins, and S. O'Rahilly Congenital leptin deficiency is associated with severe early-onset obesity in humans Nature 387 1997 903 908
142. G.J. Morton, J.E. Blevins, D.L. Williams, K.D. Niswender, R.W. Gelling, C.J. Rhodes, D.G. Baskin, and M.W. Schwartz Leptin action in the forebrain regulates the hindbrain response to satiety signals J. Clin. Invest. 115 2005 703 710
143. K.G. Mountjoy, M.T. Mortrud, M.J. Low, R.B. Simerly, and R.D. Cone Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control-circuits in the brain Mol. Endocrinol. 8 1994 1298 1308
144. N. Naito, I. Kawazoe, Y. Nakai, and H. Kawauchi Melanin-concentrating hormone-like immunoreactive material in the rat hypothalamus; characterization and subcellular localization Cell Tissue Res. 253 1988 291 295
145. M. Nakazato, N. Murakami, Y. Date, M. Kojima, H. Matsuo, K. Kangawa, and S. Matsukura A role for ghrelin in the central regulation of feeding Nature 409 2001 194 198
146. M. Narita, Y. Nagumo, S. Hashimoto, M. Narita, J. Khotib, M. Miyatake, T. Sakurai, M. Yanagisawa, T. Nakamachi, S. Shioda, and T. Suzuki Direct involvement of orexinergic systems in the activation of the mesolimbic dopamine pathway and related behaviours induced by morphine J. Neurosci. 26 2006 398 405
147. M. Narita, Y. Nagumo, M. Miyatake, D. Ikegami, K. Kurahashi, and T. Susuki Implication of protein kinase C in the orexin-induced elevation of extracellular dopamine levels and its rewarding effects Eur. J. Neurosci. 31 2007 336 348
148. E. Naslund, J. Bogefors, S. Skogar, P. Gryback, H. Jacobsson, J.J. Holst, and P.M. Hellstrom GLP-1 slows solid gastric emptying and inhibits insulin, glucagon, and PYY release in humans Am. J. Physiol. 277 1999 R910 R916
149. N.M. Neary, C.J. Small, M.R. Druce, A.J. Park, S.M. Ellis, N.M. Semjonous, C.L. Dakin, K. Fillipsson, F. Wang, A.S. Kent, G.S. Frost, M.A. Ghatei, and S.R. Bloom Peptide YY3-36 and glucagon-like peptide-17-36 inhibit food intake additively Endocrinology 146 2005 5120 5127
150. K. Nonogaki, L. Abdallah, E.H. Goulding, S.J. Bonasera, and L.H. Tecott Hyperactivity and reduced energy cost of physical activity in serotonin 5-HT(2C) receptor mutant mice Diabetes 52 2003 315 320
151. T. Onaga, R. Zabieski, and S. Kato Multiple regulation of peptide YY secretion in the digestive tract Peptide 23 2002 279 290
152. L. Orio, I. Crespo, J.A. Lopez-Moreno, C. Reyes-Cabello, F. Rodriguez de Fonseca, and R. Gomez de Heras Additive effects of cannabinoid CB1 receptor blockade and cholecystokinin on feeding inhibition Pharmacol. Biochem. Behav. 98 2011 220 226
153. D. Osei-Hyiaman, M. Depetrillo, J. Harvey-White, A.W. Bannon, B.F. Cravatt, M.J. Kuhar, K. Mackie, M. Palkovits, and G. Kunos Cocaine- and amphetamine-related transcript is involved in the orexigenic effect of endogenous anandamide Neuroendocrinology 81 2005 273 282
154. K.H. Paik, D.K. Jin, K.H. Lee, L. Armstrong, J.E. Lee, Y.J. Oh, S. Kim, E.K. Kwon, and Y.H. Choe Peptide YY, cholecystokinin, insulin and ghrelin response to meal did not change, but mean serum levels of insulin is reduced in children with Prader-Willi syndrome J. Korean Med. Sci. 22 2007 436 441
155. M. Perello, I. Sakata, S. Birnbaum, J.C. Chuang, S. Osbourne-Lawrence, S.A. Rovinsky, J. Woloszyn, M. Yanagisawa, M. Lutter, and J. Zigman Ghrelin increases the rewarding value of high-fat diet in an orexin dependent fashion Biol. Psychiatry 67 2009 880 886
156. L. Peter, A. Stengel, S. Noetzel, T. Inhoff, M. Goebel, Y. Tache, R.W. Veh, N. Bannert, C. Grotzinger, B. Wiedenmann, B.F. Klapp, H. Monnikes, and P. Kobelt Peripherally injected CCK-8S activates CART positive neurones of the paraventricular nucleus in rats Peptides 6 2010 1118 1123
157. J.H. Peters, S.M. Simasko, and R.C. Ritter Modulation of vagal afferent excitation and reduction of food intake by leptin and cholecystokinin Physiol. Behav. 89 2006 477 485
158. P.T. Pfluger, J. Kampe, T.R. Castaneda, T. Vahl, D.A. D'Alessio, T. Kruthaupt, S.C. Benoit, U. Cuntz, H.J. Rochlitz, M. Moehlig, A.F. Pfeiffer, C. Koebnick, M.O. Weickert, B. Otto, J. Spranger, and M.H. Tschop Effect of human body weight changes on circulating levels of peptide YY and peptide YY3-36 J. Clin. Endocrinol. Metab. 92 2007 583 588
159. X. Pi-Sunyer, H.R. Kissileff, J. Thornton, and G.P. Smith C-terminal octapeptide of cholecystokinin decreases food intake in obese men Physiol. Behav. 29 1982 627 630
160. Pi-Sunyer, F.X., Aronne, L.J., Heshmati, H.M., Devin, J., Rosenstock, J., RIO-North America Study Group, 2006. Effect of rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients: RIO-North America: a randomized controlled trial. JAMA 295, 761-775.
161. C.S. Potes, and T.A. Lutz Brainstem mechanisms of amylin-induced anorexia Physiol. Behav. 100 2010 511 518
162. C.S. Potes, T.A. Lutz, and T. Riediger Identification of central projections from amylin-activated neurones to the lateral hypothalamus Brain Res. 1334 2010 31 44
163. D. Qu, D.S. Ludwig, S. Gammeltoft, M. Piper, M.A. Pelleymounter, M.J. Cullen, W.F. Mathes, R. Przypek, R. Kanarek, and E. Maratos-Flier A role for melanin-concentrating hormone in the central regulation of feeding behaviour Nature 380 1996 243 247
164. J.F. Rehfeld, G. Sun, T. Christensen, and J.G. Hillingso The predominant cholecystokinin in human plasma and intestine is cholecystokinin-33 J. Clin. Endocrinol. Metab. 86 2001 251 258
165. D. Renshaw, and R.L. Batterham Peptide YY: a potential therapy for obesity Curr. Drug Targets 6 2005 171 179
166. T. Riediger, D. Zuend, C. Becski, and T.A. Lutz The anorectic hormone amylin contributes to feeding-related changes of neuronal activity in key structures of the gut-brain axis Am. J. Physiol. Regul. Integr. Comp. Physiol. 286 2004 R114 R122
167. R.J. Rodgers, Y. Ishii, J.C. Halford, and J.E. Blundell Orexins and appetite regulation Neuropeptides 36 2002 303 325
168. D.R. Romsos, A.G. Swick, B.A. Chrunyk, D. Cunningham, and A.M. Mistry Intracerebroventricular recombinant leptin decreases food-intake and increases metabolic-rate in ob/ob mice Faseb J. 10 1996 1287
169. N.E. Rowland, E.C. Crews, and R.M. Gentry Comparison of Fos induced in rat brain by GLP-1 and amylin Regul. Pept. 71 1997 171 174
170. J.M. Rudski, C.J. Billington, and A.S. Levine Butorphanol increases food-reinforced operant responding in satiated rats Pharmacol. Biochem. Behav. 49 1994 843 847
171. P.A. Rushing, M.M. Hagan, R.J. Seeley, T.A. Lutz, D.A. D'Alessio, E.L. Air, and S.C. Woods Inhibition of central amylin signalling increases food intake and body adiposity in rats Endocrinology 142 2001 5035
172. T. Sakurai, A. Amemiya, M. Ishii, I. Matsuzaki, R.M. Chemelli, H. Tanaka, S.C. Williams, J.A. Richardson, G.P. Kozlowski, S. Wilson, J.R. Arch, R.E. Buckingham, A.C. Haynes, S.A. Carr, R.S. Annan, D.E. McNulty, W.S. Liu, J.A. Terrett, N.A. Elshourbagy, D.J. Bergsma, and M. Yanagisawa Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior Cell 92 1998 573 585
173. C.B. Saper, T.C. Chou, and J.K. Elmquist The need to feed: homeostatic and hedonic control of eating Neuron 36 2002 199 211
174. A.J. Scheen, N. Finer, P. Hollander, M.D. Jensen, L.F. Van Gaal, and RIO-Diabetes Study Group Efficacy and tolerability of rimonabant in overweight or obese patients with type 2 diabetes: a randomised controlled study Lancet 368 2006 1660 1672
175. S. Shacham, Y. Marantz, and H. Senderowitz Novel 5-HT6 receptor antagonists for the treatment of obesity Obes. Res. 13 2005 A192
176. M. Shintani, Y. Ogawa, K. Ebihara, M. Aizawa-Abe, F. Miyanaga, K. Takaya, T. Hayashi, G. Inoue, K. Hosoda, and M. Kojima Ghrelin, an endogenous growth hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway Diabetes 50 2001 227 232
177. G. Shor-Posner, A.P. Azar, S. Insinga, and S.F. Leibowitz Deficits in the control of food intake after paraventricular nucleus lesions Physiol. Behav. 35 1986 883 890
178. J. Simiand, M. Keane, P.E. Keane, and P. Soubrie SR 141716, a CB1 cannabinoid receptor antagonist, selectively reduces sweet food intake in marmosets Behav. Pharmacol. 9 1998 179 181
179. 3-36 on appetite, energy intake, energy expenditure, glucose and fat metabolism in obese and lean subjects Am. J. Physiol. 292 2007 E1062 E1068
180. J.W. Sohn, Y. Xu, J.E. Jones, K. Wickman, K.W. Williams, and J.K. Elmquist Serotonin 2C receptor activates a distinct population of arcuate pro-opiomelanocortin neurons via TRPC channels Neuron 71 2011 488 497
181. B.G. Stanley, A.S. Chin, and S.F. Leibowitz Feeding and drinking elicited by central injection of neuropeptide Y: evidence for a hypothalamic site(s) of action Brain Res. Bull. 14 1985 521 524
182. T.R. Stratford, A.E. Kelley, and K.J. Simansky Blockade of GABA(A) receptors in the medial ventral pallidum elicits feeding in satiated rats Brain Res. 825 1999 199 203
183. 6 Receptor Antagonist BVT5182 Decreases Food Intake and Body Weight in Both Rats and Mice 2004 Society for Neuroscience P75.8
184. 6 receptor antagonist BVT5182 reduces body weight of high fat diet-induced mice Proceedings of the 12th European Congress of Obesity, Helsinki 2003 P1 094
185. J. Tam, V.K. Vemuri, J. Liu, S. Bátkai, B. Mukhopadhyay, G. Godlewski, D. Osei-Hyiaman, S. Ohnuma, S.V. Ambudkar, J. Pickel, A. Makriyannis, and G. Kunos Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity J. Clin. Invest. 120 2010 2953 2966
186. K. Teff Nutritional implications of the cephalic-phase reflexes: endocrine responses Appetite 34 2000 206 213
187. C. Thomsen, H. Storm, J.J. Holst, and K. Hermansen Differential effects of saturated and monounsaturated fats on postprandial lipemia and glucagon-like peptide 1 responses in patients with type 2 diabetes Am. J. Clin. Nutr. 77 2003 605 611
188. M. Tschop, R. Wawarta, R.L. Reipel, S. Friedrich, M. Bindlingmaier, R. Landgraf, and C. Folwaczny Postprandial decrease of circulating human ghrelin levels J. Endocrinol. Invest. 24 2001 19 21
189. N. Tsujino, and T. Sakurai Orexin/hypocretin: a neuropeptide at the interface of sleep, energy homeostasis, and reward system Pharmacol. Rev. 61 2009 162 176
190. M.D. Turton, D. O'Shea, I. Gunn, S.A. Beak, C.M. Edwards, K. Meeran, S.J. Choi, G.M. Taylor, M.M. Heath, P.D. Lambert, J.P. Wilding, D.M. Smith, M.A. Ghatei, J. Herbert, and S.R. Bloom A role for glucagon-like peptide-1 in the central regulation of feeding Nature 379 1996 69 72
191. T.P. Vahl, D.L. Drazen, R.J. Seeley, D.A. D'Alessio, and S.C. Woods Meal-anticipatory glucagon-like peptide-1 secretion in rats Endocrinology 151 2010 569 575
192. L.F. Van Gaal, A.M. Rissanen, A.J. Scheen, O. Ziegler, S. Rossner, and RIO-Europe Study Group Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study Lancet 365 2005 1389 1397
193. C. Verdich, A. Flint, J.P. Gutzwiller, E. Näsland, C. Beglinger, P.M. Hellström, S.J. Long, L.M. Morgan, J.J. Holst, and A. Astrup A meta-analysis of the effect of glucagon-like peptide-1 (7-36) amide on ad libitum energy intake in humans J. Clin. Endocrinol. Metab. 86 2001 4382 4389
194. A.N. Verty, W.M. Boon, P.E. Mallet, I.S. McGregor, and B.J. Oldfield Involvement of hypothalamic peptides in the anorectic action of the CB receptor antagonist rimonabant (SR 141716) Eur. J. Neurosci. 29 2009 2207 2216
195. A.N. Verty, J.R. McFarlane, I.S. McGregor, and P.E. Mallett Evidence for an interaction between CB1 cannabinoid and melanocortin MC4-R receptors in regulating food intake Endocrinology 45 2004 3224 3231
196. N./M. Vittoz, B. Schmeichel, and C.W. Berridge Hypocretin/orexin preferentially activates caudomedial ventral tegmental area dopamine neurons Eur. J. Neurosci. 28 2008 1629 1640
197. J. Wang, and K.L. Leibowitz Central insulin inhibits hypothalamic galanin and neuropeptide Y gene expression and peptide release in intact rats Brain Res. 777 1997 231 236
198. P.J. Wellman, P.S. Clifford, J.A. Rodriguez, S. Hughes, C. Di Francesco, S. Melotto, M. Tessari, M. Corsi, A. Bifone, and A. Gozzi Brain reinforcement system function is ghrelin dependent: studies in the rat using pharmacological fMRI and intracranial self-stimulation Addict. Biol. 21 2011 [Epub ahead of print]
199. T. Wenger, K.A. Jamali, C. Juanéda, J. Léonardelli, and G. Tramu Arachidonyl ethanolamide (anandamide) activates the parvocellular part of hypothalamic paraventricular nucleus Biochem. Biophys. Res. Commun. 237 1997 724 728
200. A.M. Wren, C.J. Small, C.R. Abbott, W.S. Dhillo, L.J. Seal, M.A. Cohen, R.L. Batterham, S. Taheri, S.A. Stanley, M.A. Ghatei, and S.R. Bloom Ghrelin causes hyperphagia and obesity in rats Diabetes 50 2000 2540 2547
201. A.M. Wren, L.J. Seal, M.A. Cohen, A.E. Brynes, G.S. Frost, K.G. Murphy, W.S. Dhillo, M.A. Ghatei, and S.R. Bloom Ghrelin enhances appetite and increases food intake in humans J. Clin. Endocrinol. Metab. 86 2001 5992
202. R.J. Wurtman, and J.J. Wurtman Brain serotonin, carbohydrate-craving, obesity and depression Obes. Res. 3 1995 477S 480S
203. G.S.H. Yeo, S. Farooqi, S. Aminian, D.J. Halsall, R.G. Stanhope, and S. O'Rahilly A frameshift mutation in MC4-R associated with dominantly inherited human obesity Nat. Genet. 20 1998 111 112
204. M.R. Yeomans, and R.W. Gray Selective effects of naltrexone on food pleasantness and intake Physiol. Behav. 60 1996 439 446
205. M.R. Yeomans, and R.W. Gray Opioid peptides and the control of human ingestive behaviour Neurosci. Biobehav. Rev. 26 2002 713 728
206. J. Zhang, and R.C. Ritter Circulating GLP-1 and CCK-8 reduce food intake by capsaicin-insensitive, non-vagal mechanisms Am. J. Physiol. Regul. Integr. Comp. Physiol. 2011 [Epub ahead of print]
207. H. Zheng, L.M. Patterson, C.B. Phifer, and H.R. Berthoud Brain stem melanocortinergic modulation of meal size and identification of hypothalamic POMC projections Am. J. Physiol. Regul. Integr. Comp. Physiol. 289 2005 R247 R258
208. L. Zhou, T. Williams, J.L. Lachey, T. Kishi, M.A. Cowley, and L.K. Heisler Serotonergic pathways converge upon central melanocortin systems to regulate energy balance Peptides 26 2005 1728 1732
209. J.M. Zigman, J.E. Jones, C.E. Lee, C.B. Saper, and J.K. Emlquist Expression of the ghrelin receptor mRNA in the rat and the mouse brain J. Comp. Neurol. 494 2006 528 548