Hyperactivity and reduced energy cost of physical activity in serotonin 5-HT2C receptor mutant mice

Diabetes

Volumn 52, Issue 2, 2003, Pages 315-320

  Nonogaki, Katsunori ^a,b   Abdallah, Luna ^a   Goulding, Evan H ^a   Bonasera, Stephen J ^a   Tecott, Laurence H ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

SEROTONIN 2C RECEPTOR;

AGE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BASAL METABOLIC RATE; BODY COMPOSITION; CONTROLLED STUDY; DIET RESTRICTION; ENERGY EXPENDITURE; FOOD INTAKE; GENE MUTATION; GLUCOSE HOMEOSTASIS; HYPERACTIVITY; HYPERPHAGIA; LIPID METABOLISM; LOCOMOTION; MOUSE; NONHUMAN; OBESITY; PHYSICAL ACTIVITY; PRIORITY JOURNAL; SEROTONINERGIC SYSTEM;

ANIMALS; ENERGY METABOLISM; FASTING; FEEDING BEHAVIOR; HYPERKINESIS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOTOR ACTIVITY; MUSCLE FIBERS; MUSCLE, SKELETAL; RECEPTOR, SEROTONIN, 5-HT2C; RECEPTORS, SEROTONIN; X CHROMOSOME;

EID: 0037315191     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.52.2.315     Document Type: Article

References (20)

1. Kennett GA, Curzon G: Potencies of antagonists indicate that 5-HT1c receptors mediate 1-3(chlorophenyl) piperazine-induced hypophagia. Br J Pharmacol 103:2016-2020, 1991
2. Tecott LH, Sun LM, Akana SF, Strack AM, Lowenstein DH, Dallman MF, Julius D: Eating disorder and epilepsy in mice lacking 5HT2C serotonin receptors. Nature 374:542-546, 1995
3. Curzon G, Gibson EL, Oluyomi AQ: Appetite suppression by commonly used drugs depends on 5-HT receptors but not on 5-HT availability. Trends Pharmacol Sci 18:21-25, 1997
4. Halford JC, Blundell JE: Separate systems for serotonin and leptin in appetite control. Ann Med 32:222-232, 2000
5. Julius D, MacDermott AB, Axel R, Jessell TM: Molecular characterization of a functional cDNA encoding the serotonin 1c receptor. Science 241:558-564, 1988
6. Wright DE, Seroogy KB, Lundgren KH, Davis BM, Jennes L: Comparative localization of serotoninlA, 1C, and 2 receptor subtype mRNAs in rat brain. J Comp Neurol 351:357-373, 1995
7. Nonogaki K, Strack A, Dallman M, Tecott LH: Leptin-insensitive hyperphagia and type 2 diabetes in mice with a mutated serotonin 5-HT2C receptor gene. Nat Med 4:1152-1156, 1998
8. Vickers SP, Clifton PG, Dourish CT, Tecott LH: Reduced satiating effect of d-fenfluramine in serotonin 5-HT2C receptor mutant mice. Psychopharm 143:309-314, 1999
9. Heisler L, Chu HM, Brennan T, Danao J, Bajwa P, Parsons L, Tecott LH: Elevated anxiety and antidepressant-like responses in serotonin 5-HT1A receptor mutant mice. Proc Natl Acad Sci U S A 95:15049-15054, 1998
10. Heusner AA: Body size and energy metabolism. Ann Rev Nutr 5:267-293, 1985
11. Wigston DJ, English AW: Fiber-type proportions in mammalian soleus muscle during postnatal development. J Neurobiol 23:61-70, 1992
12. Hill JO, Saris WHM: Energy expenditure in physical activity. In Handbook of Obesity. Bray GA, Bouchard C, James WPT, Eds. New York, M. Dekker, 1998, p. 457-474
13. Baker EJ, Gleeson TT: The effects of intensity on the energetics of brief locomotor activity. J Exp Biol 202:3081-3087, 1999
14. Levine JA, Eberhardt NL, Jensen MD: Role of nonexercise activity thermogenesis in resistance to fat gain in humans [see comments]. Science 283:212-214, 1999
15. Kotz CM, Billington CJ, Levine AS: Obesity and aging. Clin Geriatr Med 15:391-412, 1999
16. Borsheim E, Knardahl S, Høstmark AT, Bahr R: Adrenergic control of post-exercise metabolism. Acta Physiologica Scandinavica 162:313-323, 1998
17. Minokoshi Y, Kim YB, Peroni OD, Fryer LGD, Muller C, Carling D, Kahn BB: Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature 415:339-343, 2002
18. Dulloo AG, Stock MJ, Solinas G, Boss O, Montani JP, Seydoux J: Leptin directly stimulates thermogenesis in skeletal muscle. FEBS Lett 515:109-113, 2002
19. Flegal KM: Trends in body weight and overweight in the U.S. population. Nutr Rev 54:S97-100, 1996
20. Seidell JC, Flegal KM: Assessing obesity: classification and epidemiology. Br Med Bull 53:238-252, 1997